Clinical trials: Illness, Critical
Hypovolemia
Plasma-Lyte 148® versUs Saline Study
The aim of PLUS is to conduct a multi-centre, blinded, randomised, controlled trial (RCT) to determine whether fluid resuscitation and therapy with a "balanced" crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality…
- Trial name
- PLUS (NCT02721654)
- Testing
- Plasma-Lyte 148®, 0.9% sodium chloride
- Where
- 51 sites in Australia, New Zealand
- Volunteers
- 5,037 people
- Sponsor
- The George Institute
Gastroesophageal Reflux Disease, Critically Ill
Gastroesophageal Reflux Disease (GERD) Among ICU Survivors
Gastro-esophageal reflux disease (GERD) is a condition characterized by reflux of stomach contents causing troublesome symptoms and complications.
- Trial name
- NCT05193266
- Where
- India
- Volunteers
- 116 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Critical Illness, Acute Respiratory Distress Syndrome
TelePORT Pilot Study
Although more than 50% of survivors of critical illness experience one or more post-intensive care syndrome (PICS) problems, there are still no validated interventions for the management of PICS.
- Conditions
- Critical Illness, Acute Respiratory Distress Syndrome, Septic Shock
- Trial name
- TelePORT (NCT03926533)
- Testing
- Telehealth
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Vanderbilt University
Emergency Medical Services, Critical Illness
Development of an AI-based Emergency Imaging Multi-Disease Rapid Joint Screening System
Introduction: Early and rapid diagnosis of etiology is often an important part of saving the lives of patients in emergency department.
- Conditions
- Emergency Medical Services, Critical Illness, Emergency Service, Hospital, Machine Learning
- Trial name
- Al-MDS (NCT05974163)
- Testing
- radiomic of CT
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Critical Illness
Evaluate the Relevance of the Use of Peripheral Venous Blood Gases for the Care of Patients in the S.A.U.V (Vital Emergency Rooms) of the CHU de Caen
concordance between the lactate values on peripheral venous and arterial blood gases in all patients receiving an arterial sample on their arrival in the S.A.U.V.
- Trial name
- GDS (NCT05971615)
- Testing
- peripheral venous blood gases
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
COVID-19, Delirium
HD-Tdcs and Pharmacological Intervention For Delirium In Critical Patients With COVID-19
The goal of this clinical trial Is conducted to evaluate the efficacy and safety of active or sham HD-tDCS in combination with dexmedetomidine in patients with moderate to severe ARDS due to COVID-19 with delirium in intensive…
- Conditions
- COVID-19, Delirium, Critical Illness
- Trial name
- COVID-19 (NCT05963958)
- Testing
- Active HD-tDCS
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Suellen Andrade
Early Mobilization, Critically Ill
Effect of Early Extracorporeal Diaphragm Pacing Combined With Tilt Table in Ventilated Patients.
The aim of this study is to test the effect of 1week of extracorporeal diaphragm pacing (EDP) combined either with or without tilt table verticalization (TTV) on diaphragm function in patients with mechanical ventilation compared…
- Conditions
- Early Mobilization, Critically Ill, Mechanical Ventilation, Diaphragm Dysfunction
- Trial name
- NCT05953649
- Testing
- Extracorporeal Diaphragm Pacing, Tilt Table Verticalization, Conventional Physiotherapy
- Volunteers
- 90 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sepsis, Critical Illness
Assessment of the Anti-inflammatory Effect of Heparin Infusion Versus Subcutaneous Injection in Septic Patients
Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep venous thrombosis (DVT), is a common and severe complication of critical illness.
- Trial name
- NCT04313790
- Testing
- Heparin Infusion, subcutaneous heparin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Damanhour University
Candida Sepsis, Candidiasis, Invasive
Early Identification of Candida in Intra-abdominal Candidiasis
Intra-abdominal candidiasis remains the first origin of invasive candidiasis in critically ill patients with a mortality up to 60%. This high mortality is partly related to delay of anti-fungal treatment administration.
- Conditions
- Candida Sepsis, Candidiasis, Invasive, Peritonitis Infectious, Critically Ill
- Trial name
- ICCA (NCT05264571)
- Testing
- calscreener, Metabolic profile, optical microscopy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Critical Illness, Social Isolation
Reducing Isolation and Feeling of Loneliness During Critical Illness
The trial is a pilot-randomized trial testing feasibility and limited-efficacy of delivering social engagement using technologic strategies to reduce periods of social isolation.
- Conditions
- Critical Illness, Social Isolation, Anxiety, Depression
- Trial name
- SOCIAL (NCT05537311)
- Testing
- Social Engagement
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Kirby Mayer
Critical Illness
Peripheral Oxygen Saturation (SpO2) Directed Oxygen Therapy
Investigators hypothesized that a relative low SpO2 directed oxygen therapy would reduced the mortality in patients staying longer than 72 hours in ICUs.
- Trial name
- POSDOT (NCT02999932)
- Testing
- SpO2 directed oxygen therapy
- Where
- 13 sites in China
- Volunteers
- 1,706 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Kidney Injury
Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults
The goal of this RCT is to compare the effectiveness of aminophylline and furosemide combination vs furosemide alone in producing effective diuresis in critically ill adults in ICU.
- Trial name
- NCT05933642
- Testing
- Aminophylline, Frusemide
- Where
- Malaysia
- Volunteers
- 132 people
- Sponsor
- University of Malaya
Intubation, Intratracheal, Critical Illness
Post-extubation Assessment of Laryngeal Symptoms and Severity
The goal of this study is to learn more about voice and airway problems that patients experience during and after the time patients have an oral endotracheal tube in patients' airway to help patients breathe while receiving…
- Conditions
- Intubation, Intratracheal, Critical Illness, Mechanical Ventilation Complication, Complication of Ventilation Therapy
- Trial name
- PALSS (NCT03726086)
- Testing
- laryngoscopy
- Where
- United States
- Volunteers
- 365 people
- Sponsor
- Johns Hopkins University
Critical Illness
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
The purpose of this study is to evaluate the efficacy and safety of fospropofol disodium for injection compared to propofol for deep sedation in mechanically ventilated ICU patients.
- Trial name
- NCT05870514
- Testing
- Fospropofol disodium for injection, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaobo Yang, MD
Critically Ill
Evaluation of the Perception of Quality of Care of Patients Admitted to a Medical-Surgical ICU
The objective of this prospective observational cohort study is to describe the perception of quality of care of patients or reference companions admitted to a medical-surgical ICU.
- Trial name
- NCT05931809
- Testing
- Serqual tool
- Volunteers
- 200 people
- Sponsor
- Hospital Sao Domingos
Critical Illness, Therapeutic Drug Monitoring
Anti-Xa Level With Thromboprophylactic Dosage Nadroparin in Critically Ill COVID-19 and Non-COVID-19 Patients
Primary objective The objective of this study is to compare anti-Xa levels obtained with a standard high dose thrombosis prophylaxis in COVID-19 intensive care-patients compared with anti-Xa levels obtained with a normal dose…
- Conditions
- Critical Illness, Therapeutic Drug Monitoring, Venous Thromboembolism
- Trial name
- NADRO (NCT05926518)
- Testing
- blood sampling
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Rijnstate Hospital
Burns, Critical Illness
Indirect Calorimetry in Patients at Risk of Malnutrition
Burn patients treated in an outpatient clinic and ICU survivors are at risk of malnutrition. There are no clear guidelines determining the energy target in those two populations.
- Conditions
- Burns, Critical Illness, Indirect Calorimetry, Resting Energy Expenditure
- Trial name
- NCT04500483
- Testing
- indirect calorimetry
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University of Liege
Critical Illness, Cognition Disorder
Cognitive Exercises in Survivors of a Prolonged ICU Stay.
This study concerns patients who survived intensive care, after a minimum stay of 7 days and presenting cognitive disorders (with a score ≤ 26 on the MoCA test) during the post-intensive care follow-up consultation one month…
- Trial name
- NCT05111275
- Testing
- Cognitive exercises
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- University of Liege
Intubation; Difficult or Failed, Educational Problems
Difficult Airway Simulation-based Training
Difficult airways remain a significant problem in anaesthesia, intensive care and emergency medicine. Simulation-based training gives better outcomes compared to non-simulation and non-intervention education.
- Conditions
- Intubation; Difficult or Failed, Educational Problems, Critical Illness
- Trial name
- NCT05913492
- Testing
- Simulation training
- Where
- Ukraine
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Bogomolets National Medical University