Clinical trials: Illness, Critical
Pancreatitis
Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube
The purpose of this study is to assess the effect of erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube.
- Trial name
- NCT00999232
- Testing
- Erythromycin
- Sponsor
- Canisius-Wilhelmina Hospital
Critical Illness, Muscle Loss
Investigating the Anabolic Response to Resistance Exercise After Critical Illness (ARTIST-2)
ICU survivors often suffer from long-term functional disability. An attenuated response to physical exercise in skeletal muscle after critical illness may contribute to persisting weakness.
- Trial name
- ARTIST-2 (NCT05261984)
- Testing
- Resistance exercise, Oral protein supplementation
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Critical Illness, COVID-19
Neurocognitive Impairment in Patients With COVID-19
Delirium and acute neurocognitive impairment are increasingly observed in adult and pediatric patients with COVID-19. Prospective clinical studies combining clinical and laboratory examinations including specific biomarkers of…
- Conditions
- Critical Illness, COVID-19, Central Nervous System Injury, Delirium
- Trial name
- NCoV (NCT04359914)
- Where
- Germany
- Volunteers
- 118 people
- Sponsor
- University of Rostock
Sarcopenia, Cancer
CT-Determined Sarcopenia and Mortality in Critically Ill Cancer Patients
The goal of this observational study is to evaluate the association between computed tomography-determined sarcopenia and muscle quality impairment with 28-day mortality in adult patients (aged 18 and older) with solid or…
- Conditions
- Sarcopenia, Cancer, Critical Illness, Malnutrition
- Trial name
- NCT07761481
- Testing
- Computed Tomography Muscle Assessment (HUAC)
- Where
- Mexico
- Volunteers
- 23 people
- Sponsor
- Hospital H+ Queretaro
Sepsis, Septic Shock
Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients
Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Respiratory Acidosis
- Trial name
- ENTERPRISE (NCT03966664)
- Testing
- In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in isolated plasma., In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in whole blood, Biomolecular analysis of plasma proteins.
- Where
- 2 sites in Czechia, Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Aortic Diseases, Intensive Care Unit Syndrome
Muscle Recovery Following Aortic Surgery Induced ICUAW.
To identify determinants of 'good and bad recovery' from ICUAW and build knowledge around the timing of these processes. Also, the investigators want to discover the effects of ICUAW on physical function and HRQoL following…
- Conditions
- Aortic Diseases, Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy
- Trial name
- VARIANCE (NCT03714399)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Barts & The London NHS Trust
Critical Illness
Quadriceps Muscle Activation and Oxygenation Responses During Usual Care Compared to Individualized Interval and Constant Work Rate Bed-cycling. An Experimental Study.
### Study Summary - AcuteBike-ICU Bed-cycling is commonly used as part of early rehabilitation in critically ill patients in the intensive care unit (ICU).
- Trial name
- AcuteBike-ICU (NCT07882719)
- Testing
- usual care constant work rate bedcycling, Individualized constant work rate bedcycling, Individualized interval bedcycling
- Volunteers
- 29 people
- Sponsor
- KU Leuven
Critical Illness, Sepsis
Dapagliflozin in Patients With Critical Illness
To assess the effects of dapagliflozin on a composite hierarchical endpoint in critically ill patients.
- Trial name
- DEFENDER (NCT05558098)
- Testing
- Dapagliflozin 10mg Tab, Standard of Care
- Where
- 23 sites in Brazil
- Volunteers
- 507 people
- Sponsor
- Hospital Israelita Albert Einstein
Shock, Pulmonary Congestion
Cardiometry in Hypotensive and Pumonary Congestion
Assessment of validity of electrical cardiometry (EC) to measure fluid responsiveness and extravascular lung water that is expressed in the form of (thoracic fluid content) .
- Trial name
- NCT06730087
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Cancer
Application of Artificial Intelligence and Iron Metabolism Markers in Predicting ICU Outcomes for Critically Ill Cancer Patients
This study aimed to develop a more accurate way to predict the 30-day survival of cancer patients admitted to the intensive care unit (ICU).
- Trial name
- NCT07408661
- Volunteers
- 1,137 people
- Sponsor
- Tongji University
Critical Illness, Terminal Illness
Prevalence of Potentially Inappropriate Treatments
A multicenter point prevalence study in Turkish intensive care units.
- Conditions
- Critical Illness, Terminal Illness, Potentially Inappropriate Medication List
- Trial name
- INAPPT-ICU (NCT03520270)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,128 people
- Sponsor
- Istanbul University
Acute Pulmonary Embolism (PE)
Prognostic Factors for Acute Pulmonary Embolism in Critically Ill Patients
Acute pulmonary embolism (PE) is an important cause of in-hospital mortality and may be rapidly fatal if not diagnosed and treated.
- Trial name
- NCT01839266
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Infectious Diseases
Safety and Efficacy Study of High Dose Colistin
Colistin is a rapidly acting bactericidal antimicrobial agent that possesses a post antibiotic effect against MDRO Gram-negative bacteria, such as as Pseudomonas aeruginosa, Acinetobacterbaumannii, and Klebsiella pneumonia.
- Trial name
- NCT02162966
- Testing
- High Dose Colistin, Standard Dose Colistin
- Where
- Saudi Arabia
- Volunteers
- 330 people
- Sponsor
- King Saud Medical City
COVID-19
Low Dose Whole Lung Radiation Therapy for Patients With COVID-19 and Respiratory Compromise
Low doses of radiation in the form of chest X-rays have been used to treat people with pneumonia. This treatment was found to be effective by reducing inflammation and with minimal side effects.
- Trial name
- VENTED (NCT04427566)
- Testing
- Radiation therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Ohio State University
Critical Illness, Hyperoxia
Safe Limits in Saturation (SLIM-study)
A study consisting of a prospective and retrospective cohort in the ICU, ER and pulmonary department in a university hospital in Amsterdam and a teaching hospital in Alkmaar, the Netherlands.
- Conditions
- Critical Illness, Hyperoxia, Hypoxia
- Trial name
- SLIM (NCT02666937)
- Where
- Netherlands
- Volunteers
- 879 people
- Sponsor
- Amsterdam UMC, location VUmc
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Transbronchial Lung Cryobiopsy in Undiagnosed Acute Respiratory Failure
In patients with acute hypoxemic respiratory failure whose diagnosis is not established after initial evaluation, obtaining a histopathological diagnosis may improve the patients' prognosis.
- Trial name
- NCT05754866
- Testing
- Transbronchial lung cryobiopsy, Transbronchial lung biopsy
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Critical Illness, Enteral Nutrition
Trial of Enteral Glutamine on Clinical Outcomes in Critically Ill Patients
Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients, possibly in part through an attenuation of the proinflammatory cytokine response and a Immune function.
- Conditions
- Critical Illness, Enteral Nutrition, Multiple Organ Failure, Infection Complication
- Trial name
- NCT02998931
- Testing
- Glutamin, Maltodextrin
- Where
- 2 sites in Iran
- Volunteers
- 200 people
- Sponsor
- Shahid Beheshti University
Renal Angina, Acute Kidney Injury
Study of the Prediction of Acute Kidney Injury in Children Using Risk Stratification and Biomarkers
Acute kidney injury (AKI) is a common clinical event with severe consequences. In the pediatric intensive care unit (PICU), AKI occurs in almost 10% of all patients and evidence suggests that children are dying not just with AKI…
- Trial name
- AKI-CHERUB (NCT01735162)
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Critical Care, Intensive Care, Critical Illness
Dosage of Early Rehabilitation of ICU Patients
Rehabilitation already begins in the intensive care unit (ICU) to maintain or restore the functional capacity of ICU patients and to counteract the long-term effects of intensive care treatment.
- Conditions
- Critical Care, Intensive Care, Critical Illness, Physiotherapy, Early Ambulation
- Trial name
- ERUPT (NCT06960642)
- Where
- Austria
- Volunteers
- 6,000 people
- Sponsor
- Medical University of Vienna
Bacterial Colonization, Multidrug Resistant Organisms
Enteral Nutrition and Colonization Resistance Through Microbiota Modulation in Critically Ill Patients
The goal of this clinical trial is to learn whether enteral nutrition enriched with fiber can influence gut microbiota and improve resistance to colonization with multidrug-resistant bacteria in critically ill patients.
- Conditions
- Bacterial Colonization, Multidrug Resistant Organisms, Critical Illness, Gut Microbiota Dysbiosis
- Trial name
- MICRON (NCT07719673)
- Testing
- Fibre-Enriched Enteral Nutrition, Standard Enteral Nutrition
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
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