Clinical trials: Illness, Critical
Pulmonary Perfusion, Ventilation-Perfusion Ratio
Non-apnea Electrical Impedance Tomography for Bedside Ventilation-Perfusion Assessment: a Prospective Cross-over Validation Study
Title: Validating the Accuracy of Lung Blood Flow Monitoring Without Breath-Holding Under Spontaneous Breathing Support Purpose: The purpose of this study is to evaluate the accuracy of a new Electrical Impedance Tomography (EIT)…
- Conditions
- Pulmonary Perfusion, Ventilation-Perfusion Ratio, Respiratory Insufficiency, Critical Illness
- Trial name
- NELSB (NCT07489950)
- Testing
- Saline-contrast EIT with a non-apnea algorithm
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ruijin Hospital
Mitochondrial Oxygenation Measurement, Measurement Error
Mitochondrial Oxygen Measurement Variability in Critically Ill Patients (INOX Variability Study)
To determine the between- and within-subject variability of the mitochondrial oxygenation measurement with the COMET device over time in healthy subjects and in hemodynamically stable subjects admitted to the intensive care unit.
- Conditions
- Mitochondrial Oxygenation Measurement, Measurement Error, Healthy
- Trial name
- NCT04626661
- Testing
- COMET measurement system
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Critical Illness, Muscle Loss
Investigating the Anabolic Response to Resistance Exercise During Critical Illness
ICU patients often suffer from rapid and severe muscle loss. It is not known if physical therapy can mitigate the muscle wasting associated with critical illness.
- Trial name
- ARTIST-1 (NCT05197231)
- Testing
- Resisted knee extension exercise, IV amino acids
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska University Hospital
Shock, Septic, Sepsis
Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock.
In patients with septic shock, low levels of circulating immunoglobulins are common and they are kinetic, particularly of immunoglobulin M (IgM), seems to be related with clinical outcome.
- Conditions
- Shock, Septic, Sepsis, Hypoglobulinemia
- Trial name
- IgM-FAT (NCT04182737)
- Testing
- IgM-enriched polyclonal immunoglobulins titer-based treatment, IgM-enriched polyclonal immunoglobulins Flat treatment
- Where
- Italy
- Volunteers
- 356 people
- Sponsor
- Massimo Girardis
COVID-19, Virus; Pneumonia
PEEP Incremental and Decremental Alveolar Recruitment of Critically Ill Corona Virus Disease-19 (COVID-19) Patients
COVID-19 originated from Severe Acut Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection leads to critical condition due to hypoxemic respiratory failure with the background of viral pneumonia.
- Conditions
- COVID-19, Virus; Pneumonia, Atelectasis
- Trial name
- NCT04360837
- Testing
- alveolar recruitment
- Where
- Hungary
- Volunteers
- 2 people
- Sponsor
- Szeged University
Critical Illness
Music Listening: A Mechanistic Trial
A randomized within-subject crossover trial to compare the effects of live and recorded music listening on biomarkers of stress and pain among children receiving mechanical ventilation in the pediatric intensive care unit.
- Trial name
- NCT05541029
- Testing
- Live music, Recorded music, Usual care
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- University of Pittsburgh
Critical Illness
Continuous Glucose Monitoring With a Subcutaneous Sensor During Critical Illness and Surgery
We hypothesize that measurements of interstitial fluid (ISF) glucose by the FreeStyle Navigator (Abbot Diabetes Care), a continuous glucose monitoring system, will correlate with blood glucose (BG) values in surgical and ICU…
- Trial name
- NCT00694473
- Testing
- Freestyle Navigator
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Massachusetts General Hospital
Delirium, Trauma
Early Delirium Prediction Via Serial EEG Trajectories and Machine Learning
The goal of this observational study is to develop a machine learning model that can predict delirium in trauma patients before it clinically appears.
- Conditions
- Delirium, Trauma, Brain Dysfunction, Critical Illness
- Trial name
- NCT07536854
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Ajou University School of Medicine
Critical Illness Myopathy, Guillain Barré Syndrome
High-Tech Rehabilitation Pathway for Acute Adult Neuromuscular Diseases - Fit4MedRob-Acute MND Project
The goal of this study is determine if a high-tech rehabilitation circuit is more effective than usual rehabilitation methods in improving functional outcome, particularly balance control, for patients with acute neuromuscolar…
- Conditions
- Critical Illness Myopathy, Guillain Barré Syndrome, Critical Illness Polyneuromyopathy (CIPNM)
- Trial name
- Fit4MR-AcMND (NCT06822231)
- Testing
- High-tech rehabilitative treatment, Rehabilitation
- Where
- 8 sites in Italy
- Volunteers
- 124 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Critical Illness
Hemodynamic Variations During Remote Ischemic Conditioning in Critical Ill Patients
The main objectives of this study are to evaluate the changes in hemodynamics occurring during the remote ischemic conditioning (RIC) procedure and to compare the hemodynamic responses elicited by passive leg raising before and…
- Trial name
- HERICA (NCT06536231)
- Testing
- Remote ischemic conditioning
- Where
- Lithuania
- Volunteers
- 50 people
- Sponsor
- Lithuanian University of Health Sciences
Sepsis, Relative Adrenal Insufficiency
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis
The purpose of this pilot study is to (1) examine the changes in gene expression in patients who suffer from severe sepsis and whose shock (inadequate oxygen delivery to vital organs) state does not respond to fluid and…
- Trial name
- NCT00185783
- Testing
- Hydrocortisone Administration (Standard of Care Therapy)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Critically Ill
New Stable Isotope Method to Determine Protein Requirements in Critically Ill Children
The need for certain components of food (i.e. protein) for critically ill children is not clear. It is important to have critically ill children fed adequately to prevent that their condition becomes worse or that recovery takes…
- Trial name
- NCT01511354
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Texas A&M University
Acute Kidney Injury (Nontraumatic)
Exploring the Relationship Among BNP, Fluid Status and Acute Kidney Injury in Critically Ill Patients
B-type natriuretic peptide (BNP) is rapidly released by the ventricles of the heart in response to myocardial stretch. This cardiac neurohormone is mostly elevated in patients with fluid overload or myocardium dysfunction.
- Trial name
- NCT02095275
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Stress Disorders, Post-Traumatic, Anxiety
Anxiety and Depression in Relatives of Critically Ill Patients: Spouses Versus Other Close Relatives
The main objective of this study is to compare the rate of reported anxiety / depression (HADS >= 8) among spouses and other family members in ICU patients.
- Conditions
- Stress Disorders, Post-Traumatic, Anxiety, Depression
- Trial name
- StressRéa (NCT01589575)
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Extubation Failure, Mechanical Ventilation
Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients
Extubation failure, defined as the need for reintubation after planned removal of the endotracheal tube, occurs in up to 20% of critically ill patients and is associated with prolonged mechanical ventilation, longer intensive…
- Conditions
- Extubation Failure, Mechanical Ventilation, Critical Illness
- Trial name
- APEX (NCT07659275)
- Where
- Brazil
- Volunteers
- 800 people
- Sponsor
- Universidade Federal de Pernambuco
Hypernatremia, Critical Illness
Prospective Analysis Into Development of Hypernatremia in Critically Ill Patients
Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay.
- Trial name
- HYPNIC II (NCT05085223)
- Testing
- Daily urine collection for biochemical analysis, Subanalysis for comparison of 24hour urine collection versus spot-check measurements
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
ICU-acquired Weakness, Mechanical Ventilation
eCASH and Early Goal-Directed Mobilization to Prevent ICU-Acquired Weakness
This single-center, prospective, randomized controlled trial aims to evaluate whether an eCASH concept-based analgesia and sedation strategy combined with early goal-directed mobilization can reduce the incidence of intensive…
- Conditions
- ICU-acquired Weakness, Mechanical Ventilation, Critical Illness
- Trial name
- eCASH-EGDM (NCT07677488)
- Testing
- eCASH-Based Analgesia and Sedation Strategy Combined With Early Goal-Directed Mobilization, Routine ICU Nursing Care
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Critical Illness
Study on the Measurement Method of the Left Diaphragm
This study intends to use ultrasound to measure the bilateral diaphragmatic ultrasound indicators in critically ill patients, focusing on the left diaphragm, and to explore the consistency and reliability among various ultrasound…
- Trial name
- LD (NCT07559669)
- Volunteers
- 35 people
- Sponsor
- Shanghai Zhongshan Hospital
Aspergillosis; Pulmonary, Invasive (Etiology)
Posaconazole for the Prevention of Influenza-associated Aspergillosis in Critically Ill Patients
The objective of this study is to deliver proof of concept that antifungal prophylaxis can reduce the incidence of Influenza Associated Aspergillosis (IAA) in ICU (intensive care unit) patients with severe influenza.
- Trial name
- POSA-FLU (NCT03378479)
- Testing
- SOC +Posaconazole 18 MG/ML (milligram/milliliter), standard of care (SOC)
- Where
- 12 sites in Belgium, France and 1 more
- Volunteers
- 88 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Critical Illness
Neuroendocrine Dysfunction in Critically Ill Pediatric Patients
Research studies in adults have shown that certain hormones may be decreased or may not work normally which contributes to how sick a person becomes. The purpose of this project is to study hormones in children.
- Trial name
- NCT00207896
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Children's Healthcare of Atlanta
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