Clinical trials: Illness, Critical
Cardiac Output
Non-invasive Cardiac Output Monitoring (esCCO™) in Critically Ill Patients Within ICU
Evaluation of a non-invasive technique to measure cardiac output (esCCO™) with the "clinical goldstandard" of the transcardiopulmonal thermodilution technique (PiCCO®).
- Trial name
- NCT02682615
- Where
- Germany
- Sponsor
- University Hospital Schleswig-Holstein
Critically Ill Patients
Impact of Interventions on Admission SOFA Score on Clinical Outcomes of Critically Ill Patients
Introduction: The SOFA score (Sequential Organ Function Assessment) and its derived measures, such as the Delta SOFA, are used worldwide to determine the severity and prognosis of critically ill patients.
- Trial name
- NCT05790915
- Testing
- Standardized interventions
- Where
- Brazil
- Volunteers
- 849 people
- Sponsor
- Hospital Sao Domingos
Pulse Oximetry, Disparities
Beyond Race: Objectively Assessed Skin Color and Its Association With Pulse Oximeter Bias in Critically Ill Infants
The overall objective of this proposal is to quantify the bias in pulse oximeter reported oxygen saturation (SpO2) by evaluating its measures compared to the gold standard blood gas measured arterial oxygen saturation (SaO2)…
- Conditions
- Pulse Oximetry, Disparities, Infants
- Trial name
- NCT05994417
- Volunteers
- 200 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Critical Care, Intensive Care, Critical Illness
Validation of the Turkish RDOS Using End-Tidal Carbon Dioxide
Dyspnea is a complex and distressing symptom frequently observed in critically ill patients and is associated with increased morbidity, mortality, and prolonged intensive care unit (ICU) stay.
- Trial name
- NCT07383389
- Volunteers
- 64 people
- Sponsor
- Istinye University
Food Intake, Critically Ill Patients
Optimization of Oral Diet in Critically Ill Patients
The purpose of the present study is to evaluate the effects of a personalized oral diet in the critically ill patients during ICU stay and after as compared usual oral diet.
- Conditions
- Food Intake, Critically Ill Patients, Nutrition
- Trial name
- NAP-REA (NCT03354260)
- Testing
- Personalized adapted oral diet and nutritional education
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Hemodynamics, Blood Pressure Monitoring
Non-Invasive Blood Pressure Monitoring in ICU Patients Using the DARE Device
This study tests a new non-invasive device called DARE to monitor blood pressure in patients in intensive care. It compares the device's readings to standard invasive methods and also looks at how well it measures other vital…
- Conditions
- Hemodynamics, Blood Pressure Monitoring, Intensive Care Units, Critical Illness
- Trial name
- NCT07052123
- Testing
- MultiSense® Non-Invasive Hemodynamic Monitoring Device
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Kidney Failure, Acute, Critical Illness
Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated.
- Trial name
- NCT00316576
- Testing
- Blood sampling for PCR
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Caen
Critical Illness
Air Suspension Biodegradable Patient Transport Pad
On the one hand, transferring patient from bed to bed is usually handling by the manual lifting of several staffs or utilizing bedsheet, slide sheet , shovel-style stretcher or other devices to move and lift patients.
- Trial name
- NCT03858374
- Testing
- transferred by air-suspending mattress, transferred by slide board, transferred by bedsheet
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Critically Ill Patients, Hemodynamic Instability
Sigh35 and End-expiratory Occlusion Test (EEOT) for Assessing flUid Responsiveness in Critically Ill Patients Undergoing Pressure Support Ventilation
The application of a brief SIGH of 4 seconds at 35 cmH20 has shown to reliably predict fluid responsiveness in critically ill patients undergoing pressure support ventilation.
- Conditions
- Critically Ill Patients, Hemodynamic Instability, Mechanical Ventilation Pressure High
- Trial name
- SETUP (NCT04924920)
- Testing
- SIGH, EEOT, Fluid challenge
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Humanitas Clinical and Research Center
Critically Ill
A Trial to Assess the Effect of High Nitrogen Intake in Critically Ill Patients
The patients with sepsis are in high risk of malnutrition, which could contribute to infection, difficulty in weaning from ventilators.
- Trial name
- NCT02106624
- Testing
- nitrogen supply
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Shanghai Zhongshan Hospital
Intensive Care Unit, Mortality
Capillary Refill Time Calculated With a Video-assisted Method Has a Better Reproducibility Than Visual Method in Critically Ill Patients
Capillary refill time is the time it takes for the skin to regain its initial colour after moderate pressure. It is usually performed on the patient index finger, middle finger or ring finger with the examiner's thumb and index…
- Conditions
- Intensive Care Unit, Mortality, Reliability
- Trial name
- EVITREC (NCT05573659)
- Testing
- time of cutaneous recoloration, video assisted cutaneous recoloration
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Trauma Injury, Sepsis
Pathological Myeloid Activation After Sepsis and Trauma
The goal of this observational study is to better understand what happens to circulating blood after a patient experiences severe trauma injury.
- Conditions
- Trauma Injury, Sepsis, Immunosuppression, Chronic Critical Illness
- Trial name
- NCT05616130
- Testing
- Data Collection, Bone marrow collection and blood collection, Serial interviews to complete surveys and questionnaires
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of Florida
Gastrointestinal Injury
Biomarkers and Bowel Sounds in Patients With Acute Gastrointestinal Injury
The incidence of gastrointestinal diseases is high in intensive care unit (intensive care unit,ICU). In critically ill patients, the intestinal tract is the "engine" of multiple organ dysfunction syndrome (Multiple organ…
- Trial name
- BABSIPWAGI (NCT04769830)
- Testing
- Bowel sound
- Where
- China
- Volunteers
- 172 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Critical Illness
Nutrient Uptake During Continuous Enteral Feeding
Continuous enteral nutrition is used to feed patients in intensive care who are unable to eat normally. The goal of this observational study is to learn about the uptake of nutrients from feeding formula.
- Trial name
- NCT05628844
- Testing
- Continuous enteral feeding
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Felix Liebau
Critical Illness
Lactoferrin Use in ICU Patients
Introduction: Lactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.
- Trial name
- RCT (NCT05936528)
- Testing
- Lactoferrin, Antioxidant therapies, Dexamethasone
- Where
- Egypt
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Psychotic Disorders
Critical Time Intervention in the Transition From Hospital to Community in People With Severe Mental Illness
This study will evaluate the effectiveness of a psychosocial treatment, Critical Time Intervention, in easing the transition from hospital to community in people with severe mental disorders.
- Trial name
- NCT00621465
- Testing
- Critical Time Intervention (CTI), Usual care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York State Psychiatric Institute
Delirium, Critical Illness
Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery
"Postoperative delirium is a common and serious complication following cardiac surgery, particularly among older adults who require intensive care.
- Conditions
- Delirium, Critical Illness, Aged, Cardiopulmonary Bypass
- Trial name
- NCT07265128
- Testing
- Midazolam, Remimazolam
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Volume Overload, Tissue Perfusion
Non-Invasive Cardiometry and Ultrasound Guided Inferior Vena Cava Collapsibility Index in Assessing Fluid Responsiveness
43 patients between 18-60 years presenting with criteria of sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection, suspected or documented infection and an acute increase ≥2 SOFA…
- Trial name
- NCT05104528
- Testing
- OSYPKA Medical ICONTM Noninvasive CardiometerTM Model C3, Fujifilm Sonosite M-Turbo C Ultrasound system
- Where
- Egypt
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Critical Illness, Heart Failure
Effects of Negative Pressure Ventilation Onto Hemodynamics and Right Ventricular Funktion in Patients After Implantation of a Left Ventricular Assist Device.
All patients undergoing an implantation of a durable left ventricular assist device and monitored by pulmonary artery catheter showing no adverse events after surgery are included in the study and ventilated for 15 minutes using…
- Conditions
- Critical Illness, Heart Failure, LVAD
- Trial name
- NPV LVAD (NCT07034599)
- Testing
- Negative pressure ventilation, positive pressure ventilation
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Karlsburg Hospital
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
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