Clinical trials: Imaging
Cystic Fibrosis, Asthma
Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
Aim of this study is to evaluate image quality and reproducibility of Xenon-129 and Inert fluorinated (19F) gas Magnetic Resonance Imaging (MRI) and to evaluate changes in lung structure and function in participants with cystic…
- Trial name
- NCT02740868
- Testing
- Xenon-129 and Perfluoropropane (19F), Magnetic Resonance Imaging, Lung Clearance Index
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Prostatic Neoplasms, Prostate Cancer
Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor
Background: The current standard treatment of prostate cancer is either surgery or radiation. Typically, this includes either the removal or radiation of the whole prostate gland.
- Conditions
- Prostatic Neoplasms, Prostate Cancer, Prostate Adenocarcinoma
- Trial name
- NCT05616650
- Testing
- 18F-DCFPyL, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute (NCI)
The GLP-1-mediated Gut-kidney Axis
Acute Effects of GLP-1 on Renal Hemodynamics
This study investigates the hypothesis, that GLP-1's suppression of ANG II and natriuretic action increase medullary perfusion and decrease oxygen consumption, leading to higher tissue oxygenation.
- Trial name
- GLP1RRBF (NCT04337268)
- Testing
- Glucagon-Like Peptide 1, saline 0.9%
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stroke, Ischemic, Inflammation
MR Evidence of Cardiac Inflammation Post-Stroke
The present study is an investigator initiated, single-centre, prospective, proof-of-concept cohort study aiming to enroll 44 patients with acute middle cerebral artery (MCA) ischemic stroke, involving the right (n=22) and left…
- Conditions
- Stroke, Ischemic, Inflammation, Myocardial Injury
- Trial name
- MIRACLE (NCT05714618)
- Testing
- Gadolinium-enhanced cardiac MRI, B Natriuretic Peptide, Systemic inflammatory markers
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Luciano A. Sposato
Glioblastoma Multiforme
MRI Predictors of Response to Tumor Treating Fields
Patients with glioblastoma, an aggressive brain tumor, are recommended to undergo treatment with tumor treating fields using the Optune device as part of standard of care therapy.
- Trial name
- NCT03642080
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Cognitive Decline, Alzheimer Disease
Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study
We will conduct a Tau PET scan in cognitively normal older adults, enrolled in the Aging Brain Cohort Dedicated to Diversity Study (ABCD2-Tau) study at the University of Pennsylvania's Penn Memory Center/Alzheimer's Disease Core…
- Trial name
- ABCD2-TAU (NCT05393388)
- Testing
- [18F]AV-1451
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Renal Cell Carcinoma
Imaging Correlates of Renal Cell Carcinoma Biological Features
This pilot study is designed to evaluate imaging parameters indicative of underlying tumor biology. Patients with large renal masses (>3 cm, or at the discretion of the investigator) who are planning to undergo nephrectomy will…
- Trial name
- NCT01665703
- Testing
- FDG PET/MR
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Exercise Behavior, Multiple Myeloma
Exercise Phenotyping Prior to Chemotherapy in Newly Diagnosed Multiple Myeloma (MM-Exercise)
MM-Exercise is a prospective, single-centre, observational pilot study of patients with newly diagnosed multiple myeloma who have not yet started chemotherapy and whose resting echocardiogram is unremarkable or only mildly…
- Trial name
- MM-Exercise (NCT07851493)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technical University of Munich
Multiple Sclerosis, Relapsing-Remitting
TOTEM RRMS : TestOsterone TreatmEnt on Neuroprotection and Myelin Repair in Relapsing Remitting Multiple Sclerosis
Centra nervous system (CNF) damage in multiple sclerosis (MS), are mainly attributed to myelin destruction, axonal abnormalities and subsequent degeneration, and are responsible for serious deficiencies.
- Trial name
- TOTEM-RRMS (NCT03910738)
- Testing
- Nebido® Testosterone Undecanoate 1000 Mg/4 mL Solution for Injection, MRI, Assessment of impact of MS on cognition; quality of life; fatigue; anxiety/depression and work and activities
- Where
- 5 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Localization-related Epilepsy, Partial Epilepsy
Improving Lesion Detection in Children With Magnetic Resonance Imaging (MRI)-Negative Partial Epilepsy Using Diffusion Tensor Imaging
Focal cortical dysplasia is one of the most common lesions responsible for medically refractory epilepsy in the pediatric population.
- Trial name
- NCT00894478
- Testing
- Diffusion Tensor Imaging (DTI), Magnetoencephalography
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Endocarditis, Bacterial
IMAGE-Endocarditis: Resonance Magnetic Imaging at the Acute Phase of Endocarditis
Patients with definite or possible infective endocarditis are included in this protocol, at the acute phase of the disease.
- Trial name
- IMAGE (NCT00144885)
- Testing
- Modification of therapy
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis
Efficacy and Safety of AIN457 (Secukinumab) in Patients With Relapsing Multiple Sclerosis
To evaluate the efficacy and safety of AIN457 versus placebo in patients with relapsing multiple sclerosis.
- Trial name
- NCT01874340
- Testing
- AIN457
- Where
- 13 sites in Belgium, Czechia and 8 more
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Glioblastoma, Esophageal Cancer
Serial MRI Scans During Radiation Therapy
This is a phase 1 study to determine the feasibility and utility of using serial magnetic resonance imaging (MRI) to assess treatment response during and after radiation therapy (standard of care cancer treatment) for…
- Conditions
- Glioblastoma, Esophageal Cancer, Radiotherapy, Magnetic Resonance Imaging
- Trial name
- RELAY (NCT04188535)
- Testing
- MRI IMAGING
- Where
- 2 sites in United States
- Volunteers
- 149 people
- Sponsor
- Dana-Farber Cancer Institute
Prostate Cancer, Prostate Cancer (Adenocarcinoma)
ABlative Radiotherapy (for) Unfavorable Prostate Tumors 2.0
Published clinical evidence confirms that a single dose of 24 Gy provides unprecedented long-term local control in primary and metastatic prostate cancer with safe toxicity profiles, provided that exposure of surrounding healthy…
- Conditions
- Prostate Cancer, Prostate Cancer (Adenocarcinoma), Prostate Cancer Non-Metastatic
- Trial name
- ABRUPT 2 (NCT07407608)
- Testing
- SBRT, SDRT
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- University of Milano Bicocca
Coronary Artery Disease (CAD), Stable Angina Pectoris
Identification of Lesion Characteristics in Coronary Plaques Using Multimodality Intravascular Imaging and Novel Photon-counting CT in Stable Angina
Coronary artery disease, caused by the furring up of the heart arteries by atherosclerosis, is a major cause of death in the UK.
- Conditions
- Coronary Artery Disease (CAD), Stable Angina Pectoris, Ischaemic Heart Disease (IHD)
- Trial name
- ILUMINA (NCT07864025)
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Queen Mary University of London
Cholecystitis, Cholecystitis, Chronic
Shortwave Infrared Surgical Imaging Device Study
The goal of this observational study is to perform an in-human assessment of an investigational shortwave infrared (SWIR) imaging device, aimed to enhance the visualization of critical anatomical structures during surgical…
- Conditions
- Cholecystitis, Cholecystitis, Chronic, Chronic Calculous Cholecystitis, Primary Hyperparathyroidism
- Trial name
- NCT07744425
- Testing
- Observational study of SWIR imaging device in surgery
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Cision Vision, Inc.
Sunscreen
A Study to Evaluate the Whitening Effect of Mineral Sunscreens in Multi-Cultural Skin Tones
The purpose of this study is to evaluate the whitening potential effect of different mineral sunscreens across multi-cultural skin tones through instrumentation, imaging, and self-assessment and also evaluate the relationship…
- Trial name
- NCT05565625
- Testing
- Sunscreen A, Sunscreen B, Sunscreen C
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Hepatocellular Carcinoma (HCC), Liver Cirrhosis
FAST (Focused Abbreviated Screening Technique)-MRI Study
The purpose of this study is to compare the diagnostic value of a reconstructed abbreviated Magnetic Resonance Imaging (MRI) from a full clinical exam, compared to ultrasound (US) for screening of liver cancer.
- Trial name
- NCT04539717
- Where
- 2 sites in United States
- Volunteers
- 820 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Schizophrenia, Transcranial Magnetic Stimulation
Personalized Dual-target RTMS for Patients with Refractory Schizophrenia
The goal of this clinical trial is to evaluate the efficacy of personalized dual-target rTMS for treating patients with refractory schizophrenia and to investigate its underlying neural mechanisms using functional MRI.
- Conditions
- Schizophrenia, Transcranial Magnetic Stimulation, Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- NCT06732817
- Testing
- Active rTMS was administered using a transcranial magnetic stimulator (Rapid2; MagStim).
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Anhui Medical University
Cervix Cancer
Intra-Pelvic Organ Motion for Cervix Cancer Patient Using Imaging
Patients with cervix cancer having radiotherapy experience side-effects because the radiotherapy fields have to be quite large to account for tumour movement in the pelvis during treatment, this irradiates a lot of normal…
- Trial name
- NCT00957450
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto