Clinical trials: Immediate Effect
Asthma
A Study to Evaluate the Effect of Repeat Doses of GW870086X in Mild to Moderate Asthmatics
This study will measure the effect of repeat inhaled doses of GW870086X on lung function.
- Trial name
- NCT00945932
- Testing
- GW870086X
- Where
- 8 sites in Germany
- Volunteers
- 37 people
- Sponsor
- GlaxoSmithKline
Complication, Postoperative
Preoperative High Dose Steroids for Liver Resection- Effect on Complications in the Immediate Postoperative Period
Background: Several randomized clinical trials have shown beneficial effects of pre-operative glucocorticoids on post-operative complications.
- Trial name
- STEREO (NCT03403517)
- Testing
- Methylprednisolone, Dexamethasone
- Where
- Denmark
- Volunteers
- 174 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Asthma, Aspirin-Induced, Chronic Rhinosinusitis With Nasal Polyps
Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab)
Primary objective: to investigate the efficacy of Mepolizumab 100 milligram (mg) every month compared to placebo in reducing validated Sinonasal Outcome Test -22 score and on reducing endoscopic Nasal Polyp Score.
- Trial name
- AirGOs-biol (NCT04823585)
- Testing
- Mepolizumab
- Where
- Finland
- Volunteers
- 95 people
- Sponsor
- Helsinki University Central Hospital
Immediate Dental Implant Placement, Jumping Gap
Thymoquinone Around Immediate Implant
use of Thymoquinone hydrogel with bone graft in comparison to bone graft only around immediate implant-this hydrogel fill the jumping zone in comparison to using hydrogel bone graft only to increase primary stability and enhance…
- Conditions
- Immediate Dental Implant Placement, Jumping Gap, Primary Stability of the Implants
- Trial name
- Thymoquinone (NCT07391384)
- Testing
- group 1 xenograft hydrogel, immediat implant placement wit TQ and bone graft hydrogel placement around implant
- Volunteers
- 44 people
- Sponsor
- shaimaa hamdy
Asthma; Eosinophilic, Airway Remodeling
BenRalizumab Effect on Airway Remodeling in Severe asTHma
Response to biologic therapies in severe asthma is variable, with patients being either non-responders, responders or super-responders. There is currently no explanation for this broad variation in response.
- Trial name
- BREATH (NCT06288516)
- Testing
- Benralizumab 30 mg/ml
- Where
- Greece
- Volunteers
- 36 people
- Sponsor
- Aristotle University Of Thessaloniki
Seasonal Allergic Rhinitis
Seasonal Allergic Rhinitis and Driving Ability
On-the-road driving performance of untreated seasonal allergic rhinitis patients during the allergic season (exposed) is compared to driving performance outside the allergic season (in winter, not-exposed).
- Trial name
- NCT00223587
- Testing
- 1 week of treatment discontinuation
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Utrecht Institute for Pharmaceutical Sciences
Asthma
Effect of Symbicort on GR Localisation in Asthma
To investigate a possible interaction between formoterol and budesonide on GR-translocation and to compare the effect of different doses of Symbicort (80/4.5 and 2x80/4.5 mcg) with the effect of budesonide (200 mcg and 800 mcg)…
- Trial name
- NCT00159263
- Testing
- Formoterol Inhalant Powder, Budesonide Powder, Budesonide and Formoterol Product
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Imperial College London
Asthma Control
A Study Assessing the Effect of Dupilumab on Inducing Clinical Remission in Asthma
This study tests whether an asthma medication called dupilumab can help people achieve complete asthma control (called "remission") when given earlier in their disease, before asthma becomes severe.
- Trial name
- HOTHOT (NCT07309614)
- Testing
- Dupilumab Prefilled Syringe
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 150 people
- Sponsor
- Université de Sherbrooke
Allergic Rhinitis
The Effect of Exercises on Physiological Changes and Clinical Symptoms in Allergic Rhinitis Patients
1. Moderate exercise training decrease cytokine response and rhinitis symptoms in patients with allergic rhinitis 2. Moderate exercise training combined with vitamin C supplementation decrease cytokine response and rhinitis…
- Trial name
- NCT02123914
- Testing
- Aerobic exercise with Vit. C, Aerobic exercise, No exercise
- Where
- Thailand
- Volunteers
- 27 people
- Sponsor
- Chulalongkorn University
Breastfeeding, Exclusive, Mother-Child Relations
Early Versus Inmediately Skin to Skin Contact in Cesarean Section
Breastfeeding plays a fundamental role in the health of girls and boys by providing adequate nutrition, promoting development and mainly preventing diseases.
- Conditions
- Breastfeeding, Exclusive, Mother-Child Relations, Kangaroo-mother Care
- Trial name
- NCT05292924
- Testing
- Early SCC
- Volunteers
- 280 people
- Sponsor
- Asociación Mexicana de Salud Primal
Eosinophilic Esophagitis (EoE)
SAD, MAD and Food Effect Evaluation of Safety, Tolerability, and PK of AQ280 in Healthy Subjects
The principal aim of this study is to obtain safety and tolerability data when AQ280 is administered orally as single and multiple doses to healthy subjects.
- Trial name
- NCT05485779
- Testing
- AQ280
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- AQILION AB
Atelectasis
Effects of Different Inhalation Oxygen Concentrations on Postoperative Atelectasis
This study was a single-center, prospective, randomized controlled, two-arm study. This study will be conducted in the First Hospital of China Medical University.
- Trial name
- DIOCA (NCT05627024)
- Testing
- 30% Oxygen, 60% Oxygen
- Where
- China
- Volunteers
- 96 people
- Sponsor
- China Medical University, China
Asthma
Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients With Asthma (CPAP)
The CPAP trial is a 3-arm parallel design randomized sham-controlled trial. Participants are randomly assigned in equal allocation to one of three treatments: CPAP 10 cm water (H₂O) (high) vs. CPAP 5 cm H₂O (medium) vs.
- Trial name
- CPAP (NCT01629823)
- Testing
- Continuous Positive Airway Pressure device (Resmed, Swift, Mirage)
- Where
- 18 sites in United States
- Volunteers
- 209 people
- Sponsor
- American Lung Association Asthma Clinical Research Centers
Atopic Dermatitis
The Effect of a Probiotic Intervention in Healthy Subjects and Patients With Atopic Dermatitis
The study was performed to investigate the effects of a probiotic supplementation containing Lactobacillus paracasei Lpc-37, Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp. lactis DGCC 420 (B.
- Trial name
- NCT00550472
- Testing
- probiotics
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Jena
Postmenopausal, Non-lactating
Food Effects on the Relative Bioavailability of Different Dosages of Risedronate
Randomized, open-label, multi-center, 4-treatment, 4-period crossover study. The study will consist of a screening visit, study center admission (preceding Treatment Periods 1, 2, 3, and 4), 4 treatment periods (4 days each), 3…
- Conditions
- Postmenopausal, Non-lactating, Surgically Sterile
- Trial name
- NCT00717145
- Testing
- risedronate
- Where
- 3 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Warner Chilcott
Asthma
Randomised Study Comparing the Effects of Inhaled FF/GW642444M Combination, FF and GW642444M on an Allergen Induced Asthmatic Response
We propose to use an inhaled allergen challenge model to explore the individual contributions of the components of a novel long-acting beta agonist/ inhaled corticosteroid combination product and its components on protection from…
- Trial name
- NCT01128595
- Testing
- FF/GW642444M, GW642444M, Fluticasone Furoate
- Where
- 4 sites in Australia, New Zealand and 1 more
- Volunteers
- 27 people
- Sponsor
- GlaxoSmithKline
Asthma
A Study to Evaluate the Effect of a Single-Dose Intravenous Administration of MEDI-528
To evaluate the effect of MEDI-528 in adults with atopic asthma.
- Trial name
- NCT00483041
- Testing
- MEDI528 9 mg/kg
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- MedImmune LLC
Eosinophilic Gastritis, Eosinophilic Duodenitis
A Study to Assess Subcutaneous AK002 in Eosinophilic Gastritis and/or Eosinophilic Duodenitis
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, tolerability, and pharmacodynamic effect of subcutaneous lirentelimab (AK002), given monthly for 6 doses, in…
- Trial name
- ENIGMA-SC (NCT05152563)
- Testing
- AK002
- Where
- 76 sites in United States
- Sponsor
- Allakos Inc.
Atopic Dermatitis (Eczema)
The Effects of an L-histidine-Based Supplement, Eczema Topical, and Unscented Soap on Children With Eczema
The purpose of this study is to examine the effects of 2 dietary supplements containing the amino acid, L-histidine, alongside a plant-biotech topical product, and an unscented bar soap on 2 age groups of children with mild to…
- Trial name
- NCT07670676
- Testing
- Powder Supplement + Topical Oil + Unscented Soap, Gummy Supplement + Topical Lotion + Unscented Soap
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Codex Labs Corporation
Stevens-Johnson Syndrome, Drug Reaction With Eosinophilia and Systemic Symptom
Vitamin D Levels in Non-immediate Drug Hypersensitivity Case-control Study
Serum vitamin D levels in drug-induced non-immediate reactions
- Conditions
- Stevens-Johnson Syndrome, Drug Reaction With Eosinophilia and Systemic Symptom, Maculopapular Exanthem, Vitamin D Deficiency
- Trial name
- NCT06263140
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Chulalongkorn University
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