Clinical trials: Immediate Effect
Bronchial Asthma
Rapid Onset Action of Salbutamol Versus Formoterol
The hypothesis of this study is that the onset of rapid bronchodilatory effect of inhaled Formoterol (12 microgram) is comparable to that of inhaled salbutamol (200 microgram) i.e., the difference in mean forced expiratory volume…
- Trial name
- NCT00900874
- Testing
- salbutamol, Formoterol
- Where
- India
- Volunteers
- 78 people
- Sponsor
- All India Institute of Medical Sciences
Asthma
A Study of MRx-4DP0004 in Asthma
This is a multicentre, phase I/II, double-blind, placebo-controlled study of MRx-4DP0004 in participants taking long-term medication for asthma.
- Trial name
- NCT03851250
- Testing
- MRx-4DP0004
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 34 people
- Sponsor
- 4D pharma plc
Effect of Sitaxsentan on Airway Remodeling in Severe Asthma
Study on the Effects of Sitaxsentan on Airway Remodeling in Patients With Severe Asthma
Introduction. Despite adequate steroid therapy, a subpopulation of approximately 10% of asthmatics develops severe persistent airflow obstruction.
- Trial name
- Sitax (NCT01050491)
- Testing
- sitaxentan
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pharmacokinetic Profile
Cariprazine: Comparison of Slow- and Immediate-release Forms
The investigators are doing this study to compare blood levels and side effects of cariprazine when it's taken as one of two 'slow release' tablets, or as an 'immediate release' capsule.
- Trial name
- NCT02165098
- Testing
- Cariprazine prolonged release tablet A, Cariprazine prolonged release tablet B, Cariprazine capsule
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Gedeon Richter Plc.
Voice Disorders
Immersive Virtual Reality Meditation in Voice Therapy
This study aims to explore the feasibility of incorporating regular guided meditations via immersive virtual reality (IVR) at the start of voice therapy sessions to facilitate better learning and retention of treatment.
- Trial name
- NCT07176013
- Testing
- Voice therapy, Meditation, Virtual Reality
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pulmonary Function
Effects of Particulate Matter on the Pulmonary Function and Acute Exacerbation of COPD and Asthma
Particulate matter(PM) exposure has been shown to increase the morbidity and mobility of a variety of respiratory diseases, including COPD and asthma.
- Trial name
- NCT03193879
- Where
- China
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Asthma
A Phase I Study in Asthma Patients Evaluating the Effect of Doses of FlutiForm™ on the Amount, if Any, of Cortisol Produced by the Adrenal Glands
The medications being used in this study are individually approved by the Food and Drug Administration (FDA). The medication under investigation is a combination of the two medications in one inhaler.
- Trial name
- NCT00657774
- Testing
- FlutiForm 250/10 ug, FlutiForm 100/10 ug, Oral Prednisone 10mg
- Where
- 19 sites in United States
- Volunteers
- 160 people
- Sponsor
- SkyePharma AG
Asthma
A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma
The trial is an investigator-driven research study in subjects with intermittent asthma, the aim of which is to explore the likelihood of a functionally important separate leukotriene E4 (LTE4) receptor in airways and/or…
- Trial name
- E-Type (NCT01841164)
- Testing
- Montelukast, Inhaled leukotriene E4
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Karolinska University Hospital
Allergic Rhinitis, Allergic Conjunctivitis
Olopatadine Eye Drops and Allergy Skin Testing
Use of olopatadine ophthalmic solution (eye drops) will decrease allergy skin test reactivity.
- Trial name
- NCT00775658
- Testing
- olopatadine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Spontaneous Urticaria (CSU), Healthy Volunteers
Phase Ib, Randomized, Double-blind, Placebo-Controlled, Dose-Escalation Study of Alpha-0261 Tablets to Assess Safety and Tolerability in Patients With Chronic Spontaneous Urcaria (Part 1) and Food Effect in Healthy Adults (Part 2).
This is a randomized, double-blind, placebo-controlled phase 1b clinical study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of Alpha-0261 Tablets in healthy Chinese adults and in patients with…
- Trial name
- NCT07684560
- Testing
- Alpha-0261
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AlphaMol Science Ltd. (Shanghai)
Cold, Cryotherapy
Cryotherapy on Muscle Function
On-field sports injuries are a common issue that significantly impacts athletes' performance and overall health. In team sports such as football, basketball, and volleyball, muscle and joint injuries are particularly frequent.
- Conditions
- Cold, Cryotherapy, Cryotherapy Effect, Muscle Activity
- Trial name
- NCT06970366
- Testing
- Cold pack application, Cold spray application
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Okan University
Asthma
Safety Study of the Effects of Inhaled Fluticasone Furoate/GW642444 on the Hypothalamic-Pituitary-Adrenal (HPA) Axis
The purpose of this study is to assess the effect of six weeks' treatment with two once-daily strengths of Fluticasone Furoate/GW642444 Inhalation Powder on the HPA axis system
- Trial name
- NCT01086410
- Testing
- Fluticasone Furoate/GW642444 Inhalation Powder, Prednisolone Oral Capsule
- Where
- 17 sites in United States, Germany and 1 more
- Volunteers
- 185 people
- Sponsor
- GlaxoSmithKline
Asthma
The Effects of Neuromuscular Electrical Stimulation in Older Patients With Asthma
The aim of the randomized controlled study is to investigate the effects of NMES superimposed on voluntary contraction combined with patient education and exercise training program in patients with chronic obstructive pulmonary…
- Trial name
- NCT04254159
- Testing
- Superimposed Neuromuscular Electrical Stimulation, Quadriceps Strengthening, Patient Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Yeditepe University
Cardiac Disease
Lidocaine as an Endotracheal Tube (ETT) Cuff Media
Researchers will compare the effects of lidocaine versus air, as a way to fill the breathing tube cuff which is gently inflated to hold in place the trachea (airway) during surgery.
- Trial name
- NCT03343080
- Testing
- 1.8% lidocaine plus 0.76% sodium bicarbonate, Air
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Head and Neck Squamous Cell Carcinoma
Pharmacodynamic Effects and Predictive Biomarkers With Ruxolitinib in Operable Head and Neck Cancer
This study will identify baseline and/or pharmacodynamic biomarkers of response to ruxolitinib, based upon association with quantitative change in tumor size following 14-21 days of neoadjuvant ruxolitinib in patients with…
- Trial name
- NCT02593929
- Testing
- ruxolitinib
- Sponsor
- University of Pittsburgh
Attention Deficit Disorder With Hyperactivity
Adherence and Long-term Effect of OROS Methylphenidate (CONCERTA): A Follow-up Study
The objectives of this study are to investigate: 1. the evolution of ADHD symptoms, remission rate of ADHD, social and school function, and familial relationship; 2.
- Trial name
- NCT00598182
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Atopic Dermatitis Eczema
Effect of Ectoin Dermatitis Cream 7% on Skin Hydration and Skin Barrier Function
The aim of this prospective, uncontrolled clinical study is to evaluate the clinical effect of Ectoin® Dermatitis Cream-EHK02 on skin hydration and transepidermal water loss (TEWL) in subjects with atopic dermatitis after single…
- Trial name
- NCT04097327
- Testing
- Ectoin Dermatitis Cream 7% (EHK02)
- Where
- Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Bitop AG
Traumatic Brain Injury
Evaluation of the Abbott i-STAT TBI Biomarker Test
According to the Centers for Disease Control and Prevention, approximately 200,000 hospitalizations occurred in 2020 related to Traumatic Brain Injury (TBI), which does not include many TBIs treated only in emergency departments…
- Trial name
- NCT06766435
- Testing
- i-STAT TBI Test
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ankle Injury, Plantar Pressure
Immediate Effects of the HVLA Talocrural Distraction Technique in Soccer Players
This clinical trial aims to evaluate the effect of a high-speed, low-amplitude physiotherapy technique at the ankle level, when performed on amateur soccer players.
- Trial name
- NCT06653491
- Testing
- high-speed, low-amplitude talocrural decompression technique and changes at the level of mobility and plantar pressure, simulated ankle technique
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Asthma
Inhaled Corticosteroids on Airway Smooth Muscle in Asthma
The main objective is to evaluate how treatment with inhaled corticosteroids (ICS) affects the characteristics of airway smooth muscle (ASM) cells from asthmatic subjects.
- Trial name
- NCT00661973
- Testing
- budesonide
- Where
- United Kingdom
- Sponsor
- Imperial College London
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