Clinical trials: Immediate Effect
Eosinophilic Gastritis, Eosinophilic Gastroenteritis
A Study of AK002 in Patients With Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis
This is a Phase 2, double-blind, randomized, placebo-controlled study to assess the effects of AK002, given monthly for 4 doses.
- Trial name
- ENIGMA (NCT03496571)
- Testing
- AK002
- Where
- 21 sites in United States
- Volunteers
- 65 people
- Sponsor
- Allakos Inc.
Asthma
A Study of Lebrikizumab (RO5490255) in Participants With Severe Oral Corticosteroids (OCS) Dependent Asthma
This randomized, multicenter, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy of lebrikizumab compared with placebo, as measured by the ability of participants to achieve lower daily doses of…
- Trial name
- NCT01987492
- Testing
- Lebrikizumab
- Where
- 71 sites in United States, Australia and 14 more
- Volunteers
- 230 people
- Sponsor
- Hoffmann-La Roche
Asthma
Effects of an Exercise Program for Children With Asthma
exercise program in the pulmonary function and cardiorespiratory fitness in children with asthma and respiratory symptoms
- Trial name
- NCT02693301
- Testing
- Exercise program
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Universidad Europea de Madrid
Asthma, Chronic Obstructive Pulmonary Disease
Trial Comparing Effect of He/O2 to Medical Air on Pulmonary Function Disease
This clinical trial will include healthy volunteers, COPD patients and asthmatic patients who will breathe He/O2 78:22, He/O2 65:35 and medical air consecutively in a randomised order.
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Healthy
- Trial name
- NCT00801307
- Testing
- spirometer
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Air Liquide SA
Healthy
A Comparison of the Effects of Extended Release Tacrolimus (Advagraf®) vs. Immediate Release Tacrolimus (Prograf®) on Kidney Function in Healthy Male Volunteers
The purpose of the study is to evaluate the drug profiles (pharmacokinetics) and effects (pharmacodynamics) of Advagraf® and Prograf® on the kidneys.
- Trial name
- NCT01681134
- Testing
- Advagraf®, Prograf®
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Canada, Inc.
Trigger Points
Immediate Effects of Self-myofascial Release on Latent Trigger Point Sensitivity
Latent myofascial trigger points (LMTRP) which impair neuromuscular performance occur in both, patients and asymptomatic subjects. As evidence suggests that LMTRP can transform into active trigger points, therapy seems warranted.
- Trial name
- NCT02609412
- Testing
- Static compression of LMTRP, Dynamic self-myofascial release of calf
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Goethe University
Allergic Asthma
A Phase IIa Study of Subcutaneous AER 001 on Antigen Challenge In Atopic Asthmatic Subjects (28 Day Study)
This is a single center, double-blind, randomised parallel group design study to investigate the effects of AER 001 on the late phase asthmatic resonse in asthmatic subjects.
- Trial name
- NCT00535028
- Testing
- AER 001
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Aerovance, Inc.
Asthma
Withania Somnifera for Moderate-to-Severe Persistent Asthma
This randomized, double-blind, placebo-controlled study evaluated Withania somnifera root powder as a complementary therapy in adults with moderate-to-severe persistent asthma receiving standard asthma treatment.
- Trial name
- WISTA (NCT07787507)
- Testing
- Withania somnifera Root Powder, Standard Asthma Treatment
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Aligarh Muslim University
Asthma
Study to Assess Airway Inflammation Effects of FlutiForm® pMDI Low and High Dose in Adults With Mild to Moderate Asthma
This is a dose-response study to determine how various measurements of airway inflammation respond to high and low dose FlutiForm®, and compared to placebo.
- Trial name
- FLT2503 (NCT00995800)
- Testing
- Fluticasone propionate / Formoterol fumarate
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Mundipharma Research Limited
Asthma, Exercise-Induced
The Effect of Physical Exercise in a Cold Air Environment on Normal Volunteers and Asthmatic Patients
The purpose of the study is to compare airway physiologic reactions to physical exercise in a cold air environment (-5°C, 60% relative humidity) between normal volunteers and subjects with mild/moderate asthma.
- Trial name
- ALASCAIR1 (NCT03840044)
- Testing
- Cold air exercise test
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Low Back Pain, Mechanical
Cryotherapy and TENS on Low Back Pain
This study aim analyze the immediate effects of conventional transcutaneous electrical nerve stimulation (TENS) and Burst TENS combined or not with cryotherapy in patients with non-specific low back pain.
- Trial name
- CTLBP (NCT03248505)
- Testing
- Conventional TENS, Burst TENS, Cryotherapy
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Allergic Rhinitis
The Effect of Allergic Rhinitis on Educational Outcomes
The study will assess the the burden of living with allergic rhinitis (AR) and the effect of AR on school performance for children and adolescents in Denmark.
- Trial name
- NCT05881577
- Testing
- Observational
- Where
- Denmark
- Volunteers
- 150,000 people
- Sponsor
- ALK-Abelló A/S
Asthma
The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma
We hypothesize that simvastatin in combination with ICS might have synergistic anti-inflammatory effects on airway inflammation in asthmatic patients
- Trial name
- NCT00792337
- Testing
- simvastatin, B1-6-12
- Where
- Thailand
- Volunteers
- 53 people
- Sponsor
- Mahidol University
Dermatitis, Atopic
Drug Drug Interaction Study Evaluating the Effect of Fluvoxamine or Fluconazole on PK and Safety of PF-04965842.
A Phase 1, Open Label, Parallel-Cohort, Randomized, Fixed Sequence Study To Evaluate The Pharmacokinetic Drug Drug Interaction Between PF-04965842 and Fkuvoxamine (cohort 1) or Fluconazole (Cohort 2) in healthy subjects.
- Trial name
- NCT03634345
- Testing
- Period 1 - Day 1: PF-04965842 administered, Period 2: Cohort 1: Fluvoxamine & PF-04965842, Period 2: Cohort 2: Fluconazole & PF-04965842
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Asthma, Airway Inflammation
Children's Exposures/Health Effects/Diesel Exhaust
The contribution of diesel exhaust (DE) to health, especially children's health, is of tremendous public health interest. DE has been associated with worsening asthma and allergies, among other important health effects.
- Trial name
- NCT00527345
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Asthma
Effect of Omalizumab on Expression of IgE Receptors in Adults With Severe, Inadequately Controlled Allergic Asthma
The aim of this study is to evaluate the expression of IgE high affinity receptors (the part of the cell associated with allergic response) in patients suffering from uncontrolled severe asthma despite long term treatment with…
- Trial name
- NCT00454051
- Testing
- Omalizumab
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Epigenetic Effects of Intranasal Steroids, Environmental Exposure
Epigenetic Health Benefits of Budesonide
Around 40% of the world's population is now impacted by allergic disease and this figure continues to rise. It is now understood that allergic disease arises from complex interactions between genetic and environmental factors.
- Trial name
- Project Ace (NCT04342039)
- Testing
- Budesonide Nasal
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Asthma
NHFT Effects on Symptatheic Drive of Asthma Patients
The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen…
- Trial name
- MSNA in Asthma (NCT05704101)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Conjunctivitis, Allergic
Treg Effector Function and Th2/Treg Ratio in Allergic Conjunctivitis: Effect of Desensitization Therapy
This study aims to evaluate the effector function and expression of TIGIT and PD-1 on Tregs, as well as the Th2/Treg ratio, in patients with allergic conjunctivitis with and without desensitization therapy, compared to healthy…
- Trial name
- INMUNOREG (NCT07171307)
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Allergic Conjunctivitis
A Study to Demonstrate the Effect of REGN5713-5715 on Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Birch Pollen Allergy
This study is researching 2 experimental drugs, REGN5713 and REGN5715, which are called REGN5713-5715 when mixed together (called "study drug") to reduce eye allergy signs and symptoms due to birch tree pollen allergy.
- Trial name
- NCT06602739
- Testing
- REGN5713, REGN5715
- Where
- 3 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- Regeneron Pharmaceuticals
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