Clinical trials: Immediate Hypersensitivity
Status Asthmaticus
Heliox-Powered Albuterol Therapy in the Treatment of Children Admitted With Acute Asthma Exacerbation
The purpose of this study is to investigate whether heliox-powered albuterol nebulizer therapy will result in reduced inpatient length of stay in children hospitalized with acute asthma exacerbations.
- Trial name
- NCT00410150
- Testing
- Helium-oxygen-driven albuterol nebulizer, Oxygen
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma, Communication
A Patient Advocate to Improve Real-world Asthma Management for Inner City Adults
Few interventions to improve asthma management have targeted low-income minority asthmatic adults and even fewer have focused on the real-world practice where care is provided for these patients.
- Trial name
- HAP2 (NCT01972308)
- Testing
- Patient Advocate, Usual Care
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- University of Pennsylvania
Asthma
A Clinical Study to Evaluate Z7200 (Budesonide/Formoterol) Pharmacokinetics Profile in Healthy Volunteers
The primary objective was: to assess the bioequivalence of a single dose (two inhalations) of the test product compared to the reference product, with and without charcoal blockade.
- Trial name
- NCT02237508
- Testing
- Z7200 without oral activated charcoal, Symbicort Turbohaler without oral activated charcoal, Z7200 with oral activated charcoal
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zambon SpA
Atopic Dermatitis
Phase 2a Study of the Safety, Tolerability, and Pharmacokinetics of Topically Administered PRN473 (SAR444727) in Patients With Mild to Moderate Atopic Dermatitis
This was a Ph2a study that consists of a double-blind, intra-patient placebo-controlled treatment period and an open-label uncontrolled treatment period with objective to evaluate the safety, tolerability, PK and preliminary…
- Trial name
- NCT04992546
- Testing
- PRN473 (SAR444727)
- Where
- 12 sites in United States, Canada
- Volunteers
- 39 people
- Sponsor
- Principia Biopharma, a Sanofi Company
Asthma
Evaluation of Dupilumab in Children With Uncontrolled Asthma
Primary Objective: To evaluate the efficacy of dupilumab in children 6 to less than (<) 12 years of age with uncontrolled persistent asthma.
- Trial name
- VOYAGE (NCT02948959)
- Testing
- Dupilumab, Asthma Controller Therapies, Asthma Reliever Therapies
- Where
- 99 sites in United States, Argentina and 16 more
- Volunteers
- 408 people
- Sponsor
- Sanofi
Asthma, Atopy
Imaging Study of the Lungs During an Allergic Asthma Attack
Asthma is a disease of rapidly increasing incidence that already affects more than 17 million people in the United States alone.
- Trial name
- NCT01547286
- Testing
- Standardized Cat Allergen Extract and Standardized Dust Mite Allergen, Computed Tomography imaging, functional Positron Emission Tomography imaging, Nebulized methacholine inhalation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Peanut Hypersensitivity, Food Hypersensitivity
Sublingual Immunotherapy for Peanut Allergy and Induction of Tolerance
The goal of this study will be to increase the reaction threshold (desensitization) of peanut allergic children using peanut sublingual immunotherapy and to determine if the nonreactive state of the immune system persists after…
- Conditions
- Peanut Hypersensitivity, Food Hypersensitivity, Food Allergy, Peanut Allergy
- Trial name
- SLIT-TLC (NCT01373242)
- Testing
- Liquid peanut extract (Peanut SLIT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of North Carolina, Chapel Hill
Peanut Allergy
Xolair Enhances Oral Desensitization in Peanut Allergic Patients
This is a pilot feasibility study, using Xolair pretreatment for oral peanut desensitization.
- Trial name
- NCT01290913
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Lynda Schneider
Asthma
A Study to Evaluate the Onset of Effect and Time Course of Change in Lung Function With Benralizumab in Severe, Uncontrolled Asthma Patients With Eosinophilic Inflammation
The purpose of this study is to investigate the onset and maintenance of effect of benralizumab on lung function, blood eosinophils, asthma control metrics and quality of life during 12-week treatment in patients with…
- Trial name
- SOLANA (NCT02869438)
- Testing
- Benralizumab
- Where
- 54 sites in United States, Chile and 4 more
- Volunteers
- 233 people
- Sponsor
- AstraZeneca
Asthma
The Effects of NOx and Conjugated Linoleic Acid on Asthmatics
This study will examine the hypothesis that in obese asthmatics; treatment with NOx + CLA is well tolerated, safe and will increase eNO while reducing airway oxidative stress.
- Trial name
- NICLA (NCT02433977)
- Testing
- Conjugated Linolenic Acid, Sodium Nitrite, Sodium Nitrate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Gladwin, Mark, MD
Seasonal Allergic Rhinitis
A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies
The Purpose of this study is to determine if one allergy medication (0.15% azelastine hydrochloride) is more effective than Placebo alone.
- Trial name
- NCT00660829
- Testing
- 0.15% Azelastine Hydrochloride
- Where
- 6 sites in United States
- Volunteers
- 536 people
- Sponsor
- Meda Pharmaceuticals
Atopic Dermatitis
SAR231893-LPS15497- "Dupilumab Effect on Sleep in AD Patients"
Primary Objective: To evaluate the effect of dupilumab on sleep quality in adult participants with moderate to severe atopic dermatitis (AD).
- Trial name
- NCT04033367
- Testing
- Dupilumab
- Where
- 42 sites in United States, Australia and 8 more
- Volunteers
- 188 people
- Sponsor
- Sanofi
Eczema, Atopic Dermatitis
Study Testing Response Effect of KY1005 Against Moderate-to-Severe Atopic Dermatitis, The STREAM-AD Study
This is an interventional, randomized, parallel group, treatment, Phase IIb, double blind, 5-arm study to assess the effect of Anti-OX40L Monoclonal Antibody (KY1005) in adult participants with moderate to severe atopic…
- Trial name
- STREAM-AD (NCT05131477)
- Testing
- Amlitelimab
- Where
- 103 sites in United States, Australia and 10 more
- Volunteers
- 390 people
- Sponsor
- Kymab Limited
Chronic Spontaneous Urticaria
A Study of LY3454738 in Adults With Chronic Spontaneous Urticaria
The reason for this study is to see if the study drug LY3454738 is safe and effective as treatment for participants with hives that are caused by chronic spontaneous urticaria (CSU) and that are not controlled with…
- Trial name
- NCT04159701
- Testing
- LY3454738
- Where
- 25 sites in United States, Germany and 1 more
- Volunteers
- 52 people
- Sponsor
- Eli Lilly and Company
Asthma, COPD
Can we Reduce Hospital Attendance Without Compromising Care by the Use of Telephone Consultation
Consultation time in busy respiratory clinics is inevitably limited and attendance is often disruptive to patients' lives; involves time, expense, travel, and waiting; and can have effects upon occupation.
- Conditions
- Asthma, COPD, Sleep Apnea Syndromes, Interstitial Lung Diseases
- Trial name
- NCT00129701
- Testing
- Telephone consultation
- Where
- United Kingdom
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Asthma
Role of the Isomerase Pin-1 in the Development and Treatment of Asthma
Pin1 is activated in asthmatic airways, increasing cytokine mRNA stability and eosinophil survival. This study is designed to test whether the Pin1 enzyme regulates TLR/IL-1R signal pathways in multiple cells in asthma.
- Trial name
- Pin1 (NCT01691612)
- Testing
- installation of D. pteronyssinus allergens
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brigham and Women's Hospital
Asthma
Effect of Montelukast on Experimentally-Induced RV16 Infection in Asthma
People with asthma may have asthma worsening when they have an upper respiratory infection due to a virus or a common cold. Leukotrienes are increased in nasal secretions from children with Respiratory Syncytial Virus (RSV) and…
- Trial name
- NCT00359073
- Testing
- montelukast
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Wisconsin, Madison
Asthma
A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children
The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.
- Trial name
- MUPPITS-2 (NCT03292588)
- Testing
- Mepolizumab
- Where
- 9 sites in United States
- Volunteers
- 335 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Allergic Rhinitis (AR)
A Phase 1 Scintigraphy Study to Assess Nasal Deposition of Ciclesonide. Using a Novel Nasal Metered Dose Inhaler
This study is an open label, single dose, single site, randomized, cross over study that will assess nasal deposition of radioactivity following nasal inhalation of a ciclesonide radiolabeled solution via a novel nasal Metered…
- Trial name
- NCT01371786
- Testing
- ciclesonide nasal aerosol, mometasone Aqueous (AQ) nasal spray
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Sumitomo Pharma America, Inc.
Atopic Dermatitis
A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of SUN13834 in Adult Subjects With Atopic Dermatitis
The purpose of the study is to explore the efficacy and safety of SUN13834 vs placebo in adult participants with atopic dermatitis.
- Trial name
- NCT00717769
- Testing
- SUN13834
- Where
- 28 sites in United States
- Volunteers
- 270 people
- Sponsor
- Daiichi Sankyo
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