Clinical trials: Immediate Hypersensitivity
Asthma
Study to Evaluate the Impact of FeNO Assessments on Asthma Management Decisions in Subject 7 to 60 Years of Age
Objective: To evaluate the impact of FeNO assessments on asthma treatment decisions. Secondary objectives: Evaluate the ability of physicians to correctly assess airway inflammation using standard clinical assessment tools (i.e.…
- Trial name
- NCT01729247
- Testing
- NIOX MINO® Instrument (09-1100)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aerocrine AB
Asthma
Study to Assess the Efficacy and Safety of Budesonide (PT008) in Adult Subjects With Mild to Moderate Persistent Asthma
Study to assess the efficacy and safety of four doses of budesonide inhalation aerosol (BD MDI, PT008) relative to placebo MDI in adult subjects with mild to moderate persistent asthma.
- Trial name
- NCT02105012
- Testing
- BD MDI 320 µg, BD MDI 160 µg, BD MDI 80 µg
- Where
- 41 sites in United States
- Volunteers
- 147 people
- Sponsor
- Pearl Therapeutics, Inc.
Chronic Spontaneous Urticaria
Study to Investigate the Efficacy and Safety of QGE031 in Adolescent Patients With Chronic Spontaneous Urticaria (CSU)
This clinical study was designed to evaluate the pharmacokinetics, safety and efficacy of ligelizumab in children from 12 to < 18 years of age, with chronic spontaneous urticaria (CSU).
- Trial name
- NCT03437278
- Testing
- Ligelizumab
- Where
- 20 sites in Argentina, Belgium and 8 more
- Volunteers
- 49 people
- Sponsor
- Novartis Pharmaceuticals
Urticaria, Chronic Spontaneous Urticaria
Study Evaluating the Efficacy and Safety of Povorcitinib in Adults With Chronic Spontaneous Urticaria
This study is being conducted to evaluate the efficacy and safety of povorcitinib in adults with CSU that is inadequately controlled using SOC treatments.
- Conditions
- Urticaria, Chronic Spontaneous Urticaria, Chronic Idiopathic Urticaria, Hives
- Trial name
- NCT05936567
- Testing
- Povorcitinib
- Where
- 42 sites in United States, Germany and 1 more
- Volunteers
- 136 people
- Sponsor
- Incyte Corporation
Asthma
Phase 2 Study to Evaluate RPT193 in Adults With Moderate to Severe T2-high Asthma
Randomized, multi-center, double-blind, placebo-controlled, parallel group, proof of-concept study with RPT193 in subjects with T2-high, moderate-to-severe asthma who are partially controlled on medium or high doses of inhaled…
- Trial name
- NCT05935332
- Testing
- RPT193
- Where
- 29 sites in United States, Bulgaria and 2 more
- Volunteers
- 38 people
- Sponsor
- RAPT Therapeutics, Inc., a member of the GSK plc group of companies
Asthma
New Breath Actuated MDI Symbicort Compared to Symbicort pMDI and Budesonide pMDI for 12 Weeks Twice a Day
This is a comparison of the efficacy of the Symbicort breath actuated dose inhaler to the Symbicort pressured meter dose inhaler after 12 weeks of a twice a day dose.
- Trial name
- BAI (NCT01360021)
- Testing
- Symbicort, Budesonide
- Where
- 41 sites in United States, Bulgaria and 2 more
- Volunteers
- 214 people
- Sponsor
- AstraZeneca
Depression, Asthma
Antidepressant Treatment at an Inner City Asthma Clinic
Asthma is common with an increasing prevalence and mortality especially in low-income and minority populations. The course of asthma appears to be influenced by mood and emotions.
- Trial name
- NCT01324700
- Testing
- High severity group: Escitalopram, Low severity group: Escitalopram
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University of Texas Southwestern Medical Center
Asthma
Safety and Efficacy Study of Adding GSK2190915 to Low Dose Inhaled Corticosteroid Treatment for Asthma Subjects > or = 12 Years of Age
The primary objective of this study is to evaluate the efficacy and safety of adding GSK2190915 100mg, GSK2190915 300mg or placebo tablets administered once daily to fluticasone propionate 100mcg inhalation administered twice…
- Trial name
- NCT01156792
- Testing
- FP 100, GSK2190915 100, GSK2190915 300
- Where
- 32 sites in United States
- Volunteers
- 162 people
- Sponsor
- GlaxoSmithKline
Oxygen Consumption
Change in Oxygen Consumption Following Inhalation Beta Agonists in Healthy Adults
Albuterol is the most commonly used β agonist to treat reversible lower airway obstruction. Albuterol contains a racemic mixture of two enantiomers. Levalbuterol contains the single R form enantiomer.
- Trial name
- NCT02802111
- Testing
- Albuterol, Levalbuterol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Allergic Conjunctivitis
Study Evaluating the Efficacy and Safety of PRT-2761 for the Treatment of Acute and Chronic Allergic Conjunctivitis
To evaluate the efficacy and safety of two concentrations of PRT-2761 as a topical ophthalmic solution for the treatment of the signs and symptoms of acute and chronic allergic conjunctivitis.
- Trial name
- NCT03320434
- Testing
- PRT-2761 0.5%, PRT-2761 1%, Patanol
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- ORA, Inc.
Asthma, Lung Diseases
Childhood Asthma Management Program (CAMP) Phases I (Trial), II (CAMPCS), III (CAMPCS/2), and IV (CAMPCS/3)
The purpose of this study is to evaluate the long term effects of anti-inflammatory therapy compared to bronchodilator therapy on the course of asthma, particularly on lung function and bronchial hyperresponsiveness, and on…
- Trial name
- CAMP (NCT00000575)
- Testing
- Nedocromil, Budesonide
- Volunteers
- 1,041 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Asthma, PTSD
Assessing Inflammatory and Behavioral Pathways Linking PTSD to Increased Asthma Morbidity in WTC Workers
Asthma and post-traumatic stress disorder (PTSD) are the most common conditions in World Trade Center (WTC) rescue and recovery workers.
- Trial name
- NCT04552301
- Testing
- Cognitive Processing Therapy, Psychotherapy, Targeted Asthma Education
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Asthma
Efficacy and Safety of Navarixin (SCH 527123) in Participants With Allergen-Induced Asthma (P05363)
Evaluation of treatment in participants with mild asthma.
- Trial name
- NCT00688467
- Testing
- Navarixin
- Volunteers
- 19 people
- Sponsor
- Merck Sharp & Dohme LLC
Esophagitis
A Pilot Study of the Treatment of Eosinophilic Esophagitis With Omalizumab
Eosinophilic esophagitis (EE) is an increasingly recognized condition characterized by dysphagia, food impaction or other obstructive esophageal symptoms in children and young adults.
- Trial name
- NCT00123630
- Testing
- omalizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Peanut Allergy
Oral Desensitization to Peanut in Peanut Allergic Children and Adults Using CPNA Peanut OIT Safety Follow-On Study
This is a multi-center, open-label, follow-on study to gather additional information on the safety and tolerability of oral desensitization with CPNA in the subjects who participated in ARC001.
- Trial name
- NCT02198664
- Testing
- AR101 - Peanut protein capsule
- Where
- 8 sites in United States
- Volunteers
- 47 people
- Sponsor
- Aimmune Therapeutics, Inc.
Asthma, Acute Asthma
Budesonide Inhalation Suspension for Acute Asthma in Children
The purpose of this study is to determine whether the addition of budesonide inhalation suspension (BIS) to the standard therapy of albuterol, ipratropium bromide, and systemic corticosteroids (SCS) for moderate to severe asthma…
- Conditions
- Asthma, Acute Asthma, Reactive Airway Exacerbation
- Trial name
- NCT00393367
- Testing
- Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg, Prednisolone, prednisone, or methylprednisolone, Albuterol, ipratropium bromide
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Children's Hospital of Philadelphia
Allergic Asthma
A Study of Omalizumab in the Prevention of Allergen Induced Airway Obstruction in Adults With Mild Allergic Asthma
This was a multicenter, randomized, double-blind, parallel-group, three-arm, placebo-controlled study designed to demonstrate the efficacy of two different formulations of omalizumab compared with placebo in reducing the airway…
- Trial name
- AQUA (NCT00434434)
- Testing
- omalizumab
- Volunteers
- 61 people
- Sponsor
- Genentech, Inc.
Asthma, Allergic Rhinitis
Clinical Response to Rhinovirus Challenge
Rhinovirus (RV) infections represent the most common cause of asthma exacerbations in children and adolescents. The investigators hypothesize that the immune responses generated in the nose of allergic rhinitics and asthmatics…
- Trial name
- NCT02910401
- Testing
- Rhinovirus (GMP RV16 HRV-16)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Asthma
Use of Dexamethasone in Pediatric Asthma Exacerbations
The purpose of this study is to compare the efficacy of a single dose of dexamethasone vs. two doses of dexamethasone in mild and moderate asthma exacerbations pediatric patients.
- Trial name
- NCT02192827
- Testing
- Dexamethasone Sodium Phosphate Injection
- Where
- United States
- Volunteers
- 318 people
- Sponsor
- University at Buffalo
Asthma, Vitamin D Deficiency
Vitamin D Oral Replacement in Asthma
The overall objective of the study is to determine the pharmacokinetics of Vitamin D supplementation in children who have asthma and are overweight or obese.
- Conditions
- Asthma, Vitamin D Deficiency, Pediatric Obesity
- Trial name
- VDORA1 (NCT03686150)
- Testing
- Vitamin D3 oral regimen
- Where
- 15 sites in United States
- Volunteers
- 112 people
- Sponsor
- IDeA States Pediatric Clinical Trials Network
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