Clinical trials: Immune, open to volunteers
Type 1 Diabetes
C-Carbs: A CGM-guided Approach to Teaching Carb Awareness
The goal of this randomized study is to learn whether a CGM-guided insulin dosing education program can help adults with diabetes improve how they dose mealtime insulin. The main question it aims to answer is: 1.
- Trial name
- C-Carbs (NCT07807280)
- Testing
- C-Carbs Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Graft vs Host Disease
Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Background: Chronic graft-versus-host disease (cGVHD) is an immune system disorder that can occur in people who have had a stem cell transplant. cGVHD can affect multiple organs and increase risk of disability and death.
- Trial name
- NCT05531786
- Testing
- Pacritinib
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Autoimmune Diseases
JY231(Internal Clinical Drug Code) Injection for the Treatment of Refractory Autoimmune Diseases
Early exploratory clinical study of the safety, tolerability and initial efficacy of JY231 injection in the treatment of refractory autoimmune diseases
- Trial name
- JY231、ADs (NCT06243159)
- Testing
- JY231
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanxi Bethune Hospital
Asthma (Diagnosis)
Changing Lifestyle to Improve Quality of Life in Spanish Adolescents With Asthma
The goal of this clinical trial is to evaluate if a multicomponent lifestyle intervention can improve health-related quality of life in adolescents with asthma.
- Trial name
- CLiQ-Asthma (NCT07870980)
- Testing
- Lifestyle-change intervention
- Volunteers
- 96 people
- Sponsor
- Universitat Internacional de Catalunya
Relapsed/Refractory Systemic Light Chain Amyloidosis
A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)
This study is researching an experimental drug called linvoseltamab ("study drug"). This study is focused on patients who have AL amyloidosis that has returned or have failed other therapies and need to be treated again.
- Trial name
- LINKER-AL2 (NCT06292780)
- Testing
- Linvoseltamab
- Where
- 21 sites in United States, Greece and 4 more
- Volunteers
- 220 people
- Sponsor
- Regeneron Pharmaceuticals
Follicular Lymphoma, Refractory B-Cell Lymphoma
Chidamide Combined With Linperlisibon for the Treatment of Refractory/Relapsed Follicular Lymphoma
To observe the safety and efficacy of Chidamide combined with Linperlisib in the treatment of refractory and relapsed follicular lymphoma.
- Conditions
- Follicular Lymphoma, Refractory B-Cell Lymphoma, Relapsed Non-Hodgkin Lymphoma
- Trial name
- NCT06158386
- Testing
- Chidamide combined with Linperlisib
- Where
- China
- Volunteers
- 33 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Multiple Sclerosis (MS) - Relapsing-remitting
Monthly Monitoring of Plasma NfL in Treated Relapsing-remitting Multiple Sclerosis to Detect Persistent Infraclinical Disease Activity
Reference MRI scan is recommended 6 months after treatment onset in patients with multiple sclerosis (MS), and follow-up scans at 12 months later to monitor subclinical activity.
- Trial name
- MoMo-NfL (NCT07292480)
- Testing
- Monthly pNfL monitoring
- Where
- 6 sites in France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
T Cell Acute Lymphoblastic Leukemia, T Cell Lymphoblastic Lymphoma
Anti-CCR9 CAR T Cells for T Cell Leukaemia/Lymphoma
The goal of this clinical trial is to learn if anti-CCR9 CAR T cells (which will be made using the patient's own blood cells) are safe and which dose should be used in children and adults with T cell leukaemia and lymphoma.
- Trial name
- FRACTALL (NCT07300683)
- Testing
- CARCCR9 T cells
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Rheumatoid Arthritis (RA), Remote Patient Monitoring
BloodTrackR Usability and Concordance Study (BUCS): Evaluating a Smart Home-Based Blood Collection Platform for Remote Monitoring in Rheumatoid Arthritis
The BloodTrackR Usability and Concordance Study (BUCS) is evaluating a novel home-based blood collection device and companion mobile application for people with rheumatoid arthritis.
- Trial name
- BUCS (NCT07660029)
- Testing
- BloodTrackR - Home Blood Collection Platform
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Ulster
Cardiac Sarcoidosis, Sarcoidosis of the Heart
Exosome-based Omic Signatures of Disease Activity in Cardiac Sarcoidosis (EXODACS)
The purpose of this study is to develop a prospective cohort of patients with and without cardiac sarcoidosis as well as active and inactive disease to develop a prospective biobank from which exosome analysis of peripheral blood…
- Conditions
- Cardiac Sarcoidosis, Sarcoidosis of the Heart, Sarcoidosis With Myocarditis, Sarcoidosis, Cardiac
- Trial name
- EXODACS (NCT07604220)
- Testing
- Exosome Analysis
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Mayo Clinic
Graft Versus Host Disease (cGvHD)
Ex Vivo-Expanded Regulatory T Cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic GVHD
Hematopoietic Stem Cell Transplant (HCT) has been used to treat children and adults who have leukemia, lymphoma and other cancers of blood and immune cells since the 1970s. For many of these forms of cancer, HCT works well.
- Trial name
- EVENT (NCT06991361)
- Testing
- EVE-Treg
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Sarah Nikiforow, MD
Chronic Inflammatory Disease, Angioedema
Deployment o the Multidisciplinary Prospective Cohort Imminent
Immune-mediated inflammatory diseases (IMIDs) most often affect young patients and have high impact on morbidity and mortality with a significant alteration in the quality of life of patients with professional, social and…
- Conditions
- Chronic Inflammatory Disease, Angioedema, Severe Asthma, Lupus
- Trial name
- IMMINeNT (NCT04334031)
- Testing
- Biobanking with genetic analysis, SF-12 questionnaire
- Where
- France
- Volunteers
- 2,200 people
- Sponsor
- University Hospital, Lille
Multiple Myeloma, Smoldering Multiple Myeloma
Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Multiple Myeloma (MM) Precursor Conditions
The key aim of the study is to define the two biologically and clinically distinct entities: progressive versus stable myeloma precursor conditions.
- Conditions
- Multiple Myeloma, Smoldering Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance
- Trial name
- TRANSFORMM (NCT05361694)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Miami
Rheumatic Diseases, Inflammatory Arthritis
Personalized Outreach for Equitable Treatment in Rheumatology
The primary goal of this study is to determine whether providing patient honoraria and/or outreach services can improve the attendance rate of appointments at an inner city rheumatology clinic in Vancouver, British Columbia.
- Conditions
- Rheumatic Diseases, Inflammatory Arthritis, Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
- Trial name
- POET-Rheum (NCT07022756)
- Testing
- Honoraria, Outreach
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
ITP - Immune Thrombocytopenia
Multi-target Drugs Sequential Combination Therapy in Adults Patients With Newly Diagnosed Primary Immune Thrombocytopenia
This prospective, single-arm, multicenter, exploratory study will enroll 38 adults patients with newly diagnosed primary immune thrombocytopenia (ITP).
- Trial name
- NCT07788456
- Testing
- standard-dose methylprednisolone/prednisone., thrombopoietin receptor agonist(TPO-RA), including but not limited to hetrombopag or eltrombopag., rituximab.
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
This is a first-in-human Phase 1a/1b multicenter, open-label study designed to evaluate the safety and anti-cancer activity of NX-5948 in patients with advanced B-cell malignancies.
- Conditions
- Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL)
- Trial name
- NCT05131022
- Testing
- NX-5948
- Where
- 62 sites in United States, France and 6 more
- Volunteers
- 572 people
- Sponsor
- Nurix Therapeutics, Inc.
Advanced Hepatocellular Carcinoma (HCC)
Different First-line Immunotherapy for Advancer Hepatocellular Carcinoma: A Prospective Observational Study on Efficacy and Immune Microenvironment
To evaluate the efficacy and immune microenvironment changes in advanced hepatocellular carcinoma (HCC) patients receiving different first-line immunotherapy.
- Trial name
- HCC-IM-1 (NCT07147101)
- Testing
- Sintilimab, Bevacizumab Biosimilar, Camrelizumab
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fudan University
Multiple Sclerosis, Cognitive Dysfunction
HOBSCOTCH-MS-Efficacy Trial
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with…
- Conditions
- Multiple Sclerosis, Cognitive Dysfunction, Memory Disorders, Memory Impairment
- Trial name
- NCT06951919
- Testing
- Home Based Self- management and Cognitive Training Changes lives in Multiple Sclerosis (HOBSCOTCH-MS)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
B Cell Lymphoma
Exploratory Study on the Efficacy of Zebutinib as Maintenance Therapy Following CAR-T Cell Therapy in Patients With Non-Hodgkin B-Cell Lymphoma
This study is a single-center, Phase IV clinical trial designed to collect and analyze data on the efficacy and safety of zanubrutinib as maintenance therapy following CAR-T cell therapy in subjects with non-Hodgkin B-cell…
- Trial name
- NCT07198373
- Testing
- Maintenance Therapy Group
- Volunteers
- 40 people
- Sponsor
- Beijing GoBroad Hospital
Asthma (Diagnosis)
Pressurized Meter Dose Inhaler V/S Dry Powder Inhaler
This study compares two commonly used inhalation devices in asthma management. It focuses on evaluating how effectively PMDIs and DPIs deliver the same combination of inhaled corticosteroids and long-acting beta agonists in…
- Trial name
- NCT07372573
- Testing
- Pressurized Metered Dose Inhaler (pMDI), Dry Powder Inhaler
- Where
- Pakistan
- Volunteers
- 210 people
- Sponsor
- University of Health Sciences Lahore
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