Clinical trials: Immune Deficiency, active
Human Papilloma Virus, Human Papilloma Virus Vaccine
Advancing HPV Vaccination Among HIV Positive Adults: The CHAMPS Study
People living with HIV (PLWH) are 28 times more likely to be diagnosed with Human Papillomavirus (HPV) - associated anal cancer than the general population.
- Trial name
- CHAMPS (NCT05065840)
- Testing
- CDC 4 Pillars Program
- Where
- 4 sites in United States
- Volunteers
- 267 people
- Sponsor
- Emory University
Haemophilia A (Moderate or Severe), Hemophilia, Classic
A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis
The rationale for conducting this open-label phase 4 study is to assess whether once-weekly prophylaxis with efanesoctocog alfa (50 IU/kg) improves the disease course of existing synovial hypertrophy and prevents the risk of…
- Conditions
- Haemophilia A (Moderate or Severe), Hemophilia, Classic, Haemophilia, Hemophilia
- Trial name
- NCT06752850
- Testing
- Efanesoctocog alfa
- Where
- 10 sites in Italy, Norway and 2 more
- Volunteers
- 37 people
- Sponsor
- Swedish Orphan Biovitrum
Hereditary Angioedema
HAELO: A Phase 3 Study to Evaluate NTLA-2002 in Participants With Hereditary Angioedema (HAE)
This Phase 3 study aims to evaluate the efficacy and safety of NTLA-2002 compared to placebo in participants with HAE.
- Trial name
- NCT06634420
- Testing
- NTLA-2002, Normal Saline IV Administration
- Where
- 29 sites in United States, Australia and 7 more
- Volunteers
- 80 people
- Sponsor
- Intellia Therapeutics
Chronic Lymphocytic Leukemia
Description of the Immune Deficiency in Patients With Untreated Chronic Lymphocytic Leukemia and Search for Predictive Factors of Infectious Risk
Chronic Lymphocytic Leukemia (CLL) is the most common adult leukemia in western countries. CLL is most often discovered incidentally when a blood test carried out for another reason highlights an increase of subpopulation of…
- Trial name
- NCT06475469
- Testing
- Blood sampling & Chest CT without injection
- Where
- France
- Volunteers
- 75 people
- Sponsor
- CHU de Reims
Epstein-Barr Virus Infections, Primary Immune Deficiency Disorder
EBV-specific Cytotoxic T-lymphocytes (CTLs) for Refractory EBV Infection
Related donor Epstein-Barr Virus (EBV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults with refractory EBV…
- Trial name
- NCT03266653
- Testing
- cytotoxic t-lymphocytes
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- New York Medical College
Primary Immune Deficiency
Study to Evaluate the Pharmacokinetics, Efficacy, Tolerability, and Safety of Subcutaneous Human Immunoglobulin (Newnorm) in Patients With Primary Immunodeficiency Diseases
Prospective, open-label, single-arm, multicentre Phase 3 study to evaluate the pharmacokinetics, efficacy, tolerability, and safety of subcutaneous human immunoglobulin (Newnorm) in patients with primary immunodeficiency diseases
- Trial name
- NCT04640142
- Testing
- Newnorm
- Where
- 23 sites in United States, Germany and 5 more
- Volunteers
- 50 people
- Sponsor
- Octapharma
Substance Abuse, Substance Addiction
The Trans-Led Care Study
This study is testing a new mutual-help group called "the TLC program" for transgender adults who use substances or are recently in recovery.
- Conditions
- Substance Abuse, Substance Addiction, Substance Use Disorder (SUD), Substance Use (Drugs, Alcohol)
- Trial name
- TLC (NCT06880705)
- Testing
- The TLC Program
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Illinois Institute of Technology
Shwachman-Diamond Syndrome, SDS
Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform
The Shwachman-Diamond Syndrome Global Patient Survey and Collaboration Program (SDS-GPS) is an opportunity for patients and their families - from anywhere in the world - to share their experience living with SDS via a safe…
- Conditions
- Shwachman-Diamond Syndrome, SDS, IBMF, Congenital Neutropenia
- Trial name
- SDS-GPS (NCT06999954)
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Shwachman-Diamond Syndrome Alliance Inc
Viral Infection, Hematopoietic Stem Cell Transplantation (HSCT)
Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts
This is a Phase I dose-escalation study to evaluate the safety of norovirus -specific T-cell (NST) therapy for chronic norovirus infection in participants following hematopoietic stem cell transplantation (HSCT) or who are…
- Conditions
- Viral Infection, Hematopoietic Stem Cell Transplantation (HSCT), Primary Immunodeficiency Disorders (PID)
- Trial name
- ATLANTIC (NCT04691622)
- Testing
- Norovirus -specific T-cell (NST) therapy
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Children's National Research Institute
Human Immunodeficiency Virus, HIV Infections
Cross-disciplinary HIV Integrated Mental Health Support Intervention
The proposed project seeks to develop and test an intervention to improve engagement in HIV and mental health care for young Black gay, bisexual and other men who have sex with men (YB-GBMSM) in Ryan White clinics.
- Trial name
- CHIMES (NCT04833829)
- Testing
- CHIMES Intervention, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 850 people
- Sponsor
- Emory University
ANCA-IgG-positive ANCA Associated Vasculitis
Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis
The goal of this phase I/II clinical trial is to investigate anti-CD 19 chimeric antigen receptor T cell (CAR-T cell) therapy in patients with antineutrophil cytoplasmic antibodies (ANCA) immunoglobulin (IgG) positive ANCA…
- Trial name
- IDEAL (NCT06590545)
- Testing
- KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy
- Volunteers
- 8 people
- Sponsor
- David Simon
Immune Thrombocytopenia, Thrombotic Thrombocytopenic Purpura
Longitudinal Cohort of Thrombosis and Hemostasis Diseases
This is a multicenter, prospective, longitudinal, observational cohort study to investigate thrombosis and hemostasis diseases in Chinese patients.
- Conditions
- Immune Thrombocytopenia, Thrombotic Thrombocytopenic Purpura, Hemophilia A, Acquired, Disseminated Intravascular Coagulation
- Trial name
- NCT06727669
- Where
- 5 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
HIV/AIDS, Young Adult
Intervention for Virologic Suppression in Youth
The goal of this randomized clinical trial is to test the effect of a technology-based intervention with an Adaptive Treatment Strategy (ATS) among youth living with HIV (YLWH) (18-29 years old).
- Conditions
- HIV/AIDS, Young Adult, Mobile Health, Mental Health Issue
- Trial name
- iVY (NCT05877729)
- Testing
- Standard of Care, Video-counseling+app
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Francisco
HIV Infections
Cardiovascular Responses to Exercise in People Living With HIV/AIDS: Effects of Exercise Training
Patients living with HIV (PLWHIV) have compromised muscle metaboreflex, which can cause exercise intolerance. This randomized controlled clinical trial will verify the effects of regular exercise on autonomic and hemodynamic…
- Trial name
- NCT04512456
- Testing
- Exercise training
- Where
- Brazil
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
Methamphetamine Abuse, Hiv
Methamphetamine, PrEP, and Intersectional Stigma Study
The goal of this clinical trail is to test the developed eMPrISe study in HIV-negative, adult, Latino men who have sex with men (MSM) who use non-injection substances.
- Conditions
- Methamphetamine Abuse, Hiv, Social Stigma
- Trial name
- eMPrISe (NCT05784467)
- Testing
- Methamphetamine, PrEP, and Intersectional Stigma (eMPrISe) study
- Volunteers
- 20 people
- Sponsor
- Arizona State University
HIV Infection, HBV Infection
"Pregnancy and Viral Infections: Impact on Pregnant Women and Their Children. French Prospective Cohort"
The VIROPREG study is a French prospective multicenter cohort study that aims to assess the impact of viral infections and antiviral treatments received during pregnancy on maternal and child health.
- Conditions
- HIV Infection, HBV Infection, HDV Infection, HCV Infection
- Trial name
- VIROPREG (NCT07412977)
- Testing
- Blood sampling, Umbilical cord blood sampling, Survey using a questionnaire
- Where
- France
- Volunteers
- 5,160 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV (Human Immunodeficiency Virus), Continuum of Care
Adaptation and Implementation of an Evidence-based Approach to Advance HIV Prevention and Care
Transgender women in the intervention condition will attend TransAction individual risk reduction sessions; skill building and open group support sessions, and social events between baseline and 3-month assessment.
- Conditions
- HIV (Human Immunodeficiency Virus), Continuum of Care, Stigma
- Trial name
- NCT07495059
- Testing
- TransAction
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
HIV/AIDS, Medication Adherence
INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)
Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission.
- Conditions
- HIV/AIDS, Medication Adherence, Habits
- Trial name
- INMIND (NCT06949774)
- Testing
- Daily Text Messages, Incentivization based on timely ART adherence
- Where
- Uganda
- Volunteers
- 550 people
- Sponsor
- RAND
Allergic Rhinitis, Allergic Rhinitis (AR)
Effect of Combined Probiotics and Vitamin D on Symptoms of Allergic Rhinitis
The goal of this clinical trial is to learn if taking probiotics, vitamin D, or both together can help lower symptoms of allergic rhinitis (AR) and improve quality of life in adults.
- Trial name
- NCT07115342
- Testing
- Standard Allergic Rhinitis Treatment, Combined Vitamin D and Probiotics Supplementation
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
HIV Infections
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of a New Formulation of Cabotegravir Long-Acting Administered Intramuscularly in a 4-month Dosing Interval (Q4M)
This study will evaluate the pharmacokinetics (PK), safety, and tolerability of a new formulation of Cabotegravir (CAB) dosed every 4-months (Q4M) for pre-exposure prophylaxis (PrEP) in participants at risk of HIV-1 acquisition.
- Trial name
- NCT06741397
- Testing
- CAB LA, New formulation of CAB LA
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare