Clinical trials: Immune Function
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission
Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant
This randomized phase II trial studies the safety and how well multi-peptide cytomegalovirus (CMV)-modified vaccinia Ankara (MVA) vaccine works in reducing CMV complications in patients previously infected with CMV and are…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Chronic Lymphocytic Leukemia
- Trial name
- NCT02506933
- Testing
- Laboratory Biomarker Analysis, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine
- Where
- 3 sites in United States
- Volunteers
- 102 people
- Sponsor
- City of Hope Medical Center
HIV Infection, Inflammation
Effect of Raltegravir on Endothelial Function in HIV-Infected Patients
Recent studies suggest that HIV patients are at increased risk for cardiovascular events; however, the mechanisms underlying this increased risk remain unclear.
- Conditions
- HIV Infection, Inflammation, Cardiovascular Disease, HIV Infections
- Trial name
- NCT00843713
- Testing
- raltegravir
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of California, San Francisco
HIV Infections
Evaluation of Renal Function, Efficacy, and Safety When Switching From Tenofovir/Emtricitabine Plus a Protease Inhibitor/Ritonavir, to a Combination of Raltegravir (MK-0518) Plus Nevirapine Plus Lamivudine in HIV-1 Participants With Suppressed Viremia and Impaired Renal Function (MK-0518-284)
To evaluate changes in renal function, efficacy, and safety when switching from a combination of tenofovir/emtricitabine (TDF/FTC) plus a protease inhibitor/ritonavir (PI/r) to a combination of raltegravir (MK-0518) plus…
- Trial name
- RANIA (NCT02116660)
- Testing
- Raltegravir (MK-0518), Nevirapine, Lamivudine
- Volunteers
- 11 people
- Sponsor
- Merck Sharp & Dohme LLC
Persian Gulf Syndrome
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
The purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 GWI subjects.
- Trial name
- NCT00810368
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Georgetown University
Type 1 Diabetes
EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes
Diabetes is increasingly common among youth, forecasting early complications. Type 1 (T1D) cause early heart disease, shortening lifespan despite modern improvements in control of blood sugars and other risk factors for heart…
- Trial name
- EMERALD (NCT01808690)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Human Immunodeficiency Virus, Coronary Artery Disease
Effect of Evolocumab on Coronary Endothelial Function
The investigators propose a pilot study using (1) MRI to assess coronary artery endothelial function, (2) brachial ultrasound to assess systemic endothelial function, (3) serum markers of inflammation and of endothelial cell…
- Trial name
- EVOLVE (NCT03500302)
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University