Clinical trials: Immune Function and Intestinal Microbiota
Sclerosis, Multiple
Gut Microbiota Composition, Cognitive Function, and Physical Fitness in Multiple Sclerosis Patients
The evidence suggests that multiple sclerosis (MS) induces a decline in motor and cognitive function and provokes a shift in gut microbiome composition in patients.
- Trial name
- MSDANCE (NCT06220409)
- Testing
- Dance classes
- Where
- Slovakia
- Volunteers
- 29 people
- Sponsor
- Comenius University
Pre-diabetic
The Effect of Insoluble Yeast Beta-glucan Intake on Pre-diabetic Patients
There is a lot of evidence to show that the yeast beta-glucan has immunomodulatory, anti-inflammatory, anti-infective effects.However,few work was done on the relationship between yeast bata-glucan and the immune function of…
- Trial name
- NCT03495362
- Testing
- Yeast Beta-glucan
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Huazhong University of Science and Technology
Multiple Myeloma, MGUS
Intestinal Flora and Immunity in Monoclonal Gammopathy Patients
This study aims to investigate the characteristics of the gut microbiota and immune function status in patients with monoclonal gammopathy complicated by infection, and to analyze the correlation between the two.200 patients…
- Conditions
- Multiple Myeloma, MGUS, Gut Microbiota, Infections
- Trial name
- NCT06539832
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Allergic Asthma, Allergic Rhinitis
Study of the Frequency and of the Regulatory Function of Positive T Lymphocytes Dual CD4CD8aa (DP8a) Specific to a Bacteria of the Intestinal Microbiota (Faecalibacterium Prausnitzii) in Atopic Dermatitis, Asthma and Allergic Rhinitis
The prevalence of allergic diseases (atopic dermatitis, asthma, rhinitis, conjunctivitis and food allergy) has increased dramatically in industrialized countries over the last 20-30 years.
- Conditions
- Allergic Asthma, Allergic Rhinitis, Atopic Dermatitis
- Trial name
- Prévall-DP (NCT02908360)
- Testing
- double positive T cells (CD4 + / CD8 +) to the specific peripheral blood of F prauznitzii analyse
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Nantes University Hospital
Healthy Volunteers
The Effects of the Synbiotic Ecologic 825/scFOS on Intestinal Barrier Function and Immune Modulation
In the present pilot study, the investigators will study the effects of a novel synbiotic, which is a mix of probiotics (Ecologic 825) in the presence of a prebiotic (short chain fructo-oligosaccharide (scFOS)), on mucosal…
- Trial name
- CRIB (NCT02018900)
- Testing
- Ecologic 825/scFOS
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 1 Diabetes
Effect of Prebiotics on the Gut Microbiome Profile and Beta Cell Function
Data suggest that intestinal microbiota might be critically involved both in autoimmunity and in glucose homeostasis. An acetylated and butyrylated form of high amylose maize starch (HAMS-AB) that increases beneficial short chain…
- Trial name
- NCT04114357
- Testing
- Acetylated and Butyrylated High Amylose Maize Starch
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Common Variable Immunodeficiency, Vascular Diseases
Composition and Function of Gut Microbiota in Porto-sinusoidal Vascular Disease Associated With Variable Common Immunodeficiency
This aim of this study is the evaluation of the gut microbiota imbalance occurrence and its characterization in patients with common variable immunodeficiency associated to an enteropathy with or without porto-sinusoidal vascular…
- Trial name
- MI-MVPS (NCT05481554)
- Testing
- Stool sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Disease, Immune Function
Omega 3 and Fibre Intervention Study to Improve Metabolic Health
Metabolic syndrome represents a major health burden worldwide affecting 20-30% of the population. This clustering of abnormalities that confers an increased risk of cardiovascular disease and type 2 diabetes mellitus, is the…
- Conditions
- Metabolic Disease, Immune Function, Cardiovascular Diseases, Systemic Inflammation
- Trial name
- NCT03442348
- Testing
- Omega 3 fatty acid, Inulin fibre
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Probiotics
Effect of Probiotic Administration on Gut Flora Composition
Healthy human gut contains a large number of bacteria, which belong to several different species. Some genes in these bacteria encode enzymes that the human body cannot produce.
- Trial name
- NCT03330678
- Testing
- Probiotic (VSL#3)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Blood Pressure, Body Composition, Immune Function
Evaluating the Effects of a Synbiotic Versus Probiotic or Placebo on Gut Microbiota and Cardiometabolic Health: A Randomized Double-Blind Placebo Controlled Trial
Accordingly, the purpose of this study is to evaluate the efficacy of 1) supplementation with Synbiotic (Plexus® Triplex), 2) commercially-available Probiotic, or 3) placebo control over 30 days on the gut microbiome…
- Trial name
- GUTRCT (NCT06544915)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Colorectal Cancer (MSI-H), Malnutrition (Calorie)
Dietary Fiber and Probiotics in Advanced Colorectal Cancer
This single-center, prospective, randomized controlled trial was conducted to evaluate the efficacy of a 12-week combined dietary fiber and probiotic supplementation on gut microbiota, immune function, nutritional status, and…
- Trial name
- NCT07194954
- Testing
- Combined Dietary Fiber and Probiotics., Standard Nutritional Support
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Hospital of Hebei Medical University
Metabolic Effects, Immunosuppressive Agents
Impact of SCFA Supplementation on Gut Microbiome Composition of Kidney Transplant Recipients
This is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effects of high-dose short-chain fatty acid (SCFA) supplementation on the gut microbiome and host metabolome in stable kidney…
- Conditions
- Metabolic Effects, Immunosuppressive Agents, Renal Function, Adverse Events
- Trial name
- RENOBIOME (NCT07024238)
- Testing
- SCFA
- Where
- Slovakia
- Volunteers
- 41 people
- Sponsor
- University Hospital, Martin
Healthy Adults
Probiotic LR08 Improves Gut and Metabolism
Evaluate the efficacy and safety of LR08 as a dietary supplement compared to a placebo in enhancing intestinal health and immune function in healthy adults.
- Trial name
- NCT06875362
- Testing
- Probiotic
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Fermented Vegetable Intake, Fermented Vegetable Acceptability
Fermented Vegetables and Gut Microbiome Pilot Study
The purpose of this research is to determine the effect of fermented vegetable consumption on LAB abundance and tolerability of the intervention in young healthy people before conducting a full RCT with older participants.
- Conditions
- Fermented Vegetable Intake, Fermented Vegetable Acceptability, Gut Health, Gut Microbiome
- Trial name
- NCT06883994
- Testing
- Fermented vegetable intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Gut Microbiota, Immune Function
The Effect of a Prebiotic, Probiotic and Synbiotic on the Gut Microbiota and Immune Response of Older Volunteers (GOS)
Healthy older volunteers will be recruited to a study where they will be given four different treatments over a 28 week period. These treatments include: a prebiotic, a probiotic, a synbiotic (prebiotic + probiotic) and a…
- Trial name
- NCT01586247
- Testing
- Synbiotic, Prebiotic, Probiotic
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Healthy, Healthy Nutrition
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial
The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B.
- Trial name
- BEGIN (NCT06452199)
- Testing
- B. infantis
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Obesity
The Symbiont-Restore Study
Within the framework of the Science Foundation Ireland funded Microbe Restore Project, the Symbiont Restore Study is an Investigator-initiated trial which explores the prospective health advantages associated with a particular…
- Trial name
- NCT05942586
- Testing
- Probiotic capsule (L. reuteri PB-W1™), Prebiotic sachet (Prebiotic Blend)
- Where
- Ireland
- Volunteers
- 137 people
- Sponsor
- University College Cork
Immune System, Stress
Impact of Peanut Consumption on Stress, Immune Function, Inflammation, and Cardiovascular Health in High-Stress Individuals
The purpose of this research is to determine whether peanut consumption improves indicators of cardiovascular disease (CVD) risk in human subjects following the consumption of study foods.
- Conditions
- Immune System, Stress, Chronic Stress, Cardiovascular Health
- Trial name
- NCT07735221
- Testing
- Peanuts, roasted, salted with skins, Isocaloric food
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center