Clinical trials: Immune Reconstitution
Solid Tumor Malignancies
ALI Post Radiation Therapy in Patients With Lung and Esophageal Canter
The goal of this clinical research study is to learn if giving autologous lymphocyte infusions to patients who are receiving chemotherapy and radiation for non-small cell lung cancer or esophageal cancer is safe and effective.
- Trial name
- NCT04668833
- Testing
- Autologous lymphocyte infusion (ALI)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
HIV Infections
A Pilot Project of Virologic, Pharmacologic and Immunologic Correlates of Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution Following Maraviroc Therapy
This research study is being done to find out how the immune system in the small intestines improves after taking antiretroviral (anti-HIV) medications.
- Trial name
- NCT00870363
- Testing
- maraviroc in combination with 2 NRTIs (dual nucleoside reverse transcriptase inhibitor), maraviroc plus raltegravir in combination with 2 NRTIs (dual nucleoside reverse transcriptase inhibitor), efavirenz [or other NNRTI (non-nucleoside reverse transcriptase inhibitor)]
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
COVID-19, Lymphocytopenia
InterLeukin-7 to Improve Clinical Outcomes in Lymphopenic Patients With COVID-19 Infection ( ILIAD-7-US-O )
Comparison of the effects of CYT107 vs Placebo administered IM at 10μg/kg twice a week for three weeks on immune reconstitution of lymphopenic COVID-19 patients
- Trial name
- ILIAD-7-US-O (NCT04426201)
- Testing
- CYT107
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Revimmune
HIV Infections
A Study to Compare the Effects of Two Anti-HIV Drug Combinations on the Immune Systems of HIV-Infected Patients
The purpose of this study is to examine how the immune systems of HIV-infected patients react to 2 anti-HIV drug combinations.
- Trial name
- NCT00002448
- Testing
- Ritonavir, Efavirenz, Saquinavir
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Hoffmann-La Roche
Lymphoma
Evaluation of Immunological Reconstitution After Haploidentical Bone Marrow Transplantation
Evaluation of immunological reconstitution after haploidentical BMT using a nonmyeloablative preparative regimen and post-transplant cyclophosphamide in patients with poor prognosis lymphoma
- Trial name
- NCT01891578
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Armando Santoro, MD
Malignancy, Cancer
Immune Reconstitution Monitoring and Pneumococcal Vaccination in Patients Treated With CAR-T Cells
This is a prospective interventional study designed to investigate the effect of Immune Reconstitution clinic visits and pneumococcal vaccination (PCV-21) on infection risk, anti-infective prophylaxis adherence, and vaccine…
- Conditions
- Malignancy, Cancer, Hematological Malignancies, Lymphoma
- Trial name
- NCT07071909
- Testing
- Commercial CAR-T, Investigational CAR-T
- Where
- United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Germ Cell Tumor, Leukemia
CpG 7909 in Treating Patients Who Have Undergone Autologous Stem Cell Transplant
RATIONALE: Giving CpG 7909 after an autologous stem cell transplant may make a stronger immune response and prevent or delay the recurrence of cancer.
- Conditions
- Germ Cell Tumor, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00369291
- Testing
- keyhole limpet hemocyanin, tetanus toxoid
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Hematologic Diseases, Hematologic Malignancies
Dose-ranging Study of a Single Administration of T-cell Add-back Depleted of Host Alloreactive Cells in Patients Undergoing a Peripheral Blood Stem Cell Transplant From a Related, Haploidentical Donor
The purpose of this study is to determine the maximum tolerated dose and evaluate the safety of the administration of donor lymphocytes depleted of alloreactive T-cells following a stem cell transplant from a related…
- Trial name
- NCT00993486
- Testing
- Donor lymphocyte preparation depleted of functional host alloreactive T-cells (ATIR)
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Kiadis Pharma
Cytomegalovirus Infection
A Trial to Study How the Body Fights Off Cytomegalovirus (CMV) in Hematopoietic Transplant Recipients.
This study is being done to determine how the body fights off a common virus known as Cytomegalovirus (CMV). CMV is a virus that commonly infects humans and causes disease in patients with compromised immune function such as…
- Trial name
- NCT00273143
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
HIV Infections
Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection
The purposes of this study are: 1. To understand whether the use of HIV therapy in persons with more advanced HIV disease results in greater side effects. 2.
- Trial name
- NCT00885664
- Testing
- Truvada (tenofovir/emtricitabine), Kaletra (lopinavir/ritonavir)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Invasive Fungal Disease, Chronic Disseminated Candidiasis
Hepatosplenic CANdidiasis : PETscan and Immune Response Analysis
The purpose of this study is to determine whether F18 fluorodeoxyglucose (18F-FDG) positron-emission tomography scan (PET scan) is useful for the therapy strategy of hepatosplenic candidiasis.
- Conditions
- Invasive Fungal Disease, Chronic Disseminated Candidiasis, Hematological Malignancies, Hematopoietic Stem Cell Transplantation
- Trial name
- CANHPARI (NCT01916057)
- Testing
- 18F-FDG PET Scan
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Sepsis With Septic Shock
Immune Reconstitution of Immunosuppressed Sepsis Patients
A multicenter, randomized, double-blinded, placebo-controlled study of two dosing frequencies of recombinant Interleukin-7 (CYT107) treatment to restore absolute lymphocyte counts in sepsis patients; IRIS-7A (Immune…
- Trial name
- IRIS-7a (NCT02797431)
- Testing
- Interleukin-7
- Where
- 3 sites in France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Limoges
Acquired Immune Deficiency Syndrome Virus, HIV Infections
Research on Effect of Traditional Chinese Medicine (TCM) on Immune Reconstitution of HIV/AIDS Patients After Highly Active Antiretroviral Therapy (HAART)
Chinese prescriptions can inhibit viral replication according to the course of viral replication, and the effects is similar to the effect of HAART, and even better than the anti-viral and immune reconstitution of HAART due to…
- Trial name
- NCT00974454
- Testing
- Fuzheng 2
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Immune Reconstitution Inflammatory Syndrome, Immune Reconstitution Syndrome
Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) Treatment Trial
Tuberculosis is the most common opportunistic infection (OI) in HIV-infected persons worldwide, including in South East Asia. Significant numbers of patients experience tuberculosis-related paradoxical immune reconstitution…
- Conditions
- Immune Reconstitution Inflammatory Syndrome, Immune Reconstitution Syndrome, Tuberculosis, HIV-infection/Aids
- Trial name
- NCT01442428
- Testing
- Dexamethasone, Atorvastatin, Naproxen
- Where
- 3 sites in Thailand
- Sponsor
- University of Minnesota
Cytomegalovirus Cell Mediated Immunity, Stem Cell Transplantation, Hematopoietic
Impact of CMV-Specific Immune Reconstitution at the End of Letermovir Prophylaxis on the Development of Late Cytomegalovirus Infection in Hematopoietic Stem Cell Transplant Recipients (INMUNOEND)
Cytomegalovirus (CMV) infection is a common complication in patients undergoing hematopoietic stem cell transplantation (SCT). Fixed-duration letermovir (LTV) prophylaxis during the first 100 days post-SCT is effective and safe…
- Trial name
- INMUNOEND (NCT06814301)
- Testing
- Periodic immunological monitoring of CMV-specific immune reconstitution will be performed using QTF-CMV
- Where
- Spain
- Volunteers
- 123 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Hematologic Disease and Disorders
Reconstruction Kinetics of γδ T Cells After Unrelated Cord Blood Transplantation
The primary objective is to investigate the correlation between specific patterns of γδ T cell reconstitution after umbilical cord blood transplantation and key clinical outcomes.
- Trial name
- NCT07782684
- Testing
- Umbilical Cord Blood Transplantation as Treatment of Adult Patients with Hematologic Disorders
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Anhui Provincial Hospital
Acquired Immune Deficiency Syndrome, HIV Infections
Study on the Antiviral Therapy and Immune Reconstitution of Chinese HIV/AIDS Patients
This study will recruit 520 treatment-naive and 150 treatment-experienced patients to take the first line or second line of antiviral therapy.
- Trial name
- NCT00872417
- Testing
- first line ARV (3TC+NVP+D4T or 3TC+NVP+AZT), second line ARV therapy (3TC+TDF+LPV/RTV)
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Peking Union Medical College
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Safety and Efficacy of ATIR101 as Adjunctive Treatment to Blood Stem Cell Transplantation From a Haploidentical Family Donor Compared to Post-transplant Cyclophosphamide in Patients With Blood Cancer
The primary objective of this study is to compare safety and efficacy of a haploidentical T-cell depleted HSCT and adjunctive treatment with ATIR101 versus a haploidentical T cell replete HSCT with post-transplant administration…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
- Trial name
- HATCY (NCT02999854)
- Testing
- ATIR101, Cyclophosphamide, T-cell depleted HSCT from a related, haploidentical donor
- Where
- 42 sites in United States, Belgium and 11 more
- Volunteers
- 63 people
- Sponsor
- Kiadis Pharma
HIV-1 Infection, Acquired Immunodeficiency Syndrome
Fuyang Jiedu Granules Plus Antiretroviral Therapy for HIV Immune Non-Responders With Spleen-Kidney Yang Deficiency
This pragmatic randomized controlled trial evaluates whether Fuyang Jiedu Granules combined with antiretroviral therapy (ART) improves immune reconstitution in people with HIV who meet criteria for immune reconstitution failure…
- Conditions
- HIV-1 Infection, Acquired Immunodeficiency Syndrome, Immune Reconstitution Failure, Immunological Non-responder
- Trial name
- FYJD-INR-pRCT (NCT07698548)
- Testing
- Fuyang Jiedu Granules, Antiretroviral Therapy (ART)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing University of Chinese Medicine
Acquired Immune Deficiency Syndrome Virus, HIV Infections
The Effect of Combination of Traditional Chinese Medicine (TCM) and Highly Active Antiretroviral Therapy (HAART) on Immune Reconstitution of HIV/AIDS Patients
Immunity 1 (Fuzheng 1) is composed of herbs which have tonic and detoxific function. The long-term clinical application has proved the safety and effect.
- Trial name
- NCT00974519
- Testing
- Fuzheng 3, Fuzheng 1
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences