Clinical trials: Immune Related Disorder
Ankylosing Spondylitis
The Relationship Between Systemic Immune Inflammation Index and Disease Activity in Patients With Ankylosing Spondylitis
In this study, the aim was to investigate the relationship between SII and other laboratory parameters with disease activity in AS patients and to discuss its usability in the follow-up and treatment process.
- Trial name
- NCT06094673
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Multiple Sclerosis
Effect of the Vojta Therapy in Patients Multiple Sclerosis
Multiple sclerosis is the most common disabling neurological disease in young adults. Inflammation, demyelination, neurodegeneration, gliosis and repair processes are involved in its process, which are responsible for the…
- Trial name
- NCT05558683
- Testing
- Randomized clinical trial.
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Aymara Abreu Corrales
Chronic Pain, Adults 21 and Older
Efficacy of the Quell Wearable Device for Chronic Overlapping Pain Conditions
This study will examine the pain-relieving effects of a transcutaneous electrical nerve stimulator device called a Quell for persons with multiple chronic overlapping pain conditions.
- Conditions
- Chronic Pain, Adults 21 and Older, Multiple Chronic Overlapping Pain Conditions, Hypersensitivity
- Trial name
- NCT05540002
- Testing
- High Intensity Quell, Low Intensity Quell
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Brigham and Women's Hospital
HIV Infections
A Study of AIDSVAX B/B and AIDSVAX B/E, Two Possible Vaccines
The purpose of this study is to see if it is safe and effective to give AIDSVAX B/B or AIDSVAX B/E, two potential HIV vaccines, to HIV-negative volunteers.
- Trial name
- NCT00002402
- Testing
- MN rgp120/HIV-1 and GNE8 rgp120/HIV-1, MN rgp120/HIV-1 and A244 rgp120/HIV-1, Aluminum hydroxide
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- VaxGen
Lymphoma
Liposomal Doxorubicin Plus Combination Chemotherapy in Treating Patients With AIDS-Associated Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00004162
- Testing
- sargramostim, methotrexate, pegylated liposomal doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Type 1 Diabetes Mellitus, Lipohypertrophy
Innovative Insulin Injection Sites Map to Minimize Lipohypertrophy Risk
Background: Patients on long-term insulin therapy frequently develop a condition called lipohypertrophy (LH), which involves the accumulation of abnormal fatty tissue at insulin injection sites.
- Trial name
- NCT07561086
- Testing
- Insulin Injection Site Mapping Tool
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Helwan University
Advanced Solid Tumors
Study to Test How Well Patients With Advanced Solid Tumors Respond to Treatment With the Elimusertib in Combination With Pembrolizumab, to Find the Optimal Dose for Patients, How the Drug is Tolerated and the Way the Body Absorbs, Distributes and Discharges the Drug
The purpose of the study is to test how well patients with advanced solid tumors respond to treatment with elimusertib (BAY1895344) in combination with pembrolizumab.
- Trial name
- NCT04095273
- Testing
- Elimusertib (BAY1895344), Pembrolizumab (Keytruda®)
- Where
- 16 sites in United States, Germany and 3 more
- Volunteers
- 56 people
- Sponsor
- Bayer
Asthma
Cognitive Behavior Therapy for Anxiety-related Asthma in Adults.
This is a study to develop a protocol on Cognitive behavior therapy (CBT) for asthma-related anxiety that in a consecutive study can be translated to internet-delivered CBT.
- Trial name
- NCT03158194
- Testing
- CBT for anxiety-related asthma
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Karolinska Institutet
HIV, Stress Disorder
CBSM Intervention Via mHealth to Ameliorate HIV-related Fatigue
The purpose of this study is to create a smartphone, tablet and web-based application to help people deal with stress. Stress often increases fatigue in people with HIV infection, so successfully dealing with stress could help…
- Conditions
- HIV, Stress Disorder, Human Immunodeficiency Virus, Fatigue
- Trial name
- NCT03149094
- Testing
- CBSM-SMI, CBSM-SMI control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Graves Ophthalmopathy
Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye Disease
Graves' orbitopathy (GO) affects about 50% of patients with Graves' disease (GD), and some cannot be cured by current treatments.
- Trial name
- TED (NCT03324022)
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Arthritis, Rheumatoid
Self-management Nursing Intervention for Women With Rheumatoid Arthritis
Introduction. Chronic autoimmune diseases are catalogued as catastrophic conditions that generate a negative impact on the health and well-being of the affected person.
- Trial name
- NCT06337370
- Testing
- Chronic Disease Self Management Program, Conventional Intervention- Standard care
- Where
- Colombia
- Volunteers
- 44 people
- Sponsor
- Universidad Nacional de Colombia
Head and Neck Cancer
Exploring the Neuro-Immune Basis of Cancer-Related Fatigue Using Behavioral Measures
The goal of this research study is to learn more about fatigue and how it affects your behavior as well as your willingness to learn new behaviors.
- Trial name
- NCT02255773
- Testing
- Computerized Tasks, Questionnaires
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Multiple Myeloma, Non-Hodgkin Lymphoma
Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL
This is a phase I trial with pilot expansion of HLA-haploidentical or HLA-mismatched related donor nicotinamide expanded-natural killer (NAM-NK) cell based therapy for patients with relapsed or refractory multiple myeloma (MM) or…
- Conditions
- Multiple Myeloma, Non-Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, Mantle-Cell Lymphoma
- Trial name
- NCT03019666
- Testing
- Nicotinamide Expanded Haploidentical or Mismatched Related Donor Natural Killer Cells
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Crohn Disease
A Smartphone Application for Added Psychological Wellbeing in Crohn's Disease
Psychological intervention by COBMINDEX application to reduce psychological stress among CD patients, fatigue and pain and improve the patients' well being, quality-of-life and disease-coping skills, as well as improvement of the…
- Trial name
- COBMINDEX (NCT06221254)
- Testing
- COBMINDEX digital application, Human therapist (Control)
- Where
- 4 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Soroka University Medical Center
Pneumonia, Pneumocystis Carinii, HIV Infections
A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
Evaluate the effectiveness rate of dapsone plus trimethoprim as a therapy for the first episode of Pneumocystis carinii pneumonia (PCP) in AIDS patients.
- Trial name
- NCT00002283
- Testing
- Trimethoprim, Sulfamethoxazole, Dapsone
- Where
- United States
- Sponsor
- Jacobus Pharmaceutical
HPV Infection, HIV Infections
Feasibility of HPV Testing With Mail-delivered Sample Collection Kits
People living with human immunodeficiency virus (PLWH) have an estimated 1.6-6.0 times increased risk of developing oropharyngeal cancer (OPC) compared with individuals in the general population.
- Conditions
- HPV Infection, HIV Infections, HPV-Related Malignancy
- Trial name
- NCT07087145
- Testing
- Mail-based Saliva Sample Kit, Study-related Surveys
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- University of California, San Francisco
Alcohol Abuse
Reducing Unsafe Alcohol Use in HIV-Positive Individuals
The main aim of this study is to test an intervention to reduce unsafe drinking among HIV-positive primary care patients. The intervention consists of a brief motivational interview, which is combined with daily alcohol…
- Trial name
- NCT00371969
- Testing
- Enhanced Motivational Interview, Standard Motivational Interview or viewing DVD
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Alcoholism, HIV Infection
Genetic Factors and Interrelationships for Sexual Orientation, Susceptibility to HIV and Kaposi's Sarcoma, Alcoholism and Psychological Traits, and Histocompatibility Antigens
We propose to test, by DNA linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of Kaposi's sarcoma and other outcomes…
- Conditions
- Alcoholism, HIV Infection, Homosexuality, Kaposi's Sarcoma
- Trial name
- NCT00001294
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Graft vs Host Disease, Allogeneic Hematopoietic Cell Transplantation
The Effect of Folinic Acid Rescue Following MTX GVHD Prophylaxis on Regimen Related Toxicity and Transplantation Outcome
The purpose of this study is to assess the impact of folinic acid (FA) -rescue following methotrexate (MTX) graft-versus-host disease (GVHD) prophylaxis on regimen related toxicity and transplantation outcomes after allogeneic…
- Conditions
- Graft vs Host Disease, Allogeneic Hematopoietic Cell Transplantation, Mucositis
- Trial name
- NCT02506231
- Testing
- Folinic acid
- Volunteers
- 160 people
- Sponsor
- Rabin Medical Center
Lupus Nephritis
Association Between Neuropathy and Some Autoantibodies in Systemic Lupus Erythematosus (SLE) Patients
1. Frequency of peripheral neuropathy associated with lupus nephritis 2. Sensitivity and specificity of some biomarkers used in diagnosis and follow up of SLE with lupus nephritis and peripheral neuropathy
- Trial name
- NCT06610422
- Volunteers
- 159 people
- Sponsor
- Assiut University
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