Clinical trials: Immune Related Disorder
HIV Infections
A Phase I Safety and Immunogenicity Trial of the Facilitated HIV-1 Gag-Pol DNA Vaccine (APL-400-047, Apollon, Inc.) Given Intramuscularly by Needle and Syringe or Biojector 2000 Needle-Free Jet Injection System in HIV-1 Uninfected Adult Volunteers
To evaluate the safety, tolerability and immunogenicity in humans of the APL-400-047 vaccine when administered intramuscularly by needle and syringe at 1 of 3 doses or by Biojector at the intermediate dose.
- Trial name
- NCT00001088
- Testing
- APL 400-047, Bupivacaine hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non-Hodgkin's Lymphoma
Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma
In previous studies, the investigators found that in patients with Hodgkin's lymphoma (HL) treated with ABVD (adriamycin, bleomycin, vinblastine and decarbazine) the absence of alopecia may predict for a poor response to…
- Trial name
- NCT00969462
- Testing
- Doxorubicin
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- Meir Medical Center
Rheumatoid Arthritis, Cannabis
Therapeutic Response of Cannabidiol in Rheumatoid Arthritis
The study will randomly assign Rheumatoid Arthritis (RA) patients on stable RA therapy to either placebo or cannabidiol (CBD). The overall goal of this proposal is to examine the efficacy and safety of CBD treatment as adjunctive…
- Trial name
- NCT04911127
- Testing
- 200mg Cannabidiol by capsules twice daily, 400mg Cannabidiol by capsules twice daily
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of California, Los Angeles
Drug Hypersensitivity, DRESS Syndrome
Origin and Function of Eosinophilic Polynuclear During DRESS Syndrome
Drug Hypersensitivity Syndrome or DRESS for "Drug Reaction with Eosinophilia and Systemic Symptoms" is a serious drug allergy which can be life-threatening for patients with serious organ damage.
- Trial name
- DRESSEO (NCT04330118)
- Where
- 11 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Autoimmune Diseases
Exploratory Study on the Treatment of Relapsed and Refractory Immune Related Diseases With WGb-0301 Injection
The exact etiology and pathogenesis of immune related diseases (such as autoimmune hepatitis, systemic lupus erythematosus, etc.) have not been fully elucidated, and are generally believed to be the result of multiple factors…
- Trial name
- NCT07349823
- Testing
- WGb-0301 injection
- Volunteers
- 47 people
- Sponsor
- West China Hospital
Graves Disease, Graves Ophthalmopathy
Systemic Inflammation, Thyroid Autoimmunity and Neuroretinal Changes in Graves Disease
This retrospective observational study aims to evaluate the relationship between systemic inflammatory parameters, thyroid autoimmunity markers, and neuroretinal structures in patients with Graves disease.
- Trial name
- NCT07480720
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Immune Thrombocytopenic Purpura
Health-related Quality of Life and Fatigue in Adult Patients With Primary Immune Thrombocytopenic Purpura (pITP)
Symptoms of Primary Immune Thrombocytopenic Purpura (pITP), such as spontaneous bruising, menorrhagia, mucosal bleeding and other symptoms might significantly affect the HRQOL of pITP patients.
- Trial name
- NCT01510873
- Testing
- HRQOL evaluation
- Where
- 29 sites in Italy
- Volunteers
- 424 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
HIV Infections
A Study of DTC in Patients With AIDS and AIDS Related Complex
To determine if ditiocarb sodium (sodium diethyldithiocarbamate; DTC) restores immune and host defense function; if DTC ameliorates the AIDS related complex (ARC) symptoms in patients with AIDS and ARC; if DTC prevents…
- Trial name
- NCT00002069
- Testing
- Ditiocarb sodium
- Where
- 8 sites in United States
- Sponsor
- Merieux Institute
Cerebral Palsy, Sensitivity
Daily Living Activities in Young Adults With Cerebral Palsy
This study explored the relationship between sensory function and occupational performance in young adults with Cerebral Palsy. Using standardized assessments, researchers compared tactile sensitivity and discrimination between…
- Conditions
- Cerebral Palsy, Sensitivity, Motor Skills Disorders, Activity, Motor
- Trial name
- Palsy202503 (NCT06909994)
- Testing
- individual assessments
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Universidad de Burgos
Cytomegalovirus Infections, HIV Infections
A Multiple Dose Crossover Pharmacokinetics Study to Evaluate the Effects of Food on the Absorption of Oral Ganciclovir
This study is designed to determine the influence of food on the absorption and relative bioavailability of oral ganciclovir by comparing the absorption of oral ganciclovir in a fed and fasting state at steady state plasma levels.
- Trial name
- NCT00002251
- Testing
- Ganciclovir
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Hoffmann-La Roche
Medication Overuse Headache
Medication-overuse Headache: 4 Years Follow up
From 1 January 2004 to 31 December 2006 64 individuals with probable medication overuse headache were included in a randomized, 1-year open-labeled, multicentre study to evaluate the effect of early introduction of prophylactic…
- Trial name
- MOHfollowup (NCT00918671)
- Testing
- No new specific intervention
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Acquired Immunodeficiency Syndrome
Bioequivalence Study of Two Formulations With the Association of Tenofovir 300 mg and Emtricitabine 200 mg.
Objective: To evaluate the relative bioavailability of a new formulation containing a combination of emtricitabine 200 mg and tenofovir disoproxil fumarate 300 mg (T) and compare this formulation with the branded formulation (R)…
- Trial name
- NCT02583464
- Testing
- Tenofovir disoproxil fumarate and emtricitabine
- Where
- Argentina
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laboratorio Elea Phoenix S.A.
Antiphospholipid Syndrome, Immune Disease
Monitoring the Antiphospholipid Syndrome:TOXicity of Drugs (APSTOX)
Several drugs and chemotherapies seem to have an impact on the immune system. This study investigates reports of immune toxicities such as antiphospholipid syndrome, including the International classification of disease ICD-10…
- Conditions
- Antiphospholipid Syndrome, Immune Disease, Adverse Drug Event, Drug Toxicity
- Trial name
- APSTOX (NCT03994302)
- Testing
- Drug inducing antiphospholipid syndrome
- Where
- France
- Volunteers
- 2,700 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
HIV Infections, Hepatitis C
Interleukin-2 (IL-2), Pegylated Interferon (PEG-IFN Alfa-2b), and Ribavirin (RBV) Treatment in Patients With Hepatitis C and HIV Coinfection
This study will test the safety and effectiveness of a new treatment for hepatitis C (HCV) in patients who also have HIV. The usual treatment for HCV in people who are not HIV-infected is interferon-alfa (IFN) with ribavirin…
- Trial name
- NCT00015652
- Testing
- Ribavirin, Aldesleukin, Peginterferon alfa-2b
- Where
- 8 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonitis, Interstitial, Immune Checkpoint Inhibitors (ICIs)
Exploratory Study on the Efficacy and Safety of Nebulized hUC-MSC-Derived Exosomes for Non-Acute CIP
Study Objectives The primary objective of Phase II is to evaluate the percentage of lesion resolution on high-resolution computed tomography (HRCT) as assessed by independent blinded reviewers.
- Conditions
- Pneumonitis, Interstitial, Immune Checkpoint Inhibitors (ICIs), Mesenchymal Stem Cells, Exosomes
- Trial name
- NCT07599111
- Testing
- Nebulized hUCMSC-Exos, Nebulized normal saline
- Volunteers
- 40 people
- Sponsor
- Zhou Chengzhi
Asthma
Genetic Association With Various Severities, Phenotypes and Endotypes of Asthma.
There is limited information on genetics associated with asthma in Chinese. An earlier meta-analysis found that ADAM33, FcεRIb, RANTES, TNF-a, ACE, b2-AR, IL-4R and IL-13 genes could be proposed as asthma susceptible genes in the…
- Trial name
- NCT06196034
- Testing
- No intervention
- Where
- 2 sites in Hong Kong
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Alcohol Use Disorder, Hiv
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1
This study seeks to determine the feasibility, acceptability, and preliminary efficacy of an intervention consisting of off-label use of a medication with strong efficacy data for alcohol use disorder (AUD) with medical…
- Trial name
- HARP (NCT06004830)
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Lymphoma, Physical Exercise
Effects of Exercise Training in Survivors of Lymphoma
This study aims to compare the effects of aerobic exercise with or without addition of resistance exercise to usual care in individuals treated with anthracyclines for lymphomas and to compare exercise effects to age- and…
- Conditions
- Lymphoma, Physical Exercise, Cardiotoxicity, Cardiovascular Diseases
- Trial name
- LYMfit (NCT06270667)
- Testing
- Aerobic Exercise, Combined Aerobic and Resistance Exercise
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Healthy Individuals, Allergic Rhinitis
Health Effects of Wood Smoke and Traffic-Related Air Pollution Exposures: a Necessary Comparison
Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time.
- Trial name
- WADE (NCT06749093)
- Testing
- Filtered Air (FA), Wood Smoke (WS), Diesel Exhaust (DE)
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
Amifostine Followed by High Dose Chemotherapy in Treating Patients With Hematologic Cancer or Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs such as amifostine may protect normal cells from the side effects of chemotherapy.
- Conditions
- Breast Cancer, Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Lymphoma
- Trial name
- NCT00003269
- Testing
- sargramostim, amifostine trihydrate, cisplatin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Scripps Health