Clinical trials: Immune Surveillance, open to volunteers
Severe Asthma, Chronic Rhinosinusitis With Nasal Polyps(CRSwNP)
Tezepelumab (Tezspire) Regulatory Postmarketing Surveillance in Korea
The objectives of this study are to describe the incidence of adverse events and the effectiveness of tezepelumab in patients receiving tezepelumab as indicated for severe asthma or CRSwNP in South Korea.
- Trial name
- Tezepelumab (NCT06998095)
- Volunteers
- 210 people
- Sponsor
- AstraZeneca
Transfusion Reaction, Transfusion Related Complication
Transfusion Surveillance in Anaesthesia
the aim of this register is to collect exhaustively the different data available surrounding a transfusion act in the context of an active haemorrhage.
- Conditions
- Transfusion Reaction, Transfusion Related Complication, Anesthesia, Anesthesia; Shock
- Trial name
- STAR (NCT06403163)
- Testing
- Transfusion
- Where
- Belgium
- Volunteers
- 50,000 people
- Sponsor
- Erasme University Hospital
Immune Checkpoint Therapy
STRICT - Surveillance With TRoponin During Immune Checkpoint Therapy
To learn if monitoring blood levels of heart injury (troponin levels) in cancer participants treated with immune checkpoint inhibitors will lead to decreased heart-related side effects.
- Trial name
- NCT06337097
- Testing
- Troponin surveillance, Standard of care
- Where
- United States
- Volunteers
- 980 people
- Sponsor
- M.D. Anderson Cancer Center
Stem Cell Surveillance
Rapid Response of Stem Cells and Immune Cells for Efficacy
The goal for this clinical trial is to compare rapid effects of four products on stem cells, immune activation, and mitochondrial function. A double-blind, placebo-controlled, cross-over study design will be used.
- Trial name
- NCT07127705
- Testing
- Chaga Mushroom, Ginseng extract, Olive extract
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Quality of Life (QOL), Mismatch Repair Deficient Colorectal Cancer
Research on Effective Strategies After Immunotherapy for Mismatch Repair-deficient Early-stage GI Tumors
This cohort study is divided into two parts: Part A: Registry Cohort All patients with non-metastatic, MMRd/MSI-H colorectal cancers (and other gastrointestinal cancers for exploratory analysis) who have signed the general…
- Conditions
- Quality of Life (QOL), Mismatch Repair Deficient Colorectal Cancer, Microsatellite Instability-High Colorectal Cancer, Stage II Colorectal Cancer
- Trial name
- RESIST (NCT07829081)
- Testing
- Active surveillance after complete response to immunotherapy in MMRd GI cancers, Stand of Care
- Where
- 3 sites in Switzerland
- Volunteers
- 234 people
- Sponsor
- University Hospital, Basel, Switzerland
Multiple Sclerosis
Post-Authorization Safety Study for Assessment of Pregnancy Outcomes in Patients Treated With Mayzent
This study will utilize a prospective, observational, exposure cohort design to examine pregnancy and infant outcomes in women and infants who are exposed to siponimod during pregnancy to treat MS.
- Trial name
- NCT04933552
- Testing
- Siponimod
- Where
- United States
- Volunteers
- 867 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus, Type 1
General Use-results Surveillance With Awiqli in Patients With Diabetes Mellitus
The purpose of the study is to investigate the safety and effectiveness of Awiqli in participants with diabetes mellitus under real world clinical practice in Japan. Participants will get Awiqli as prescribed by the study doctor.
- Trial name
- NCT06807190
- Testing
- Insulin Icodec
- Where
- 116 sites in Japan
- Volunteers
- 630 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Anti-viral Action Against Type 1 Diabetes Autoimmunity
The study GPPAD-05 AVAnT1A is a phase 4 clinical trial intending to enroll 2252 children, who will be randomly assigned to receive COVID-19 vaccination (Comirnaty® 3 μg Omicron XBB.1.5 or new variant Comirnaty vaccines ) or…
- Trial name
- NCT06452654
- Testing
- Comirnaty Injectable Product, Sodium Chloride 0.9% Inj
- Where
- 9 sites in Austria, Belgium and 3 more
- Volunteers
- 2,252 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Respiratory Syncytial Virus (RSV) Infection, Acute Lower Respiratory Tract Infections
Assessing the Burden of Respiratory Syncytial Virus (RSV)
This study examines the impact of Respiratory Syncytial Virus (RSV) on people of all ages, from infants to the elderly. It uses hospital records collected between January 2018 and December 2024 to understand: How often does RSV…
- Conditions
- Respiratory Syncytial Virus (RSV) Infection, Acute Lower Respiratory Tract Infections, Bronchiolitis, Pneumonia
- Trial name
- NCT07015255
- Where
- United Arab Emirates
- Volunteers
- 1,500 people
- Sponsor
- Abu Dhabi Health Services Company
Immune Surveillance
Clinical Trial: Rapid Immune Modulating Effects
The goal for this clinical trial is to compare the immune effects of three different medicinal mushrooms to a placebo. The mushrooms include Agaricus, Reishi, and Turkey Tail.
- Trial name
- NCT07195552
- Testing
- Agaricus blazei, Reishi, Turkey Tail
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Plasma Cell Dyscrasias, Monoclonal Gammopathy of Undetermined Significance
Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource
The investigators are researching patients with diseases of their plasma cells in order to improve their quality and length of life.
- Conditions
- Plasma Cell Dyscrasias, Monoclonal Gammopathy of Undetermined Significance, AL Amyloidosis, Multiple Myeloma
- Trial name
- B-SCR-MM (NCT01408225)
- Testing
- tissue banking
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Mediastinal Lymphoma, Hodgkin Lymphoma
Lymphoma Patients Undergoing Mediastinal Radiotherapy in the Era of Modern Chemoradiation
Malignant anterior mediastinal tumors essentially include lymphomas and thymomas. The location of mediastinum is anatomically close to several critical organs such as heart, lung, and breasts, which might be affected meaningfully…
- Conditions
- Mediastinal Lymphoma, Hodgkin Lymphoma, Non Hodgkin Lymphoma
- Trial name
- NCT03969693
- Testing
- Standard treatment protocol with combined chemoradiation
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Chang Gung Memorial Hospital
Multiple Mieloma
Infection Surveillance of R/R Multiple Myeloma Patients Treated With Elranatamab as Clinical Practice in Italy
The primary objective of this study is to measure the infection rate and presentation pattern in first 12 months of therapy with elranatamab as standard clinical practice in adult patients with Relapsed/Refractory Multiple…
- Trial name
- RISE (NCT07564128)
- Volunteers
- 50 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Schnitzler Syndrome
A Study to Assess the Effectiveness and Safety of Canakinumab in Clinical Use in Patients With Schnitzler's Syndrome
The aim of this study is to assess the effectiveness and safety of Ilaris (canakinumab) in clinical use in patients with Schnitzler's syndrome.
- Trial name
- NCT07598422
- Where
- 5 sites in Japan
- Volunteers
- 10 people
- Sponsor
- Novartis Pharmaceuticals
Adenocarcinoma, Prostate Cancer
Multitargeted Recombinant Ad5 PSA/MUC-1/Brachyury-Based Immunotherapy (TriAdeno) Vaccine With IL-15 Superagonist N-803 in Participants With Clinically Localized Prostate Cancer Undergoing Active Surveillance
Background: Prostate cancer is the second most common cause of cancer-related death among men in the United States. Early-stage, low-grade prostate cancer is managed with active monitoring.
- Conditions
- Adenocarcinoma, Prostate Cancer, Neoplasms, Carcinoma
- Trial name
- NCT07574541
- Testing
- TriAdeno vaccine, N-803
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Type 1 Diabetes Mellitus
Long Term Surveillance of Islet Transplant Recipients Following Complete Graft Loss
This is a single-center, prospective, open label study in islet transplant recipients following islet graft loss.
- Trial name
- NCT02000687
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rodolfo Alejandro
Immunity, Respiratory Infection
Childhood Infection and Immunity Longitudinal Cohort
This prospective observational study will enroll approximately 1,200 children from birth through 7 years of age in Zhejiang Province, China.
- Conditions
- Immunity, Respiratory Infection, Asthma
- Trial name
- NCT07815925
- Where
- 2 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial Center for Disease Control and Prevention
Multiple Sclerosis, Pregnancy
Kesimpta (Ofatumumab) Pregnancy Registry
The Kesimpta Pregnancy Registry is an observational, exposure cohort designed study to examine pregnancy and infant outcomes in women and infants who are exposed to Kesimpta (ofatumumab) during pregnancy to treat MS.
- Trial name
- NCT05634967
- Testing
- Kesimpta
- Where
- United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Food Allergy in Children, Food Allergy in Infants
The Significance of a Timely Food Allergy Diagnosis and Optimal Surveillance of Nutritional Status in Children
The aim of this study is to gain more knowledge on the nutritional and immunological aspects of allergy to milk and eggs in children.
- Trial name
- NCT05287074
- Where
- Lithuania
- Volunteers
- 200 people
- Sponsor
- Vilnius University
Immune Surveillance
Clinical Trial on Rapid Immune Modulating Effects
The goal for this clinical trial is to document rapid effects of a nutritional blend on immune cells. A double-blind, placebo-controlled, cross-over study design will be used.
- Trial name
- NCT07206407
- Testing
- Nutraceutical blend
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc