Clinical trials: Immune System Function
Multiple Sclerosis
Augmented Reality-Based Dual-Task Training in People With Multiple Sclerosis
Multiple Sclerosis (MS) is the most common NDD affecting young people worldwide. MS can seriously affect quality of life and hinder daily functional activities.
- Trial name
- MS (NCT07434934)
- Testing
- Augmented Reality Exercises
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- University of Sharjah
Lupus Erythematosus, Systemic
The Role of Lipids in Immune Cell Function in SLE Patients
The overall aim of this project is to investigate the different types of immune cells found in the blood of patients with Systemic Lupus Erythematosus (SLE) and healthy donors.
- Trial name
- NCT04361734
- Testing
- Blood sampling to include Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University College, London
Asthma
Measuring Small-Airways Disease Improvement After Step-up to Extrafine TRIple or High-dose ICS/LABA in Patients Uncontrolled on Medium Dose ICS/LABA eXploring T2 Inflammation
The goal of this observational study is to investigate the change in small airway function through the R5-R19 index in oscillometry at 12 weeks in adults with asthma.
- Trial name
- MATRIX (NCT07372521)
- Volunteers
- 130 people
- Sponsor
- University Hospital, Ioannina
Human Immunodeficiency Virus
Platelets Study: Influence of the Antiretroviral Treatment on the Platelet Physiology During HIV Infection
HIV infection is associated with an immune activation and an inflammatory response - despite an active antiretroviral therapy - which may lead notably but not exclusively to cardiovascular diseases.
- Trial name
- PLAQUETTE (NCT02532348)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Asthma, Vitamin D Deficiency
Vitamin D in Pediatric Asthma: a Randomized Controlled Open-label Pilot Trial
This is a pilot randomized controlled trial of lower vs. higher dose vitamin D supplementation in D-deficient asthmatic children, to determine necessary sample sizes for outcome measures in a larger multisite study, and to…
- Trial name
- D-Asthma (NCT02054975)
- Testing
- Vitamin D2 + vitamin D3, Vitamin D3
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Nationwide Children's Hospital
Cystic Fibrosis, Immune Function
Glutamine Supplementation in Cystic Fibrosis
Patients with cystic fibrosis develop frequent and potentially life-threatening lung infections. Recent studies suggest that the nutrient "glutamine" may help the body fight off infection.
- Trial name
- CFG (NCT01051999)
- Testing
- Glutamine, L-alanine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Emory University
HIV Seropositivity, ART
Effects of VSL#3 on Neuro-cognitive Profile of HIV Patients
Aim of the study is to evaluate the effects of a change in the intestinal microflora on the neuro-cognitive profile of patients with HIV infection receiving HAART treatment.
- Trial name
- NCT02276326
- Testing
- VSL#3 sachets
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Policlinico Umberto I
HIV, HIV Infections
The Tatelo Plus Study
The purpose of this study is to advance pediatric HIV treatment and cure research by evaluating the impact of a combination of three anti-HIV-1 broadly neutralizing antibodies (bNAbs) or analytic treatment interruption (ATI) on…
- Trial name
- NCT06508749
- Testing
- PGDM1400LS, VRC07-523LS, PGT121.414.LS
- Where
- 2 sites in Botswana
- Volunteers
- 41 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes, Hypoglycemia
Brain Ketone Metabolism in Type 1 Diabetes
This study is designed to examine the value of infusing BHB in type 1 diabetic subjects during experimentally induced hypoglycemic episode in conjunction with testing of cognitive function.
- Trial name
- NCT02471040
- Testing
- Beta-hydroxybutyrate, Normal Saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Leukemia
Evaluation of Brain Changes in ALL Patients on Therapy
The study is aimed at assessing changes in the brain of patients from 6 to 18 years old with a diagnosis of acute lymphoblastic leukemia during chemotherapy.
- Trial name
- NCT04767152
- Testing
- MRI
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Diabetes Mellitus, Type 1, Systolic Dysfunction
Tumor Necrosis Factor-alpha Levels and Cardiac Functions in Type 1 Diabetes Mellitus
The goal of this clinical trial is to learn about the effect of type 1 diabetes mellitus on cardiac functions and evaluate the correlation of the dysfunction with the tumor necrosis factor-α (TNF-α) an inflammation-related…
- Conditions
- Diabetes Mellitus, Type 1, Systolic Dysfunction, Diastolic Dysfunction
- Trial name
- NCT06129448
- Testing
- transthoracic echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sirnak State Hospital
Asthma (Diagnosis), Pulmonary Function
Effect of Linvemastat in Patients With Partially Controlled Asthma (syMMPonia)
This study explores a potential new treatment for adults with moderate-to-severe asthma using a drug called linvemastat, which targets an enzyme linked to lung inflammation.
- Conditions
- Asthma (Diagnosis), Pulmonary Function, Moderate-to-Severe Asthma
- Trial name
- syMMPonia (NCT07191535)
- Testing
- linvemastat
- Volunteers
- 135 people
- Sponsor
- Foresee Pharmaceuticals Co., Ltd.
Asthma
Predictors of Asthma Exacerbations in Children
The purpose of this study is to determine whether parameters of the pulmonary function tests and the bronchial hyperresponsiveness to methacholine are predictors of asthma exacerbations.
- Trial name
- NCT01449435
- Testing
- Methacholine challenge testing
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Multiple Sclerosis, Nutrition
Nutritional Status and Muscle Function in Ambulatory Multiple Sclerosis Patients With Dysphagia
The aim of this study is to evaluate the relationship between dysphagia severity and indicators of nutritional status and muscle function in ambulatory patients diagnosed with Multiple Sclerosis (MS) who have swallowing…
- Conditions
- Multiple Sclerosis, Nutrition, Swallowing
- Trial name
- NCT07564921
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Sanko University
Diabetes, Diabetes Mellitus, Type 1
A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function
This trial is conducted globally. The aim of this trial is to assess the clinical proof-of-principle of NNC0114-0006 and liraglutide on preservation of beta-cell function in adult subjects with newly diagnosed type 1 diabetes…
- Trial name
- NCT02443155
- Testing
- NNC0114-0006, liraglutide
- Where
- 108 sites in United States, Austria and 16 more
- Volunteers
- 308 people
- Sponsor
- Novo Nordisk A/S
Head and Neck Cancer, Urologic Cancer
In-depth Characterization of Circulating and Infiltrating Immune Subsets and Tumor Cells in Cancer Patients
The aim of this study is to describe the tumor microenvironment of solid tumors and to understand the changes induced by anti-cancer treatments, particularly those developed by Innate Pharma.
- Conditions
- Head and Neck Cancer, Urologic Cancer, Lung Cancer, Breast Cancer
- Trial name
- FUTURE (NCT06827639)
- Testing
- blood collection, tissue specimen collection
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Multiple Sclerosis
MSPT Device Usability Study
The primary objective of this feasibility study is to evaluate the functionality (e.g., as defined by the primary endpoints) of the fully integrated Multiple Sclerosis Performance Test (MSPT) device, when used by unsupervised…
- Trial name
- MSPT (NCT02664324)
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Biogen
Acromegaly
PegvisOMant and the Immune SystEm (PROMISE)
This is a prospective observational pilot study for the evaluation of immune cells phenotype in acromegalic patients in comparison with a control population and to investigate the impact of disease control and different medical…
- Trial name
- NCT05069324
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- University of Roma La Sapienza
Asthma
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT01225913
- Testing
- fluticasone/salmeterol in all asthmatics, budesonide/formoterol or fluticasone/salmeterol in all asthmatics
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Gelb, Arthur F., M.D.
Digital Osteoarthritis or Rheumatoid Arthritis
Functional Imaging of Digital Osteoarthritis and Rheumatoid Arthritis Using 99mTc-NTP 15-5 in Nuclear Medicine
This study is a phase Ii clinical trial aimed to evaluate the performance of 99mTc-NTP 15-5 to identify a pathological hand joint in each group ; digital osteoarthrosis and rheumatoid arthritis
- Trial name
- CARSPECT II (NCT07624994)
- Testing
- 99mTc-NTP 15-5 at a diagnostic activity of 15 MBq/kg
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Jean Perrin
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