Clinical trials: Immune System Function
Type 1 Diabetes
Denosumab for Type 1 Diabetes
Type 1 diabetes (T1D) arises from abnormal immune cell-mediated injury to beta cells that make insulin. The injured beta cells can then no longer make the needed amount of insulin to stay healthy.
- Trial name
- NCT06524960
- Testing
- Denosumab
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- City of Hope Medical Center
Neurogenic Bladder, Multiple Sclerosis
Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS
Neurogenic overactive bladder (NOAB), characterized by urinary frequency, urgency or urgency incontinence symptoms occurring during the storage phase of the bladder, is the most common urinary complaint in multiple sclerosis…
- Conditions
- Neurogenic Bladder, Multiple Sclerosis, Overactive Bladder
- Trial name
- MSBLADDER (NCT06072703)
- Testing
- Magstim Rapid2 System
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The Methodist Hospital Research Institute
Scoliosis
Scoliosis and Functional Outcomes in Children With Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may affect musculoskeletal development and posture in children.
- Trial name
- NCT07433894
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Osteoarthritis, Avascular Necrosis
Comprehensive Nano - Post Market Clinical Follow-Up Study
This data collection project is intended to provide clinical outcomes data to engineering, marketing as well as fulfill the post market surveillance requirements of various regulatory authorities.
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Revision
- Trial name
- NCT03423953
- Testing
- Comprehensive Nano
- Where
- 5 sites in Austria, Canada and 2 more
- Volunteers
- 194 people
- Sponsor
- Zimmer Biomet
Cirrhosis, Liver, Splenectomy; Status
The Effect of Laparoscopic Splenectomy on the Immune Function for Cirrhosis Patients
In this study, the investigators compared the improvement of and azygoportal disconnection related indicators in patients with liver cirrhosis after laparoscopic splenectomy.
- Trial name
- ELSI (NCT05339269)
- Testing
- Laparoscopic splenectomy
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Northern Jiangsu People's Hospital
Depressive Symptoms, Anxiety
Pilot Feasibility Trial of the Family Strengthening Intervention in Rwanda (FSI-R)
The research will examine the following Specific Aims: Specific Aim 1: To adapt a U.S.-developed family-focused and strengths-based prevention program to the context of HIV/AIDS-affected families in Rwanda (the…
- Conditions
- Depressive Symptoms, Anxiety, Parenting
- Trial name
- NCT01509573
- Testing
- Family Strengthening Intervention in Rwanda (FSI-R)
- Where
- Rwanda
- Volunteers
- 82 people
- Sponsor
- Harvard School of Public Health (HSPH)
Spinal Cord Injuries, Cerebral Palsy
LEAP a New Overground Body Weight Support Robot: Usability Trial
People with central nervous system disorders such as spinal cord injury, stroke, cerebral palsy, Parkinson's disease, multiple sclerosis, etc… often have impaired lower extremity function that limits activities of daily life and…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Parkinson Disease, Multiple Sclerosis
- Trial name
- LEAP (NCT03458169)
- Testing
- Therapist LEAP session feedback, Participant LEAP session feedback, LEAP risk control validation
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Multiple Sclerosis
Clinical Pilates for Balance and Function in Multiple Sclerosis
This randomized controlled trial evaluated the effects of an 8-week Clinical Pilates program on balance and physical function in individuals with multiple sclerosis (MS).
- Trial name
- MS-PILATES (NCT07800039)
- Testing
- Clinical Pilates-Based Rehabilitation, Conventional Exercise-Based Physiotherapy
- Where
- Greece
- Volunteers
- 21 people
- Sponsor
- University of Patras
Electrode Site Reaction, Therapy
Functional Electrostimulation on the Upper Lip in Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease where immune cells attack the body, triggering an inflammatory response. A study comparing multifield FES and conventional FES on upper extremity motor skills and functional…
- Conditions
- Electrode Site Reaction, Therapy, Directly Observed Therapy
- Trial name
- EM/2024 (NCT06638775)
- Testing
- Fesia Grasp, GLOBUS ELITE
- Volunteers
- 30 people
- Sponsor
- Universidad de Burgos
Multiple Sclerosis (MS) - Relapsing-remitting, Upper Extremity Dysfunction
Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
This pilot mixed-method study will evaluate the feasibility, preliminary efficacy, and user experience of a home-based wearable Focal Vibration Therapy (FVT) intervention for improving upper extremity (UEx) function in people…
- Trial name
- NCT07376772
- Testing
- wearable focal vibration therapy
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Florida
Multiple Sclerosis
Costs, Quality of Life and Functional Outcomes in Veterans Treated for Multiple Sclerosis With Beta-Interferon l-B (Betaseron)
The treatment of multiple sclerosis was evolving in light of specific drug therapies to treat the disease, refinements and acceptance of imaging with MRI to diagnose and monitor the disease process, and progress in understanding…
- Trial name
- NCT00439257
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- US Department of Veterans Affairs
Stroke
Home-Based Automated Therapy of Arm Function After Stroke Via Tele-Rehabilitation
Constraint-Induced Movement therapy, also known as CI therapy, is an approach to physical rehabilitation derived from basic behavioral and neuroscience research.
- Trial name
- NCT01157195
- Testing
- Tele-AutoCITE, CI therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Asthma
Lung Function Outcomes Following Removal of Airway Mucus Plugs in Patients With Asthma (FOCUS)
This is a single-center study that will evaluate the safety and tolerability of removal of mucus plugs by bronchoscopy in patients with asthma.
- Trial name
- FOCUS (NCT05748912)
- Testing
- Therapeutic bronchoscopy for removal of mucus plugs
- Where
- United States
- Sponsor
- University of California, San Francisco
Sjogren's Syndrome, Digestive System Abnormalities
Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome
the investigators propose to carry out a prospective study consisting of a systematic research of digestive symptoms in patients with SGSp with the validated Global symptom score (GSS) questionnaire, which allowed to grades…
- Trial name
- GASTRO-SGS (NCT03157011)
- Testing
- Global symptom score (GSS) questionary
- Where
- France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Limoges
HIV Infection
SNAP: Switching Nucleoside Analogues Protocol - Lipoatrophy and Mitochondrial Function
HIV infected subjects receiving antiretroviral treatment for greater than 6 years with be evaluated for clinical lipoatrophy and mitochondrial function after switching nucleoside analogues from stavudine (d4T) to tenofovir…
- Trial name
- NCT00225082
- Testing
- Nucleoside analogue switch
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwestern University
Breast Cancer
Acupuncture Chemotherapy-Induced Peripheral Neuropathy (CIPN) IRG
The goal of this clinical research study is to compare the level of effectiveness for 2 acupuncture treatment schedules for chronic CIPN in breast cancer survivors.
- Trial name
- NCT01815346
- Testing
- Acupuncture, Questionnaires, Hand Function and Balance Tests
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Rheumatoid Arthritis (RA)
Self-Care Education for Joint Stiffness and Functional Ability in Rheumatoid Arthritis
Rheumatoid arthritis is a chronic inflammatory autoimmune disease that may cause joint stiffness, pain, reduced mobility, and impaired functional ability.
- Trial name
- NCT07761767
- Testing
- self care educational program for the study group, Routine care
- Volunteers
- 110 people
- Sponsor
- Assiut University
Arthritis
Evaluation of the Active Living Every Day Exercise Program for People With Arthritis
The primary goal of this study is to assess the effectiveness and feasibility of the Active Living Every Day Physical Activity Program (ALED) for people with arthritis.
- Trial name
- NCT00146367
- Testing
- Active Living Every Day
- Volunteers
- 355 people
- Sponsor
- Centers for Disease Control and Prevention
Multiple Myeloma
Prospective Evaluation of Taste Function In Multiple Myeloma Patients Undergoing Autologous Hematopoietic Cell Transplantation
The purpose of this study is to study taste disturbances on patients with myeloma who received high dose melphalan.
- Trial name
- NCT03276481
- Testing
- Oral microbiota assessment, Comprehensive chemical gustometry, Measurement of salivary flow
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Multiple Sclerosis
The Effect of Backward Walking Training on Balance, Gait and Functional Mobility in Patients With Multiple Sclerosis
Backward walking training can be a useful treatment approach, providing novel balance and gait challenges. It can lead to improve balance, gait and functional mobility in neurologic populations.
- Trial name
- NCT05505383
- Testing
- Exercise training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Saglik Bilimleri Universitesi
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