Clinical trials: Immune System Function
Multiple Myeloma, Impaired Renal Function
Pharmacokinetics of Lenalidomide (Revlimid®) in Patients With Multiple Myeloma and Impaired Renal Function
The purpose of this study is to determine the pharmacokinetic profile of Revlimid® in patients presenting with Multiple Myeloma and impaired renal function, the safety of Revlimid® in the enrolled patients population.
- Trial name
- NCT00779922
- Testing
- lenalidomide
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Poitiers University Hospital
Asthma, Cough Variant Asthma
Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests
Cough is a common, disruptive and at times disabling symptom which often prompts patients to seek medical attention. Determining the cause(s) of chronic cough can be challenging, and costly.
- Trial name
- NCT01064245
- Testing
- high-dose methacholine challenge test, mannitol challenge test
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Dr. Diane Lougheed
Diabetic Nephropathies, Kidney Failure, Chronic
Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease
Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes.
- Conditions
- Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
- Trial name
- SUGARNSALT (NCT06217302)
- Testing
- Sotagliflozin
- Where
- 19 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- Alessandro Doria
Multiple Sclerosis, Mixed Reality
Validity and Reliability of Mixed Reality-Based Mobility Tests in Multiple Sclerosis
Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system, with common symptoms including muscle weakness, balance impairments, gait difficulties, and fatigue.
- Trial name
- NCT07361965
- Testing
- Clinical Assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Selcuk University
Neurocognitive Impairment, Mild
Statin TReatment for COVID-19 to Optimise NeuroloGical recovERy
STRONGER is an international, investigator initiated and conducted, pragmatic clinical trial to determine whether 40mg atorvastatin daily can improve neurocognitive function in adults with long COVID neurological symptoms.
- Trial name
- STRONGER (NCT04904536)
- Testing
- Atorvastatin, Standard Care
- Where
- Australia
- Volunteers
- 190 people
- Sponsor
- The George Institute
Esophageal Stricture, Eosinophilic Esophagitis
EndoFLIP Use in Upper GI Tract Stenosis
The purpose of this study is to investigate the use of a functional luminal imaging probe to characterize benign esophageal luminal strictures before and after dilation and identify predictors of response to therapy.
- Conditions
- Esophageal Stricture, Eosinophilic Esophagitis, Zenkers Diverticulum, Schatzki Ring
- Trial name
- EndoFLIP (NCT02354716)
- Testing
- EndoFLIP
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Multiple Sclerosis
Lung Volume Recruitment for Lung Function and Cough Impairment in Multiple Sclerosis
Multiple sclerosis is a neurological disease that can affect lung function and cough efficacy. This pilot study will examine whether the lung volume recruitment technique can slow down the decline in lung function and cough.
- Trial name
- NCT01891071
- Testing
- Lung volume recruitment
- Where
- 2 sites in Canada
- Volunteers
- 35 people
- Sponsor
- Ottawa Hospital Research Institute
Multiple Sclerosis
Relıabılıty and valıdıty of the supıne-to-stand Test wıth Multiple Sclerosis
Background: Supine-to-Stand Test (SST) requires muscle strength, flexibility, and dynamic balance and can be used as a marker of functional motor competence in patients with Multiple Sclerosis (pwMS).
- Trial name
- NCT06790992
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Sanko University
Asthma in Children
Effect of a Daily Text Reminder on Asthma Medication Use, Symptom Control, and Lung Function in Children
The goal of this clinical trial is to learn if a daily text reminder ("AdhasText") can help children with asthma use their inhalers regularly, control their symptoms, and improve their lung function.
- Trial name
- NCT07053839
- Testing
- Daily Text Reminder
- Where
- Peru
- Volunteers
- 64 people
- Sponsor
- ROXANA AZNARAN TORRES
Spinal Cord Injuries, Multiple Sclerosis
Validity and Reliability of Turkish Version Leg Activity Measure
Patient-filled scales minimize the burden of data collection for clinicians in a clinical setting. Therefore, Leg activity measure, a new self-report measure of active and passive function in the leg, has been developed.
- Conditions
- Spinal Cord Injuries, Multiple Sclerosis, Stroke
- Trial name
- NCT05182411
- Testing
- assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Colorectal Surgery
Effects of Postoperative Pain Management on Immune Function After Laparoscopic Resection of Colorectal Cancer
The purpose of this study is to compare postoperative immune function (e.g. NK cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal…
- Trial name
- NCT02012244
- Testing
- fentanyl-based analgesia, local anesthetic wound infiltration-based anlagesia
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Severance Hospital
Sarcoidosis, Sarcoidosis, Pulmonary
The Role of Physical Activity and Diet Within Pulmonary Sarcoidosis
This project focuses on the sub-group population with pulmonary sarcoidosis - a condition that causes red swollen tissue called granulomas to develop in organs such as the lungs.
- Conditions
- Sarcoidosis, Sarcoidosis, Pulmonary, ILD, Interstitial Lung Disease
- Trial name
- NCT03336736
- Testing
- Exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Kingston University
Eosinophilic Esophagitis (EoE)
Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)
The goal of this study is to research Dupilumab, an FDA approved medication in treating patients diagnosed with Eosinophilic esophagitis (EoE). The drug works by controlling allergic inflammation of the esophagus.
- Trial name
- NCT06665971
- Testing
- Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
HIV Seropositivity
Effects of Cannabidiol (CBD) on the Activation of Autophagy and Inflammation Genes, Functional Consequences in Virologically Controlled HIV-infected Patients
Autophagy and apoptosis are natural cellular mechanisms which consist for the first in a recycling and elimination process of potentially toxic cellular waste, and for the second in a process of cellular suicide when it becomes…
- Trial name
- GALIG-CBD (NCT05306249)
- Testing
- CBD LGP 50
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Immune Thrombocytopenia
The Alteration of Macrophage Function in the Spleen Tissues From Patients With Primary Immune Thrombocytopenia
This project was undertaken by Qilu Hospital of Shandong University and other well-known hospitals in China. In order to report the alteration on the macrophage function in the spleen tissue of primary immune thrombocytopenia…
- Trial name
- ITP (NCT01869049)
- Where
- China
- Sponsor
- Shandong University
Lymphoma, Sarcoma
WATCH (Wearable Artificial inTelligence for Cardiac Function and Health Monitoring)
The purpose of this study is to find a cost effective cardiovascular (CV) surveillance of cancer survivors over long periods of time to prevent the risk of progression of heart failure (HF) and related morbidity and mortality.
- Trial name
- NCT07058064
- Testing
- Electrocardiogram, Echocardiogram, LVEF echocardiogram
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Mayo Clinic
Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting
Home Based Functional Balance Intervention for Multiple Sclerosis
The study involves a two-arm, Phase 1, randomized controlled clinical trial designed to establish the feasibility and effects of a Functional Balance Intervention (FBI) on physical and cognitive function, as well as measures of…
- Conditions
- Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (MS) Primary Progressive, Multiple Sclerosis (MS) Secondary Progressive
- Trial name
- HomeFBIinMS (NCT07355387)
- Testing
- Multicomponent balance intervention consisting of four components including dual-tasking, functional strength, vestibular and dynamic balance., Stretching
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Illinois Chicago
Multiple Sclerosis, Kinesiophobia
Evaluation of the Presence and Effects of Kinesiophobia in Multiple Sclerosis
The aim of this study was to evaluate the presence of kinesiophobia in multiple sclerosis and to investigate the effect of kinesiophobia on physical activity, functional status, quality of life and depression.
- Trial name
- NCT06167447
- Testing
- questionnaire and examination
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gazi University
Constipation
A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation
Constipation is common in the general population, especially in women and in the elderly. Hard stool is a complaint often associated with constipation, which suggests that stool softening would provide a major benefit in the…
- Trial name
- NCT02073006
- Testing
- Natural Fibre Supplement
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Asthma
Alternate Nostril Breathing With Incentive Spirometry on Lung Function Among Asthma Patients
To compare effects of Alternate Nostril Breathing exercise with incentive spirometer on lung functions (forced vital capacity, forced expiratory volume, and peak expiratory flow rate) in Asthma patients.
- Trial name
- NCT07110116
- Testing
- Alternate nostril breathing with Incentive Spirometery, Incentive spirometery
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
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