Clinical trials: Immune System Function
HIV Infections
Perspective Memory and Executive Functions in HIV+ Patients
The primary goal of this observational study is to evaluate prospective memory in HIV+ patients compared to healthy subjects. The secondary goal is to examine the relationship between prospective memory and Hot Cognition…
- Trial name
- (3514) (NCT05752578)
- Testing
- Neuropsychological testing
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Joint Disease
PMCF Study for PROFEMUR® Am Femoral Components and PROCOTYL® O HA Coated Acetabular Components
MicroPort Orthopedics (MPO) is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its total hip arthroplasty (THA) and resurfacing components marketed in the European Union (EU).
- Trial name
- NCT02507258
- Testing
- PROFEMUR® Am Femoral Stem w/ PROCOTYL® O Shell
- Where
- France
- Sponsor
- MicroPort Orthopedics Inc.
Multiple Sclerosis
Chewing Under Dual-Tasking in MS
This study aims to investigate the effects of visual, auditory, and motor dual-task conditions on chewing performance in individuals with multiple sclerosis, compared with healthy controls.
- Trial name
- NCT07366216
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Multiple Sclerosis, Weakness
Effects of the Cross-Training in Patients With Multiple Sclerosis
The purpose of this study is to determine whether, in patients with multiple sclerosis presenting with marked asymmetry of strength, training the less-affected limb with a Cross-Training approach may induce a meaningful transfer…
- Conditions
- Multiple Sclerosis, Weakness, Fatigue
- Trial name
- CTSM (NCT02010398)
- Testing
- Cross-Training healthy subjects, Cross-Training multiple sclerosis, Standard-training multiple sclerosis
- Where
- 3 sites in Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Inflammation, Nutrition, Healthy
Probiotic Beer to Enhance Gut Health and Immune System Function
This study investigates the immunological and gut microbiome effects of moderate probiotic beer consumption.
- Trial name
- PBEER (NCT05401604)
- Testing
- Moderate probiotic beer consumption, Moderate normal beer consumption
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Rheumatoid Arthritis
Clinical Disease Activity and Modulation of Synovial Lymphoid Structures and B Cell Function in Rheumatoid Arthritis
This study will be an open label observational prospective study assessing the clinical efficacy of antiTNFα therapy and the alteration/impact on the synovial tissue, with specific regard to lymphoid aggregation, over a period of…
- Trial name
- NCT02528292
- Testing
- Synovial biopsy, Anti-TNF therapy
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Barts & The London NHS Trust
Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Relapsing-Remitting
Exercise Effects in Multiple Sclerosis
A growing body of work suggests that regular exercise can support symptom management and improve physical function for people living with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis, Chronic Progressive
- Trial name
- NCT05496881
- Testing
- Exercise Group 1, Exercise Group 2, Exercise Group 3
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- University of Regina
Multiple Sclerosis
Exercise on Multiple Sclerosis Patients
Multiple sclerosis (MS) patients are characterized by thermoregulatory failure, known as Uthoff's phenomenon. Precisely, 60-80% of the MS patients present adverse clinical symptoms when their body temperature is increased.
- Trial name
- NCT04125628
- Testing
- Exercise with cooling, Exercise without cooling
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Cardiac Toxicity, Chemotherapeutic Agent Toxicity
Cardiac Magnetic Resonance Imaging in Patients With Non-Hodgkin Lymphoma or Hodgkin Lymphoma Receiving Doxorubicin
RATIONALE: Diagnostic procedures, such as cardiac magnetic resonance imaging, may help doctors detect early changes in the heart caused by chemotherapy.
- Conditions
- Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Lymphoma
- Trial name
- NCT00577798
- Testing
- contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Idiopathic Parkinson's Disease, Multiple Sclerosis
Online Cognitive Training in PD, MS and Depressed Patients Treated With Electroconvulsive Therapy
In Parkinson's disease, Multiple Sclerosis and depressed patients treated with electroconvulsive therapy, cognitive dysfunction is prevalent. However, treatment of these dysfunctions is in its infancy.
- Conditions
- Idiopathic Parkinson's Disease, Multiple Sclerosis, Elderly Post Electric Convulsive Therapy
- Trial name
- NCT02525367
- Testing
- Online cognitive training, Active control condition
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Amsterdam UMC, location VUmc
Asthma
The Dallas Asthma Brain and Cognition (ABC) Study
Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which exerts a substantial burden on quality of life and can influence other health domains if not adequately controlled.
- Trial name
- NCT03794856
- Testing
- Functional and Structural Magnetic Resonance Imaging (research grade), Cognitive Function Testing (non-diagnostic), Asthma and Psychological Questionnaires (non-diagnostic)
- Where
- 2 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Asthma Management, Time Restricted Eating
Investigating the Impact of Early Time-Restricted Eating on Health Outcomes and Quality of Life in Adults With Mild Controlled Asthma Compared to Healthy Adults
This study aims to explore how early time-restricted eating (eTRE) - where all daily meals are eaten within a specific time window - affects health and quality of life in adults.
- Trial name
- eTRE (NCT07345572)
- Testing
- Early Time-Restricted Eating (eTRE) and Habitual Diet (HD), Habitual Diet (HD) and Early Time-Restricted Eating (eTRE)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- De Montfort University
Rheumatic Arthritis
Effects of Paraffin Wax Therapy and Dry Cupping on Pain and Wrist Function in Patients With Rheumatoid Arthritis
Rheumatoid arthritis is a chronic inflammatory disease that can cause pain, stiffness, and reduced functional performance in the wrist and hand joints.
- Trial name
- PDC-RA (NCT07905651)
- Testing
- Paraffin Wax Therapy, Dry cupping
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- University of Baghdad
Chronic Sinusitis With Nasal Polyps
Adelmidrol in Chronic Sinusitis
The goal of this study is to evaluate whether a nasal spray containing adelmidrol, a mast cell modulator and precursor of palmitoylethanolamide, can reduce inflammation, improve symptoms, and decrease nasal polyp size in patients…
- Trial name
- AdeCroS (NCT07675512)
- Testing
- Adelmidrol spray -Rinidrol, Nasonex Nasal Spray, Nasonex Nasal Spray + Rinidrol
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
HIV Associated Neurocognitive Disorder, HIV Dementia
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
The purpose of this study is to longitudinally characterize and evaluate changes in synaptic density in the brain using novel positron-emission tomography (PET) scans; magnetic resonance imaging (MRI), and clinical laboratory…
- Conditions
- HIV Associated Neurocognitive Disorder, HIV Dementia, HIV Encephalitis, Healthy
- Trial name
- ART (NCT05586581)
- Testing
- SV2A PET, TSPO PET
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yale University
Lung Diseases, Obstructive, Asthma
Monitoring Asthma and COPD in Primary Care
The purpose of this study is to determine the clinical effectiveness and cost-effectiveness of a written expert advice for GPs on additional diagnostic, treatment, and referral of patients based on half-yearly monitoring routines…
- Trial name
- Monaco (NCT00542061)
- Testing
- half-yearly monitoring routine
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 1
Advanced Hybrid Closed Loop System (AHCL) in Older Patients With Type 1 Diabetes Mellitus
The trial is a randomized controlled, parallel group design study. Patients will be followed up during approximatively 12 months.
- Trial name
- NCT06236256
- Testing
- MiniMed™ 780G Advanced Hybrid Closed Loop (AHCL) system, MDI/CSII
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Sheba Medical Center
Multiple Myeloma
A Study of Belantamab Mafodotin Monotherapy in Multiple Myeloma Participants With Normal and Varying Degree of Impaired Renal Function
Belantamab mafodotin is an antibody-drug conjugate (ADC) containing humanized anti- B-cell maturation antigen (BCMA) monoclonal antibody (mAb).
- Trial name
- DREAMM12 (NCT04398745)
- Testing
- Belantamab mafodotin
- Where
- 4 sites in Greece, South Korea
- Volunteers
- 36 people
- Sponsor
- GlaxoSmithKline
Graves Disease, Mental Fatigue
Validating Immunological Markers Associated With Mental Fatigue in Graves' Disease
Mental fatigue occurs in many diseases and the reasons are mostly unknown. The investigators hypothesize that remaining mental fatigue after restored euthyroidism in Graves' disease is an autoimmune complication.
- Trial name
- NCT06081439
- Where
- Sweden
- Volunteers
- 430 people
- Sponsor
- Vastra Gotaland Region
Type 1 Diabetes, Heart Disease
Haptoglobin Phenotype, Vitamin E and High-density Lipoprotein (HDL) Function in Type 1 Diabetes
The purpose of the study is to determine whether the function of the good cholesterol (HDL cholesterol) as well as its subfractions (via NMR spectroscopy) is altered among people with type 1 diabetes and a variation in the…
- Trial name
- HAP-E (NCT01098994)
- Testing
- Vitamin E, Dummy pills
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Pittsburgh
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