Clinical trials: Immune System Function
Type 1 Diabetes, Basal-bolus Multiple-dily Insulin Injections
Self-management of Type 1 Diabetes Under Functional Insulin Therapy
Therapeutic education of patients is a mandatory component of intensive insulin therapy of type 1 diabetes in order to reach optimal safety and efficacy.
- Conditions
- Type 1 Diabetes, Basal-bolus Multiple-dily Insulin Injections, Insulin Pump (CSII)
- Trial name
- EVAUTODIAB (NCT02272348)
- Testing
- Training course to functional insulin therapy, Usual diabetes management.
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus, Type 1
Anhydroglucitol in Children With Type 1 Diabetes
The investigators will measure blood levels of 1,5-anhydroglucitol in children with type 1 diabetes and correlate them with parameters related to functional beta-cell mass in diabetic patients.
- Trial name
- NCT05594706
- Testing
- Measurement of blood levels of 1,5-anhydroglucitol
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Bronchial Asthma
Coupled Inspiratory and Expiratory Muscle Training in Children With Bronchial Asthma
This study was designed to assess the effect of inspiratory and expiratory muscle training in the same cycle on respiratory muscle strength, pulmonary functions, perception of asthma symptoms in children with bronchial asthma.
- Trial name
- NCT05212558
- Testing
- Inspiratory muscle training, Combined inspiratory and expiratory muscle training
- Where
- Saudi Arabia
- Volunteers
- 51 people
- Sponsor
- Cairo University
Addison Disease, Hypoaldosteronism
Adrenal Function After Living Kidney Donation
The success of kidney transplantation is hampered by the shortage of organs. One attractive strategy is the use of kidneys from living donors.
- Trial name
- NCT00251836
- Testing
- Laparoscopic hand-assisted donor nephrectomy
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Asthma
6-Minute Pegboard and Ring Test Unsupported Arm Function Exercise Test in Asthma Patients
Exercise intolerance is one of the most problems in chronic obstructive pulmonary disease (COPD) and occurs not only in performing lower body tasks but also in performing arm activities.
- Trial name
- NCT03693664
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Hacettepe University
Stroke
Brain State-dependent PCMS in Chronic Stroke
After stroke, people often have difficulty using their hands. Combined brain and nerve stimulation can strengthen the neural pathways that control hand function.
- Trial name
- NCT04830163
- Testing
- Brain state-dependent paired corticomotoneuronal stimulation (PCMS)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Texas at Austin
Graves Disease, Graves' Disease
Impact of Vitamin D Therapy on Thyroid Function and Antibody Levels in Pediatric Graves' Disease
The goal of this randomized pilot feasibility clinical trial is to determine the feasibility of implementing a protocol for a larger trial to assess the effects of high-dose vitamin D supplementation in pediatric patients (9-17…
- Conditions
- Graves Disease, Graves' Disease, Hyperthyroidism
- Trial name
- NCT07369063
- Testing
- Ergocalciferol 50,000 IU, Methimazole
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Exercise Triggered Asthma, Gastroesophageal Reflux
Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppression
We propose that acid reflux affects respiratory dynamics (breathing) in patients who are exercising and that athletes improve their exercise capacity with acid suppression therapy.
- Trial name
- NCT00444236
- Testing
- Nexium
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Utah
Hemiplegia, Spasticity
Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment
This trial is part of the spastiCRYO clinical research project. The primary objective of this clinical trial is to test the hypothesis: "Upper limb nerve cryoneurolysis is non inferior to the usual care and has therapeutic add…
- Conditions
- Hemiplegia, Spasticity, Shoulder Spasticity, Shoulder Stiffness
- Trial name
- spastiCRYO-UL (NCT06782464)
- Testing
- Treatment
- Where
- Luxembourg
- Volunteers
- 50 people
- Sponsor
- Centre National de Rééducation Fonctionnelle et de Réadaptation
Rheumatoid Arthritis
Textured Insoles and Foot Massage in Individuals Diagnosed With Rheumatoid Arthritis
The aim of this study is to determine and compare the effects of using textured insoles and plantar massage on balance in patients with rheumatoid arthritis.
- Trial name
- NCT05045898
- Testing
- plantar massage, textured insoles
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gazi University
Juvenile Idiopathic Arthritis
Effect of Pulsed Magnetic Field Versus Low Level Laser Therapy on Functional Performance in Children With Juvenile Idiopathic Arthritis
the purpose of this study is to compare between the effect of pulsed magnetic field versus low level laser therapy on functional performance in children with juvenile idiopathic arthritis
- Trial name
- NCT06226012
- Testing
- pulsed magnetic field, Low level laser
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Shrouk Abd Elmohsen Taha Basiony Elnhrawy
Type 1 Diabetes
Early High-Dose Vitamin D and Residual β-Cell Function in Pediatric Type 1 Diabetes
The project aims to study the effect of early high-dose vitamin D supplementation on type 1 diabetes in children and adolescents receiving intensive insulin therapy.
- Trial name
- NCT05270343
- Testing
- Cholecalciferol (Vit D3) 400Unit Cap
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Melanoma
Study to Assess Safety and Immune Response of Stage IIB-IV Resected Melanoma After Treatment With MAGE-A3 ASCI
The goals of this study are to 1) assess the safety of recombinant MAGE-A3 protein combined with AS15 Immunological Adjuvant System (recMAGE-A3 + AS15) as an Antigen-Specific Cancer Immunotherapeutic (MAGE-A3 ASCI) when…
- Trial name
- Mel55 (NCT01425749)
- Testing
- recMAGE-A3 + AS15 ASCI
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Craig L Slingluff, Jr
Asthma (Diagnosis)
Comparative Effects of Alternative Nostril Breathing Versus Buteyko Breathing on Control Pause, Dyspnea and Pulmonary Function in Patients With Bronchial Asthma
Bronchial asthma is a chronic inflmmatory airway disease characterized by recurrent episodes of dyspnea, wheezing, and airflow limitation. Dysfunctional breathing pattern and chronic hyperventilation
- Trial name
- NCT07529847
- Testing
- Alternative Nostril Breathing Technique along with standard pharmacological management, Buteyko breathing along with pharmacological management
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Foundation University Islamabad
Arthritis, Rheumatoid, Pain
Pain Modulation in Rheumatoid Arthritis (RA) - Influence of Adalimumab
The purpose of this study is to obtain increased knowledge concerning central pain and fatigue processing in rheumatoid arthritis, and how these conditions are influenced by treatment with Tumor Necrosis Factor (TNF) blockade…
- Conditions
- Arthritis, Rheumatoid, Pain, Fatigue
- Trial name
- PARADE (NCT01197144)
- Testing
- adalimumab
- Where
- 2 sites in Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska Institutet
Neurologic Disorder, Parkinson Disease
High Intensity Functional Training for Individuals With Neurologic Diagnoses and Their Care Partners
Individuals with and without neurologic diagnoses greatly benefit from participation in regular exercise but the majority are physically inactive.
- Conditions
- Neurologic Disorder, Parkinson Disease, Spinal Cord Injuries, Spina Bifida
- Trial name
- SHIFT-AR (NCT05951985)
- Testing
- HIFT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Arkansas Colleges of Health Education
Alzheimer's Disease
Effects of an Anti-Inflammatory Drug in Alzheimer's Disease
The purpose of this study is to evaluate the effects of the drug cyclophosphamide (CY) on inflammation and immune responses in individuals with Alzheimer's Disease (AD).
- Trial name
- NCT00013650
- Testing
- Cyclophosphamate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Guillain-Barre Syndrome
Effects of Proprioceptive Neuromuscular Training on Sensory and Motor Function in Guillain Barre Syndrome
This study aims to determine the effects of Proprioceptive Neuromuscular Training on Sensory versus Motor Function in patients presenting with Guillain Barre Syndrome.
- Trial name
- NCT05491096
- Testing
- Proprioceptive Neuromuscular Training, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Leukemia, Long-term Effects Secondary to Cancer Therapy in Adults
Ovarian Damage in Young Premenopausal Women Undergoing Chemotherapy for Cancer
RATIONALE: Comparing results of diagnostic procedures, such as ultrasound, done before, during, and after chemotherapy may help doctors learn about the side effects of chemotherapy and help plan the best treatment.
- Conditions
- Leukemia, Long-term Effects Secondary to Cancer Therapy in Adults, Long-term Effects Secondary to Cancer Therapy in Children, Lymphoma
- Trial name
- NCT00402935
- Testing
- laboratory biomarker analysis, fertility assessment and management, management of therapy complications
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Multiple Sclerosis
Preventing the Progression of Multiple Sclerosis: Early Rehabilitative Treatment and Multimodal Assessment - Part A
Motor performance of people with Multiple Sclerosis (PwMS) can decline since the onset of the disease. Longitudinal studies are needed to detect early worsening in mobility and balance using wearable devices for activity tracking…
- Trial name
- NCT06219291
- Testing
- Observational
- Where
- 3 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
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