Clinical trials: Immune System Function
Disorder of Immune Function
Effect of Zinc Supplementation on Serum Zinc Level in Nursing Home Elderly
Background: Zinc supplementation has the potential to improve serum zinc levels and immunity of zinc deficient nursing home elderly.
- Trial name
- NCT01599572
- Testing
- zinc supplementation
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tufts University
Diabetes Mellitus, Type 1
Monotherapy With Rapamycin in Long-standing Type 1 Diabetes
This study is a phase 2, single-center, prospective, randomized, double-blind, placebo-controlled, 3-arm parallel group (1:1:1) intervention trial to determine the efficacy of 4 weeks rapamycin treatment and 4 weeks rapamycin…
- Trial name
- MONORAPA (NCT02803892)
- Testing
- rapamycin, Vildagliptin
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Piemonti Lorenzo
Chronic Pain, Fibromyalgia
Effects of Fasting on Self Efficacy
The study aims to investigate if a 7 day therapeutic fasting regimen will affect self-efficacy of patients with chronic diseases the effects of fasting on physical and mental well-being, quality of life and body awareness/image…
- Conditions
- Chronic Pain, Fibromyalgia, Rheumatoid Arthritis, Gout
- Trial name
- TheraFast (NCT02113111)
- Testing
- Fasting
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universität Duisburg-Essen
Type 1 Diabetes
Immune Function and the Progression to T1D
To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune…
- Trial name
- NCT05899439
- Testing
- blood draw
- Where
- 3 sites in United States
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- University of Florida
Asthma
Roflumilast Plus Montelukast in Adults With Severe Asthma
This study will evaluate the effect of roflumilast 500 μg once daily (QD) plus montelukast 10 mg QD versus 10 mg montelukast QD alone on predose (trough) prebronchodilator forced expiratory volume in the first second (FEV1).
- Trial name
- NCT01765192
- Testing
- Roflumilast, Montelukast
- Where
- 13 sites in Germany, Hungary and 1 more
- Volunteers
- 64 people
- Sponsor
- AstraZeneca
Obesity, Weight Loss
Evaluation of Bariatric Endoscopic Antral Myotomy (BEAM) as a Treatment for Obesity
In the proposed study, we will be evaluating the effects of pylorus sparing antral myotomy alone, without concomitant endoscopic sleeve gastroplasty (ESG), on weight loss for subjects undergoing the procedure with a history of…
- Conditions
- Obesity, Weight Loss, Delayed Gastric Emptying Following Procedure, Obesity, Mild
- Trial name
- BEAM (NCT05713071)
- Testing
- Bariatric Endoscopic Antral Myotomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis, Breath Tests
The Relationship Between Mechanical Properties of Respiratory and Lower Extremity Muscles and Other Parameters in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease characterised by deterioration in the mechanics of the lower extremities and respiratory muscles and a decrease in respiratory function.
- Conditions
- Multiple Sclerosis, Breath Tests, MyotonPRO
- Trial name
- NCT07202780
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Sanko University
Graves Disease, Mental Fatigue
Validating Immunological Markers Associated With Mental Fatigue in Graves' Disease
Mental fatigue occurs in many diseases and the reasons are mostly unknown. The investigators hypothesize that remaining mental fatigue after restored euthyroidism in Graves' disease is an autoimmune complication.
- Trial name
- NCT06081439
- Where
- Sweden
- Volunteers
- 430 people
- Sponsor
- Vastra Gotaland Region
Hematologic Malignancies, Inherited Disorders of Metabolism
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.
- Conditions
- Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders
- Trial name
- NCT01351545
- Testing
- A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)
- Where
- 142 sites in United States
- Volunteers
- 99,999 people
- Sponsor
- Center for International Blood and Marrow Transplant Research
Multiple Sclerosis, Cognitive Rehabilitation
Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis
Despite the need for cognitive rehabilitation, there is a paucity of well-designed research studies to investigate treatment approaches or their effectiveness in MS.
- Trial name
- REACTIV (NCT01207856)
- Testing
- specific cognitive rehabilitation, non specific cognitive rehabilitation, no intervention
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Type 1 Diabetes Mellitus
Cardiopulmonary Fitness, Lung Function, Muscular Oxygen Saturation, and Quality of Life in T1DM
The purpose of this study is to compare the differences of 1. cardiopulmonary fitness 2. lung function 3. muscular oxygen saturation 4. quality of life between type 1 diabetes mellitus and healthy adults.
- Trial name
- NCT01727661
- Testing
- exercise testing with near-infrared spectroscopy, lung function testing, quality of life
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Asthma
A Study to Investigate the Effect on Lung Function of BDA Formulated With a Next Generation Propellant Compared With an Approved Asthma Treatment (BDA With HFA Propellant) in Participants With Asthma
The purpose of this study is to assess the PD equivalence of the approved asthma combination therapy, BDA, delivered using the proposed replacement propellant HFO compared with BDA delivered using the currently approved…
- Trial name
- NCT06502366
- Testing
- BDA MDI HFO 160/180 μg, BDA MDI HFA 160/180 μg
- Where
- 128 sites in United States, China and 4 more
- Volunteers
- 424 people
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
Long-Term Assessment of Safety and Physical Function With AMG 108 in RA
The purpose of this study is to assess long-term safety of SC AMG 108 in the treatment of RA
- Trial name
- NCT00369473
- Testing
- AMG 108
- Volunteers
- 690 people
- Sponsor
- Amgen
HIV, AIDS
TMC278-TiDP6-C130: Pharmacokinetics, Safety and Tolerability of TMC278 in Subjects With Mildly or Moderately Impaired Hepatic Function.
The purpose of this study is to investigate the pharmacokinetics (how the drug is absorbed into the bloodstream, distributed in the body and eliminated from the body) after a single dose and after repeated administration of…
- Conditions
- HIV, AIDS, Hepatic Impairment
- Trial name
- NCT00736905
- Testing
- TMC278
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Muscle Damage, Inflammation
Protein and Recovery From Exercise-induced Muscle Damage
Intense, eccentric resistance exercise causes muscle damage, soreness, inflammation, and a loss of muscle function. Protein-amino acid supplementation before, during, and following damaging resistance exercise may reduce muscle…
- Trial name
- NCT02034721
- Testing
- Protein supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Allergies
Effects of Co-Exposure to Air Pollution and Allergen
The investigators are investigating the effects of combined exposures to diesel exhaust and allergens on lung function and on the immune system.
- Trial name
- NCT01792232
- Testing
- Allergen, Saline
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Graves Disease, Graves' Disease
Impact of Vitamin D Therapy on Thyroid Function and Antibody Levels in Pediatric Graves' Disease
The goal of this randomized pilot feasibility clinical trial is to determine the feasibility of implementing a protocol for a larger trial to assess the effects of high-dose vitamin D supplementation in pediatric patients (9-17…
- Conditions
- Graves Disease, Graves' Disease, Hyperthyroidism
- Trial name
- NCT07369063
- Testing
- Ergocalciferol 50,000 IU, Methimazole
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Type 1 Diabetes
Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes
Insulin resistance (IR) is an important contributor to increased cardiovascular disease risk in type 1 diabetes (T1D). Non-esterified fatty acid elevation is a significant contributor to IR in T1D and may be a target of…
- Trial name
- AcT1 (NCT01816165)
- Testing
- Acipimox
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Relapsing-Remitting Multiple Sclerosis
A fMRI(Functional Magnetic Resonance Imaging) Research Study to Learn More About Multiple Sclerosis and Individuals Potentially Experiencing Memory Difficulties
The purpose of this study is to determine if medication designed to improve memory will help patients with Multiple Sclerosis (MS) who are experiencing memory problems using fMRI to track brain activity.
- Trial name
- NCT00315367
- Testing
- Donepezil HCI (drug)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Neurognostics
HIV/AIDS
The Effect of Arsenic Trioxide on Eliminating HIV-1 Reservoir Combined With cART
To evaluate the safety and efficacy of arsenic trioxide combined with cART in eliminating latent HIV-1 reservoir, providing potential strategies for AIDS functional cure.
- Trial name
- NCT03980665
- Testing
- Arsenic Trioxide
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou 8th People's Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.