Clinical trials: Immune System Tolerance
Obesity
Safety and Tolerance of a Nutritional Intervention Program- In.Form 1.2
The study evaluated and the safety, tolerance and acceptability of a lifestyle modification program with nutritional supplementation in generally healthy overweight subjects with cardiometabolic risk factors.
- Trial name
- NCT03098056
- Testing
- PROG2
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nature's Sunshine Products, Inc.
Weight Management
Tolerance and Appetite Reduction of a Nutritional Solution With Intragastric Gelation Properties
The physical properties of a food product, such as its gelling properties in the stomach can influence how full a person may feel after its consumption.
- Trial name
- NCT07127198
- Testing
- Beverage Variant 1 (low gelation properties), Beverage Variant 2 (medium gelation properties), Beverage Variant 3 (high gelation properties)
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Malnutrition
EnergieShake® Acceptability and Tolerance Study
This open-label, prospective, controlled intervention study involves evaluating tolerance and acceptability of an Oral Nutrition Supplement (ONS; EnergieShake®) in 16 adult patients who are already taking an ONS.
- Trial name
- NCT02788032
- Testing
- EnergieShake oral supplement
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Anaiah Healthcare Pvt Ltd
Melanoma
Trial of an Intratumoral Injections of INXN-3001 in Subjects With Stage III or IV Melanoma
The purpose of this study is to test the safety of an investigational combination drug/immunotherapy for the treatment of Stage III/IV melanoma.
- Trial name
- NCT00815607
- Testing
- INXN-1001, INXN-3001
- Where
- 8 sites in United States
- Volunteers
- 12 people
- Sponsor
- Alaunos Therapeutics
Herpes Simplex, HIV Infections
An Open Study of Foscarnet Treatment of Acyclovir-Resistant Herpes Simplex Virus in Patients With the Acquired Immunodeficiency Syndrome and Other Immunodeficiencies
To evaluate the safety and efficacy of intermittent intravenous (IV) foscarnet in the treatment of acyclovir-resistant herpes simplex virus (HSV) infections in AIDS patients and other immunocompromised patients.
- Trial name
- NCT00002021
- Testing
- Foscarnet sodium
- Where
- 2 sites in United States
- Sponsor
- Astra USA
Relapsed/Refractory Multiple Myeloma(MM)
LCAR-F33S in Treatment of Relapsed/Refractory Multiple Myeloma
A prospective, single-arm, open-label dose-exploration and expansion study to evaluate the safety, tolerability, pharmacokinetics, and antitumor efficacy characteristics of LCAR-F33S in patients with relapsed/refractory multiple…
- Trial name
- NCT07100067
- Testing
- LCAR- F33S cells intravenous infusion
- Where
- 4 sites in China
- Volunteers
- 35 people
- Sponsor
- Nanjing Legend Biotech Co.
Healthy Volunteers, Glucose Tolerance
Glucose Tolerance Study
The goal of this clinical trial is to assess whether TRPTI (oleoylethanolamide) can improve glucose tolerance in healthy adults aged 18 years and above with BMI 18.5-29.9 kg/m².
- Trial name
- OEAGTT (NCT07412730)
- Testing
- TRPTI 150mg, TRPTI 300mg
- Where
- Australia
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- RDC Clinical Pty Ltd
Overactive Bladder Syndrome
Efficacy, Tolerability and Impact on Quality of Life of Propiverine in Patients With Overactive Bladder Syndrome
The purposes of this study were to assess Quality of Life (QoL) and urination urge, incontinence, and micturition frequency including nocturia after 4 and 12 weeks treatment with propiverine.
- Trial name
- NCT02024945
- Testing
- Propiverine
- Volunteers
- 437 people
- Sponsor
- Takeda
Adrenocortical Carcinoma
Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)
This study will investigate the safety and efficacy of Relacorilant in combination with Pembrolizumab for Patients with Adrenocortical Carcinoma which Produces Too Much Stress Hormone (Cortisol).
- Trial name
- NCT04373265
- Testing
- Relacorilant, Pembrolizumab
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Corcept Therapeutics
Parkinson Disease
Study on the Safety, Tolerance and Pharmacokinetics of Phenlarmide Tablets
1. To evaluate the safety and tolerability of Phenlarmide tablets in patients with Parkinson's disease in the early and middle stages. 2.
- Trial name
- NCT04693039
- Testing
- Phenlarmide
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shijiazhuang Yiling Pharmaceutical Co. Ltd
Advanced Breast Cancer
A Clinical Trial of TQB3909 Tablets in Patients With Breast Cancer
TQB3909 is an inhibitor targeting B-cell lymphoma (BCL)-2 protein. By binding to BCL-2 protein, TQB3909 releases Pro apoptotic proteins such as BCL-2-Anatagonist/Killer 1(BAK), BCL-2 associated X (BAX) protein and BCL-2…
- Trial name
- NCT05775575
- Testing
- TQB3909 tablets
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Intractable Epilepsy
Ketogenic Diet Drink Study
An evaluation of the tolerance, compliance, acceptability and safety of a nutritionally complete liquid feed for use as part of the ketogenic diet (KD) in children 8+ years, adolescents and adults with intractable epilepsy or…
- Trial name
- NCT03196271
- Testing
- Ketocal 2.5:1
- Where
- 9 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- Nutricia UK Ltd
Healthy
Single Increasing Dose Followed by Maintenance Dose Tolerance Study of BIIR 561 CL in Healthy Male Volunteers
The objective of the present study is to obtain information about the safety, tolerability and pharmacokinetics of BIIR 561 after continuous intravenous administration of increasing doses in healthy young volunteers
- Trial name
- NCT02222961
- Testing
- BIIR 561 CL
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Burns
Oleogel-S10 Versus Standard of Care in Healing of Grade 2a Burn Wounds
The main goal of this phase III clinical trial is to show safety and efficacy of Oleogel-S10 in the acceleration of wound healing of grade 2a burn wounds.
- Trial name
- NCT01657292
- Testing
- Oleogel-S10 ointment, Octenilin® wound gel
- Where
- 9 sites in Germany, Sweden and 2 more
- Volunteers
- 61 people
- Sponsor
- Birken AG
Malnutrition
Tolerance and Compliance of a High Caloric, High Protein Oral Nutritional Supplement - Free Intake
The aim of the study is to assess gastro-intestinal tolerance, palatability, compliance, and use of a high caloric, high protein oral nutritional supplement (ONS) in elderly people
- Trial name
- NCT02938234
- Testing
- High caloric, high protein ONS
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Fresenius Kabi
Healthy
Single Increasing Doses of BIII 890 CL in Healthy Young Male Volunteers and in Healthy Elderly Male and Female Volunteers
Safety, tolerability and pharmacokinetics of BIII 890
- Trial name
- NCT02269215
- Testing
- BIII 890 CL
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Enteral Nutrition
Enteral Formula Tolerance in Pediatric Patients
The purpose of this prospective study seeks to assess ability to achieve enteral feeding goals with standard polymeric enteral formula in a stable, pediatric tube-fed population.
- Trial name
- NCT02779335
- Testing
- Enteral Formula
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Société des Produits Nestlé (SPN)
Metastases, Neoplasm, Colorectal Neoplasms
Magnetic-Targeted Doxorubicin in Treating Patients With Cancer Metastatic to the Liver
MTC-DOX is Doxorubicin or DOX, a chemotherapy drug, that is adsorbed, or made to "stick", to magnetic beads (MTCs). MTCs are tiny, microscopic particles of iron and carbon.
- Conditions
- Metastases, Neoplasm, Colorectal Neoplasms, Esophageal Neoplasms, Stomach Neoplasms
- Trial name
- NCT00041808
- Testing
- MTC-DOX for Injection, Chemotherapy
- Where
- 4 sites in United States, Germany
- Volunteers
- 20 people
- Sponsor
- FeRx
Solid Tumor
Phase I Clinical Study for Evaluation of Pharmacokinetic, Safety, Tolerance of Norcantharidin Lipid Microsphere for Injection in Patients With Solid Tumor
This study was designed as a single-center, open, non-randomized trial.
- Trial name
- NCT04673396
- Testing
- Norcantharidin Lipid Microsphere for Injection, Sodium Demethylcantharidate Injection
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Beijing Nuokangda Pharmaceutical Technology Co., Ltd.
Type 2 Diabetes
A Study Comparing the Safety, Tolerance, and Efficacy of Various Doses of SK-0403 Versus Placebo and Sitagliptin 100 mg in Patients Not Well-Controlled on Metformin Therapy
The purpose of this study is to evaluate the safety and efficacy of a range of doses of SK-0403 in subjects with type 2 diabetes that are not adequately controlled on metformin alone.
- Trial name
- NCT01169090
- Testing
- SK-0403, Sitagliptin
- Where
- 40 sites in United States
- Volunteers
- 620 people
- Sponsor
- Kowa Research Institute, Inc.