Clinical trials: Immune System Tolerance
Obesity
A Tolerance and Pharmacokinetic Study of Trodusquemine in Healthy Volunteers
The purpose of this study is to evaluate the safety and tolerance of single intravenous (through a vein) doses of trodusquemine. Different amounts of trodusquemine will be given to each volunteer group throughout the study.
- Trial name
- NCT00509132
- Testing
- trodusquemine
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Genaera Corporation
Impaired Glucose Tolerance
HSK7653 in Chinese Patients with Impaired Glucose Tolerance
This study is being done to evaluate the efficacy, safety of HSK7653 in chinese participants with impaired glucose tolerance.
- Trial name
- NCT04727580
- Testing
- HSK7653 10mg Q2W, HSK7653 25mg Q2W
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Advanced Malignant Solid Tumor
A Study to Evaluate the Tolerance and Pharmacokinetics of TQB3303 Tablets
TQB3303 tablet is a small molecule oral drug inhibiting cyclin-dependent kinases 4 and 6 (CDK4 / 6). Based on current research, overexpression of positive regulatory proteins in the cell cycle is one of the important reasons for…
- Trial name
- NCT04275050
- Testing
- TQB3303
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Blood Glucose
Dose Response Study of a Natural Extract for Reducing Post Prandial Blood Glucose
Randomized, balanced incomplete block design dose response study of efficacy, with 4 different dosages of mulberry fruit powdered extract added to cooked rice compared to a reference treatment (cooked rice only).
- Trial name
- NCT04256746
- Testing
- Boiled Rice, Boiled Rice+0.37 gr mulberry fruit powdered extract, Boiled Rice+0.75 gr mulberry fruit powdered extract
- Where
- India
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
PKU
Evaluation of PKU UP
PKU UP is a prospective, single-arm, open-label, 26-week acceptability study to evaluate PKU UP for the dietary management of participants with phenylketonuria (PKU).
- Trial name
- PKU UP (NCT05995717)
- Testing
- PKU UP
- Where
- 7 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- Vitaflo International, Ltd
Advanced Cancer
A Phase I Study of TQ-B3395 on Tolerance and Pharmacokinetics
To study the pharmacokinetic characteristics of TQ-B3395 in the human body, recommend a reasonable regimen for subsequent research.
- Trial name
- NCT02944864
- Testing
- TQ-B3395
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Gaucher Disease Type 3
A Phase I/II Clinical Study to Evaluate the Safety and Efficacy of VGN-R08b in Patients With Type III Gaucher's Disease
A phase I/II clinical study to evaluate the tolerance, safety and efficacy of VGN-R08b intracerebroventricular injection in patients with type III Gaucher's disease
- Trial name
- NCT07603050
- Testing
- VGN-R08b
- Volunteers
- 12 people
- Sponsor
- Shanghai Vitalgen BioPharma Co., Ltd.
Rheumatoid Arthritis (RA)
Comparison of Methotrexate (MTX) and the VIBEX™ MTX Device
Relative Bioavailability Comparison study
- Trial name
- NCT01618968
- Testing
- MTX
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Antares Pharma Inc.
Allergic Rhinoconjunctivitis
Tolerability of Grazax in Patients With Hayfever in Real Life Settings
The purpose of this study is to assess the safety profile of specific immunotherapy with Grazax for three consecutive grass pollen seasons.
- Trial name
- GRAAL (NCT01433510)
- Testing
- Grazax
- Where
- France
- Volunteers
- 628 people
- Sponsor
- ALK-Abelló A/S
Maple Syrup Urine Disease
Liquid Valine and Isoleucine in Maple Syrup Urine Disease
This is a prospective, observational research study in 5 children with Maple Syrup Urine Disease (MSUD). Subjects who are currently taking a valine and isoleucine supplement for MSUD will be recruited for a 56 day trial, of a new…
- Trial name
- NCT06581991
- Testing
- Valine oral solution (50mg/ml) and isoleucine oral solution (25mg/ml)
- Volunteers
- 5 people
- Sponsor
- Meta Healthcare Ltd
Atopic Eczema
Skin Tolerance Study of Betamethasone Creams in Atopic Eczema and the Preventative Properties of a Moisturiser
Topical steroid creams as well as moisturizing creams are important parts of the treatment strategy of atopic eczema. This study aims to investigate the tolerance of a new strong steroid cream in comparison to an already marketed…
- Trial name
- NCT00576238
- Testing
- betamethasone valerate, urea
- Where
- 5 sites in Sweden
- Volunteers
- 55 people
- Sponsor
- ACO Hud Nordic AB
Pediculosis Capitis (Head Lice)
A Pharmacokinetic (PK) Study of NatrOVA Topical Creme (1%) in Pediatric Subjects 6 to 24 Months of Age
This is an open label, single center, single dose PK study of NatrOVA Creme Rinse (1%), an investigational treatment for head lice and nits, in normal, healthy infants.
- Trial name
- NCT00410709
- Testing
- NatrOVA Creme Rinse (1%)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- ParaPRO LLC
Parkinson Disease
A Study to Evaluate the Human Tolerance and Pharmacokinetics of LY03003
This study is to evaluate the human tolerance and pharmacokinetics of LY03003.
- Trial name
- NCT04627155
- Testing
- LY03003
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Hepatectomy
Topical rhThrombin as an Adjunct to Hemostasis During Segmental Hepatectomy
rhThrombin is a serine protease from human.The study is to assess the Safety, Tolerability, Immunogenicity and efficacy of rhThrombin.
- Trial name
- NCT03611426
- Testing
- rhThrombin ( Topical )
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Melanoma
A Phase Ib Study of PRJ1-3024 for Treatment of Advanced or Metastatic Melanoma
This is a Phase Ib, open-label study to determine the safety and preliminary efficacy of PRJ1-3024 in China subjects with unresectable local advanced or metastatic melanoma
- Trial name
- NCT06727630
- Testing
- PRJ1-3024
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhuhai Yufan Biotechnologies Co., Ltd
Obesity
BLOSSOM: Behavioral Modification and Lorcaserin Second Study for Obesity Management
The purpose of this study is to assess the weight loss effect of lorcaserin during and at the end of 1 year of treatment in overweight and obese patients.
- Trial name
- NCT00603902
- Testing
- Lorcaserin 10 mg once daily (QD), Lorcaserin 10 mg twice a day (BID)
- Where
- United States
- Volunteers
- 4,008 people
- Sponsor
- Eisai Inc.
Allergy
Tolerance of Cereals for Atopic Children
In this study, non allergenic cereals will be tested in infants with atopic symptoms. The test will be performed in a hospital.
- Trial name
- NCT01029184
- Testing
- commercialized complete cereals, commercialized complete cereals with additional ingredient
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Société des Produits Nestlé (SPN)
Disease Related Malnutrition
Tolerance and Acceptability Evaluation of an Oral Nutrition Supplement
To evaluate the tolerance (gastrointestinal) and acceptability of a new Oral Nutrition Supplement in patients with or at risk of disease related malnutrition, taken either orally or via a feeding tube
- Trial name
- NCT07417514
- Testing
- Shot Style protein supplement
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Aymes International Limited
HIV Infections
Phase I/II Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients
To determine the tolerance and side effects of a combination of lentinan and didanosine (ddI) compared with ddI alone. To determine whether the combination of lentinan and ddI produces a significant immunorestorative effect…
- Trial name
- NCT00002098
- Testing
- Lentinan, Didanosine
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- AJI Pharma USA
Enteral Tube Nutrition
Evaluation of the Gastro-intestinal Tolerance of an Upgraded Composition of an Enteral Tube Feed for Adults
This study evaluates the gastro-intestinal tolerance, nutritional intake, and acceptability of an upgraded composition of an enteral tube feed for adults in need of long term nutritional support.
- Trial name
- NCT05902806
- Testing
- Upgraded tube feed
- Where
- Netherlands
- Volunteers
- 101 people
- Sponsor
- Nutricia Research