Clinical trials: Immune System Tolerance
Nicotinamide Adverse Reaction
Tolerance and Efficacy Nicotinamide (Vitamin B3) in Dominant Optic Atrophy OPA1
Dominant Optic Atrophy (hereafter known as DOA) is a neurodegenerative pathology of the optic nerve inducing progressive loss of central visual field and visual acuity. There is currently no proven treatment for this disease.
- Trial name
- NICOPA1-TOL (NCT06007391)
- Testing
- Nicotinamide
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Angers
Egg Allergy
Pancake Oral Immunotherapy For Egg Allergy In Inducing Tolerance
Oral immunotherapy (OIT) using raw/ cooked egg has good desensitisation outcomes but is associated with frequent and sometimes severe adverse events (anaphylaxis is not uncommon).
- Trial name
- POET (NCT07192510)
- Testing
- Pancake oral immunotherapy
- Where
- Singapore
- Volunteers
- 23 people
- Sponsor
- KK Women's and Children's Hospital
Prediabetes
Evaluation of Chiglitazar Sodium With Lifestyle Intervention for Reversing Prediabetes
This multicenter, randomized, double-blind, placebo-controlled trial aims to evaluate the efficacy and safety of Chiglitazar Sodium combined with lifestyle intervention for reversing prediabetes to normal glucose metabolism.
- Trial name
- NCT07558525
- Testing
- Chiglitazar sodium
- Where
- 30 sites in China
- Volunteers
- 472 people
- Sponsor
- Second Xiangya Hospital of Central South University
Knee Osteoarthritis
Pilot, Prospective, Comparative Multicentric Study Evaluating the Effects on the Arthrosis Biomarkers, the Clinical Effectiveness, the Tolerance of an Intra-articular Injection of Hyaluronic Acid KARTILAGE CROSS Versus Placebo in Patients Suffering From Knee Osteoarthritis
Intra-articular hyaluronic acid injections, also known as viscosupplementation, are a treatment option for knee osteoarthritis that serves to restore the decreasing rheological properties of synovial fluid.
- Trial name
- EPIKART (NCT02951585)
- Testing
- KARTILAGE CROSS
- Volunteers
- 81 people
- Sponsor
- Laboratoires Vivacy
Malnutrition
A Study of an Oral Nutritional Supplement in a Malnourished Population With GI Tolerance Impairment
The purpose is to observe the compliance to a high-calorie, high protein peptide-based nutritional supplement after 3 months in a malnourished population with impaired gastrointestinal tolerance living in nursing homes and as…
- Trial name
- NCT02698540
- Testing
- Nutritional Supplement
- Where
- 23 sites in Spain
- Volunteers
- 95 people
- Sponsor
- Abbott Nutrition
X-Linked Adrenoleukodystrophy, Adrenomyeloneuropathy
Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD)
The purpose of this study is to assess the safety, tolerance, pharmacokinetics, and pharmacodynamics of sobetirome, a selective thyroid hormone analog, in adult male X-ALD patients.
- Trial name
- NCT01787578
- Testing
- Sobetirome
- Where
- United States
- Sponsor
- Thomas S. Scanlan
Obstructive Sleep Apnea (OSA)
A Post-marketing Surveillance of the Negative Pressure Sleep Therapy System to Treat Obstructive Sleep Apnea
This is a post-marketing surveillance study to investigate the efficacy and safety of the Negative Pressure Sleep Therapy System for the treatment of obstructive sleep apnea.
- Trial name
- NCT02698059
- Testing
- iNAP® Sleep Therapy System (iNAP)
- Where
- 8 sites in Germany, Taiwan
- Volunteers
- 63 people
- Sponsor
- Somnics, Inc.
Safety Issues, Tolerance
Phase1 First in Human Ascending Dose Study to Evaluate the Safety and Tolerability of FC-12738 in Health Adults
A Phase I, Randomized, Double-Blind, Placebo-Controlled, First-in-human, Single-Ascending-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of retro enversio (RT) thymopentin in Healthy Adult…
- Trial name
- NCT05978908
- Testing
- FC-12738, Saline
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Neurodegenerative Disease Research Inc
HIV Infections, Lipodystrophy
Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities
The purpose of this study is to see whether metformin alone, rosiglitazone alone, or metformin and rosiglitazone together will lower insulin levels in the blood and decrease fat in the abdomen or other parts of the body.
- Conditions
- HIV Infections, Lipodystrophy, Hyperinsulinemia
- Trial name
- NCT00015691
- Testing
- Metformin hydrochloride, Rosiglitazone maleate
- Where
- 34 sites in United States
- Volunteers
- 105 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Fat, Liver Fibrosis
Effect of Erugliflozin On Liver Fat, Liver Fibrosis and Glycemic Control in Type II DM Patients With NASH/NAFLD
Open-label, prospective, single-arm, multicenter study to determine effects of Ertugliflozin on liver fat, liver fibrosis \& glycemic control in subjects with Type 2 Diabetes Mellitus (T2DM) with Non-Alcoholic Fatty Liver Disease…
- Conditions
- Liver Fat, Liver Fibrosis, Glycemic Control, Body Weight Changes
- Trial name
- Ertu-NASH (NCT05644717)
- Testing
- Ertugliflozin 5 mg, 15mg
- Where
- Pakistan
- Volunteers
- 164 people
- Sponsor
- Getz Pharma
Epilepsy, Aging Disorder
ZEBinix® Retention Rate in Epilepsy in Elderly Patients
The incidence of provoked and unprovoked seizures is known to increase with advancing age. Eslicarbazepine acetate (ESL) is one of the third generation of antiepileptic drugs (AEDs) that have been developed in the last ten years…
- Conditions
- Epilepsy, Aging Disorder, Aging, Epilepsy; Seizure
- Trial name
- ZEBRE (NCT04221282)
- Testing
- Zebinix
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Impaired Glucose Tolerance
Measurement of the Free Fraction of 25-hydroxyvitamin D in Serum
In the circulation 25-hydroxyvitaminD (25(OH)D) is bound to the vitamin D binding protein (DBP) and albumin. According to the free hormone hypothesis, it is, however, the free fraction that is biologically active.
- Trial name
- NCT01771380
- Where
- Norway
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Bariatric Surgery, Hormonal Response
Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid Obesity
Obesity is a major global health problem. Bariatric surgery is the most effective treatment, leading to substantial weight loss and improvement in obesity-related comorbidities.
- Conditions
- Bariatric Surgery, Hormonal Response, Post Bariatric Hypoglycemia
- Trial name
- CU BYPASS-DJB (NCT07747779)
- Testing
- Sleeve gastrectomy with duodenojejunal bypass, Roux-en-Y gastric bypass
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Chulalongkorn University
Stable Angina Pectoris
Extended-Release RANCAD in the Patients With Stable Angina Pectoris
A double-blind, randomized, placebo-controlled, parallel study to evaluate the effects of add-on RANCAD on exercise tolerance and angina frequency in patients with stable angina pectoris.
- Trial name
- NCT02294942
- Testing
- RANCAD
- Where
- 6 sites in Taiwan
- Volunteers
- 75 people
- Sponsor
- TSH Biopharm Corporation Limited
Food Allergy in Infants
The Tolerance of Organic Formula Milk and Its Fecal Microbiome Characteristic in Infants
This interventional study aims to investigate the tolerance of organic formula milk on infants supplemented with organic formula milk.
- Trial name
- TOFeM (NCT05215080)
- Testing
- Organic Formula Milk
- Where
- Indonesia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Hypoxic Tolerance
This WP specifically aims to elucidate the effects of IEK on hypoxic tolerance and the development and severity of AMS symptoms, blood and tissue oxygenation status, as well as sleep quality during an episode of acute exposure to…
- Trial name
- NCT05588427
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Advanced Malignant Tumors
A Clinical Trial Evaluating Injection of TQB6411 in Subjects With Advanced Malignant Tumors
TQB6411 for injection is an antibody-conjugated drug (ADC) targeting EGFR/c-Met. After injecting blood intravenously, the antibody part of this product binds to the surface of EGFR and c-Met on tumor cells to block the activation…
- Trial name
- NCT07043751
- Testing
- TQB6411 injection
- Where
- 19 sites in China
- Volunteers
- 216 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Gastrointestinal Complication
Duckweed Intake Study
The study aims to study the impact of frequent intake of 150-180 gram duckweed on gastrointestinal complaints and several other health related biomarkers. The study has a randomised parallel design.
- Trial name
- DIS (NCT03677583)
- Testing
- Duckweed, Spinach
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Mental Health Disorders
Examining the Effect of Mental Health Disorders on Vascular Function and Exercise Tolerance
Specific Aim #1: Examining the impact of mental health disorders (PTSD and GAD) on peripheral vascular function and sympathetic nervous system activity in young individuals.
- Trial name
- NCT03216980
- Testing
- PTSD/GAD Antioxidant, Healthy Control Antioxidant
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Elderly Patients, Metastatic Prostate Cancer
Predictive fActors for toleraNce to Taxane Based CHemotherapy In Older adultS Affected by mEtastatic Prostate Cancer
Aiming to explore predictive factors of fitness to taxane chemotherapy in elderly patients, the investigators collected data from a prospective mono-centric database of patients aged >/= 70 years old treated in our department…
- Trial name
- ANCHISES (NCT05471427)
- Testing
- Taxane chemotherapy
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.