Clinical trials: Immune System Tolerance
Glucose Intolerance, Sleep Deprivation
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
- Conditions
- Glucose Intolerance, Sleep Deprivation, Sleep
- Trial name
- NCT04868539
- Testing
- Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Pain
Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment
Peroperative opioids are known to induce N-Methyl-D-Aspartate dependent enhancement of postoperative hyperalgesia. For patients with current opioid treatment, these phenomena could be exagerated and could produce greater…
- Trial name
- PROTOX (NCT00210158)
- Testing
- Air, Protox
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Institut Bergonié
Healthy
Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Fentanyl
The purpose of this project is to test how fentanyl, an analgesic currently employed in the pre-hospital setting by the US Army, alters the capacity to tolerate a hemorrhagic insult in humans.
- Trial name
- NCT04136548
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Bladder Cancer
Safety, Dose Tolerance, Pharmacokinetics, Pharmacodynamics of CPX-POM in Patients With Newly Diagnosed or Recurrent Bladder Tumors
This is a phase II, single center open label to determine safety, dose tolerance, PK and PD of the recommended Phase 2 dose (RP2D) of CPX-POM administered in patients with any newly diagnosed or recurrent bladder tumors.
- Trial name
- NCT04525131
- Testing
- CPX-POM
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- CicloMed LLC
Area Under Curve, Pharmacokinetics
The Safety and Pharmacokinetics of Primapur and Gonal-f
The purpose of the current phase I study was to establish bioequivalence, safety, and tolerance of single 300 IU subcutaneous dose of follitropin alfa biosimilar (Primapur) in comparison to that of reference follitropin alfa…
- Conditions
- Area Under Curve, Pharmacokinetics, Absorption
- Trial name
- NCT03857230
- Testing
- Follitropin alfa (Primapur), Follitropin alfa (Gonal-F)
- Where
- Russia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- IVFarma LLC
Breast Cancer
Radiofrequency of Breast Cancers in Non Surgical Patients
To determine the efficacy and tolerance of ultrasonography (US)-guided percutaneous radiofrequency (RF) ablation with endocrine therapy in elderly patients with breast cancer who decline or are not candidates for surgery.
- Trial name
- RF-SEIN (NCT00210223)
- Testing
- ultrasonography (US)-guided percutaneous radiofrequency (RF) ablation with endocrine therapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Institut Bergonié
Colorectal Cancer
Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- OMEGA (NCT00467142)
- Testing
- bevacizumab, fluorouracil, irinotecan hydrochloride
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Institut Bergonié
ANCA-Associated Vasculitis
Defining Immune Tolerance in ANCA-associated Vasculitis (AAV)
The goal of the study is to find biological markers (certain proteins or cellular markers found in a blood test) that will inform doctors which patients diagnosed with ANCA-associated vasculitis (AAV) are most likely to be able…
- Trial name
- AAV (NCT01934504)
- Testing
- Venipuncture for blood sample collection
- Where
- 3 sites in United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Food Hypersensitivity, Milk Hypersensitivity
Study of Milk Allergy and Tolerance in Children
The purpose of this study is to determine if children who are allergic to milk can increase tolerance through frequent dose-escalation every 6 months versus 12 months leading to eventual tolerance of less heated milk and…
- Trial name
- NCT00778258
- Testing
- Baked Milk, Non-baked Milk
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Peanut Hypersensitivity, Food Hypersensitivity
Sublingual Immunotherapy for Peanut Allergy and Induction of Tolerance
The goal of this study will be to increase the reaction threshold (desensitization) of peanut allergic children using peanut sublingual immunotherapy and to determine if the nonreactive state of the immune system persists after…
- Conditions
- Peanut Hypersensitivity, Food Hypersensitivity, Food Allergy, Peanut Allergy
- Trial name
- SLIT-TLC (NCT01373242)
- Testing
- Liquid peanut extract (Peanut SLIT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of North Carolina, Chapel Hill
Impaired Glucose Tolerance, Oxidative Stress
Effect of Dietary Glycemic Index on Beta-cell Function
The study will determine if increasing the highs and lows of blood glucose levels (glycemic variability) impairs insulin secretion in people with impaired glucose tolerance and/or impaired fasting glucose who are at risk for…
- Conditions
- Impaired Glucose Tolerance, Oxidative Stress, Prediabetes, Impaired Fasting Glucose
- Trial name
- GIdiet (NCT01386645)
- Testing
- low glycemic index (LGI) diet, high glycemic index diet plus N-acetylcysteine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Solid Tumor, Adult, Triple Negative Breast Cancer
AVID100 in Advanced Epithelial Carcinomas
Approximately 90 male and female patients with documented solid tumor malignancies of epithelial origin that are locally advanced or metastatic, and either refractory to standard therapy or for whom no standard therapy is…
- Conditions
- Solid Tumor, Adult, Triple Negative Breast Cancer, Head and Neck Squamous Cell Carcinoma, Non Small Cell Lung Cancer
- Trial name
- NCT03094169
- Testing
- AVID100 IV
- Where
- 10 sites in United States
- Volunteers
- 49 people
- Sponsor
- Formation Biologics
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
Polycystic ovary syndrome (PCOS) affects 5-10% of women in the United States. Its onset is usually at the time of puberty with manifestations of menstrual irregularity, hirsutism, and obesity.
- Trial name
- NCT00203996
- Testing
- continuous positive airway pressure (CPAP), depot leuprolide plus estrogen/progestin replacement, pioglitazone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy Volunteers, Brain Lesion
Pharmacokinetics, Pharmacodynamics Profile and Tolerance of P03277 in Healthy Subjects and Patients With Brain Lesions
The primary objective of this study was to evaluate the safety (clinical and biological) and pharmacokinetics (plasma and urine) profile of P03277 following single administration at ascending dose levels in healthy subjects.
- Trial name
- NCT03603106
- Testing
- P03277
- Where
- Belgium
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Guerbet
Peripheral Arterial Disease, Hypertension
Strength Training in Walking Tolerance in Intermittent Claudication Patients
Background: Muscle atrophy and reduced leg strength are related to exercise intolerance in patients with intermittent claudication (IC), suggesting that strength training (ST) could improve exercise performance in these patients.
- Conditions
- Peripheral Arterial Disease, Hypertension, Diabetes
- Trial name
- NCT00879697
- Testing
- Walking Training, Strength Training
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo
Type 2 Diabetes, Healthy
Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function
Pioglitazone, a drug used in treatment of type 2 diabetes has been shown to improve insulin sensitivity in skeletal muscle, liver, and fat cells.
- Conditions
- Type 2 Diabetes, Healthy, Impaired Glucose Tolerance
- Trial name
- PIO-EX (NCT00845182)
- Testing
- Pioglitazone, Exenatide, Pioglitazone and Exenatide
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Sleep, Insomnia
Treatment of Insomnia and Glucose Metabolism
Available data suggest that obtaining adequate sleep is associated with a better ability of the body to use carbohydrates as a source of energy and a lower risk of developing diabetes.
- Conditions
- Sleep, Insomnia, Insulin Resistance
- Trial name
- NCT00724282
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Pain, Peripheral Neuropathy
A Study to Compare the Safety and Tolerability of Sativex® in Patients With Neuropathic Pain.
The purpose of this study is to assess the safety and tolerability of long term therapy with Sativex® in relieving neuropathic pain.
- Trial name
- NCT00713323
- Testing
- Sativex®
- Where
- United Kingdom
- Volunteers
- 380 people
- Sponsor
- Jazz Pharmaceuticals
Insulin Resistance
The Effects of Altering Physical Activity on Cardiometabolic Health
The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular…
- Trial name
- PIA (NCT01879059)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Liver Transplant Recipients, Liver Transplantation
Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients
The primary objective of this study is to assess the efficacy of immunosuppression withdrawal (ISW) in pediatric liver transplant (tx) recipients.
- Conditions
- Liver Transplant Recipients, Liver Transplantation, Immunosuppression
- Trial name
- iWITH (NCT01638559)
- Testing
- Immunosuppression withdrawal
- Where
- 12 sites in United States, Canada
- Volunteers
- 161 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)