Clinical trials: Immune System Tolerance
Impaired Glucose Tolerance
HSK7653 in Chinese Patients with Impaired Glucose Tolerance
This study is being done to evaluate the efficacy, safety of HSK7653 in chinese participants with impaired glucose tolerance.
- Trial name
- NCT04727580
- Testing
- HSK7653 10mg Q2W, HSK7653 25mg Q2W
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Sedation During Bronchoscopy
Comparison of Respiratory Tolerance to I.V. Versus Sublingual Sedation During Bronchoscopy. (TORSIV)
Bronchoscopy is a technique which currently allows the investigation of many respiratory diseases (infections, neoplasia, inflammation…) as well as endobronchial therapeutic procedures.
- Trial name
- TORSIV (NCT01698892)
- Testing
- I.V Sedation, sublingual sedation
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Nantes University Hospital
Arthroscopic Surgical Procedures
Effects of VR and White Noise During Arthroscopy (VR/WN_ ART)
Background: Today, arthroscopy is widely used in the diagnosis and of treatment intra-articular diseases. Arthroscopy is considered a procedure that disturbs the patient's comfort because it is a very invasive and painful…
- Trial name
- (VR/WN_ ART) (NCT05992714)
- Testing
- Virtual Reality Glasses group, white noise group
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Seher Tanrıverdi
Lung Transplantation
Prospective Intervention Study to Improve HRQoL and Exercise Tolerance After Lung Transplantation (Ergo-LTx)
A prospective, interventional rehabilitation program was initiated to improve exercise capacity and psychosocial functioning in patients after lung transplantation (LTx) and to evaluate long-term effects on health-related quality…
- Trial name
- Ergo-LTx (NCT00753155)
- Testing
- exercise training; psychosocial support
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Advanced Malignant Solid Tumor
A Study to Evaluate the Tolerance and Pharmacokinetics of TQB3303 Tablets
TQB3303 tablet is a small molecule oral drug inhibiting cyclin-dependent kinases 4 and 6 (CDK4 / 6). Based on current research, overexpression of positive regulatory proteins in the cell cycle is one of the important reasons for…
- Trial name
- NCT04275050
- Testing
- TQB3303
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Revisional Bariatric Surgery
Comparing Revisional Laparoscopic Roux-en-Y Gastric Bypass Versus Ringed Revisional Roux-en-Y Gastric Bypass After Laparoscopic Sleeve Gastrectomy
Obesity remains a major global health challenge, with rising prevalence and significant metabolic, cardiovascular, and gastrointestinal comorbidities.
- Trial name
- NCT07436013
- Testing
- Standard revisional RYGB, Revisional Banded RYGB
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Blood Glucose
Dose Response Study of a Natural Extract for Reducing Post Prandial Blood Glucose
Randomized, balanced incomplete block design dose response study of efficacy, with 4 different dosages of mulberry fruit powdered extract added to cooked rice compared to a reference treatment (cooked rice only).
- Trial name
- NCT04256746
- Testing
- Boiled Rice, Boiled Rice+0.37 gr mulberry fruit powdered extract, Boiled Rice+0.75 gr mulberry fruit powdered extract
- Where
- India
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Chronic Pancreatitis, Pancreatogenic Type 3C Diabetes Mellitus
Evaluation of OGTT in Patients With Post-pancreatitis Diabetes Mellitus for Diagnosis and Characterization
To evaluate the islet function and insulin secretion pattern of post-pancreatitis diabetes mellitus by oral glucose tolerance testing, and to explore the pathophysiological characteristics of PPDM-C which provide evidence for the…
- Conditions
- Chronic Pancreatitis, Pancreatogenic Type 3C Diabetes Mellitus, Diabetes Mellitus, Oral Glucose Tolerance Test
- Trial name
- NCT05989867
- Testing
- blood test, Continuous Glucose Monitor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Pain, Lumbar Disc Herniation
The Diagnostic and Prognostic Value of Two Quantitative Clinical Tests in Patients With Lumbar Disc Herniation
This study will investigate whether two clinical tests can be used to diagnose and predict the outcome in patients with lumbar disc herniation undergoing surgery and non-surgery treatment.
- Conditions
- Pain, Lumbar Disc Herniation, Back Pain, Spinal Diseases
- Trial name
- NCT03832036
- Testing
- Paraspinal Mapping and Quantitative Sensory Pain Test
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Spine Centre of Southern Denmark
Cystic Fibrosis
Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF
Cystic fibrosis has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-AOX (NCT02690064)
- Testing
- Acute Antioxidant, Chronic Antioxidant
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Augusta University
Neat OGTT, OGTT With Added Sucralose
Sucralose and Lactisole Additions to OGTT in Humans
In the present study, our objective was to determine whether T1R2-T1R3 influences glucose metabolism bidirectionally via hyperactivation with sucralose and inhibition with sodium lactisole in mixture with glucose loads during…
- Conditions
- Neat OGTT, OGTT With Added Sucralose, OGTT With Added Lactisole
- Trial name
- SLOGTT (NCT05900193)
- Testing
- TAS1R2/3 agonist or antagoinst admixture to oral glucose tolerance test
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy Aging, Healthy Diet
Effects of Respiratory Muscle Exercises on Glucose Tolerance in Healthy Adults
To evaluate the acute effects of respiratory muscle exercises vs. a control intervention on blood glucose kinetics in healthy adults after an oral glucose tolerance test.
- Trial name
- NCT04520763
- Testing
- 5min respiratory muscle exercises, 15min respiratory muscle exercises
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Therapeutic Plasma Exchange
TPE in Rennes Hospital
To assess the indications, tolerance and side effects of therapeutic plasma exchange (TPE) performed at a University Hospital over 8 years
- Trial name
- COMPLASMA (NCT03888417)
- Testing
- Therapeutic plasma exchange (TPE)
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Rennes University Hospital
Nutritional Deficiency, Breast Cancer
Tolerance to Immunomodulatory Nutritional Therapy in Oncology Patients Undergoing Chemotherapy and Radiotherapy
The importance of nutritional support is established in some types of neoplasms, especially those involving the digestive tract.
- Conditions
- Nutritional Deficiency, Breast Cancer, Anal Cancer
- Trial name
- NESTLE (NCT07021378)
- Testing
- Dietary Supplement, Control Cohort A, Control cohort B
- Where
- 2 sites in Brazil
- Volunteers
- 16 people
- Sponsor
- D'Or Institute for Research and Education
Healthy
Effects of a Diet Based on Inulin-rich Vegetables on Gut Health and Nutritional Behaviour in Healthy Humans
Inulin-type fructans (ITF) are fermentable dietary fibres that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behaviour is a matter of debate.
- Trial name
- NCT03540550
- Testing
- Diet based on inulin-rich vegetables
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
PKU
Evaluation of PKU UP
PKU UP is a prospective, single-arm, open-label, 26-week acceptability study to evaluate PKU UP for the dietary management of participants with phenylketonuria (PKU).
- Trial name
- PKU UP (NCT05995717)
- Testing
- PKU UP
- Where
- 7 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- Vitaflo International, Ltd
Turner Syndrome, Idiopathic Short Stature
Study to Identify Markers of Insulin Resistance During Growth Hormone Treatment for Short Stature
Growth hormone treatment improves body fat distribution but also causes insulin resistance. Scientists have recently linked insulin resistance with special stores of fat in the muscles, which can be measured by magnetic resonance…
- Trial name
- NCT00121875
- Testing
- somatropin (rDNA)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Glucose Tolerance Impaired in Pregnancy
Women With Minor Degrees of Glucose Intolerance and the Postpartum Glucose Tolerance Test
The aim of this study is to offer a 75g postpartum glucose tolerance test to women with minor degrees of glucose intolerance and to assess if these women are significantly different from women who were diagnosed as GDM…
- Trial name
- NCT03623412
- Testing
- 75g oral glucose tolerance test, 75g GTT
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Overweight, Pre Diabetes
DPP4 Activity, Microvascular Reactivity and Inflammation
Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides involved in inflammation, immunity and vascular function.
- Conditions
- Overweight, Pre Diabetes, Diabetes Mellitus Type 2 Without Complication
- Trial name
- DPP4 (NCT03178019)
- Testing
- Laser-Doppler methods
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Impaired Glucose Tolerance
ACute and Chronic Effects of Saxagliptin
Glucose ACCES study will explore the acute and long term (12-week treatment) effects of saxagliptin in patients with impaired glucose tolerance during fasting and after a standardised breakfast.
- Trial name
- ACCES (NCT01521312)
- Testing
- saxagliptin
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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