Clinical trials: Immune System Tolerance
Vitiligo
Combination of Methotrexate and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo
This is a phase 2, randomized, double blind, multicenter study evaluating the efficacy and safety of the combination of methotrexate plus UVB TL01 in vitiligo.
- Trial name
- METVI (NCT04237103)
- Testing
- Methotrexate
- Where
- 4 sites in France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Bordeaux
Diabetes
Identification and Characterization of Diabetes in Low-resource Populations
The true burden of diabetes in sub-Saharan Africa (SSA) is unknown as most of the countries do not have good quality data. As such, the overall estimate of diabetes prevalence is largely based on modelled estimates, which may not…
- Trial name
- DOP (NCT05487079)
- Where
- Uganda
- Volunteers
- 11,700 people
- Sponsor
- MRC/UVRI and LSHTM Uganda Research Unit
Stroke, Ischemic, Stroke Sequelae
PLAsticity, Security and Tolerance to Intermittent Hypoxic Conditioning Following Stroke
By inducing endogenous neuroprotection, hypoxic post-conditioning following stroke may represent a harmless and efficient non-pharmacological innovative neuro-therapeutic modality aiming at inducing neuroplasticity and brain…
- Trial name
- PLASTIHC (NCT05210088)
- Testing
- Hypoxia, intermittent, Normoxia
- Where
- France
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Type 2
Gastric Emptying - Implications for the Pathogenesis of Type 2 Diabetes
People of black African and Caribbean descent have a greater risk of developing type 2 diabetes than white Europeans. The aim of this study is to increase our knowledge of how the condition may arise, and what underlies this…
- Trial name
- NCT03864562
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
IgE-Mediated Hypersensitivity, Allergy
Safety of Ertapenem in Beta-lactam Allergic Patients.
The purpose of this study is to assess cross-reactivity and tolerability of ertapenem in patients with IgE-mediated allergy to at least one beta-lactam molecule.
- Trial name
- NCT01159379
- Testing
- ertapenem
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Catholic University of the Sacred Heart
Short Bowel Syndrome
MENDD Tolerance Assessment Study
This study will utilize approved devices in an off-label manner to create forces required to induce intestinal lengthening. Radial and longitudinal forces are both required, and two devices will be used to create forces in order…
- Trial name
- NCT06185088
- Testing
- Coda® Balloon Catheters, Double Balloon Endoscope (DBE)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Allergy Milk, Allergy;Food
Dietary Choice for the Management of Cow's Milk Allergy Influences Other Allergic Manifestations
Food allergy is a common chronic condition in childhood. Recent studies have suggested that the natural history of food allergy has changed during the last two decades, with an increased prevalence, severity of clinical…
- Conditions
- Allergy Milk, Allergy;Food, Allergic Asthma, Allergic Conjunctivitis
- Trial name
- ATMAII (NCT03861910)
- Testing
- hypoallergenic formulas
- Where
- Italy
- Volunteers
- 365 people
- Sponsor
- Federico II University
Renal Transplantation
Combined Kidney and Hematopoietic Stem Cell Transplantation for Tolerance Induction
Combined transplantation of kidney and bone marrow between HLA-matched sibling donor-recipient pairs to induce immune tolerance in order to enable complete discontinuation of immunosuppressive therapy without kidney rejection.
- Trial name
- NCT05086003
- Testing
- Combined kidney and bone marrow transplantation
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Pediculosis Capitis (Head Lice)
A Pharmacokinetic (PK) Study of NatrOVA Topical Creme (1%) in Pediatric Subjects 6 to 24 Months of Age
This is an open label, single center, single dose PK study of NatrOVA Creme Rinse (1%), an investigational treatment for head lice and nits, in normal, healthy infants.
- Trial name
- NCT00410709
- Testing
- NatrOVA Creme Rinse (1%)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- ParaPRO LLC
Endocarditis, Acute Kidney Injury
Renal Tolerance of Amoxicillin and Cloxacillin Combination
2015 European Society of Cardiology Guidelines have proposed the combination of Ampicillin and Cloxacillin for initial empirical treatment of infective endocarditis in acute severely ill patients (before pathogen identification).
- Trial name
- Amox-Cloxa (NCT05142891)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Hypoxemia, Altitude Hypoxia
Effects of Continuous Positive Airway Pressure on Peripheral Oxygen Saturation, Work of Breathing, and Exercise Tolerance at Altitude
Dyspnea and exercise intolerance are well known to travelers who have experienced time at high elevations, greater than 2500 meters (8200 feet).
- Trial name
- NCT05971290
- Testing
- Continuous positive airway pressure, Ambient air
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson Disease
A Study to Evaluate the Human Tolerance and Pharmacokinetics of LY03003
This study is to evaluate the human tolerance and pharmacokinetics of LY03003.
- Trial name
- NCT04627155
- Testing
- LY03003
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
SEPP1 Levels in Differnet Glucose Tolerance Status
Human Selenoprotein P Concentration With Glucose Tolerance Status
Recently, seslenium(Se) has known as important regulator in metabolic status, lipid profile, atherosclerosis progression. SEPP1(selenoprotein P1)is a secreted protein from mainly liver.
- Trial name
- NCT01258426
- Volunteers
- healthy volunteers welcome
- Sponsor
- Korea University
Hepatectomy
Topical rhThrombin as an Adjunct to Hemostasis During Segmental Hepatectomy
rhThrombin is a serine protease from human.The study is to assess the Safety, Tolerability, Immunogenicity and efficacy of rhThrombin.
- Trial name
- NCT03611426
- Testing
- rhThrombin ( Topical )
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
HIV Infections, Tuberculosis
A Pilot Study of Methodology to Rapidly Evaluate Drugs for Bactericidal Activity, Tolerance, and Pharmacokinetics in the Treatment of Pulmonary Tuberculosis Using Isoniazid and Levofloxacin
To evaluate the methodology for rapidly determining the early bactericidal activity (EBA), tolerance, and pharmacokinetics of isoniazid and levofloxacin in the treatment of pulmonary tuberculosis (TB).
- Trial name
- NCT00000778
- Testing
- Isoniazid, Pyridoxine hydrochloride, Levofloxacin
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy
Non-Immunoglobulin E-mediated Food Allergies in Children
Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFA) are an evolving web of clinical conditions characterized by subacute and/or chronic symptoms and include food protein-induced enterocolitis syndrome (FPIES), food…
- Conditions
- Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy, Food Protein-Induced Proctocolitis, Food Protein-Induced Enterocolitis Syndrome
- Trial name
- NIGEFA (NCT04462978)
- Testing
- Non IgE-mediated food allergy
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federico II University
Single Transplant, 5 Years of Follow-up After Transplant, in Which an Attempt Was Made to Suspend IS
De Novo Metabolic Syndrome in Liver Transplant Patients After Immunosuppression Withdrawal
Evaluate de novo onset of metabolic syndrome, NAFLD and NASH in liver transplant recipients who have discontinued immunosuppressive therapy ("tolerant") and in those taking immunosuppressive therapy ("non-tolerant").
- Trial name
- NCT05808192
- Testing
- Immunosuppressive
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- University of Rome Tor Vergata
Pulmonary Diseases, Oxygen Therapy
Effects of High-Flow Nasal Cannula on Exercise Outcomes in Lung Transplant Candidates: A Pilot Study
The study evaluated patients on the national lung transplant waiting list. It was pioneering in assessing high-complexity patients with severe pulmonary diseases subjected to a cardiopulmonary rehabilitation protocol using a…
- Conditions
- Pulmonary Diseases, Oxygen Therapy, High-flow Nasal Cannula, Exercise Tolerance
- Trial name
- NCT06620081
- Testing
- Performance Tests, Functional Tests
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Israelita Albert Einstein
Melanoma
A Phase Ib Study of PRJ1-3024 for Treatment of Advanced or Metastatic Melanoma
This is a Phase Ib, open-label study to determine the safety and preliminary efficacy of PRJ1-3024 in China subjects with unresectable local advanced or metastatic melanoma
- Trial name
- NCT06727630
- Testing
- PRJ1-3024
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhuhai Yufan Biotechnologies Co., Ltd
Postprandial Glucose, GI Tolerance
A Crossover Study Evaluating the Postprandial Glycemic Response of Three Sweeteners in a Mixed Meal Setting
This study is using a double-blind, randomize crossover evaluating the impact of three different sweeteners on postprandial glycemic response in a mixed meal setting.
- Trial name
- NCT07895628
- Testing
- LOAM Fiber-based Sweetener, Sugar, Stevia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- LOAM Science
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