Clinical trials: Immune System Tolerance
Chronic Obstructive Pulmonary Disease
Influence of the VitaBreath on Exercise Tolerance in COPD
People with COPD have more air in their lungs than other people (this problem with high lung volumes is called "hyperinflation").
- Trial name
- NCT03068026
- Testing
- VitaBreath, Pursed Lip Breathing technique
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- North Tyneside General Hospital
Overweight
Effect of Calanus Oli on Intra-abdominal Fat, Glucose Tolerance and Lipids in Man
Preliminary studies in rats and mice indicate that calanus oil reduce accumulation of intra-abdominal fat. Pilot studies in humans have shown no adverse effects.
- Trial name
- NCT01193543
- Testing
- calanus oil, olive oil
- Where
- Norway
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Lentigo, Solar Lentigo
Evaluation of the Tolerance (Main Objective) and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-inflammatory Hyperpigmentation) on the Face
The goal of this clinical trial is to compare the 3 different prototype of cyto-selective cryotherapy devices (name of the devices : CRYONOVE) use in brown spots on the face of subject from different ethnicities.
- Conditions
- Lentigo, Solar Lentigo, Post Inflammatory Hyperpigmentation
- Trial name
- CS5_10B (NCT06305897)
- Testing
- CRYONOVE (EC14_4osc), CRYONOVE (EC+05_1osc), CRYONOVE (EC+05_2osc)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cryonove Pharma
Pulmonary Disease, Chronic Obstructive
Effect of Tiotropium Inhalation Capsules (Spiriva) on Exercise Tolerance in COPD Patients
The objective of this trial is to determine whether tiotropium inhalation capsules (Spiriva, Bromuro de Tiotropio), compared to placebo, enhances the improvement in exercise tolerance seen in patients with chronic obstructive…
- Trial name
- NCT00157235
- Testing
- Tiotropium bromide
- Where
- 12 sites in Italy
- Volunteers
- 234 people
- Sponsor
- Boehringer Ingelheim
Relapsed/Refractory Multiple Myeloma
LCAR-M61SQ in Treatment of Relapsed/Refractory Multiple Myeloma
A prospective, open-label dose-exploration and expansion study to evaluate the safety, tolerability, pharmacokinetics, and antitumor efficacy characteristics of LCAR-M61SQ in patients with relapsed/refractory multiple myeloma.
- Trial name
- NCT06888752
- Testing
- Cell injection
- Volunteers
- 35 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
HIV Infections
The Safety and Effectiveness of 935U83 in HIV-Infected Patients
To assess the safety, tolerance, and steady-state pharmacokinetics of multiple oral doses of 935U83 administered to patients with HIV infection. To obtain preliminary evidence of antiretroviral activity of 935U83.
- Trial name
- NCT00002338
- Testing
- Raluridine
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Glaxo Wellcome
Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy
Non-Immunoglobulin E-mediated Food Allergies in Children
Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFA) are an evolving web of clinical conditions characterized by subacute and/or chronic symptoms and include food protein-induced enterocolitis syndrome (FPIES), food…
- Conditions
- Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy, Food Protein-Induced Proctocolitis, Food Protein-Induced Enterocolitis Syndrome
- Trial name
- NIGEFA (NCT04462978)
- Testing
- Non IgE-mediated food allergy
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federico II University
Pain, Peripheral Neuropathy
A Study to Determine the Maintenance of Effect After Long-term Treatment of Sativex® in Subjects With Neuropathic Pain
The purpose of this study is to assess the maintenance of effect after long-term treatment of Sativex® in subjects with neuropathic pain.
- Trial name
- NCT00713817
- Testing
- Sativex®
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Jazz Pharmaceuticals
Glaucoma
Comparative Effectiveness and Tolerance of Subliminal Subthreshold Transscleral Cyclophotocoagulation
Glaucoma, progressive optical neuropathy, is the leading cause of irreversible blindness in the world. Glaucoma treatment aims to lower intraocular pressure (IOP) by using medication, laser and surgery.
- Trial name
- NCT03961035
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Pain, Pain, Neuropathic
Local and Widespread Hypoalgesic Effects of Neurodynamic Mobilization in Healthy Controls
Background \& Significance Pain is the primary reason many patients seek care from healthcare professionals who utilize various manual therapy techniques.
- Trial name
- NCT03674489
- Testing
- Neurodynamic Slider Mobilization, Neurodynamic Tensioner Mobilization
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brenau University
Tolerance
ElectroPoration In a Clinical Setting
This is a single-blind, single-center, randomized, study in healthy subjects in which the volunteer patients will remain blind with respect to the voltage strength received.
- Trial name
- EPIC (NCT04698694)
- Testing
- Electroporation with voltage amplitude of 40 V (corresponding to an electric field strength of 100 V/cm), Electroporation with voltage amplitude of 60 V (corresponding to an electric field strength of 150 V/cm)
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Malnutrition
EnergieShake® Acceptability and Tolerance Study
This open-label, prospective, controlled intervention study involves evaluating tolerance and acceptability of an Oral Nutrition Supplement (ONS; EnergieShake®) in 16 adult patients who are already taking an ONS.
- Trial name
- NCT02788032
- Testing
- EnergieShake oral supplement
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Anaiah Healthcare Pvt Ltd
Borderline Hypokalemia
The Effects of Potassium on Glucose Metabolism in African Americans
African Americans suffer a disproportionately high risk of diabetes compared to other Americans. Reasons for race disparities in diabetes incidence are not completely understood.
- Trial name
- NCT02236598
- Testing
- K+ supplement
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Duke University
Invasive Candidiasis
Empirical Antifungal Treatment in ICUS
Invasive Candida infections are burdened with a high mortality rate and is very common in intensive care units. This study aims to evaluate the efficacy of empirical treatment with micafungin in adult patients with suspected…
- Trial name
- EMPIRICUS (NCT01773876)
- Testing
- Micafungin
- Where
- 22 sites in France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Grenoble
HIV Infection, Liver Failure
Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients
This phase I/II, multi-center study is designed to determine the pharmacokinetic profile of Raltegravir in patients with end stage liver disease and to assess drug-drug interaction when Raltegravir is combined with…
- Conditions
- HIV Infection, Liver Failure, Evidence of Liver Transplantation
- Trial name
- LIVERAL (NCT01022476)
- Testing
- Raltegravir potassium
- Where
- France
- Volunteers
- 14 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Type 1 Diabetes, Hypoglycemia
Insulin Tolerance Test Study in Patients With Type 1 Diabetes
The primary objective of this study is to determine the safety, tolerability and pharmacodynamics of pitolisant in patients with Type 1 Diabetes
- Trial name
- NCT04026750
- Testing
- Pitolisant
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- High Point Clinical Trials Center
Dentofacial Functional Disorder
TolTwiCare : Qualitative Evaluation Routine Care From Primary Tolerance of a Prefabricated and Removable Orthosis
The TwiCare® device is a removable brace that can be used in orthopedic referred to stimulate mandibular growth or in interception / contention.
- Trial name
- TolTwiCare (NCT02907450)
- Testing
- TwiCare®.
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Pompe Disease
Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease
This is a longitudinal natural history study of Infantile Pompe disease. The investigators will regularly collect and review medical information regarding the diagnosis of Pompe disease, response to enzyme replacement (ERT) using…
- Trial name
- NCT01665326
- Testing
- Observational
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Lymphoma, Myeloma
Effects of Aerobic Training and Inspiratory Muscle Training in Patients During Hematopoietic Stem Cell Transplantation
The hospitalization for hematopoietic stem cell transplantation (HSCT) impairs the physical functioning and functional capacity, but aerobic physical training and, more recently, inspiratory muscle training, have shown benefits…
- Conditions
- Lymphoma, Myeloma, Leukemia, Aplastic Anemia
- Trial name
- NCT03373526
- Testing
- Inspiratory Muscle Training, Aerobic Training
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Daniel Godoy Martinez
Rheumatoid Arthritis
Effectiveness Intraarticular Corticosteroid
The purpose of this study is to compare the small and large dose of corticosteroid used in intraarticular injection of wrist.
- Trial name
- NCT01851278
- Testing
- Triamcinolone hexacetonide
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
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