Clinical trials: Immune System Tolerance
Chronic Obstructive Pulmonary Disease, Oxygen/Therapeutic Use
Correction of Exercise-induced Desaturation by Acute Oxygen Supply and Exercise Responses in COPD
In the literature, the effects of acute oxygen administration on exercise tolerance and related symptoms have often appeared to be contradictory.
- Trial name
- RePox-1 (NCT02055885)
- Where
- 2 sites in France
- Volunteers
- 255 people
- Sponsor
- 5 Santé
Diabetes
Single Ascending Oral Doses of SY-008 in Healthy Subjects
This is a phase Ⅰ，single-center, randomized, double-blinded, placebo-controlled, single ascending dose trial of SY-008 in healthy subjects.
- Trial name
- NCT03462589
- Testing
- SY-008
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Suzhou Yabao Pharmaceutical R&D Co., Ltd.
HIV-1 Infection, PREGNANCY
Evaluation of Raltegravir During the Third Trimester of Pregnancy
The purpose of this study is to assess the evolution of raltegravir concentration in the mother (between the 3rd trimester of pregnancy and one month post-delivery) and her neonate, when this drug is used to prevent…
- Trial name
- ANRS 160 RalFE (NCT02099474)
- Testing
- Study of pharmacokinetic properties of raltegravir during the 3rd trimester of pregnancy
- Where
- France
- Volunteers
- 83 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Acne
Sunscreen Efficacy Against the Reccurence of Lesions Post-sun Exposure in Acneic Subjects
The aim of this study is firstly to assess the tolerance of the sunscreen RV4857A-CD2110 after 28 days and 57 days of at least a twice daily on the study areas, secondly to assess anti-imperfection efficacy after 28 days and 57…
- Trial name
- NCT05168397
- Testing
- RV4857A
- Where
- Portugal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Dermo Cosmetique
Prediabetes, Hyperglycemia
Personalized Smartphone-assisted Coaching System to Improve Glucose Homeostasis in Adults With Prediabetes
Sweetch is a personalized mobile-health platform coaching system (mobile phone app) designed to promote adherence to physical activity guidelines for people with prediabetes.
- Conditions
- Prediabetes, Hyperglycemia, Postprandial Hyperglycemia, Impaired Glucose Tolerance
- Trial name
- NCT02896010
- Testing
- Sweetch App + DBWS, Sweetch App Alone
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Johns Hopkins University
Cytomegalovirus Retinitis, HIV Infections
A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral Ganciclovir
To determine the pharmacokinetics (blood levels) of three dose treatment plans of oral ganciclovir during a 28-day dosing period.
- Trial name
- NCT00000668
- Testing
- Ganciclovir
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Premature Infant Disease
Effects of Lactobacillus Reuteri in Premature Infants
This application a phase II clinical trial to address the possible active mechanisms of probiotics and to obtain preliminary efficacy and safety data after the administration of a probiotic, Lactobacillus reuteri a population of…
- Trial name
- Reuteri (NCT01181791)
- Testing
- Lactobacillus reuteri
- Where
- 2 sites in Chile
- Volunteers
- 65 people
- Sponsor
- University of Miami
HIV Infections
A Study of PMPA in HIV-Infected Patients
The purpose of this study is to see if it is safe and effective to give PMPA to HIV-infected patients. This study also examines how the body handles PMPA.
- Trial name
- NCT00002180
- Testing
- Tenofovir
- Where
- 2 sites in United States
- Sponsor
- Gilead Sciences
Treatment-naive or Relapsed or Refractory Acute Myeloid Leukemia (AML)
A Study to Evaluate the Tolerance and Efficacy of Mitoxantrone Hydrochloride Liposome Injection Combined With Cytarabine in Patients With Acute Myeloid Leukemia (AML)
This is an open-label, multi-cohort, multi-center Phase Ib/II clinical study to evaluate the tolerance and efficacy of Mitoxantrone Hydrochloride liposome injection combined with cytarabine in patients with Acute Myeloid Leukemia…
- Trial name
- NCT05100303
- Testing
- Mitoxantrone Hydrochloride liposome injection, Cytarabine (LoDAC)
- Where
- China
- Volunteers
- 58 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Insulin Resistance, Diabetes Mellitus
A Crossover Study of the Acute Effects of Olanzapine in Healthy Volunteers
The purpose of this clinical research study is to examine the acute hormonal and metabolic effects of the drug olanzapine, as well as appetite effects, in healthy volunteers.
- Trial name
- NCT00741026
- Testing
- Olanzapine 10 mg po qhs for 3 days
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Conditions Influencing Health Status
Effects of Probiotics in Immune System of Healthy Adults
The present report describes the design of a clinical trial performed on healthy adult individuals to check whether the daily intake of the new Hero strains contribute to intestinal colonization, under safe and tolerable…
- Trial name
- SETOPROB (NCT01479543)
- Testing
- Probiotic CNCM I-4034, Probiotic CNCM I-4035, Probiotic CNCM I-4036
- Where
- 4 sites in Spain
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Hero Institute for Infant Nutrition
Lymphatic Disease, HIV Infections
The Safety and Effectiveness of Isoprinosine in Patients With Weakened Immune Systems and Lymph Node Disease
The objective of this Phase III, randomized, double-blind, placebo-controlled study in patients with immunologic deficiency is to determine the effect of Isoprinosine in producing an immuno-restorative response within the study…
- Trial name
- NCT00002296
- Testing
- Inosine pranobex
- Where
- United States
- Sponsor
- Newport Pharmaceuticals International
Chronic Lung Diseases
Enhanced External Counterpulsation for Patients With Ventilation Disorders
This study evaluates enhanced external counterpulsation as a non-pharmacological therapy for patients with severe and moderate ventilation disorders due to chronic lung diseases (chronic obstructive pulmonary disease, bronchial…
- Trial name
- NCT07075835
- Testing
- Enhanced external counterpulsation
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Phenylketonuria
Kuvan® in Phenylketonuria Patients Less Than 4 Years Old
This is a Phase 3b, multicenter, open-label, randomized, controlled study to evaluate efficacy, safety and population pharmacokinetics of sapropterin dihydrochloride (Kuvan®) in less than 4 year-old infants and children with…
- Trial name
- SPARK (NCT01376908)
- Testing
- Kuvan®, Phenylalanine (Phe)-restricted diet
- Where
- 22 sites in Austria, Belgium and 7 more
- Volunteers
- 56 people
- Sponsor
- BioMarin Pharmaceutical
Impaired Glucose Tolerance, Myocardial Infarction
Assessment of an Alpha-glucosidase Inhibitor to Block Cardiac Events in Patients With MI and IGT
The purpose of this study is to evaluate whether an alpha-glucosidase inhibitor, a drug for the suppression of postprandial hyperglycemia, could reduce the recurrence of myocardial infarction in patients with impaired glucose…
- Trial name
- NCT00212017
- Testing
- voglibose, diet and exercise therapy
- Where
- Japan
- Volunteers
- 3,000 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Spinal Cord Injury, Tetraplegia
Study of the Impact of the Use of a Corset on the Respiratory Function of Patients With Spinal Cord Injury
Corsets are often used in the management of patients with a spinal cord injury. They may help to rigidify the patients' trunk which might help some patients to sit upright; their use may also reduce the sensation of dyspnea some…
- Conditions
- Spinal Cord Injury, Tetraplegia, Paraplegia
- Trial name
- Garchoise (NCT01569360)
- Testing
- Corset
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia, Tolerance
Tolerance to Sevoflurane in Children Undergoing Repeated Drug Exposure
Deep sedation or general anesthesia is frequently required for infant that need radiotherapy to treat malignancies. As radiation therapy usually consist of several sessions, these patients are exposure to several consecutive…
- Trial name
- NCT04188782
- Testing
- Sevoflurane
- Where
- 2 sites in Chile
- Volunteers
- 24 people
- Sponsor
- University of Chile
Growth
Growth and Tolerance of a Partially Hydrolyzed Infant Formula
The purpose of this research study is to compare the growth and tolerance of infants who consume either an infant formula with intact proteins or an infant formula with partially hydrolyzed proteins through approximately 12…
- Trial name
- NCT05047978
- Testing
- Cow's milk protein infant formula, Partially hydrolyzed protein infant formula
- Where
- 13 sites in United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Gastrointestinal Tolerance of Probiotics in Infants
Evaluating the Impact of Synbiotic Supplementation on Infants and Toddlers
Background and Significance: Bifidobacterium longum subspecies infantis (B. infantis) and other infant associated Bifidobacterium (such as Bifidobacterium longum subspecies longum and Bifidobacterium breve) are known to be…
- Trial name
- NCT06746285
- Testing
- Synbiotic Supplement
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Persephone Biosciences
Safety Issues, Tolerance
Phase 1 SAD/MAD Study of CVN766 in Healthy Volunteers
Randomized, Double-Blind, Placebo-Controlled, Safety, Tolerability, and Pharmacokinetic Study of Escalating Single and Multiple Doses of CVN766 in Healthy participants.
- Trial name
- NCT05105243
- Testing
- CVN766
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Cerevance
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