Clinical trials: Immune System Tolerance
Pain, Analgesics
Mentholated Cream Containing Oxygenated Glycerol Triesters on Acute Pain of the Muscles and Joints
A single center trial to evaluate the efficacy, tolerance, and acceptability of Oxygenated Glycerol Triesters (OGT) mentholated cream on acute musculoskeletal pain in normal healthy adult volunteers suffering from a recent…
- Trial name
- NCT01387750
- Testing
- Mentholated Cream, Mentholated Cream with OGT
- Volunteers
- 71 people
- Sponsor
- NEMA Research, Inc.
Fetal Growth Retardation
Study to Examine Insulin Resistance During Growth Hormone Treatment for Short Stature Due to Low Birthweight
Insulin resistance is common among children with low birthweight. Moreover, growth hormone treatment for ensuing short stature also causes insulin resistance. Our objective is to examine these processes.
- Trial name
- NCT00120497
- Testing
- somatropin (rDNA)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Gastroesophageal Reflux
Study on the Tolerance and Efficacy of a New Anti Regurgitation Formula
The aim of this study is to evaluate the efficacy of a new thickened formula on regurgitation.
- Trial name
- SONAR (NCT02425423)
- Testing
- New thickened formula
- Where
- 3 sites in Belgium, France
- Volunteers
- 100 people
- Sponsor
- United Pharmaceuticals
Diabetes
Role of Pioglitazone in Preventing Diabetes
A three year prospective, double blinded, placebo controlled, randomized clinical trial in impaired glucose tolerance (IGT) subjects to study the effect of pioglitazone in preventing the conversion to Diabetes.
- Trial name
- NCT00276497
- Testing
- Pioglitazone
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.V. Hospital for Diabetes
Inflammatory Bowel Diseases
Pharmacokinetics and Pharmacodynamics Clinical Study of VC005 Tablets in Healthy Subjects
This clinical trial consists of two parts：1. a randomized, double-blind, single-center, placebo-controlled, dose-escalation PK study; 2. food effects and drug metabolism transformation study.
- Trial name
- NCT05138770
- Testing
- VC005 Tablets, VC005 Tablets food effects group
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Neoplasms, Medication Toxicity
Study of Orally-Administered AMXT 1501 Dicaprate in Normal Healthy Volunteers
This is a Phase 1 study, which will assess the safety, PK, and pharmacodynamics (PD) of orally-administered AMXT 1501 dicaprate in normal healthy male volunteers.
- Conditions
- Neoplasms, Medication Toxicity, Tolerance
- Trial name
- NCT03077477
- Testing
- AMXT 1501
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aminex Therapeutics, Inc.
Heart Transplantation
Induction of Donor Specific Tolerance in Recipients of Cardiac Allografts by Donor Stem Cell Infusion
The goal of this research study is to establish chimerism and avoid graft-versus-host disease in patients who need a heart transplant.
- Trial name
- NCT00497757
- Testing
- enriched hematopoetic stem cell infusion
- Volunteers
- 62 people
- Sponsor
- Suzanne T. Ildstad
Distress, Emotional, Internalizing Mental Health Symptoms
Piloting a School-Based Distress Tolerance Skills Program for Adolescents
Research suggests that an individual's perceived ability to withstand distressing or upsetting emotions (i.e., distress tolerance; DT) is a common risk factor across several mental health conditions that commonly emerge during…
- Trial name
- STRIDE (NCT06638853)
- Testing
- Distress Tolerance Skills Training
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Gestational Diabetes, Other "Heavy-For-Dates" Infants
Pregnancy Outcomes and Maternal Insulin Sensitivity
The PROMIS study will focus on maternal insulin sensitivity thourghout pregnancy and postpartum in a moderate to high risk population (BMI ≥25 kg/m2) in developing adverse pregnancy outcomes.
- Conditions
- Gestational Diabetes, Other "Heavy-For-Dates" Infants, Small for Gestational Age Infant, Diabetes Mellitus, Type 2
- Trial name
- PROMIS (NCT04315545)
- Testing
- meal tolerance test
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
HIV Infections
Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks
To evaluate the interaction of probenecid with zidovudine (AZT). Because AZT is eliminated quickly from the body, it must be taken frequently.
- Trial name
- NCT00000670
- Testing
- Probenecid, Zidovudine
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 2
Comparative Effectiveness of POC-A1c vs the Current Standard Based on OGTT for Early Detection DM2 in Colombia
Evaluate the impact of conducting a screening questionnaire (FINDRISC) and the implementation of a point-of-care HBA1c test for those with identified risk to suffer Diabetes in ten years, to improve the proportion of patients…
- Trial name
- EDDIT-1 (NCT05440968)
- Testing
- Point of Care - Glycated Hemoglobin (A1c), Oral Glucose Tolerance Test
- Where
- Colombia
- Volunteers
- 902 people, healthy volunteers welcome
- Sponsor
- Humberto Reynales MD MSc PhD
Stage, Prostate Cancer
Sulforadex in Healthy Volunteers SAD
To determine the safety and tolerability of single escalating doses of Sulforadex® in healthy male volunteers.
- Trial name
- NCT01948362
- Testing
- Sulforadex, Alpha cyclodextrin
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Evgen Pharma
Immune Tolerance
Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation
This research study is to determine if donor blood stem cells given after living, related, HLA antigen (Ag) haplotype match or living, unrelated donor kidney transplantation.
- Trial name
- CIRM (NCT03292445)
- Testing
- Immune tolerance after kidney transplant, Donor blood stem cells and T cells
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Samuel Strober
Invasive Ductal Breast Carcinoma
Efficacy and Tolerance of an Ovarian Stimulation Protocol Combining Follicle Stimulating Hormone (FSH) and Degarelix Acetate in Female Candidates for Fertility Preservation Before Chemotherapy for Breast Cancer
The present investigation aims to evaluate the efficacy of an innovative protocol of controlled ovarian stimulation for breast cancer patients, who are candidates for fertility preservation.
- Trial name
- DEGASTIM (NCT03947151)
- Testing
- Degarelix injection(s)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Iron Deficiency Anemia, Coronary Artery Disease
Non-Interventional Study of Ferretab® Comp. (Ferrous Fumarate + Folic Acid Prolonged-Release Capsules) Effects in Adult Patients With Iron Deficiency Anemia and Cardiovascular Disease
The goal of this observational study is to learn how well Ferretab® comp. works and how safe it is for adults with iron deficiency anemia and cardiovascular disease who are receiving treatment as part of their usual medical care.
- Conditions
- Iron Deficiency Anemia, Coronary Artery Disease, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- PROMETHEUS (NCT07753031)
- Where
- 5 sites in Russia
- Volunteers
- 389 people
- Sponsor
- Alcea
Wound, Chronic Ulcer
Study of Tolerance to the Application of Cold Plasma in the Treatment of Chronic Wounds
Chronic wounds affect many patients, with no downward trend in recent decades. This is a significant economic and social issue, and this condition has an impact on functional disabilities and quality of life, especially among the…
- Trial name
- PLASMA-SAFE (NCT07564739)
- Testing
- cold plasma treatment with helium 1min/10cm2, cold plasma treatment with helium 3min/10cm2, dressings impregnated with ions induced by exposure to plasma
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Impaired Glucose Tolerance
Preliminary Safety and Efficacy Study of Extracellular Vesicle Infusion in the Intervention of Age-related Phenotypes With Impaired Glucose Tolerance.
The objective of this exploratory study was to evaluate the initial safety of human mesenchymal stem cell-derived extracellular vesicle infusion in an age-related phenotype with impaired glucose tolerance
- Trial name
- NCT06495437
- Testing
- Intravenous infusion of extracellular vesicle preparation derived from Wharton's jelly mesenchymal stem cells.
- Volunteers
- 20 people
- Sponsor
- BEAUTECH
Blood Glucose
Exploratory Study of Efficacy on Selected Natural Extracts Reducing Post Prandial Blood Glucose Response
Randomized, balanced, incomplete block design exploratory study of efficacy, with 8 active treatments (4 treatments per subject; 35 or 37 subjects per treatment) compared to a reference treatment (all 72 subjects).
- Trial name
- NCT04258501
- Testing
- Mulberry fruit, Mulberry leaf, White bean
- Where
- India
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Advanced or Metastatic Gastric Cancer, Advanced or Metastatic Liver Cancer
Study of Metatinib Tromethamine Tablet
This is an open-label, multicenter study designed to assess the safety, tolerability, preliminary efficacy and pharmacokinetics of Metatinib Tromethamine tablet in patients with advanced or metastatic gastric cancer, liver…
- Conditions
- Advanced or Metastatic Gastric Cancer, Advanced or Metastatic Liver Cancer, Advanced or Metastatic CRC, Advanced or Metastatic Non Squamous NSCLC
- Trial name
- NCT02650375
- Testing
- Metatinib Tromethamine
- Where
- 3 sites in China
- Volunteers
- 24 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Lentigo, Solar Lentigo
Interventional, Monocentric, Double-blind Randomized Category 2b Study Evaluating the Evaluation of the Tolerance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post -Inflammatory Hyperpigmentation (Pih)) on the Face
The goal of this clinical trial is to compare the 2 different prototype of cytoselectivecryotherapy devices (name of the devices : CRYONOVE) use in brown spots on the face of subject from different ethnicities.
- Conditions
- Lentigo, Solar Lentigo, Post Inflammatory Hyperpigmentation
- Trial name
- CS5_10 (NCT06361251)
- Testing
- CRYONOVE (EC14_4osc), CRYONOVE (EC05osc)
- Where
- South Africa
- Volunteers
- 30 people
- Sponsor
- Cryonove Pharma
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