Clinical trials: Immune System Tolerance
Headlice Infections
Randomized Controlled Trial Comparing Efficacy and Tolerance of Four Pediculicides
THe main goal of our randomized controlled trial with blinded observer will be to compare four pediculicide products acting mechanically, Paranix Spray, Paranix Lotion, Paranix Mousse and Hedrin against a reference product acting…
- Trial name
- NCT00758823
- Testing
- Paranix
- Where
- India
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Omega Pharma
Growth
The Effects on Growth of a Non-Routine Infant Formula
A study to evaluate the growth and development of term infants fed either an extensively hydrolyzed formula with probiotics, a partially hydrolyzed formula with probiotics, or an extensively hydrolyzed formula without probiotics
- Trial name
- NCT00655720
- Testing
- infant formula
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Type 2 Diabetes
The Effect of Vinegar on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes
This open, randomized, cross-over, placebo-controlled study aims to investigate the effects of vinegar on glucose metabolism, endothelial function and circulating lipid levels in subjects with impaired glucose tolerance or type 2…
- Trial name
- NCT02309424
- Testing
- Vinegar
- Volunteers
- 20 people
- Sponsor
- Attikon Hospital
Breast Cancer
BENEFIT OF MECHANICAL ISCHEMIC PRECONDITIONING ON TOLERANCE OF ADIPOSE TISSUE TO ISCHEMIA REPERFUSION OF TYPE DIEP (DEEP INFERIOR EPIGASTRIC PERFORATOR) FREE FLAPS.
Breast cancer is the most common cancer amongst women in terms of frequency, with more than 50 000 newly diagnosed cases per year in France. The average 5-year survival rate for women with breast cancer is around 85%.
- Trial name
- PRIMIDIEP (NCT05373069)
- Testing
- Mechanical ischemic preconditioning of diep-type flap
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Quality of Life, Postoperative Complications
Low Pressure Pneumoperitoneum and Deep Neuromuscular Block vs. Standard During RARP to Improve Quality of Recovery; a Randomized Controlled Study.
Intra-abdominal pressure (IAP) needed to create sufficient workspace during laparoscopic surgery affects the surrounding organs with ischemia-reperfusion injury and a systemic immune response.
- Conditions
- Quality of Life, Postoperative Complications, Acute Pain, Immune System Tolerance
- Trial name
- RECOVER-2 (NCT04250883)
- Testing
- Low intra-abdominal pressure, Deep neuromuscular blockade (NMB), Standard intra-abdominal pressure
- Where
- Netherlands
- Volunteers
- 97 people
- Sponsor
- Radboud University Medical Center
Insulin Resistance, Type 2 Diabetes Mellitus
Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes
The purpose of this study is to examine the effects of treating insulin resistance on memory and attention, brain glucose utilization, and proteins in spinal fluid.
- Trial name
- NCT00212290
- Testing
- pioglitazone, nateglinide
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy Term Infants Solely Formula Fed
Assessment of Feeding Tolerance in Infants Fed Cow Milk Formula
To compare the number of infants who discontinue from study formula due to formula intolerance as documented by the investigator. Hypothesize there will be no difference between formula groups.
- Trial name
- NCT00666120
- Testing
- Enfamil LIPIL with iron, Good Start Supreme with DHA and ARA
- Where
- 18 sites in United States
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Vitiligo
Determining the Tolerance of Depigmented Skin to Targeted Phototherapy Using UVB in Patients With Vitiligo
The purpose of this study is to determine if vitiligo patients develop tolerance to ultraviolet light therapy, a type of treatment available for vitiligo.
- Trial name
- NCT00367224
- Testing
- 6 to 9 ultraviolet B treatments, Skin biopsies
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Cholestasis, Progressive Familial Intrahepatic 3
Second-line Therapy of Unresectable Cholangiocarcinoma by RADIOEMBOLIZATION
Cholangiocarcinoma (CCK) is a rare tumor (2000 new cases/year in France) with very poor prognosis (overall survival < 3% at 5 years).
- Trial name
- CHOLANGIOSIR (NCT01383746)
- Testing
- Yttrium microsphere injection
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastrointestinal Tolerance
Tolerance of Infants Fed a Hydrolysate Formula
This is a prospective, randomized, multicenter study to assess the tolerance of infant formulas.
- Trial name
- NCT03628183
- Testing
- Hydrolysate Infant Formula 1, Hydrolysate Infant Formula 2
- Where
- 5 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Infant, Newborn
Comparative Gastrointestinal Tolerance of Various Infant Formulas in Healthy Term Infants
The objective of this study is to assess the comparative gastrointestinal (GI) tolerance of normal term infants to two experimental soy-based formulas, relative to a commercially available soy-based formula.
- Trial name
- NCT00798382
- Testing
- soy protein formula, Commercially available soy formula, Soy formula experimental #2
- Where
- 17 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Advanced Solid Tumors
A Study to Evaluate the Tolerance, Efficacy and Pharmacokinetics of TQB3558 Tablets
This is a study to evaluate the maximum tolerated dose (MTD) , occurrence of all adverse events (AE) and serious adverse events (SAE) , pharmacokinetic parameters and antitumor effect of TQB3558 tablets in Chinese adult patients…
- Trial name
- NCT04408079
- Testing
- TQB3558
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
COPD
Continuous Chest Wall Vibration in COPD Rehabilitation
Dyspnea, the sensation of breathing discomfort or shortness of breath, is one of the main symptoms for patients affected by Chronic Obstructive Pulmonary Disease (COPD), particularly during exercise.
- Trial name
- NCT03644888
- Testing
- Cycle ergometer training, Airway clearance program, Vibration therapy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
End Stage Renal Disease
Trial of Adoptive Immunotherapy With TRACT to Prevent Rejection in Living Donor Kidney Transplant Recipients
Regulatory CD4+CD25+ T cells (Treg) derived from the thymus and/or peripheral tissues have been demonstrated to broadly control T cell reactivity (14).
- Trial name
- TRACT (NCT02145325)
- Testing
- Expanded Tregs
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
Milk Allergy
Xolair Treatment for Milk Allergic Children
This is a pilot feasibility study, using Xolair pretreatment for oral milk desensitization. The major assessment will be safety, and the investigators will evaluate for any type of reaction, including allergic reactions that…
- Trial name
- NCT00968110
- Testing
- omalizumab
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Boston Children's Hospital
Safety Issues, Effect of Drug
MB07133 for the Treatment of Patients With Unresectable Hepatocellular Carcinoma
A randomized, open, multicenter clinical trial design was adopted, planned to be conducted in three stages, with 91 participants expected to be included in the study to evaluate the efficacy, tolerance, and safety of different…
- Conditions
- Safety Issues, Effect of Drug, Tolerance
- Trial name
- MB07133 (NCT06141096)
- Testing
- MB07133
- Where
- China
- Volunteers
- 91 people
- Sponsor
- Xi'an Xintong Pharmaceutical Research Co.,Ltd.
Gastrointestinal Tolerance, Healthy Population
Evaluating the Impact of Fat and Sugar Replacer Blends on Gastrointestinal Tolerance in Biscuits
This study is a randomized, double-blind, crossover trial aiming at evaluating the gastrointestinal tolerance and bowel habits of sugar- and fat- replacer ingredients and blends (maltitol, polydextrose, allulose and EPG)
- Trial name
- NCT07372482
- Testing
- Test sandwiched biscuits with creme, Control sandwiched biscuit with sugar
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Acne Vulgaris
A Study to Evaluate the Tolerance of an Acne Treatment in Sensitive Skin Subjects With Mild to Moderate Acne Vulgaris
The study will look to evaluate the tolerance of a light therapy-based acne mask device in participants who report having sensitive skin.
- Trial name
- NCT03128723
- Testing
- Acne Mask
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Colic, Gastrointestinal Tract Infections
Safety of Lactobacillus Reuteri (L. Reuteri) in Healthy Adults
This study will evaluate the safety and tolerability of the probiotic Lactobacillus reuteri (LR) in healthy adult patients. Patients will be randomized to receive either LR or placebo orally each day for a total of 60 doses.
- Trial name
- NCT00922727
- Testing
- L. reuteri, Sunflower Oil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Tumor, Solid, Cancer, Metastatic
Phase I Study of SHR9146 + SHR-1210 +/- Apatinib in Patients With Advanced Solid Tumors
This phase I trial is designed to efficiently identify the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) for the combination therapy regimen of the IDO1 inhibitor SHR9146 when administered in combination with…
- Conditions
- Tumor, Solid, Cancer, Metastatic, Neoplasm Malignant
- Trial name
- NCT03491631
- Testing
- SHR9146+SHR-1210, SHR9146+SHR-1210+Apatinib
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
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