Clinical trials: Immune System Tolerance
Liver Transplant Rejection
Graft Rejection or Tolerance Affected by Serial Change of Anti-donor Lymphocyte Antibody After Liver Transplantation
Liver is an organ that is well-known for its immune tolerant capacity. However, there were still controversial issues about the impact of immunologic challenge after liver transplantation on the graft function.
- Trial name
- NCT01444079
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yonsei University
CP (Cerebral Palsy)
Tolerance of a Motorized Orthosis Reproducing Walking Movement vs Conventional Standing-up Devices in Child With CP
Cerebral palsy (CP) includes all the sensorimotor development disorders leading to balance, gait and movement disruptions. These disorders are related to lesions of the central nervous system (CNS) that occurs at birth or during…
- Trial name
- EOMEC/CP (NCT02669160)
- Testing
- PC Innowalk, Conventional passive stander
- Where
- 4 sites in France
- Volunteers
- 25 people
- Sponsor
- Lille Catholic University
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Simplification of CF-related Diabetes Screening at Home
Cystic fibrosis (CF)-related diabetes (CFRD) is the most common complication after pulmonary complications. This specific form of diabetes is associated with an increased morbidity and mortality.
- Trial name
- AtHome (NCT03227094)
- Testing
- Standard OGTT, Home-based OGTT (Beverage), Home-based OGTT (Candy)
- Where
- 2 sites in Canada
- Volunteers
- 37 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
HIV Infection
Immunogenicity and Tolerance of Two Strategies of Anti-HAV Vaccination in HIV-infected Patients
Immunogenicity is reduced in immunocompromised patients. The aim of this prospective randomized study is to evaluate tolerance and immunogenicity of 2 doses versus 3 doses of anti-HAV vaccine in HIV-1 infected patients with CD4…
- Trial name
- HEPAVAC (NCT00190242)
- Testing
- group1, group2
- Where
- 2 sites in France
- Volunteers
- 99 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Vasospasm, Subarachnoid Hemorrhage
Safety of Intravenous Milrinone for the Treatment of Subarachnoid Hemorrhage-induced Vasospasm
The aim of this study is to evaluate the tolerance of intravenous milrinone combined to the current standard treatment for cerebral vasospasm following subarachnoid hemorrhage.
- Trial name
- MilriSpasm (NCT03517670)
- Testing
- Rhythmic tolerance, Hematological tolerance, Milrinone efficiency on cerebral vasospasm
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Diabetes Mellitus, Bariatric Surgery Candidate
Paraoxonase and HDL Qualities in Glycaemia and Inflammation
The incidence of coronary heart disease (CHD) is significant in the super-obese and diabetics. Inflammation is believed to play an important part in the development of CHD, and the large collection of abdominal fat in the obese…
- Trial name
- PON1 (NCT02169518)
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Heart Failure, Chronic Obstructive Pulmonary Disease
Effects of HIIT in Tolerance to Exercise of Individuals With HF and Coexisting COPD
INTRODUCTION: The complexity of the pathophysiology of heterogeneous diseases such as heart failure and obstructive pulmonary disease causes a different approach to these diseases or with a view as much as a better understanding…
- Trial name
- NCT04350541
- Testing
- High-intensity interval training, Continuous aerobic training
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal de Pernambuco
Metabolic Syndrome
Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome
The investigators previous research has suggested that lipid (fatty) composition in the muscle cells of mice plays a key role in their insulin sensitivity.
- Trial name
- COMP-SR (NCT02122666)
- Testing
- muscle biopsy
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Gastrointestinal Discomfort, Performance Status
A Safety/Tolerance Phase, Ascending Single Dose Study to Evaluate the Safety and Tolerability of G3P-01, a Food-Grade Pectic Product, in Healthy Volunteers
This is an interventional, open-label study to evaluate the safety, tolerability and PK of escalating single doses of G3P-01 in 10 healthy adult subjects.
- Trial name
- G3P-01-01 (NCT05296083)
- Testing
- G3P-01
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- SQ Innovation, Inc.
Complication of Prematurity
Effect of Extensively Hydrolyzed Liquid Human Milk Fortifier on Growth and Tolerance in Moderately Premature Infants
The purpose of this study is for the researchers to examine the safety and efficacy of liquid human milk fortifier (HMF) in moderately preterm infants compared to powdered human milk fortifier.
- Trial name
- NCT02632266
- Testing
- Powder HMF, Liquid HMF
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Acne Vulgaris
A Study to Evaluate the Efficacy and Tolerance of 2 Acne Treatment Regimens on Subjects With Mild to Moderate Acne
This study will compare two different acne treatment regimens for the treatment of acne. Half of participants will receive a cleanser and a light therapy mask, while half of the participants will receive a cleanser, a light…
- Trial name
- NCT03124381
- Testing
- Cleanser, Acne Mask, Cleanser, Gel-Cream, Acne Mask
- Where
- 2 sites in United States
- Volunteers
- 126 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Telerehabilitation
The Influence of Telerehabilitation Focused on Respiratory Muscle Training
Pulmonary rehabilitation, which includes respiratory muscle training, is effective in improving the functional status of patients with various types of the respiratory system diseases, including bronchial asthma, interstitial…
- Trial name
- NCT05533151
- Testing
- Respiratory muscle training
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Palacky University
Oral Glucose Tolerance Test, Low Birth Weight
Association Between Low Plasma Glucose After Oral Glucose Tolerance Test in Pregnancy With Impaired Fetal Growth
Objective: To study the association of low maternal plasma glucose in 2 hour 75 g oral glucose tolerance test (OGTT) in women with impaired birth weight and determinate if this result is predictive of low birth weight (<10th…
- Trial name
- NCT04144595
- Testing
- 2 hour 75 g Oral glucose tolerance test
- Where
- Mexico
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Phenylketonurias
Evaluation of PKU Explore France
PKU explore France is an exploratory study to evaluate the acceptability of PKU explore, a food for special medical purposes, for use in the dietary management of phenylketonuria in infants from 6 months to 3 years of age…
- Trial name
- NCT04898829
- Testing
- PKU explore
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Vitaflo International, Ltd
Cystic Fibrosis-related Diabetes
EnVision CF Multicenter Study of Glucose Tolerance in Cystic Fibrosis
Cystic Fibrosis Related Diabetes has been identified by the CF community as one of the top ten priorities for CF research. In CF clinical decline due to dysglycemia begins early, prior to diagnosis of diabetes and increases…
- Trial name
- NCT03650712
- Testing
- Oral glucose tolerance test, Continuous glucose monitoring, Dexa scan
- Where
- 4 sites in United States
- Volunteers
- 317 people
- Sponsor
- Katie Larson Ode
Rheumatoid Arthritis
Rheumatoid Arthritis:Tolerance Induction by Mixed Chimerism
Rheumatoid arthritis disease is believed to be due to immune cells, cells that normally protect the body and are now causing damage to the body.
- Trial name
- NCT00282412
- Testing
- Hematopoietic Stem Cell Transplantation, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Northwestern University
Purpura, Thrombocytopenic, Idiopathic, Autoimmune Thrombocytopenia
The ITP-RITUX Cohort: Rituximab in Immune ThrombocytoPenia.
The primary purpose of the study is to describe by a prospective observational study the serious adverse events occurring in patients treated off-label by rituximab for Immune Thrombocytopenia.
- Trial name
- ITP-RITUX (NCT01101295)
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Henri Mondor University Hospital
HIV Infections
Phase I Study of the Safety, Tolerance, and Pharmacokinetics of 9-[2-(Bispivaloyloxymethyl)Phosphonylmethoxyethyl]Adenine (Bis-POM PMEA; Adefovir Dipivoxil) in HIV-Infected Patients
To study the safety, tolerance, and pharmacokinetics of a single dose of bis-POM PMEA (adefovir dipivoxil) when administered by the oral route in patients with HIV infection.
- Trial name
- NCT00002128
- Testing
- Adefovir dipivoxil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Gilead Sciences
Orthostatic Tolerance
Racial Differences in Orthostatic Tolerance
Our central hypothesis is that baroreflex sensitivity is attenuated in black women compared to white women, and that this dysregulation will be apparent during orthostatic challenges.
- Trial name
- NCT00844181
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance (Prediabetes)
Exercise Training and Glucose Metabolism in Aging
Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are…
- Trial name
- NCT00701051
- Testing
- Aerobic exercise training, Detraining (cessation of exercise)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
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