Clinical trials: Immune System Tolerance
Hemophilia a with Inhibitor
Assessing Different FVIII Doses and Frequencies in Immune Tolerance Induction (ITI) with ADVATE Among Hemophilia a Boys with Inhibitor (INITIATE Study)
Hemophilia A is a blood coagulation disorder caused by deficient or dysfunctional clotting factor VIII (FVIII) leading to incomplete haemostasis.
- Trial name
- NCT06864975
- Testing
- Advate®
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Runhui WU
Infant Formula Intolerance
Acceptability and GI Tolerance of an Alpha-lactalbumin-enriched Formula
A single center, non-controlled trial to document the gastrointestinal (GI) tolerability of the study formula (SF), containing a whey protein concentrate enriched with alpha-lactalbumin (WPC alpha-lac) fed for 6 weeks to healthy…
- Trial name
- NCT02431377
- Testing
- S-26 Gold
- Where
- Philippines
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Cold, Cold Symptom
Ability of Beta-glucan Supplementation to Augment Immune Function
This proposed study is designed to assess the efficacy of a capsule containing beta-glucan taken orally daily as compared to a placebo capsule on the URTI symptoms, and the immune response change in marathon runners
- Conditions
- Cold, Cold Symptom, Flu, Flu Symptom
- Trial name
- NCT03769012
- Testing
- Beta-Glucan
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kemin Foods LC
Healthy
To Evaluate the PK, PD, Safety and Drug Tolerance of JW0302 in Healthy Volunteers
1. To evaluate the pharmacokinetic and pharmacodynamics characteristics after administration of Reference Drug or Test Drug in healthy volunteers under fasting conditions 2.
- Trial name
- NCT05784155
- Testing
- Test Drug(JW0302) or Reference Drug(C2206)
- Where
- South Korea
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- JW Pharmaceutical
B Cell Chronic Lymphocytic Leukemia
Tolerance and Resistance to Ibrutinib in Patients With Chronic Lymphocytic Leukemia (CLL
Assessment of the mutational profile of the residual clone and the distribution of lymphocyte subpopulations at 3 years of treatment with ibrutinib This project has an epidemiological part: to establish the percentage of…
- Trial name
- NCT03502876
- Where
- 2 sites in France
- Volunteers
- 198 people
- Sponsor
- French Innovative Leukemia Organisation
Myocardial Injury, Connective Tissue Diseases
Effect of Sacubitril/Valsartan on Reduced Right Ventricular Ejection Fraction in Patients With CTD
Heart failure, one of the leading causes of connective tissue disease (CTD) mortality, has attracted increasing attention. Currently, no known study had focused on the effect of sacubitril/valsartan on right ventricular…
- Trial name
- EARLY-MYO-CTD (NCT04197050)
- Testing
- Sacubitril / Valsartan Oral Tablet
- Where
- China
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Radiation Tolerance, Breast Neoplasms
Prediction of Individual Radiosensitivity During Radiotherapy for Breast Cancer Patients
Non-randomized clinical cohort study investigating if single nucleotide polymorphism (SNP) or inflammatory markers can predict radiosensitivity in breast cancer patients receiving radiotherapy.
- Trial name
- SENS (NCT05566613)
- Testing
- Blood sample
- Where
- Sweden
- Volunteers
- 550 people
- Sponsor
- Karolinska University Hospital
Non-small Cell Lung Cancer (NSCLC), Small Cell Lung Cancer (SCLC)
Sarcopenia and Cachexia in Patients With Lung Cancer
The PHILICA study investigates whether muscle mass, muscle strength, and muscle function are associated with treatment tolerance, quality of life and survival in patients with lung cancer.
- Trial name
- PHILUCA (NCT06730685)
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Zealand University Hospital
Impaired Glucose Tolerance
Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance
Subjects with impaired glucose tolerance will be randomized to either rosiglitazone or placebo for a 18 month period. The study will look at baseline, 12 month and 18 month data for exercise tolerance, coronary artery…
- Trial name
- NCT00733174
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Denver Research Institute
Prostatic Cancer
Clinical Trial to Examine Individual Pain Tolerance in the Use of Two Anesthetic Techniques to Perform Saturation Prostate Biopsy
To assess the effectiveness of two anesthetic techniques by measuring the pain through visual analog scale (VAS), to obtain saturation prostate biopsies.
- Trial name
- NCT02909049
- Testing
- MIDAZOLAM, MEPIVACAÍNE, FENTANILE
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Lactose Intolerance
A Bifido Bacteria to Improve Lactose Digestion and Tolerance
We want to determine if feeding a bifido bacteria that readily digests lactose and galactooligosacharides improves lactose digestion and tolerance through alteration of the microbiome.
- Trial name
- NCT05668468
- Testing
- Bifidobacterium adolescentis IVS-1 capsule
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue University
Cystic Fibrosis
Increase Tolerance for Exercise and Raise Activity Through Connectedness Trial
In this research study the investigators want to learn more about whether using a fitness tracker and accelerometer helps patients with cystic fibrosis exercise more regularly, and in turn whether it increases exercise tolerance…
- Trial name
- INTERACT (NCT02700243)
- Testing
- Fitbit
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Atopic Diathesis, Eczema-Prone Skin
Assessment of Skin Tolerance and Efficacy of a Cosmetic Product After 4 Weeks of Use on Subjects With Atopic Dermatitis
The aim of this study is to compare the efficacy and tolerability of a cosmetic product to one that is already available on the market (benchmark product).
- Trial name
- NCT05786976
- Testing
- Lotion BNO 3732, Body Lotion Benchmark product
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bionorica SE
Blood Pressure, Blood Loss
LBNP Tolerance With Skin Warming After Exercise Cold Stress
Assess the effect of skin rewarming during lower body negative pressure upon arterial blood pressure and tolerance to simulated blood loss after exercise in the cold.
- Trial name
- NCT06279897
- Testing
- Skin Surface Rewarming, Skin Surface Warming, Skin Surface Heating
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Colorado Springs
Female Subjects Undergoing COH in ART to Prevent Early Ovulation
Identify Effective Doses of SHR7280 Tablets in Controlled Ovarian Hyperstimulation (COH) for Female Subjects Undergoing Assisted Reproductive Technology (ART)
This study is a multicentre, open-label phase II dose-finding clinical trial that will recruit approximately 120 female subjects undergoing COH for in vitro fertilization (IVF) or intracytoplasmic single sperm injection (ICSI).
- Trial name
- NCT05082233
- Testing
- SHR7280 tablets
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Milk Hypersensitivity
Amino Acid Feed Children's Study
This study of the tolerance and acceptability of an amino acid based feed will assess gastrointestinal (GI) tolerance, product intake and acceptability in relation to taste, smell, texture in 20 patients between 1-10 years…
- Trial name
- NCT02569840
- Testing
- Amino Acid Feed
- Volunteers
- 30 people
- Sponsor
- Nutricia UK Ltd
Rheumatoid Arthritis
TOLERA: Tolerance Enhancement in RA
Although anti-citrullinated protein antibodies (ACPA) including anti-CCP2 antibodies are known to promote inflammation and joint destruction in patients suffering from ACPA-positive rheumatoid arthritis, there are currently no…
- Trial name
- TOLERA (NCT04120831)
- Testing
- Abatacept Injection
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Nephrotic Syndrome
The Efficacy and Tolerance of Tacrolimus Sustained-release Capsules on Refractory Nephrotic Syndrome (RNS)
It is a pilot study to explore the efficacy and safety of Tacrolimus Sustained-release Capsules (ADVAGRAF) on 6-month induction therapy of Refractory Nephrotic Syndrome (RNS).
- Trial name
- NCT01309477
- Testing
- Tacrolimus Sustained-release Capsules (ADVAGRAF)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Severe Hemophilia A
Study of First TIME Immunotolerance Induction in Severe Hemophilia A Patients With Inhibitor at High Risk of Failure: Comparison With FVIII Concentrates With or Without Von Willebrand Factor - RES.I.S.T. Naive
This is a prospective, controlled, randomized, open label study, aimed at comparing FVIII/VWF concentrates with FVIII concentrates at 200 IU/kg daily in their ability to induce immune tolerance in Haemophilia A patients with high…
- Trial name
- RESIST NAIVE (NCT01051544)
- Testing
- FVIII Concentrates, FVIII/VWF concentrates
- Sponsor
- City of Hope Medical Center
Burn Out, Psychological Disturbance
A Specialized Nutraceutical for Pre-burnout
High demands, professional overload and emotional stress are well known negative influences on mental health. Chronic stress-related occupational diseases, especially Burnout, are becoming an important issue.
- Trial name
- WELBI (NCT04532892)
- Testing
- Meta 18.06 Day and Meta 18.06 Night
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
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