Clinical trials: Immune System Tolerance
Metastatic Pancreatic Ductal Adenocarcinoma
A Study of the Safety and Tolerance of CAN04 in Combination With FOLFIRINOX in Subjects With Metastatic Pancreatic Ductal Adenocarcinoma
This study will consider the safety and effectiveness of a study drug, CAN04, in combination with FOLFIRINOX, in the treatment of metastatic pancreatic ductal adenocarcinoma.
- Trial name
- CAPAFOUR (NCT04990037)
- Testing
- CAN04, FOLFIRINOX
- Where
- 9 sites in France, Spain
- Volunteers
- 25 people
- Sponsor
- Cantargia AB
Prediabetic State, Impaired Glucose Tolerance
Effect of Linagliptin + Metformin on Patients Who do Not Achieve Normoglucemia With Metformine
The goal of this protocol is to evaluate the effect of addhing linagliptin to patients with prediabetes who do not reverse to normoglycemia after 12 months of treatment with metformin alone.
- Conditions
- Prediabetic State, Impaired Glucose Tolerance, Insulin Resistance
- Trial name
- RESCATHEME (NCT04088461)
- Testing
- Linagliptin / Metformin Oral Tablet, Metformin
- Where
- Mexico
- Volunteers
- 31 people
- Sponsor
- Universidad de Guanajuato
Body Weight, Impaired Glucose Tolerance in Obese
Effect of Cabergoline on Weight and Glucose Tolerance
The aim of this study is to determine the efficacy of cabergoline, a long-acting dopamine receptor agonist, on body weight and blood glucose in healthy obese adults. This is a randomized double-blind placebo controlled study.
- Trial name
- NCT01395602
- Testing
- Cabergoline
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Opiate Dependence, Sexually Transmitted Diseases
Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence
Before starting treatment with XR-NTX, a medication that blocks the positive effects of opioids and helps people stay off opioids, individuals who are dependent on opioids first have to endure a difficult withdrawal process.
- Conditions
- Opiate Dependence, Sexually Transmitted Diseases, HIV
- Trial name
- NCT02602795
- Testing
- Acceptance and Commitment Therapy, Information Motivation Behavioral Model
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rhode Island Hospital
Rabies
Immune Responses and Immunological Tolerance After Rabies Booster Vaccination in HIV-infected Adults
To study the humoral and cell-mediated immune responses in HIV-infected adults who had previously received rabies booster vaccination more than a year before
- Trial name
- NCT03228069
- Testing
- Blood drawn after rabies booster vaccination
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Queen Saovabha Memorial Institute
Moderate-to-severe Atopic Dermatitis
Dose Escalation Trial of CM310 in Patients With Moderate-to-Severe Atopic Dermatitis (AD)
This is a multi-center, randomized, double blind, placebo-controlled multiple dose escalation study to evaluate the safety, tolerance, PK, PD, immunogenicity and preliminary efficacy of subcutaneously CM310 in moderate-severe AD…
- Trial name
- NCT04893941
- Testing
- CM310
- Where
- 7 sites in China
- Volunteers
- 39 people
- Sponsor
- Keymed Biosciences Co.Ltd
Healthy Volunteers
A Phase I Clinical Trial of Meplazumab in Healthy Volunteer
This is a single center, double-blinded, placebo-controlled phase I clinical trail in healthy volunteer of meplazumab for injection.
- Trial name
- NCT04369586
- Testing
- meplazumab for injection
- Where
- China
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Human Papillomavirus-Negative Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma
Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer
This phase I trial tests the safety, side effects, and best dose of decitabine in combination with standard of care surgery, radiation, and/or chemotherapy and the effectiveness of the combination in treating patients with head…
- Conditions
- Human Papillomavirus-Negative Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma, Resectable Human Papillomavirus-Independent Head and Neck Mucosal Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma
- Trial name
- NCT06997094
- Testing
- Biospecimen Collection, Chemotherapy, Decitabine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Gastrointestinal Tolerance
The Effects of Soluble Corn Fiber on Gastrointestinal Tolerance and Fecal Microbiome in Healthy Children
The purpose of this study is to compare the effects of PROMITOR® Soluble Corn Fiber versus inulin on GI symptoms (tolerance), stool consistency (laxation) and fecal microbiome at levels that could contribute to closing the fiber…
- Trial name
- NCT05213494
- Testing
- Inulin, soluble corn fiber
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tate & Lyle
Coronary Heart Disease Complicated With Impaired Glucose Tolerance
Can Platelets/Lymphocytes Rate Be New Serological Index for Prognosis of Coronary Heart Disease Complicated With Impaired Glucose Tolerance: Basic Principles and Experimental Design
Background About 2/3 patients of coronary heart disease (CHD) are complicated with disorder of carbohydrate metabolism which results in hyperglycemia and subsequent abnormality of coagulation system and inflammation.
- Trial name
- NCT02149056
- Testing
- observation, Impaired Glucose Tolerance
- Volunteers
- 447 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Hebei University
Growth of Term Infants
Growth and Tolerance of Hypoallergenic Formulas
This clinical trial will evaluate two investigational hypoallergenic infant formulas with a differing protein content to determine if they provide normal growth and are well tolerated by term infants as compared to a marketed…
- Trial name
- NCT01354366
- Testing
- Infant formula
- Where
- 24 sites in United States
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Healthy Subjects
Effect of Oat Compounds on Postprandial Glucose Response
In this project we will investigate synergistic effects of oat polar lipids and beta glucans on postprandial glucose tolerance
- Trial name
- NCT05177172
- Testing
- High beta glucans, Low beta glucans, Low beta glucans + low polar lipids
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Reperfusion Injury, Myocardial Ischemia
Tolerance of Myocardium to Ischemia Injury
This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery.
- Trial name
- TOMIS (NCT02812901)
- Testing
- cardiac surgery scheduled in the morning, cardiac surgery scheduled in the afternoon
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Lille
Renal Failure
Induction of Donor-Specific Tolerance in Recipients of Live Donor Stem Cell Infusion (Compassionate Use)
Four subjects were treated under compassionate use provisions under this study with facilitating cell therapy (FCRx)
- Trial name
- NCT02051673
- Testing
- Biological/Vaccine: Enriched Hematopoetic Stem Cell Infusion
- Where
- United States
- Sponsor
- Talaris Therapeutics Inc.
Macular Degeneration
JY028 Single Vitreous Injection in a Phase 1 Clinical Trial in nAMD Patients
Phase I clinical trial on safety, tolerance, pharmacokinetics (PK) and pharmacodynamics of recombinant human anti-VEGF monoclonal antibody injection in patients with neovascular (wet) age-related macular degeneration
- Trial name
- NCT03725566
- Testing
- Experimental
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Tongren Hospital
Chronic Kidney Diseases, Renal Failure
Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)
Phase 2 basket trial including 2 open-label single-arm cohorts: REPAIR CKD cohort and REPAIR Dialysis cohort. Open label colchicine 0.3 mg daily for 8 weeks followed, in patients who tolerated the 0.3 mg dose, by forced titration…
- Trial name
- NCT06203977
- Testing
- Colchicine
- Where
- 3 sites in Canada
- Volunteers
- 96 people
- Sponsor
- Hamilton Health Sciences Corporation
Cystic Fibrosis-related Diabetes, Diabetes Mellitus
A Comparison of Clinical Parameters in With and Without Abnormal Glucose Tolerance.
Cystic fibrosis (CF) is autosomal recessive, genetic disorder cause of cystic fibrosis transmembrane regulatory (CFTR) gene mutation. CF often is observed in caucasian population.
- Conditions
- Cystic Fibrosis-related Diabetes, Diabetes Mellitus, Cystic Fibrosis
- Trial name
- NCT04503408
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Healthy Infants
To Investigate Effects of a New Infant Formula in Healthy Term Chinese Infants
This study investigates the effects of a new infant formula on growth, safety, and tolerance in healthy term Chinese infants. Screening starts after the informed consent is obtained.
- Trial name
- NCT03520764
- Testing
- New infant formula with synbiotics, Standard infant formula with prebiotics
- Where
- 6 sites in China
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Danone Nutricia
Asthma
Regular Use Tiotropium and Tolerance to Bronchoprotection in Mild Asthma
The study will assess if regular use of tiotropium (i.e. daily) results in loss of bronchoprotection against methacholine induced bronchoconstriction in those with mild asthma.
- Trial name
- NCT05113615
- Testing
- Tiotropium Bromide
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Saskatchewan
Impaired Glucose Tolerance
Prevention of Type 2 Diabetes in Children With a Family-based Healthy Lifestyle Program
The purpose of this study is to determine if the Bright Bodies (BB) Healthy Lifestyle Program can help reverse early abnormalities in glucose metabolism and prevent the progression to type 2 diabetes (T2DM) in high-risk, obese…
- Trial name
- NCT01030978
- Testing
- Bright Bodies Healthy Lifestyle Program, Control
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Yale University
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