Clinical trials: Immune System Tolerance
SMA
Study to Evaluate the Efficacy of Riluzole in Children and Young Adults With Spinal Muscular Atrophy (SMA)
This is a multicentric, randomized, double-blind study versus placebo, with two parallel groups treated to evaluate the efficacy and the tolerance of Riluzole in children and young adults (6 to 20 years of age) with SMA.
- Trial name
- ASIRI (NCT00774423)
- Testing
- Riluzole
- Where
- France
- Volunteers
- 141 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Enteral Feeding
Enteral Formula Tolerance of Standard Tube Feedings
This prospective observational study seeks to assess ability to achieve enteral feeding goals with standard tube feeding formulas.
- Trial name
- NCT02312271
- Testing
- enteral formula
- Where
- 3 sites in United States, Canada
- Volunteers
- 102 people
- Sponsor
- Société des Produits Nestlé (SPN)
Chronic Obstructive Pulmonary Disease
Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
This is a study to evaluate the effects of early pulmonary rehabilitation within 10 days after discharge from the hospital after a COPD exacerbation on exercise tolerance, exacerbations, re-admissions and the quality of life…
- Trial name
- NCT00413543
- Testing
- early pulmonary lung rehabilitation
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Isala
Healthy
Single Dose Followed by Maintenance Dose Tolerance Study of BIIR 561 CL in Healthy Elderly Male and Female Volunteers
The objective of the present study was to obtain information about the safety, tolerability and pharmacokinetics of BIIR 561 CL after continuous intravenous administration of two increasing doses in healthy elderly volunteers…
- Trial name
- NCT02223507
- Testing
- BIIR 561 CL
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Post Bariatric Surgery, Gastric Bypass
The Effects of Bariatric Surgeries on Glucose Metabolism
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
- Conditions
- Post Bariatric Surgery, Gastric Bypass, Sleeve Gastrectomy, Hypoglycemia After Gastric Bypass
- Trial name
- NCT02823665
- Testing
- Exendin-(9-39), Atropine
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pulmonary Disease, Chronic Obstructive
Effect of Tiotropium on Exercise Tolerance in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Study to investigate whether tiotropium therapy can increase duration of steady-state exercise by decreasing dynamic and static lung hyperinflation in COPD patients.
- Trial name
- NCT02172300
- Testing
- Tiotropium inhalation capsules
- Volunteers
- 198 people
- Sponsor
- Boehringer Ingelheim
Hypercholesterolemia
Pharmacokinetics and Pharmacodynamics Study of Gemcabene in Healthy Volunteers
The purpose of this study is to evaluate the multiple-dose pharmacokinetic characteristics and pharmacologic activity of gemcabene.
- Trial name
- NCT02587364
- Testing
- Gemcabene 50 mg, Gemcabene 150 mg, Gemcabene 450 mg
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Prostatic Hyperplasia
A-botulinic Toxin for Symptomatic Benign Prostate Hypertrophy
BPH is very common in elderly men, it is a stromal as well as epithelial invasion of the prostatic gland. Due to an imbalance between growth and apoptosis cellular mechanisms that are not fully elucidated.
- Trial name
- PROTOX (NCT01275521)
- Testing
- BONT-A intra-prostatic injection, Optimized medical BPH treatment
- Where
- 11 sites in France
- Volunteers
- 127 people
- Sponsor
- University Hospital, Bordeaux
Hyperglycemia, Insulin Sensitivity
The Influence of Sampling Site When Assessing Glucose Tolerance or Insulin Sensitivity With Oral Glucose Ingestion
For decades, it has been known that post-meal blood glucose concentrations were associated with the risk of T2D, which was reflected in early diagnostic guidelines.
- Trial name
- NCT02852044
- Testing
- Rest, Exercise, Dorsal Hand Vein Cannulation (heated hand technique)
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Bath
Tumor
Tolerance and Pharmacokinetics of TQ-B3233
Study of Tolerance and Pharmacokinetics of TQ-B3233 Capsule, phase I,single arm.
- Trial name
- NCT03453034
- Testing
- TQ-B3233
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Myocardial Infarction, Unstable Angina Pectoris
Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction
A three months, double-blind, randomised, parallel-group study evaluating the efficacy of sitagliptin (Januvia™) versus placebo on beta-cell function in patients with newly detected glucose abnormalities and acute myocardial…
- Conditions
- Myocardial Infarction, Unstable Angina Pectoris, Diabetes Mellitus, Impaired Glucose Tolerance
- Trial name
- BEGAMI (NCT00627744)
- Testing
- Sitagliptin
- Where
- 2 sites in Sweden
- Volunteers
- 85 people
- Sponsor
- Karolinska Institutet
Type 2 Diabetes Mellitus
Protocol for Alpha MSH Infusion Study in Patients With Type 2 Diabetes
Alpha-melanocyte stimulatory hormone (α-MSH) is a melanocyte-stimulating hormone produced by the hypothalamus and released from the pituitary gland.
- Trial name
- α-MSH & T2DM (NCT06293664)
- Testing
- α-MSH infusion
- Where
- Kuwait
- Volunteers
- 13 people
- Sponsor
- Dasman Diabetes Institute
Obstructive Jaundice, Disease as Reason for ERCP
Immune Function in Patients With Obstructive Jaundice
Patients with obstructive jaundice (OJ) often require surgical, endoscopic or radiological interventions to facilitate biliary drainage and relieve jaundice.
- Conditions
- Obstructive Jaundice, Disease as Reason for ERCP, Immune Dysfunction, Immune Tolerance
- Trial name
- NCT01367821
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sedentary Lifestyle, Hyperinsulinemia
Developing a Physiological Understanding of High Duration Activity
When muscles are not contracting, the local energy demand by muscle and use of specific fuels used to produce energy by oxidative metabolism are minimal.
- Conditions
- Sedentary Lifestyle, Hyperinsulinemia, Glucose Tolerance Impaired, Low-density-lipoprotein-type
- Trial name
- NCT05135234
- Testing
- Muscular Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Houston
Fetal Growth Retardation
Study to Examine Insulin Resistance During Growth Hormone Treatment for Short Stature Due to Low Birthweight
Insulin resistance is common among children with low birthweight. Moreover, growth hormone treatment for ensuing short stature also causes insulin resistance. Our objective is to examine these processes.
- Trial name
- NCT00120497
- Testing
- somatropin (rDNA)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Tolerance
Tolerance and Utilization of Agave Inulin in Healthy Adults
The objective of this study is to assess the tolerance and utilization of agave inulin. This will be accomplished through analyses of breath and fecal samples to quantify fermentation end-products- hydrogen, carbon dioxide, and…
- Trial name
- NCT01925560
- Testing
- Agave Inulin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Advanced Solid Tumor or Hematologic Tumor
A Study to Evaluate the Tolerance, Efficacy and Pharmacokinetics of TQB3454 Tablets
This is a open-label, multicenter, phase I study to evaluate tolerance and pharmacokinetics of TQB3454 tablets in subjects with advanced solid tumor or hematologic tumor.
- Trial name
- NCT04481607
- Testing
- TQB3454
- Where
- 5 sites in China
- Volunteers
- 96 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Food Hypersensitivity
Determining the Efficacy and Value of Immunotherapy on the Likelihood of Peanut Tolerance: The DEVIL Study
Peanut allergy is known to cause severe anaphylactic reactions.The goal of this proposal is to produce a new treatment that would benefit young subjects who have recently been diagnosed with peanut allergy by lowering the risk of…
- Trial name
- DEVIL (NCT00932828)
- Testing
- Peanut oral immunotherapy
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Glucose Intolerance
Japan Prevention Trial of Diabetes by Pitavastatin in Patients With Impaired Glucose Tolerance (J-PREDICT)
The purpose of this study is to evaluate the effects of pitavastatin for preventing diabetes in a population with impaired glucose tolerance.
- Trial name
- NCT00301392
- Testing
- life-style intervention, Life style interventions plus concomitant use of pitavastatin.
- Where
- Japan
- Volunteers
- 1,240 people
- Sponsor
- Tokyo University
Insulin Sensitivity, Glucose Intolerance
Effects of Progressive Negative Energy Balance on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function
Type 2 diabetes results from a combination of peripheral insulin resistance and beta-cell dysfunction, and manifests as fasting and postprandial hyperglycemia.
- Conditions
- Insulin Sensitivity, Glucose Intolerance, Insulin Resistance, Energy Supply; Deficiency
- Trial name
- NCT03264001
- Testing
- Negative energy balance
- Where
- Singapore
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
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