Clinical trials: Immune System Tolerance
Diet, Healthy
Chicory Fiber Effect on Satiety and GI Tolerance
The investigators are comparing 2 fiber treatments to a fiber free treatment for acute satiety and GI response.
- Trial name
- NCT04067362
- Testing
- food containing dietary fiber
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hand Joint Discomfort, Hand Joint Dysfunction
Effect and Tolerance of Standardized Exclusive Dry Extracts of Curcuma Longa and of Boswellia Serrata Among People With Hand Joint Discomfort and Dysfunction
The objective of the study is to evaluate the effect and tolerance of standardized exclusive dry extracts of Curcuma longa (CURTIL03) and of Boswellia serrata (BOSTIL01) among people with hand joint discomfort and dysfunction.
- Trial name
- FLEXOA (NCT05570123)
- Testing
- Flexofytol Forte
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Tilman S.A.
Renal Failure
Renal Allograft Tolerance Through Mixed Chimerism - SMC/MGH
The goal is to investigate the safety of the conditioning regimen, and its ability to induce donor/recipient lymphohematopoietic chimerism without Chimerism Transition Syndrome (CTS), which may result in donor-specific…
- Trial name
- NCT04540380
- Testing
- Rituximab, Fludarabine, Cyclophosphamide, Thymic irradiation and Siplizumab, Combined bone marrow and kidney transplant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Cow's Milk Allergy
Evaluation of Tolerance, Efficacy and Safety of an Hydrolyzed Formula in Infants With IgE/Non-IgE Mediated CMA.
The aim of this interventional study is to assess the hypoallergenicity of a new formula in infants having a cow milk allergy (CMA), whatever the type of CMA, meaning in both IgE-mediated and non-IgE-mediated CMA patients.
- Trial name
- MERLIN (NCT06481280)
- Testing
- Test Formula
- Where
- 2 sites in Belgium, Italy
- Volunteers
- 70 people
- Sponsor
- United Pharmaceuticals
Rheumatoid Arthritis
Tolerance, Pharmacokinetics and Preliminary Efficacy of T0001 in RA (Rheumatoid Arthritis)
The purpose of this study is to assess the MTD, Pharmacokinetics and preliminary efficacy of T0001 in Rheumatoid Arthritis.
- Trial name
- NCT02481180
- Testing
- T0001, Enbrel
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Influenza
Study to Evaluate the Safety, Tolerance and Immunogenicity of Fluviral™ in Healthy Adults
The purpose of the study is to evaluate the safety, tolerance and immunogenicity of Fluviral™ in healthy adults aged 18-64 years.
- Trial name
- NCT01389479
- Testing
- Fluviral™, Fluzone®
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sleep Disorders
Vestipitant 28-day Tolerance Study
This study is a 28-day polysomnographic and subjective assessment of oral Vestipitant 15mg/day for treatment of Primary Insomnia in adults outpatients.
- Trial name
- NCT00992160
- Testing
- GW597599
- Where
- 13 sites in Germany
- Volunteers
- 161 people
- Sponsor
- GlaxoSmithKline
Damage Muscle, Body Weight Changes
Chronic Study on Body Composition, Training, Performance, and Recovery
The chronic phase of the study will evaluate the effects of pre-exercise and post-exercise ingestion of a multi-ingredient supplement on adaptations to a 6-week exercise program consisting of both resistance training and high…
- Conditions
- Damage Muscle, Body Weight Changes, Performance Enhancing Product Use
- Trial name
- NCT04230824
- Testing
- Pre-workout plus and Protein recovery plus, 6-week resistance training program
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Distress, Emotional
Targeting Components of Distress Tolerance
The goal of this clinical trial is to learn which aspects of distress intolerance (i.e., difficulties withstanding upsetting emotional states) are the most important for improving effective emotion regulation and associated…
- Trial name
- NCT06570603
- Testing
- Self-Efficacy, Willingness, Psychoeducation
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Arkansas, Fayetteville
COPD, Rehabilitation
High-flow Nasal Cannula and Exercise Tolerance in COPD
Patients with COPD are often unable to sustain a sufficient workload during exercise. The use of external strategies to improve exercise tolerance, such as non-invasive ventilation (NIV) and high-flow nasal therapy (HFNT) have…
- Conditions
- COPD, Rehabilitation, Exercise
- Trial name
- NCT04350970
- Testing
- High flow nasal therapy, Non-invasive ventilation, Control
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Marcelo Alcantara Holanda
Pregnancy
Evaluation of Exercise Tolerance During Pregnancy
To evaluate the exercise tolerance during pregnancy and after thanks the 6MWT
- Trial name
- NCT02296060
- Testing
- 6 minutes walking test
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Bariatric Surgery, Hormonal Response
Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid Obesity
Obesity is a major global health problem. Bariatric surgery is the most effective treatment, leading to substantial weight loss and improvement in obesity-related comorbidities.
- Conditions
- Bariatric Surgery, Hormonal Response, Post Bariatric Hypoglycemia
- Trial name
- CU BYPASS-DJB (NCT07747779)
- Testing
- Sleeve gastrectomy with duodenojejunal bypass, Roux-en-Y gastric bypass
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Chulalongkorn University
Systemic Lupus Erythematosus
A Study of ICP-022 in Patients With Systemic Lupus Erythematosus (SLE)
The purpose of the study is to assess the Safety, Tolerability, PK/PD and preliminary Efficacy of ICP-022 in Subjects with Systemic Lupus Erythematosus (SLE)
- Trial name
- NCT04305197
- Testing
- ICP-022
- Where
- 11 sites in China
- Volunteers
- 60 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Impaired Fasting Glucose, Impaired Glucose Tolerance
D Vitamin Intervention in VA
This study will supplement African American male (AAM) veterans at risk for diabetes and newly diagnosed T2DM with vitamin D (low or higher dose) and evaluate whether vitamin D helps to improve early markers of diabetes.
- Conditions
- Impaired Fasting Glucose, Impaired Glucose Tolerance, Vitamin D Insufficiency
- Trial name
- DIVA (NCT01375660)
- Testing
- 50K vitamin D2
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- US Department of Veterans Affairs
Healthy
Study of Multiple-dose Kukoamine B Mesilate in Healthy Volunteers
The purpose of this study is to assess safety, tolerance and pharmacokinetics of Multiple-dose Kukoamine B Mesilate in healthy volunteers
- Trial name
- NCT02690961
- Testing
- Kukoamine B Mesilate
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tianjin Chasesun Pharmaceutical Co., LTD
Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis
Acute Effect of Sildenafil on Exercise Tolerance and Functional Capacity in COPD, IPF and Post Pneumonectomy Patients
Pulmonary diseases are increasingly important causes of morbidity and mortality in the modern world. Sildenafil, an orally administered a phosphodiesterase type 5 (PDE-5) inhibitor, targets the nitric oxide (NO) pathway.
- Trial name
- NCT01382368
- Testing
- Sildenafil
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Oxygen Consumption, Cardiorespiratory Fitness
A Study on Cardiopulmonary Exercise Tolerance Standards for Healthy Chinese Population
This project intends to conduct a large-sample, prospective, multicenter clinical cohort study in healthy populations. By utilizing a digital cardiopulmonary rehabilitation clinical data research platform, The investigators aim…
- Trial name
- MCCS-CCPETS (NCT07108296)
- Testing
- cardiopulmonary exercise testing (CPET)
- Where
- 15 sites in China
- Volunteers
- 4,620 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Changchun University of Chinese Medicine
Patient Satisfaction, Anxiety State
Effect of Binaural Beats on Level of Anxiety and Toleration in Patients Undergoing Upper Gastrointestinal Endoscopy Without Sedation
To investigate the anxiolytic effects of binaural beat-embedded audio in patients undergoing sedation-free upper gastrointestinal endoscopy
- Conditions
- Patient Satisfaction, Anxiety State, Tolerance
- Trial name
- NCT06114524
- Testing
- binaural music
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Liver Failure
TLI- and ATG-Enabled Minimization Protocol in Liver Transplantation
The unmet medical need in solid organ transplantation is to eliminate the lifelong requirement of powerful immune suppression drug combinations with their attendant side effects, and to prevent immune mediated rejection of the…
- Trial name
- TEMPO-LT (NCT07634562)
- Testing
- Anti-Thymocyte Globulin, ATG (Rabbit), Total lymphoid irradiation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
End Stage Renal Disease
Renal Allograft Tolerance Through Mixed Chimerism
This study will examine the safety and effectiveness of a combination kidney and bone marrow transplant from a haplo-identical related donor.
- Trial name
- NCT01780454
- Testing
- MEDI-507, Rituximab, Total Body Irradiation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
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