Clinical trials: Immune System Tolerance
Renal Transplantation
TAIZ -Monocytes for the Induction of Donor Specific Tolerance in Renal Allograft Recipients (Cadaver Kidney)
Induce tolerance or reduce the amount of immunosuppression after renal transplant patient (receiving cadaver kidney)with so called TAIZ-monocytes
- Trial name
- NCT00223093
- Testing
- TAIZ
- Volunteers
- 10 people
- Sponsor
- University Hospital Schleswig-Holstein
Kidney Failure, Chronic, Multiple Myeloma
Combined Bone Marrow and Kidney Transplant for Multiple Myeloma With Kidney Failure
The purpose of this study is to determine whether a combined bone marrow and kidney transplant will be effective in treating stage II or greater multiple myeloma and associated kidney failure.
- Trial name
- NCT00062621
- Testing
- Combined bone marrow and kidney transplant
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemophilia A
Safety/Efficacy Study to Assess Whether FVIII/VWF Concentrate Can Induce Immune Tolerance in Haemophilia A Patients
The purpose of this study is to assess the role of a FVIII/VWF complex concentrate (Emoclot) in successfully inducing immune tolerance (I.T.I.) in patients with Haemophilia A with inhibitors, including patients at high risk of…
- Trial name
- ITI (NCT02479087)
- Testing
- Plasma-derived FVIII/VWF concentrate
- Where
- 4 sites in Egypt, India
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Unspecified Adult Solid Tumor, Protocol Specific
Erlotinib, Trastuzumab, and Paclitaxel in Treating Patients With Advanced Solid Tumors
Phase I trial to study the effectiveness of combining erlotinib and trastuzumab with paclitaxel in treating patients who have advanced solid tumors.
- Trial name
- NCT00042809
- Testing
- paclitaxel, trastuzumab, erlotinib hydrochloride
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Scoliosis Idiopathic
Inspiratory Muscle Training in Children and Adolescents With Idiopathic Scoliosis Undergoing Schroth Therapy.
This study evaluates the effectiveness of inspiratory muscle training in children and adolescents with idiopathic scoliosis undergoing therapy with the Schroth method.
- Trial name
- NCT07177430
- Testing
- Inspiratory Muscle Training
- Where
- 2 sites in Poland
- Volunteers
- 56 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Chronic Heart Failure (CHF), Iron Deficiency
Evaluation on Performance and Oxydative Stress in Patient With Iron deficIency and Stable Heart Failure Study
ERADAL-HF is a double blinded, multi-centre, prospective, randomized, three arm study, enrolled ambulatory patients with chronic heart failure [New York Heart Association (NYHA) class II/III], with iron deficiency [defined as…
- Trial name
- ERADAL-HF (NCT04225728)
- Testing
- Iron Sucrose IV, Ferric polymaltose hydroxide complex IM, Saline solution
- Where
- Cameroon
- Volunteers
- 45 people
- Sponsor
- CN NGANOU-GNINDJIO, MD, MSc
Congestive Heart Failure
Cardiac Resynchronization Therapy, Dyspnea and Exercise Tolerance in Patients With Congestive Heart Failure (CHF)
A new therapy for patients with advanced heart failure (HF) involves the implantation of a specialized pacemaker device (Cardiac Resynchronization Therapy, CRT) that attempts to restore the synchronized contraction of the…
- Trial name
- NCT00700700
- Testing
- Active Cardiac Resynchronization Therapy (CRT)
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Queen's University
Corneal Defect
Evaluate the Tolerance, Safety and Pharmacokinetics of Germinal Peptide Eye Drops in Healthy Volunteers
Phase I Clinical Trial to Evaluate the Tolerance, Safety and Pharmacokinetics of Germinal Peptide Eye Drops in Healthy Volunteers.
- Trial name
- NCT03662971
- Testing
- Germinal peptide eye drops
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Childhood Obesity
Leipzig Childhood Obesity Study
The aim of this study is to identify polymorphisms that make children and adolescents more prone to obesity and metabolic dysfunction, as well as to identify biomarkers that are linked to causes and consequences of obesity.
- Trial name
- NCT04491344
- Where
- Germany
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Microbial Colonization, Tolerance
SEPSIS: L. Plantarum Trial
Sepsis is a life-threatening clinical syndrome and a leading cause of neonatal deaths worldwide. The burden of neonatal sepsis and severe infection (SI) is particularly high in areas of South Asia and other resource-limited…
- Conditions
- Microbial Colonization, Tolerance, Safety Issues, Infant ALL
- Trial name
- NCT05180201
- Testing
- Synbiotic, Probiotic
- Where
- 2 sites in Bangladesh
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Suppurative Osteomyelitis of Jaw, Potential Abnormality of Glucose Tolerance
Risk Factors Associated With Recurrence and Life-threatening Complications for CSOJ
Clinically, recurrence and life-threatening complications are challenging problems for chronic suppurative osteomyelitis of the jaw.
- Trial name
- NCT01670422
- Where
- China
- Volunteers
- 322 people
- Sponsor
- West China College of Stomatology
Hallux Deformity
Metatarsophalangeal Arthrodesis of the Hallux
The purpose of the study is to describe the rate of bone fusion (radiological consolidation) in the 2 groups (A and B) 4 months after the operation.
- Trial name
- ARTHRODESE (NCT05691075)
- Testing
- Arthrodesis of the metatarsophalangeal joint
- Where
- France
- Volunteers
- 3 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Chronic Rejection of Liver Transplant
Safety Study of Using Regulatory T Cells Induce Liver Transplantation Tolerance
The first trial will involve the generation of donor alloantigen-specific CD4+CD25+ Tregs from peripheral blood of pre-transplant patients, the administration of the CD4+CD25+ Tregs (1 x 106 cells/kg) at several intervals (for…
- Trial name
- Treg (NCT01624077)
- Testing
- Regulatory T cells
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Advanced Malignant Cancer
A Clinical Trial of TQB3117 Tablets in Patients With Advanced Malignant Cancer
The study is divided into two phases: dose escalation and dose extension. The dosing regimens include a single-dose study and a multiple-dose study.
- Trial name
- NCT06415903
- Testing
- TQB3117 tablets
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Advanced Cancer
Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers
The purpose of this study: Determining the Maximum Tolerated Dose (MTD), Dose-Limiting Toxicity (DLT), pharmacokinetics characteristic, and dosage regimen of phase II/III of Chlorogenic acid for injection in the advanced…
- Trial name
- NCT02245204
- Testing
- Chlorogenic acid
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd
Physical Activity, Pregnant
Study of Programm Interest 'Bouge' to Improve the Daily Physical Activity at the Pregnant Women.
Evaluate the "Bouge" digital program (smartphone application) to increase the daily physical activity of pregnant patients beguining at 15 SA
- Conditions
- Physical Activity, Pregnant, Mobile Health Apps
- Trial name
- BOUGE GROSSESS (NCT03688087)
- Testing
- Smartphone equipped with application "bouge" = Coach group
- Where
- 4 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Cow Milk Allergy
Synbiotic Extensively Hydrolysed Feed Study
This study of the tolerance and acceptability of a extensively hydrolysed formula (eHF) containing pre- and probiotics will assess gastrointestinal (GI) tolerance, product intake and acceptability in 40 infants (aged <13 months)…
- Trial name
- NCT03874104
- Testing
- Extensively Hydrolysed Formula containing Pre- & Probiotics
- Where
- 8 sites in United Kingdom
- Volunteers
- 35 people
- Sponsor
- Nutricia UK Ltd
Vitiligo
Evaluation of Effect and Tolerance of the Association of Baricitinib and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo
The purpose of this phase 2 study is to evaluate the effect and the safety of the combination of Baricitinib in combination with phototherapy in adult participants with non-segmental progressive vitiligo.
- Trial name
- BARVIT (NCT04822584)
- Testing
- Baricitinib Oral Product
- Where
- 4 sites in France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Bordeaux
Impaired Glucose Tolerance
Health Effects of Salmon Fishmeal in Humans
Diabetes contributes significantly to the burden of disease in Norway and cardiovascular disease is the main cause of mortality. Both lean and fatty fish are shown to have beneficial health effects.
- Trial name
- FishMeal (NCT03764423)
- Testing
- Salmon fishmeal, Microcrystalline cellulose
- Where
- Norway
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Chronic Hepatitis B
Clinical Study to Evaluate the Safety, Tolerance and Pharmacokinetic Characteristics of Single Administration of HRS-5635 Injection in Chinese Healthy Subjects and the Safety, Tolerance, Pharmacokinetics and Antiviral Effect of Multiple Administration in Patients With Chronic Hepatitis B
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-5635 in healthy adults and chronic hepatitis B. To explore the reasonable dosage of HRS-5635.
- Trial name
- NCT05808374
- Testing
- HRS-5635
- Where
- China
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
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