Clinical trials: Immune System Tolerance
Diabetes Mellitus, Glucose Intolerance
Prevalence of Glucose Intolerance and Risk Factors in Ethiopian Immigrants in Israel; Follow-up Study.
High risk population: Screening for impaired glucose tolerance.
- Trial name
- NCT01402362
- Where
- Israel
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Diabetes Mellitus, Type 2
Gastric Emptying - Implications for the Pathogenesis of Type 2 Diabetes
People of black African and Caribbean descent have a greater risk of developing type 2 diabetes than white Europeans. The aim of this study is to increase our knowledge of how the condition may arise, and what underlies this…
- Trial name
- NCT03864562
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Surgical Preparation of the Vagina
Tolerance of Chlorhexidine Gluconate Vaginal Cleansing Solution
Conduct a randomized control study to compare the tolerance of 4% chlorhexidine gluconate/4% isopropyl alcohol versus povidone iodine vaginal cleansing solutions for surgical preparations of the vagina.
- Trial name
- NCT03305159
- Testing
- Povidone-Iodine, 4% Chlorhexidine Gluconate
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Asthma
Regular Use Effect of Inhaled Ipratropium Bromide on Airway Responsiveness to Methacholine in Well-controlled Asthma
Study is looking at the development of tolerance to methacholine following regular use of ipratropium bromide in mild asthmatics.
- Trial name
- NCT04167280
- Testing
- Ipratropium Metered Dose Inhaler
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Saskatchewan
Respiratory Distress Syndrom, High Flow Nasal Cannula
Efficacy and Tolerance of High Flow Nasal Cannula for Respiratory Distress Syndrom in Late Preterms (34-36 Weeks)
The main objective of the study is to gather preliminary data on the effectiveness of High Flow Nasal canula (HFNC), provided since the delivery room, for ventilatory support in newborns of 34-36 weeks with moderate respiratory…
- Trial name
- PRIMAIR (NCT02958488)
- Testing
- High Flow Nasal Cannula
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Healthy Volunteer
Study of Tolerance, Biodistribution and Dosimetry of Fucoidan Radiolabeled by Technetium-99m
The development of an innovative imaging agent capable of non-invasively detecting vulnerable plaques is a major objective of research in cardiovascular pathology.
- Trial name
- NANO-ATHERO (NCT03422055)
- Testing
- 99mTc-Fucoidan SPECT
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Syndrome, Impaired Glucose Tolerance
Prevention of Type 2 Diabetes Mellitus by L-Arginine in Patients With Metabolic Syndrome
Aim The principal objective of this project is: To evaluate the efficacy of long term (18 months) L-Arginine therapy in preventing or delaying clinical onset of type 2 diabetes mellitus in subjects with impaired glucose tolerance…
- Conditions
- Metabolic Syndrome, Impaired Glucose Tolerance, Insulin Resistance, Endothelial Dysfunction
- Trial name
- L-arginine (NCT00917449)
- Testing
- L-arginine
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- IRCCS San Raffaele
Type 2 Diabetes Mellitus
Protocol for Alpha MSH Infusion Study in Patients With Type 2 Diabetes
Alpha-melanocyte stimulatory hormone (α-MSH) is a melanocyte-stimulating hormone produced by the hypothalamus and released from the pituitary gland.
- Trial name
- α-MSH & T2DM (NCT06293664)
- Testing
- α-MSH infusion
- Where
- Kuwait
- Volunteers
- 13 people
- Sponsor
- Dasman Diabetes Institute
Borderline Hypokalemia
The Effects of Potassium on Glucose Metabolism in African Americans
African Americans suffer a disproportionately high risk of diabetes compared to other Americans. Reasons for race disparities in diabetes incidence are not completely understood.
- Trial name
- NCT02236598
- Testing
- K+ supplement
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Duke University
Eczema, Dermatitis
Black Tea Compresses for Facial Eczema and Perioral Dermatitis
Facial eczema and perioral dermatitis are clinical entities that develop exclusively in the face and present a special therapeutic challenge.
- Trial name
- NCT02941432
- Testing
- Black tea compress treatment
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- University of Luebeck
Pulmonary Disease, Chronic Obstructive
Effect of Tiotropium Inhalation Capsules on Exercise Tolerance, Daily Activity and Dyspnoea in Patients With Chronic Obstructive Pulmonary Disease (COPD) Participating in 3 Weeks of Pulmonary Rehabilitation
The primary objective of the study is to investigate the effect of the combined therapy 18 μg tiotropium q.d. plus pulmonary rehabilitation versus placebo plus pulmonary rehabilitation on 6-minute walking distance (6MWD) after 7…
- Trial name
- NCT02172508
- Testing
- Tiotropium Inhalation Capsule
- Volunteers
- 15 people
- Sponsor
- Boehringer Ingelheim
Healthy Subjects
Effect of Oat Compounds on Postprandial Glucose Response
In this project we will investigate synergistic effects of oat polar lipids and beta glucans on postprandial glucose tolerance
- Trial name
- NCT05177172
- Testing
- High beta glucans, Low beta glucans, Low beta glucans + low polar lipids
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Reversal of Coagulopathy
An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N (Kcentra) Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure
The purpose of this study is to evaluate efficacy, safety and tolerance of Beriplex® P/N (Kcentra) compared with plasma in regard to rapid reversal of coagulopathy induced by vitamin K antagonists in subjects who require…
- Trial name
- BE1116_3003 (NCT00803101)
- Testing
- Beriplex® P/N (Kcentra), Fresh frozen plasma
- Where
- 30 sites in United States, Belarus and 4 more
- Volunteers
- 176 people
- Sponsor
- CSL Behring
Progressive Fibrosing Interstitial Lung Disease (PF-ILD) / Progressive Pulmonary Fibrosis (PPF)
A Study to Explore the Therapeutic Effect of HEC585 on Delaying Forced Vital Capacity (FVC) Decline and Tolerance in Progressive Fibrosing Interstitial Lung Disease (PF-ILD) Patients
The main goal of this phase llb study is to compare the efficacy and safety of two doses of HEC585 tablets with placebo which is a look-alike substance that contains no active drug in patients with progressive fibrosing…
- Trial name
- NCT05139719
- Testing
- HEC585 dose A, HEC585 dose B
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Hepatitis B, Chronic
Evaluation HEC121120 Tolerance in Healthy Subjects and Patients With Chronic Hepatitis B, Pharmacokinetics Characteristics and Antiviral Activity of Ⅰ Phase of Study
The Safety, Tolerability, Pharmacokinetics and antiviral activity Study of Anti hepatitis B virus treatment drug HEC121120 in Healthy subjects and in patients with chronic hepatitis B
- Trial name
- NCT04536532
- Testing
- HEC121120 tablets, entecavir tablets
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Enteral Nutritional Support
Evaluation of Tolerance and Safety of Early Enteral Nutrition in Children After Percutaneous Endoscopic Gastrostomy Placement
There aren't sufficient randomized prospective controlled trials in pediatric population comparing the safety and tolerance of early feeding after PEG placement (3-4 hours).
- Trial name
- NCT02777541
- Testing
- Resumption of feeding 3 hours after PEG placement, Resumption of feeding 8 hours after PEG placement
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Children's Memorial Health Institute, Poland
Malnutrition
TOLER-ENT Study: A Study to Investigate the Tolerance of the High Energy, High Protein Formula Sondalis® HP 2 kcal
A multicentre, prospective, open-label, single arm study for 2 months, involving adult patients under poorly tolerated Home Enteral Nutrition (HEN).
- Trial name
- SONDALIS (NCT05429853)
- Testing
- Sondalis® HP 2 kcal (with or without fibre)
- Where
- 2 sites in France
- Volunteers
- 17 people
- Sponsor
- Société des Produits Nestlé (SPN)
Child Nutrition Disorders
Acceptability, Gastro Intestinal Tolerance Compliance of a Paediatric Tube-feed Formula Derived From Food for Children
This is an acceptability study to evaluate the gastrointestinal tolerance and compliance over a seven-day period, of pediatric formula for the dietary management of participants with short bowel syndrome; intractable…
- Trial name
- NCT03718195
- Testing
- Pediatric Formula
- Where
- 3 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Société des Produits Nestlé (SPN)
Glucose Intolerance, Sleep Deprivation
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
- Conditions
- Glucose Intolerance, Sleep Deprivation, Sleep
- Trial name
- NCT04868539
- Testing
- Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Insulin Resistance, Glucose Tolerance
Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents
This trial is divided into different parts: Part A the EryAdo trial and Part B the EryClot trial. Part A EryAdo Trial: Childhood and adolescence are crucial periods for prevention of obesity, as obese children are five times more…
- Conditions
- Insulin Resistance, Glucose Tolerance, Body Composition, Gastrointestinal Tolerance
- Trial name
- EryAdo (NCT04966299)
- Testing
- Erythritol, Sucrose, Glucose
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
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