Clinical trials: Immune System Tolerance
NSCLC
IN10018 Combination Therapy in Advanced EGFR Mutation-positive NSCLC
This is a multicenter, open-label, phase Ib/II clinical study to evaluate the safety, tolerability, pharmacokinetics and antitumor efficacy of IN10018 in combination with third-generation EGFR-TKI (Furmonertinib is the proposed)…
- Trial name
- NCT05994131
- Testing
- IN10018, Furmonertinib
- Where
- China
- Volunteers
- 110 people
- Sponsor
- InxMed (Shanghai) Co., Ltd.
Potential Abnormality of Glucose Tolerance, Appetitive Behavior
Acute Effect of Crocus Sativus on Postprandial Glycemia
This study investigated the effects of two different doses of Crocus Sativus in glucose beverages on glycemic responses.
- Conditions
- Potential Abnormality of Glucose Tolerance, Appetitive Behavior, Blood Pressure
- Trial name
- NCT05484362
- Testing
- D-Glucose beverage as reference food, 15mg of Crocus Sativus as beverage, 30mg of Crocus Sativus as beverage
- Where
- Greece
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
Asthma, Coronary Artery Disease
A Study of the Safety and Tolerance of Regadenoson in Subjects With Asthma or Chronic Obstructive Pulmonary Disease
This study is intended to determine the safety and tolerance of regadenoson in subjects with asthma or chronic obstructive pulmonary disease.
- Conditions
- Asthma, Coronary Artery Disease, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00862641
- Testing
- Regadenoson
- Where
- 48 sites in United States
- Volunteers
- 1,009 people
- Sponsor
- Astellas Pharma Inc
Gestational Diabetes
Pregnancy on Oral Glucose Tolerance Test Implementation Status, Knowledge, and Anxiety Level
This study was planned to examine the effect of video education on pregnancy for oral glucose tolerance test implementation status, knowledge and anxiety level.
- Trial name
- NCT05686694
- Testing
- Video Education
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Ege University
Purpura, Thrombocytopenic, Idiopathic, Autoimmune Thrombocytopenia
The ITP-RITUX Cohort: Rituximab in Immune ThrombocytoPenia.
The primary purpose of the study is to describe by a prospective observational study the serious adverse events occurring in patients treated off-label by rituximab for Immune Thrombocytopenia.
- Trial name
- ITP-RITUX (NCT01101295)
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Henri Mondor University Hospital
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS)
Isoleucine Addition Treatment Effects in a Controlled Diet Study
The primary purpose of this study is to determine whether isoleucine repletion attenuates increases in insulin sensitivity typically observed when people with obesity follow a healthy, low-isoleucine diet.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS), Obesity & Overweight
- Trial name
- ISOLATE (NCT07329088)
- Testing
- L-Isoleucine, Low-isoleucine diet
- Where
- United States
- Sponsor
- Jean L. Fry
Bladder Cancer
Safety, Dose Tolerance, Pharmacokinetics, Pharmacodynamics of CPX-POM in Patients With Newly Diagnosed or Recurrent Bladder Tumors
This is a phase II, single center open label to determine safety, dose tolerance, PK and PD of the recommended Phase 2 dose (RP2D) of CPX-POM administered in patients with any newly diagnosed or recurrent bladder tumors.
- Trial name
- NCT04525131
- Testing
- CPX-POM
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- CicloMed LLC
Health, Subjective
Clinical Study of ALT-BB4 to Determine Tolerance, Safety and Pharmacokinetics in Healthy Volunteer
A Phase I Study to Evaluate the Tolerance, Safety and Pharmacokinetics of ALT-BB4 in Healthy Volunteers
- Trial name
- NCT05232175
- Testing
- ALT-BB4, 0.9%NaCl
- Where
- South Korea
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Alteogen, Inc.
Incremental Shuttle Walk Test
Reliability of the Incremental Shuttle Walk Test in University Students
The aim of this study is to evaluate the inter-rater and intra-rater reliability of the incremental shuttle walk test in university students.
- Trial name
- NCT06638281
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Siirt University
HIV Infections
Phase I Study of the Safety, Tolerance, and Pharmacokinetics of 9-[2-(Bispivaloyloxymethyl)Phosphonylmethoxyethyl]Adenine (Bis-POM PMEA; Adefovir Dipivoxil) in HIV-Infected Patients
To study the safety, tolerance, and pharmacokinetics of a single dose of bis-POM PMEA (adefovir dipivoxil) when administered by the oral route in patients with HIV infection.
- Trial name
- NCT00002128
- Testing
- Adefovir dipivoxil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Gilead Sciences
Gastrointestinal Tolerance
Evaluation of an Oral Nutrition Supplement
The objective of this study is to capture gastrointestinal tolerance (GI) information on a nutrient dense oral nutritional supplement (ONS) in healthy elderly subjects.
- Trial name
- NCT01902212
- Testing
- Oral Nutritional Supplement
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Uterine Cervical Neoplasia, Cervix Intraepithelial Neoplasia
Safety and Efficacy Study of Antiviral Local Application to Treat High Grade Cervical Intraepithelial Lesions (CIN2/3)
The purpose of this phase-II study is to evaluate the efficacy and safety of an aqueous gel containing an antiviral, administered directly on cervix exhibiting high grade squamous or glandular intraepithelial lesion (CIN 2 and 3)…
- Trial name
- Colvir-PhaseII (NCT01303328)
- Testing
- C1
- Where
- 9 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Mithra Pharmaceuticals
Enteral Feeding
Nutritional Tolerance and Safety of a Tube Feeding Formula
This open-label, prospective study will be conducted to assess the nutritional efficacy, safety, and tolerance of a concentrated, enteral formula in medically stable adults, who currently require or will require to be enterally…
- Trial name
- NCT05848583
- Testing
- Compleat 1.5
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Société des Produits Nestlé (SPN)
Human Factors, Acceptability
Human Factors Validation and Acceptability Testing of a Stimulation Device
Our team have developed a mattress topper, consisting of rubber tubes attached side to side that are deflated and inflated, mimicking dynamic touch and optimal CT stimulation (3cm/s).
- Conditions
- Human Factors, Acceptability, Tolerance
- Trial name
- NICU-TAC (NCT06659978)
- Testing
- Device tolerance, Acceptability questionnaire
- Where
- 3 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Liverpool
Rheumatoid Arthritis
Effectiveness Intraarticular Corticosteroid
The purpose of this study is to compare the small and large dose of corticosteroid used in intraarticular injection of wrist.
- Trial name
- NCT01851278
- Testing
- Triamcinolone hexacetonide
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Prediabetic State
Rimonabant In Prediabetic Subjects To Delay Onset Of Type 2 Diabetes
Primary objective: To evaluate the effect of long-term administration of Rimonabant on the time of progression to type 2 diabetes in patients with prediabetes (i.e.
- Trial name
- RAPSODI (NCT00325650)
- Testing
- Rimonabant
- Where
- United States
- Volunteers
- 2,420 people
- Sponsor
- Sanofi
Healthy
Assessment of Bupropion on Cognitive Function and Behaviour in Healthy Volunteers
To evaluate the effects of a 14-day repeated dose of 150 mg bupropion (therapeutic dose) on cognitive and executive functions, behaviour and subjective feelings, after sleep deprivation in 12 healthy male subjects.
- Trial name
- NCT00285155
- Testing
- Bupropion
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Duration of Parenteral Nutrition
Digestive and Nutritional Effects of Probiotics Supplementation in Premature Newborns
Symbiotic interaction between probiotics ("Living alimentary microbials supplemental, affecting positively host by improving intestinal microbial equilibrium" (Fuller, 1989)) and human digestive tract was amply experimented and…
- Trial name
- NCT00290576
- Testing
- Probiotics supplementation until weight reaches 1800g (Bifidobacterium Longum and Lactobacillus GG )
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Nantes University Hospital
HIV-1 Infection, PREGNANCY
Evaluation of Raltegravir During the Third Trimester of Pregnancy
The purpose of this study is to assess the evolution of raltegravir concentration in the mother (between the 3rd trimester of pregnancy and one month post-delivery) and her neonate, when this drug is used to prevent…
- Trial name
- ANRS 160 RalFE (NCT02099474)
- Testing
- Study of pharmacokinetic properties of raltegravir during the 3rd trimester of pregnancy
- Where
- France
- Volunteers
- 83 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Nurse's Role
Effect of Distress Tolerance Training on Problematic Internet Use and Psychological Wellbeing Among Faculty Nursing Students
The Internet is a social environment as well as a tool. In this digital environment, where students interact with each other, live, and generally comprehend their cultures, college students learn information.
- Trial name
- NCT05711368
- Testing
- Distress tolerance training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
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