Clinical trials: Immune Tolerance/Drug Effects
Food Allergy in Children, Obesity, Childhood
The EAT-On Study: Sensitisation, Allergy and Child Health
The EAT Study showed a reduction in both sensitisation (to all foods) and clinical food allergy (to peanut and egg) among children who consumed allergenic food early compared with those who followed standard government feeding…
- Conditions
- Food Allergy in Children, Obesity, Childhood, Food Allergen Sensitisation
- Trial name
- NCT03495583
- Testing
- Early introduction
- Where
- United Kingdom
- Volunteers
- 1,235 people
- Sponsor
- King's College London
Ovarian Cancer, Endometrial Cancer
Proactive Immune Tolerance Induction in Chemotherapy for Gynecologic Cancer
The goal of this clinical trial is to evaluate the efficacy of proactive immune tolerance induction of chemotherapy (paclitaxel and carboplatin) for patients with gynecologic cancer.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Cervical Cancer
- Trial name
- NCT06977594
- Testing
- Proactive immune tolerance induction, Standard Treatment, Paclitaxel and carboplatin
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Lymphoma, Myeloma
Effects of Aerobic Training and Inspiratory Muscle Training in Patients During Hematopoietic Stem Cell Transplantation
The hospitalization for hematopoietic stem cell transplantation (HSCT) impairs the physical functioning and functional capacity, but aerobic physical training and, more recently, inspiratory muscle training, have shown benefits…
- Conditions
- Lymphoma, Myeloma, Leukemia, Aplastic Anemia
- Trial name
- NCT03373526
- Testing
- Inspiratory Muscle Training, Aerobic Training
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Daniel Godoy Martinez
Type 1 Diabetes Mellitus
Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects
The purpose of this study is to determine whether treatment with multiple injections of GAD-Alum will preserve the body's own (endogenous) insulin production in patients who have been recently diagnosed with type 1 diabetes…
- Trial name
- TN08 (NCT00529399)
- Testing
- GAD-Alum, GAD-Alum and Aluminum hydroxide, Aluminum hydroxide
- Where
- 15 sites in United States, Canada
- Volunteers
- 145 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes, Diabetes Mellitus, Type 1
A Comparison of Postprandial Glucose After a MMTT, and the Metabolic Effects of Insulin Withdrawal in a Crossover Study in Subjects With Type 1 Diabetes
This is an inpatient treatment, double-blind, randomized, 3-way crossover study in T1DM subjects using insulin pump therapy.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Type1diabetes, Diabetes Mellitus
- Trial name
- NCT04956263
- Testing
- YG1699, Dapagliflozin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Youngene Therapeutics Inc., Ltd.
Healthy Adults, High Altitude
Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica
Human milk oligosaccharides (HMOs) are the third-most abundant component in mothers' milk and are an important prebiotic factor for the development of the gut microbiota of infants, promoting the growth of certain beneficial…
- Conditions
- Healthy Adults, High Altitude, Isolation, Social
- Trial name
- NCT06133530
- Testing
- Human milk oligosaccharides, Maltose
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- IU University of Applied Sciences
Immune Tolerance, Food Tolerance
Tregs and miRNAs in Breast Milk: Effects on Infant Food Tolerance
This prospective observational study aims to identify and characterize immunoregulatory microRNAs (miRNAs) associated with regulatory T cells (Tregs) in human breast milk and to evaluate their temporal expression patterns.
- Trial name
- NCT07744373
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Conditions Influencing Health Status
Effects of Probiotics in Immune System of Healthy Adults
The present report describes the design of a clinical trial performed on healthy adult individuals to check whether the daily intake of the new Hero strains contribute to intestinal colonization, under safe and tolerable…
- Trial name
- SETOPROB (NCT01479543)
- Testing
- Probiotic CNCM I-4034, Probiotic CNCM I-4035, Probiotic CNCM I-4036
- Where
- 4 sites in Spain
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Hero Institute for Infant Nutrition
Immune System Tolerance, Depression
ESAN II - Energy Sensing in Depression
The purpose of this study is to assess the effects of polyphenols from natural aronia juice on the immune system. Therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as…
- Conditions
- Immune System Tolerance, Depression, Obesity, Microbial Colonization
- Trial name
- NCT05432362
- Testing
- Aronia Juice
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Drug Allergy
Retrospective Study of Immediate Hypersensitivity (IHS) Reactions to Platinum Salts in the University Hospital of Nancy
To assess the efficacy of skin tests with platinum salts in patients suspects with immediate hypersensitivity reactions. All patients adressed in consultation to the Allergy Department of university hospital of nancy for an…
- Trial name
- NCT04920721
- Testing
- no intervention
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Central Hospital, Nancy, France
Innate Immune Response, Immune Tolerance
The Effects of Preceding LPS Administration on the Fluenz-induced Immune Response
To evaluate the bacterial-viral interactions between LPS and Fluenz as a model for sepsis (bacterial) and Influenza (viral) infections which are common and associated with high mortality rates in the ICU.
- Trial name
- LPS-Fluenz (NCT02642237)
- Testing
- Fluenz, LPS
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Immune Tolerance
Vitamin D Supplementation and Regulatory FoxP3+ T Cells in the GUT
In this pilot study the investigators aim to investigate the effects of vitamin D supplementation on regulatory FoxP3+ T cells in the gastrointestinal mucosa in healthy women and men.
- Trial name
- NCT01538485
- Testing
- Cholecalciferol
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
HIV Infections
Effects of BufferGel and PRO 2000/5 Gel in Men
The purpose of this study is to find out if there are any bad effects when BufferGel or PRO 2000/5 Gel are applied to the penis of HIV-infected men.
- Trial name
- NCT00016536
- Testing
- Naphthalene 2-sulfonate polymer, Carbopol polymer
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Kidney Disease
Metabolic Effects of Paricalcitol
The purpose of this study is to determine if treatment with paricalcitol, an active form of vitamin D, has beneficial effects on metabolic abnormalities in people with stage 3-4 Chronic Kidney Disease (CKD).
- Trial name
- NCT01003275
- Testing
- Paricalcitol
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Washington
HIV Infections, Pregnancy
The Safety and Effectiveness of Zidovudine in HIV-Infected Pregnant Women and Their Infants
To determine whether the rate of HIV transmission from mother to infant can be reduced by continuous oral zidovudine (AZT) treatment to HIV infected pregnant women, intravenous AZT during childbirth, and oral AZT treatment of the…
- Trial name
- NCT00000960
- Testing
- Zidovudine
- Where
- 62 sites in United States, Puerto Rico
- Volunteers
- 1,496 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Allergic Rhinitis, Effects of Immunotherapy
Distinct Response of CD4+CD25+Foxp3+ and IL-10-secreting Type I T Regulatory Cells to Cluster Specific Immunotherapy in Allergic Rhinitis Children
While allergen specific immunotherapy (SIT) is highly effective for allergic diseases in children, the underlying immunological mechanisms are unclear. Regulatory T (Treg) cells may be crucial in induction of tolerance.
- Trial name
- NCT01291381
- Testing
- Dermatophagoides pteronyssinus, Pharmacotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Tongren Hospital
Hypersensitivity Pneumonitis, Extrinsic Allergic Alveolitis
Pulmonary Rehabilitation in Patients With Chronic Fibrotic Hypersensitivity Pneumonitis
The aim is to evaluate exercise capacity, respiratory functions, respiratory and peripheral muscle strength, inspiratory muscle endurance, physical activity level, quality of life, fatigue, dyspnea, anxiety, depression and…
- Trial name
- NCT04561479
- Testing
- Pulmonary Rehabilitation, Alternative Exercises
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Ovarian Neoplasms, Immune Tolerance
Intra-peritoneal Chemotherapy in Ovarian Cancer
Ovarian cancer is the third most common gynecological malignancy worldwide. Because of late, aspecific symptoms, the disease is usually diagnosed at an advanced stage.
- Conditions
- Ovarian Neoplasms, Immune Tolerance, Neoplasms, Effects of Chemotherapy
- Trial name
- NCT02861872
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Cow's Milk Allergy
Effects of Different Dietary Regimens on Tolerance Acquisition in Children With Cow's Milk Allergy
Otherwise healthy infants (1-12 months of age at the diagnosis) with CMA were prospectively evaluated. Patients with cow's milk protein-induced anaphylaxis, eosinophilic disorders of the gastrointestinal tract, and food protein…
- Trial name
- NCT01634490
- Volunteers
- 300 people
- Sponsor
- Federico II University