Clinical trials: Immune-Inflammatory
Chronic Inflammatory Demyelinating Polyneuropathy, CIDP
Vitaccess Real CIDP Registry
Vitaccess Real CIDP (VRCIDP) is a patient registry designed to capture longitudinal observational data on chronic inflammatory demyelinating polyneuropathy (CIDP), its treatment, and impact on symptoms, daily activities, and…
- Trial name
- VRCIDP (NCT07006597)
- Volunteers
- 300 people
- Sponsor
- Vitaccess Ltd
Rheumatoid Arthritis, Sickness Behavior
7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis
This is an experimental medicine, single-centre, observational test-retest study to evaluate Filgotinib's mechanism of analgesic action in RA patients.
- Conditions
- Rheumatoid Arthritis, Sickness Behavior, Inflammatory Disease, Autoimmune
- Trial name
- TEMPO (NCT05697159)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Avascular Necrosis, Osteoarthritis
Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
This is a prospective, multi-center, non-randomized, non-controlled study designed to obtain survival and outcome data on the Continuum Metal on Polyethylene Acetabular System when used in primary total hip arthroplasty.
- Conditions
- Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis
- Trial name
- NCT01307384
- Testing
- Continuum Metal on Polyethylene Acetabular System
- Where
- 2 sites in United States
- Volunteers
- 195 people
- Sponsor
- Zimmer Biomet
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
sCD163 & CD19 as Candidate Biomarkers in CIDP and MMN
Chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are characterized by progressive deterioration in muscle strength, loss of sensibility, diminished or absent reflexes and impaired…
- Trial name
- NCT02271724
- Testing
- Lumbar puncture, Blood sample
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- University of Aarhus
Rheumatoid Arthritis
ART-I02 in Patients With Rheumatoid Arthritis With Inflamed Wrists
This study will evaluate the safety and tolerability of a single intra-articular administration of ART-I02 (AAV5.NF-kB.IFN-β), a recombinant adeno-associated virus (AAV) type 5 vector in subjects with RA and active arthritis of a…
- Trial name
- NCT03445715
- Testing
- ART-I02
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Arthrogen
Critical Illness
Impact of Supplemental Parenteral Nutrition in ICU Patients on Metabolic, Inflammatory and Immune Responses
Having previously demonstrated that supplemental parenteral nutrition to complete an insufficient enteral nutrition (EN) between D4 and D8 improves outcome after critical illness, by reducing infectious complications, the present…
- Trial name
- SPN2 (NCT02022813)
- Testing
- Supplemental parenteral nutrition (SPN)
- Where
- 2 sites in Switzerland
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Ankylosing Spondylitis (AS), Psoriasis
Real-world Effectiveness of Adalimumab on Health Outcomes in Chinese Patients With Immune-Mediated Inflammatory Diseases
The objective of this study is to evaluate the effect of adalimumab on health outcomes in participants with rheumatoid arthritis, ankylosing spondylitis and plaque psoriasis.
- Conditions
- Ankylosing Spondylitis (AS), Psoriasis, Rheumatoid Arthritis (RA)
- Trial name
- ADMIT (NCT03339089)
- Where
- 10 sites in China
- Volunteers
- 224 people
- Sponsor
- AbbVie
Rheumatoid Arthritis
Efficacy of Resistance Exercise and an Anti-Inflammatory Diet on Pain, Disease Activity, Functional Status, and Quality of Life in Patients With Rheumatoid Arthritis
This study aims to examine how resistance exercises and an anti-inflammatory diet affect pain, daily functioning, disease activity, and quality of life in people with rheumatoid arthritis.
- Trial name
- RED-RA (NCT07262112)
- Testing
- Exercise, Diet, Medical management/current medications per standard of care by personal physician.
- Volunteers
- 100 people
- Sponsor
- Berra Yamuç Tanrıöğen
Psoriasis, Pregnancy
Stelara and Tremfya Pregnancy Exposure Registry OTIS Autoimmune Diseases in Pregnancy Project
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Conditions
- Psoriasis, Pregnancy, Psoriatic Arthritis, Crohn Disease
- Trial name
- NCT02103361
- Testing
- Ustekinumab, Guselkumab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego
Inflammatory Bowel Disease
Interactions Between Immune Cells of Intestinal Mucosa or Peripheral Blood With the Extracellular Matrix in Inflammatory Bowel Disease (IBD)
The purpose of this study is to examine the effects of different environmental factors on immune cells in patients with IBD.
- Trial name
- IBD (NCT00915044)
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
HIV Infections
A Study to Monitor Patients With Primary or Early HIV Infection
The purpose of this study is to monitor patients who recently have been infected with HIV in order to learn how their immune systems respond to HIV infection and to study how the virus acts in their bodies.
- Trial name
- NCT00000911
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma; Eosinophilic
The Influence of Mepolizumab on Structural and Inflammatory Cells in Severe Eosinophilic Asthma
The IRIS study aims to investigate the way Mepolizumab affects the structure of the airway cells in patients with Severe Eosinophilic Asthma and how the immune function of these cells changes with treatment.
- Trial name
- IRIS (NCT05144087)
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Severe Pediatric Infectious Shock
Pediatric Immune Response to Infectious Shock
Infectious shocks are associated with high mortality rates (20-40%). Anti-inflammatory strategies based on the postulate that mortality related to sepsis is mainly due to an overwhelming pro-inflammatory immune response have…
- Trial name
- PedIRIS (NCT02848144)
- Testing
- blood samples, Collection of nosocomial infections
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Inflammatory Bowel Diseases
Regulation of Mucosal Healing in Inflammatory Bowel Disease
The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid…
- Trial name
- NCT04504136
- Testing
- Serial Biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Terrence A Barrett
Autoimmune Diseases, Inflammatory Disorder
Immunological Response to COVID-19 Vaccine in Patients With Autoimmune and Inflammatory Diseases Treated With Immunosuppressants and/or Biologics
Vaccination against the new coronavirus (SARS-CoV-2) was extended to patients at risk of severe forms of Covid-19, including in particular patients with autoimmune and inflammatory diseases treated by immunosuppressants and/or…
- Trial name
- COVADIS (NCT04870411)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections
BOOST: Study of Increased Dosage of Lopinavir/Ritonavir (LPV/r)
This study will look to see if increasing the standard dose of Kaletra is tolerated and if it will lower viral loads to undetectable levels.
- Trial name
- NCT00414284
- Testing
- Increased dose of Kaletra
- Where
- United States
- Sponsor
- Community Research Initiative of New England
Immunologic and Inflammatory Diseases
Incidence and Risk Factors for Infections in Patient Treated With Corticosteroids, Immunosuppressive Drugs or Biotherapy for Immunologic and Inflammatory Diseases
Infections represent the first cause of death and of morbidity in people treated for immunologic and inflammatory diseases with corticosteroids, immunosuppressive drugs or biotherapy.
- Trial name
- INFIM (NCT02280902)
- Testing
- Blood samples
- Where
- 7 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Asthma, PTSD
Assessing Inflammatory and Behavioral Pathways Linking PTSD to Increased Asthma Morbidity in WTC Workers
Asthma and post-traumatic stress disorder (PTSD) are the most common conditions in World Trade Center (WTC) rescue and recovery workers.
- Trial name
- NCT04552301
- Testing
- Cognitive Processing Therapy, Psychotherapy, Targeted Asthma Education
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Healthy, Healthy Nutrition
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial
The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B.
- Trial name
- BEGIN (NCT06452199)
- Testing
- B. infantis
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus