Clinical trials: Immune-related Adverse Event
Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ
Treating Patients With Recurrent PCNSL With Carboplatin/BBBD and Adding Rituxan To The Treatment Regimen
RATIONALE: Monoclonal antibodies, such as rituximab, can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ, Lymphoma, Thrombocytopenia
- Trial name
- NCT00074165
- Testing
- Rituxan, Cyclophosphamide, Etoposide
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- OHSU Knight Cancer Institute
HIV Infections, Clinical Outcomes
Dolutegravir and Clinical Outcomes Among ART-recipients in Brazil
Access to antiretroviral therapy (ART) in low-income and middle-income countries has been scaled-up effectively over recent years.
- Conditions
- HIV Infections, Clinical Outcomes, Adverse Drug Event, Effect of Drugs
- Trial name
- CODE (NCT04326504)
- Testing
- No intervention
- Where
- 3 sites in Brazil
- Volunteers
- 5,000 people
- Sponsor
- Fundação Bahiana de Infectologia
Renal Insufficiency,Chronic, Hiv
Switching From Tenofovir Disoproxil Fumarate to Abacavir or Tenofovir Alafenamide
Tenofovir disoproxil fumarate (TDF) is one of the most frequently used drugs to treat HIV. Long term use of TDF can induce renal toxicity.
- Conditions
- Renal Insufficiency,Chronic, Hiv, Therapeutic Agent Toxicity
- Trial name
- BACTAF (NCT02957864)
- Testing
- tenofovir alafenamide, abacavir
- Where
- 5 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- Erasmus Medical Center
Limbal Stem Cell Deficiency, Stevens-johnson Syndrome
Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
To investigate the effect of ocular surface reconstruction and assess the safety in cultivated oral mucosal epithelial cell sheet transplantation (COMET) regarding patients with cicatricial change of ocular surface.
- Conditions
- Limbal Stem Cell Deficiency, Stevens-johnson Syndrome, Ocular Cicatricial Pemphigoid, Chemical Burn
- Trial name
- NCT02149732
- Testing
- cultivated oral mucosal epithelial sheet transplantation
- Where
- 2 sites in South Korea
- Sponsor
- Seoul National University Hospital
Drug Rash With Eosinophilia and Systemic Symptoms
Comparison Between Corticosteroid and Topical Steroids in the DRESS
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and severe multiorgan adverse drug reaction occurring within 2 to 6-8 weeks after a new drug intake.
- Trial name
- DRESSCODE (NCT01987076)
- Testing
- Prednisone, Clobetasol
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Limbal Stem Cell Deficiency
Cultivated Stem Cell Transplantation for the Treatment of Limbal Stem Cell Deficiency
The purpose of this study is to determine whether cultivated stem cell transplantation is effective for the treatment of patients wtih corneal stem cell deficiency.
- Trial name
- LECT (NCT00845117)
- Testing
- Cultivated limbal stem cell graft transplantation
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Veerle Van Gerwen