Clinical trials: Immunity, Cellular
Hepatitis C
Immune Response to Hepatitis C Virus
This study will identify and characterize immune factors involved in hepatitis C infection and elimination of the virus. Individual responses to hepatitis C infection vary; some people are able to eliminate the virus, whereas…
- Trial name
- NCT00006301
- Where
- 5 sites in United States
- Volunteers
- 89 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hepatitis C
Study of the Immune Response to Hepatitis C Virus
The purpose of this study is to investigate the mechanism of a successful immune response to hepatitis C virus (HCV) infection. Currently, it is believed that the immune system is involved in responding to HCV infection, but how…
- Trial name
- NCT00237432
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Rockefeller University
Kidney Transplantation, Cytomegalovirus Infections
Introduction of mTor Inhibitors and the Activation of the Cytomegalovirus (CMV) -Specific Cellular Immune Response
Kidney transplant patients under an immunosuppressive treatment based on anti-calcineurin and mycophenolate-mofetil and induction therapy with rATG who suffer from early systemic viral replication by the CMV virus could benefit…
- Trial name
- ACTIVA (NCT04936971)
- Testing
- Switch from Mycophenolate Mofetil to Everolimus manteinance treatment in Active Comparator Arm, no intervention
- Where
- Spain
- Sponsor
- Edoardo Melilli
COVID-19, SARS-CoV-2 Infection
COVID-19: SARS-CoV-2-CZ-PREVAL-II Study
The aim of the SARS-CoV-2-CZ-PREVAL-II Study is to quantify the prevalence of participants with antibodies against SARS-CoV-2 and/or cell immunity against SARS-CoV-2 in specific subjects cohorts.
- Trial name
- NCT05096962
- Testing
- Quantitative analysis of SARS-CoV-2 antibodies, Cellular immunity
- Where
- Czechia
- Volunteers
- 7,268 people, healthy volunteers welcome
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Liver Disease, Immunosuppression
Immunity Against Varicella in Pediatric Orthotopic Liver Transplantation Recipients
Varicella is a vaccine-preventable disease, which can be severe in immunosuppressed children. Currently, the (live) vaccine is not recommended in pediatric orthotopic liver transplant recipients.
- Conditions
- Liver Disease, Immunosuppression, Varicella
- Trial name
- VZVinOLTx (NCT00492739)
- Testing
- Vaccination with VZV vaccine
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Geneva
Cancer
Mechanisms of Anti COVID-19 Humoral and Cellular Immune Response After Vaccination in a Sample of Patients and Salaried Staff From a French Anti-cancer Center
Special populations are people with a risk to dévelop severe forms of a disease. The immunogenicity and efficacy of vaccines in this population may be different compared of the general population.
- Trial name
- CANSEROVAX (NCT04935528)
- Testing
- serology and ELISPOT test, serology
- Where
- France
- Volunteers
- 539 people, healthy volunteers welcome
- Sponsor
- Centre Georges Francois Leclerc
Triple Negative Breast Cancer
Cellular Immune Responses in Triple-negative Breast Cancer - High Throughput Immunogenetic Studies
This project introduces a novel methodology for the in-depth immunogenetic characterization of the TR gene repertoire in solid tumors, holding the promise to offer unprecedented insights into the TR anti-tumor specificity and the…
- Trial name
- NCT06646263
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Institute of Applied Biosciences
HIV Infections
Treatment Intensification for HIV Infected Patients With Multi-Drug Resistant Virus
Drug resistance may develop in HIV infected patients who take anti-HIV drugs, but most patients do well if they continue taking them.
- Trial name
- NCT00102934
- Testing
- Enfuvirtide-intensified HAART
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatitis C, Chronic, Liver Diseases
Cellular Immune Responses in the Liver in Chronic Hepatitis C (CHC) Patients
In order to persist in the liver, HCV has numerous nonspecific and specific strategies to overcome the immunity of the host. The crucial step in the establishment of viral persistence and chronic hepatitis is the avoidance of…
- Conditions
- Hepatitis C, Chronic, Liver Diseases, Virus Diseases
- Trial name
- NCT01062659
- Where
- Germany
- Sponsor
- University of Ulm
Pain, Stress
6-Month Outcomes of PEMF to Nucleotide Sources Revealing Cell Sensory Experience in Pain Relief, Stress Relief and Anti Ageing Restoration
Background: The hz Clinic registry is a programme made of five scheduled cohorts designed to include participants dealing with Immunity compromise, Pain, Ageing and Stress (general and pandemic anxieties) who are to be followed…
- Conditions
- Pain, Stress, Ageing Signs, Immunity Compromise
- Trial name
- PEMF (NCT04461470)
- Testing
- epigenetic longitudinal waves
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- hz Clinic
Hepatitis B
Hepatitis B Vaccination in HIV-infected Adults With Low CD4 Cell Counts
This study aimed to evaluate the efficacy of different hepatitis B vaccination regimens in HIV-infected adults with low CD4 cell count in northern Thailand.
- Trial name
- NCT02732054
- Testing
- Recombinant Hepatitis B vaccine [(CIGB) La Habana, Cuba]
- Where
- Thailand
- Volunteers
- 16 people
- Sponsor
- Chiang Mai University
Hepato Cellular Carcinoma (HCC), Immunotherapy
Effects of Neoadjuvant Immunotherapy on Anti-tumour Immunity in Hepatocellular Carcinoma Patients Undergoing Liver Resection
Our study aims to evaluate the benefit of the administration of immunotherapy (atezolizumab), in patients with hepatocellular carcinoma (HCC), prior surgical resection of the tumor.
- Trial name
- NCT07461675
- Testing
- Atezolizumab
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Geneva, Switzerland
T Cell Response to Dried Plum, Vitamin D Influence on Immune Response
Prebiotics (Dried Plum) and Immune Function in Postmenopausal Women
Prior studies have shown that dietary supplementation with dried plums (also known as prunes) reduces bone loss in postmenopausal women.
- Conditions
- T Cell Response to Dried Plum, Vitamin D Influence on Immune Response, Dried Plum and Immune Function
- Trial name
- NCT07222111
- Testing
- Dried plums
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
SARS CoV 2 Infection, COVID-19
Humoral and Cellular Immunity in First-cycle SARS-CoV-2 Vaccinated COVID-19 Patients
Infection by the recent Coronavirus (SARS-CoV-2) has generated at a pandemic level a new pathology, called COVID-19, characterized by "flu-like" symptoms up to severe acute respiratory failure.
- Trial name
- NCT05338736
- Testing
- LIAISON SARS-CoV-2 TrimericS IgG (DiaSorin), LIAISON SARS-CoV2-IgM (DiaSorin), Human IFN-g ELISpot PLUS (ALP) (AUROGENE)
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University Magna Graecia
Pregnancy, Autoimmune Thyroid Disease
Changes in Natural Immunity in Pregnant Women With Autoimmune Thyroid Disease
Autoimmune thyroid disease (AITD) is the most common endocrine disorder in women of reproductive age, including during pregnancy. It encompasses two clinical conditions: autoimmune hyperthyroidism and hypothyroidism.
- Trial name
- CIPAT (NCT06925399)
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- University of Rijeka
Dengue Vaccines
Characterisation of Dengue Vaccine-induced Specific Immunity in Vaccinees With and Without Prior Exposure to Flavivirus Infections or Vaccination
The goal of this observational study is to learn about the immunity induced by the Qdenga® vaccine in vaccinees. Participants that will receive the Dengue vaccine as part of their routine before a travel will be asked to undergo…
- Trial name
- VaQDENV (NCT06776692)
- Testing
- Qdenga
- Where
- Italy
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Hematopoietic Stem Cell Transplant, Hematologic Malignancy
Influenza Vaccine Post Allogeneic Transplant
Study Design: This is a randomized, single center study to evaluate immune responses to the seasonal influenza vaccine in allogeneic hematopoietic stem cell transplant (HSCT) recipients who receive one vaccine or two vaccine…
- Trial name
- NCT01215981
- Testing
- Influenza vaccine
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Hepatitis B Vaccination
Immune Response to Hepatitis B Virus Booster Vaccination After 20-23 Years
This study will evaluate the humoral and cellular immune responses to a hepatitis B vaccine booster in healthy adults which received a full course of neonatal hepatitis B vaccination 20-23 years ago.
- Trial name
- NCT02166671
- Testing
- HBV booster vaccination 1dose
- Where
- South Korea
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Advanced Cancer, ADCC
Immunotherapy of Advanced Cancer Using a Combination Nimotuzumab and NK Cells
NK cells can persist and expand in vivo following adoptive transfer and may have a role in the treatment of late stage malignancies.
- Conditions
- Advanced Cancer, ADCC, NK Cell Mediated Immunity, Nimotuzumab
- Trial name
- NCT03554889
- Testing
- NK Cell adaptive transfer, Nimotuzumab
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Hangzhou Cancer Hospital
Melanoma (Skin)
Vaccine Therapy in Treating Patients With Stage II Melanoma That Can Be Removed by Surgery
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. It is not yet known what preparation of vaccine therapy is most effective for treating melanoma.
- Trial name
- NCT00003274
- Testing
- gp100 antigen, incomplete Freund's adjuvant, sargramostim
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Southern California