Clinical trials: Immunity, Cellular
Lung Cancer, Breast Cancer
Safety and Tolerability of a Modified Vaccinia Ankara (MVA)-Based Vaccine Modified to Express Brachyury and T-cell Costimulatory Molecules (MVA-Brachyury-TRICOM)
Background: This cancer vaccine was developed to help teach the body's immune system to attack and destroy cancer cells. It teaches immune cells to target the Brachyury protein.
- Conditions
- Lung Cancer, Breast Cancer, Prostate Cancer, Tumors (Others)
- Trial name
- NCT02179515
- Testing
- MVA-brachyury- TRICOM
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Cancer Institute (NCI)
Influenza Vaccination
Immunogenicity Trial of 3 Influenza Vaccines
This study is a prospective randomised trial of 3 influenza vaccine formulations with different manufacturing processes: 1) egg-grown (QIV-E); 2) cell-grown (QIV-C); and 3) recombinant protein (QIV-R).
- Trial name
- NCT05479370
- Testing
- Flublok Quadrivalent vaccine, Fluarix Quadrivalent vaccine, Flucelvax Quadrivalent vaccine
- Where
- Singapore
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Cervical Cancer, Precancerous Condition
The Effects of MBSR in Improving Immune Response to Human Papillomavirus in Patients With Cervical Dysplasia
RATIONALE: Mindfulness-based stress reduction (MBSR) may reduce patient stress and improve quality of life. It is not yet known whether mindfulness-based stress reduction is effective in improving immune response to human…
- Trial name
- NCT00653146
- Testing
- Mindfulness-Based Stress Reduction, Healthy Lifestyles
- Where
- 2 sites in United States
- Volunteers
- 186 people
- Sponsor
- Fox Chase Cancer Center
COVID19, Vaccination
Spike-specific Cellular Immune Response After COVID-19 Vaccination
Aim of this study is to evaluate whether COVID-19 vaccination induces a persistent cellular immune response. To this aim, blood samples are taken from vaccinated individuals and not immunized subjects as a control group.
- Conditions
- COVID19, Vaccination, Immune Response
- Trial name
- RIS-COV (NCT05102669)
- Testing
- analysis of immunological response, analysis of serum antibodies
- Where
- Italy
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Immunology
Impact of Egg-Based and Cell-Based Vaccine Platforms on Immune Responses to Repeated Influenza Vaccination
The goal of this clinical trial is to learn how different types of influenza (flu) vaccines affect the body's immune response over time.
- Trial name
- NCT07910266
- Testing
- Egg-Based Inactivated Influenza Vaccine, Cell-Based Inactivated Influenza Vaccine
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Breast Cancer, Estrogen Receptor-positive Breast Cancer
Evaluation of Endocrine Therapy Effects of Host Immunity in Early Stage Breast Cancer
The purpose of this research study is to learn about the effects that standard of care endocrine therapies have on the immune system's response to cancer by looking at the number and types of immune cells present and how they…
- Conditions
- Breast Cancer, Estrogen Receptor-positive Breast Cancer, Healthy
- Trial name
- NCT03719495
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Duke University
Multiple Myeloma
Effects of Bortezomib-Based Therapy on Cellular Immunity and Response to DC/Myeloma Fusion Vaccines in Vitro
The purpose of this study is to better understand what effects Bortezomib, a drug used for multiple myeloma therapy, has on the immune system.
- Trial name
- NCT01472627
- Testing
- Blood draws
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Dana-Farber Cancer Institute
Chronic Obstructive Pulmonary Disease
Innate Immunity in COPD
Chronic Obstructive Pulmonary Disease (COPD) causes obstruction to airflow when breathing out. It is a leading cause of chronic lung disease, hospitalization and death.
- Trial name
- NCT05743582
- Testing
- Bronchoscopy for sample collection, Blood donation
- Where
- 2 sites in United Kingdom
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Kidney Transplantation
Anti-BK Virus Immune Response and Kidney Transplantation
BK virus infections are very frequent during months following a kidney transplantation: a viral reactivation is observed for almost 50% of patients during first year.
- Trial name
- BKv (NCT01109186)
- Testing
- biological parameters
- Where
- France
- Volunteers
- 158 people
- Sponsor
- Nantes University Hospital
Lymphoma
Vaccine Therapy Plus Sargramostim Following Chemotherapy in Previously Untreated Aggressive Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Vaccines may make the body build an immune response to kill cancer cells.
- Trial name
- NCT00004197
- Testing
- keyhole limpet hemocyanin, sargramostim, tumor cell-based vaccine therapy
- Where
- 2 sites in United States
- Sponsor
- University of Nebraska
Spondyloarthritis
The Role of IL-23 in Chronic Inflammatory Disease: Exploring the Cellular and Molecular Targets of IL-23 Signaling in Peripheral and Axial Spondyloarthritis
This is a research study involving humans, of the interventional type with minimal risks and constraints (RIPH2). It is a multicentric, non randomized prospective study aiming to better understand the mechanisms of the response…
- Trial name
- SpA23 (NCT05290363)
- Testing
- Blood sampling, synovial aspiration
- Where
- 4 sites in France
- Volunteers
- 90 people
- Sponsor
- Institut Pasteur
Immunity; Defect Due to Antibody or Cell Mediated Immune Defect
Cytokine Production and Immunity to Varicella Zoster Virus (VZV) in Elderly Recipients of Zoster Vaccine
After immunization, particularly in older persons, some people are protected from disease by a vaccine and others are not. The investigators believe that this variable response may be due to overproduction of molecules that…
- Trial name
- NCT01288014
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Columbia University
Bladder (Urothelial, Transitional Cell) Cancer
Evaluation of ENPP1 Expression and Immune Response in Bladder Cancer Patients
This study aims to investigate the role of ENPP1 in bladder cancer (BC), specifically focusing on its impact on immune evasion, chemoresistance, and prognosis.
- Trial name
- ENPP1-BC (NCT06657755)
- Testing
- Immunohistochemistry
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Lanzhou University Second Hospital
Influenza Vaccine Allergy, Cell Mediated Reaction
Immune Response Study of Influenza Vaccine
An observational clinical study will be performed in subjects aged 12-60 years old to describe the dynamic changes of humoral immune/cellular immunity after vaccination of influenza vaccine, and to discuss the role of different…
- Trial name
- NCT01310374
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
COVID-19 Respiratory Infection, Influenza
Exercise and COVID-19 Viral T-cell Immunity
Viruses are a major health problem for the general public and at risk populations. Normally, detection of antibody titers is the gold standard for determining the effectiveness of the immune system following natural or vaccine…
- Trial name
- VIC (NCT05019456)
- Testing
- COVID-19 Vaccine
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Immune System and Related Disorders
COVID-2019 Vaccine Immune Response Base on Single Cell Multi-Omics
In recent years, single-cell high-throughput sequencing technology has developed rapidly and is widely used in research related to the immune system, breaking traditional cognition and gaining a new understanding of immune cell…
- Trial name
- NCT04871932
- Testing
- Recently Vaccination
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Whooping Cough, Pertussis
Observational Study Describing the Immune Profile Induced By Pertussis Vaccines
This is an observational study designed to describe the immune profile of toddlers and preschoolers with acellular priming after receiving a booster dose of pertussis vaccine.
- Trial name
- NCT03147898
- Where
- 2 sites in Mexico, Panama
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sanofi
Normal Physiology
Studying Cell Immune Responses to a Live Flu Vaccine in Healthy Adults
Background: One form of the influenza vaccine is a nasal spray. It uses a live but weakened flu virus. Researchers want to better under how the live vaccine interacts with the body s immune system.
- Trial name
- NCT01730144
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Allogeneic Hematopoietic Stem Cell Recipients, Acute Respiratory Infection
Signature of the Host Response to a Respiratory Viral Infection, in the Prediction of Bronchiolitis Obliterans
Bronchiolitis obliterans (BO) is the well-known manifestation of the chronic pulmonary graft-versus-host disease(GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).
- Conditions
- Allogeneic Hematopoietic Stem Cell Recipients, Acute Respiratory Infection, Parainfluenza Virus (PIV)
- Trial name
- ALLOPIV (NCT04099082)
- Testing
- samples
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy, Helminthiasis
Comparison of Immune Response in Normal Volunteers and Patients With Helminth Infections
This study will compare the structure, chemical composition and other characteristics of skin and blood in people with and without parasitic infections. Cell samples will be taken from blisters produced by suction blistering.
- Trial name
- NCT00004996
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)