Clinical trials: Immunity, Cellular
Influenza
Safety Study of Four Candidate Influenza Vaccines to Prevent Influenza Disease in the Elderly Population
As influenza vaccine efficacy is reported to be lower in elderly subjects compared to healthy adults, probably as a result of immunosenescence, there is a desire to devise ways to increase the current vaccines efficacy for this…
- Trial name
- NCT00318149
- Testing
- Fluarix, Fluarix-AS25, Fluarix-AS50
- Where
- Belgium
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Breast Cancer
Exercise Study for Breast Cancer Survivors
This study evaluates the link between muscle health and immune health in breast cancer survivors. Regular exercise is known to improve overall survival in cancer patients but the mechanism is not known.
- Trial name
- NCT04208074
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- San Diego Biomedical Research Institute
Acquired Immunodeficiency Syndrome, HIV Infections
Analysis of Immune Responses to HIV Vaccines
This study will evaluate a test designed to measure immune system responses to HIV and HIV vaccines.
- Trial name
- NCT00068978
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Metastatic Melanoma
Study of Immune Responses in Patients With Metastatic Melanoma
In this study, anti-OX40 will be given to patients with melanoma to find out how the immune system responds to treatment with anti-OX40.
- Trial name
- NCT01416844
- Testing
- anti-OX40
- Where
- United States
- Sponsor
- Providence Health & Services
CMV Specific Immune Response, Kidney Transplant
Risk Factors Associated With the Absence of CMV-specific Cellular Immune Response in the Early Post-transplant Period in Low-risk CMV-seropositive Kidney Transplant Recipients
The goal of this observational study is to identify risk factors associated with the absence of CMV-specific cellular immune response in low-risk CMV-seropositive kidney transplant recipients in the early post-transplant period.
- Conditions
- CMV Specific Immune Response, Kidney Transplant, Kidney Transplant Recipient, CMV Reactivation
- Trial name
- PREDICOR (NCT07621835)
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Immune Modulation, Tuberculosis
CD8 Reactivity to Microorganisms in Blood and Breast Milk
Background: When a person is exposed to something that causes an infection, the body sends a type of cell called CD8 T cells to attack it. Those cells are also found in breast milk.
- Conditions
- Immune Modulation, Tuberculosis, Leprosy, Pertussis
- Trial name
- NCT03084614
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Atopic Dermatitis, Staphylococcus Aureus
Staphylococcal Toxins in Atopic Dermatitis and Eczema Herpeticum
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Clinical studies have demonstrated a link between staphylococcal skin colonization and the pathogenesis of AD, but the implication of bacterial…
- Conditions
- Atopic Dermatitis, Staphylococcus Aureus, Bacterial Toxins, Immune Response
- Trial name
- STADEH (NCT04274348)
- Testing
- Skin biopsies and blood samples
- Where
- 2 sites in France
- Volunteers
- 41 people
- Sponsor
- Poitiers University Hospital
Diffuse Cutaneous Systemic Sclerosis, Rheumatoid Arthritis (RA)
Controlling Hyperactive Immunity With Long-lived Lymphocytes
This study is a Phase 1/2, open-label clinical trial to test an experimental treatment called QEL-005 in adults with two autoimmune conditions: diffuse cutaneous systemic sclerosis (dcSSc) and difficult-to-treat rheumatoid…
- Conditions
- Diffuse Cutaneous Systemic Sclerosis, Rheumatoid Arthritis (RA), Systemic Sclerosis (SSc), Autoimmune Rheumatologic Disease
- Trial name
- CHILL (NCT07473154)
- Testing
- QEL-005
- Where
- 10 sites in Germany, Spain and 1 more
- Volunteers
- 16 people
- Sponsor
- Quell Therapeutics Limited
Graft vs Host Disease, Multiple Myeloma
Active Immunization of Sibling Bone Marrow Transplant Donors Against Purified Myeloma Protein of the Recipient Undergoing Allogeneic Bone Marrow Transplantation
Both patients and marrow donors are treated on Regimen A; patients then proceed to Regimen B. The following acronyms are used: ABM Allogeneic Bone Marrow BU Busulfan, NSC-750 CF Leucovorin calcium, NSC-3590 CTX Cyclophosphamide…
- Trial name
- NCT00001561
- Testing
- Myeloma Immunoglobulin Idiotype Vaccine-KLH, GM-CSF
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Influenza, HIV
Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults
Prospective, open-labelled study which will enrol 360 participants in four groups of 80 participants including: HIV-uninfected adults without evidence of TB; HIV-infected adults without any evidence of TB; HIV-uninfected adults…
- Conditions
- Influenza, HIV, Tuberculosis
- Trial name
- TIV_HIV_TB (NCT01811823)
- Testing
- Trivalent Inactivated Influenza Vaccine
- Where
- South Africa
- Volunteers
- 301 people
- Sponsor
- University of Witwatersrand, South Africa
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination
The reconstitution of a functioning immune system after allogeneic stem cell transplantation takes months to years. Particularly memory B-lymphocytes reconstitute poorly with the current conditioning regimes.
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia, Non Hodgkin's Lymphoma
- Trial name
- B-cell therapy (NCT02007811)
- Testing
- allogeneic donor derived B-lymphocytes
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
HIV Infections
Therapeutic Vaccination Followed by Treatment Interruption in HIV Infected Patients
The aim of this trial is to find out if immune responses to HIV can be boosted in individuals who start medicines soon after being infected.
- Trial name
- NCT00058734
- Testing
- Dendritic Cells Pulsed with HIV antigens
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Renal Transplant Recipient, Immunized Against the Cytomegalovirus
Assessing the Risk of CMV Infection of the Renal Transplant About R + by Cellular Immunity Analyzed by the QuantiFERON ®-CMV Test.
Cytomegalovirus (CMV) infection was observed in over 30% of organ recipients with high morbidity. Moreover, no prophylaxis, 75% R + D-transplanted, 55%, R + D + and D-25% R + develop CMV.
- Trial name
- QUANTIC-R+ (NCT02064699)
- Testing
- CMV Infection
- Where
- 12 sites in France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Limoges
HIV Infections
A Study of Tucaresol in HIV-Infected Patients Who Are Taking Other Anti-HIV Drugs
The purpose of this study is to see if it is safe to give tucaresol to HIV-infected patients who are taking combination anti-HIV therapy (HAART).
- Trial name
- NCT00006209
- Testing
- Tucaresol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Aaron Diamond AIDS Research Center
Chronic Lymphocytic Leukemia (CLL)
The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL
Patients with chronic lymphocytic leukemia (CLL)have had very poor humoral responses to pneumococcal polysaccharide vaccine (PPV).
- Trial name
- KLL2 (NCT00919321)
- Testing
- Pneumococcal polysaccharide vaccine (PPV)
- Where
- Finland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Cardiac Surgery
Epicardial Fat Immunity extRa Cellular vesicleS HearT
The FIRST study is a monocentric observational pilot study investigating the role of extracellular vesicles (EVs) derived from epicardial adipose tissue (EAT) in cardiovascular complications associated with obesity.
- Trial name
- FIRST (NCT07817667)
- Testing
- Epicardial adipose tissue biopsy, Thoracic subcutaneous adipose tissue biopsy
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Non-small Cell Lung Cancer
Immune Response and Safety of HS110 Vaccine in Combination With Erlotinib in Patients With Non-Small Cell Lung Cancer
This study will enroll patients with locally advanced or metastatic non-EGFR mutated Non-Small Cell Lung Cancer (NSCLC) lung cancer after failure of at least one but no more than two prior approved treatment regimens.
- Trial name
- NCT01504542
- Testing
- HS110 vaccine
- Where
- United States
- Sponsor
- Heat Biologics
Allergic Rhinitis, Allergic Inflammation
Changes in Adaptive Immune Responses and Effector Cell Responses Upon Nasal Allergen Exposure - a Pilot Study
IgE-associated allergy is a hypersensitivity disease affecting more than 25% of the population in industrialised countries. The recognition of allergen by immunoglobulin E (IgE) plays a central role in the cause of allergic…
- Trial name
- NCT03644680
- Testing
- Nasal Provocation with Birch Extract, Nasal Provocation with NaCl 0.9%
- Where
- Austria
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cutaneous T-cell Lymphoma, Sezary Syndrome
In Vitro Evaluation of Immune Responses in Cutaneous T-Cell Lymphoma (CTCL)
This is an in vitro evaluation of cutaneous T-cell lymphoma using patients' blood and tissue to evaluate immune responses related to identified tumor populations and dendritic/CD 8 cells.
- Conditions
- Cutaneous T-cell Lymphoma, Sezary Syndrome, Mycosis Fungoides
- Trial name
- NCT00177190
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Celiac Disease, Malabsorption Syndromes
Immune Responses to Gluten
This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.
- Conditions
- Celiac Disease, Malabsorption Syndromes, Digestive System Disease, Intestinal Disease
- Trial name
- NCT05209568
- Testing
- Gluten Powder
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital