Clinical trials: Immunization
Genetic Predisposition
Comparative Genetic and Immune Response Analysis of Different COVID-19 Vaccine Candidates Using Multi-OMICS Approach
Reaction of the immune system and the body to a Coronavirus-19 (COVID-19) vaccination is so different and ultimately unpredictable has not yet been clarified.
- Trial name
- COVID 19-VAC (NCT04873128)
- Testing
- Multi-OMICS
- Where
- Germany
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
HPV Infection, HPV Vaccination
Effectiveness of the Q-HPV Vaccine 9-years Post Vaccination Among HIV Positive Adolescents
The risk for Human Papillomavirus (HPV) infection persists through an individual sexual life and duration of protection is critical to vaccine effectiveness in protection from oncogenic hrHPV infection.
- Trial name
- NCT05435209
- Testing
- Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recombinant Vaccine
- Where
- Kenya
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Washington
BCG Vaccination Reaction, Infections
Long Term Effects of BCG Vaccination on Infectious and Immune Mediated Diseases
Rationale: The effects of BCG vaccination have been only sporadically studied in the elderly, and the long-term effects of the vaccination have not been studied until now.
- Conditions
- BCG Vaccination Reaction, Infections, Inflammation, COVID-19
- Trial name
- BCG-LT (NCT05387655)
- Testing
- BCG
- Where
- Netherlands
- Volunteers
- 4,292 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Primary Advanced Carcinoma of the Oral Cavity or Oropharynx, Squamous Cell Carcinoma of the Head and Neck
Active Immunization of Patients With Carcinoma of Oral Cavity or Oropharynx With Autologous Dendritic Cells Transfected With DNA From Autologous Tumor
The primary goal of this study is to determine if the vaccine can be safely given to subjects, and to see what side effects occur (both good and bad) when they are given this experimental tumor vaccine.
- Trial name
- NCT00377247
- Testing
- autologous monocyte-derived dendritic cells (DC) transfected with DNA
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pittsburgh
Vaccination, Hygiene
Microbe-Literacy Germ-Watching Workshops for Hygiene and Vaccine Acceptance in Sargodha, Pakistan
This cluster randomized controlled trial evaluated whether a single microscope-based "germ-watching" workshop, delivered by Lady Health Workers (LHWs) to mothers and female caregivers of children under three years, improves…
- Conditions
- Vaccination, Hygiene, Vaccine Hesitancy, Health Knowledge Attitudes and Practice
- Trial name
- MLI-Sargodha (NCT07771738)
- Testing
- Microbe-literacy germ-watching workshop
- Where
- Pakistan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Development Synergies International (Private) Limited
Cervical Cancer
Comparing Health Services Interventions for the Prevention of HPV-related Cancer
The study aims to identify global and local determinants of HPV vaccine acceptability, HPV vaccine uptake and compliance as well as identify logistics and programmatic issues in each country to offer the HPV vaccine, as a…
- Trial name
- CoheaHr-WP4 (NCT02837926)
- Testing
- questionnaire, Gardasil vaccine, Cervarix®
- Where
- France
- Volunteers
- 63 people
- Sponsor
- CHU de Reims
Primarily Resectable Pancreatic Cancer
Low Dose Radiation to Improve T-Cell Infiltration in Pancreatic Cancer
Principal purpose of the study is the determination of an active local external beam radiotherapy dose leading to a maximum number of tumor infiltrating T-cells.
- Trial name
- IMPACT2010 (NCT01027221)
- Testing
- neoadjuvant photon radiation
- Where
- 2 sites in Germany
- Volunteers
- 32 people
- Sponsor
- German Cancer Research Center
Vaccine Hesitancy
Difference Between Patient Vaccine Hesitancy and Perception by Their Family Physician of Their Vaccine Hesitancy
The investigators will ask to a patient and his/her family physician to complete in parallel a brief questionnaire at the beginning of the consultation: for the patient: self-evaluation of his/her vaccine hesitancy (with a 0-100…
- Trial name
- DiffHésiVac (NCT04313816)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Melanoma (Skin)
Vaccine Therapy in Treating Patients With Melanoma
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Vaccine therapy may be an effective treatment for melanoma.
- Trial name
- NCT00020358
- Testing
- aldesleukin, gp100 antigen, incomplete Freund's adjuvant
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Diphtheria, Pertussis
Booster Study of Combined Diphtheria-tetanus-acellular Pertussis Vaccine in Healthy Adults
The aim of the study is to assess the safety and immunogenicity of GlaxoSmithKline Biologicals' (formerly known as SmithKline Beecham Biologicals) combined diphtheria-tetanus-acellular pertussis vaccine in healthy adults, from…
- Conditions
- Diphtheria, Pertussis, Tetanus
- Trial name
- NCT01267058
- Testing
- GSK Biologicals' combined diphtheria, tetanus, acellular pertussis vaccine, GSK Biologicals' acellular pertussis vaccine, Commonwealth Serum Laboratories' combined diphtheria and tetanus vaccine
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19 Infection
Evaluation of an Interactive Risk Information Tool to Increase COVID-19 Vaccination Incidence in Vaccine-hesitant People
Coronavirus (COVID-19) vaccines have saved millions of lives since release and remain a key tool in the fight against the pandemic.
- Trial name
- iWILL (NCT05193903)
- Testing
- Simulation, Text
- Where
- Germany
- Volunteers
- 1,188 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Hepatitis B, HIV
Comparative Efficacy of an Intensified Re-vaccination Scheme for Hepatitis B Virus Infection Among Patients Infected With HIV .
Hepatitis B virus infection is a common occurrence among patients with HIV. Effective vaccines are available, but there's some uncertainty regarding specific dosages, specially among those who have not responded to an initial…
- Trial name
- CORE-HIV (NCT02003703)
- Testing
- Recombinant Hepatitis B Virus Vaccine
- Where
- Chile
- Volunteers
- 107 people
- Sponsor
- Universidad de Valparaiso
Malignant Melanoma, Pancreatic Cancer
Survivin Peptide Vaccination for Patients With Advanced Melanoma, Pancreatic, Colon and Cervical Cancer
This study evaluates the safety, the immunological response and the clinical outcome of a vaccination with survivin peptides for patients with advanced melanoma, pancreatic, colon and cervical carcinoma.
- Conditions
- Malignant Melanoma, Pancreatic Cancer, Colon Cancer, Cervical Cancer
- Trial name
- NCT00108875
- Testing
- Survivin peptide vaccine
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Julius-Maximilians University
Anthrax
Anthrax AV7909 Boost Evaluation Study
This randomized, phase 2, double-blinded, multicenter study is designed to assess the safety and immune response kinetics of CYFENDUS™ (henceforth AV7909) administered on 2 primary series vaccination schedules followed by 6- and…
- Trial name
- ABESt (NCT05997264)
- Testing
- AV7909 Full Dose (0.5 mL), AV7909 Half Dose (0.25 mL)
- Where
- 7 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Biomedical Advanced Research and Development Authority
Preventive Immunization; Meningitis
Immunogenicity of Quadrivalent Meningococcal Conjugate Vaccine in Frequent Platelets Donors
In this study, the investigators will evaluate the immunogenicity of a quadrivalent conjugate meningococcal vaccine in healthy, plateletpheresis donors.
- Trial name
- PLAT (NCT04224311)
- Testing
- Menactra
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Influenza
Immunogenicity and Safety Study to Assess Influenza Vaccine Formulated With Haemagglutinin (HA) Antigen From Two Suppliers
The purpose of this study is to assess the humoral immune response and safety of the parenteral formulation of the 2010/2011-season virosomal subunit influenza vaccine Inflexal V using two different HA antigen suppliers (AdImmune…
- Trial name
- NCT01229371
- Testing
- Inflexal V influenza vaccine (CSL HA Antigen) 2010, Inflexal V influenza vaccine (AdImmune HA antigen) 2010/2011
- Where
- 2 sites in Switzerland
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Older Adults Without Any Specific Clinical Condition, Social Networks
A Study to Evaluate Community-Based Measures to Increase RSV Vaccine Use Among Latino Adults
In collaboration with community-based organizations, this study will focus on increasing RSV vaccine use among Latinos. The study will determine how effective community health worker counseling and text-message approaches are to…
- Conditions
- Older Adults Without Any Specific Clinical Condition, Social Networks, RSV Immunization, Vaccine Uptake
- Trial name
- NCT07171164
- Testing
- Motivate Aim: CHW text message reminders and counseling, Motivate Aim: CHW text message reminders only, Activate Aim: CHW text message reminders and counseling
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cystic Fibrosis With Gastrointestinal Manifestation
Cohort Study Evaluating the Clinical Effectiveness, Safety and Immunogenicity to the Pandemic Influenza Vaccination
Multicenter prospective cohort of approximately 1000 cystic fibrosis patients followed in the Ile de France during the 2009-2010 influenza season with the main objective to assess the effectiveness of antiviral vaccination…
- Trial name
- MUCOFLU (NCT01499914)
- Testing
- influenza vaccination
- Where
- France
- Volunteers
- 439 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Solid Tumor, Adult
EXPLORATORY STUDY Addendum to INVAC1-CT-101 (NCT02301754)
This study will be an exploratory study of long term immunogenicity of INVAC-1 in patients who participated in the INVAC1-CT-101 phase I study (between 2014 and 2018).
- Trial name
- NCT04515043
- Testing
- INVAC-1 given in the previous phase 1 NCT02301754. No new injection is required in this study.
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Invectys
Infections, Papillomavirus
Antibody Persistence for GlaxoSmithKline (GSK) Biologicals' HPV-16/18 L1 VLP AS04 Vaccine (GSK-580299) Administered in Healthy Adults and Adolescents, 6.5 Years After First Vaccination in the Primary Study
The purpose of this study is to establish the long-term persistence of the immune response and safety of the HPV vaccine in healthy females who were aged 9 to 25 years in the primary study (NCT00541970).
- Trial name
- NCT02100618
- Testing
- Blood sampling
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline