Clinical trials: Immunologic Memory
Healthy
Transcriptomics Signature of Anti Vaccinia Memory B Cells
Analyse the transcriptomic signature of anti vaccinia memory B cells at a short time after vaccination as compared to the signature already established in long-lived memory B cells.
- Trial name
- NCT02556489
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
HIV Infections, Memory
Prevalence and Predictors of Neurocognitive Impairment Among HIV-infected Patients
Despite the advent of highly active antiretroviral therapy (HAART), the prevalence of neurocognitive impairment among HIV-infected patients continues to be an important issue.
- Trial name
- NCT00893815
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
HIV Infections
Immunologic Memory (Supp. of ATN 024)
This is an exploratory, laboratory-based evaluation of cellular immune response to immunization with hepatitis B surface antigen in HIV-infected and HIV-uninfected adolescents. This is a substudy of ATN 024 and ATN 025.
- Trial name
- NCT00142753
- Testing
- Engerix B, Twinrix for ATN 024, Recombivax
- Where
- 4 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Memory Impairment, HIV/AIDS
COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old
Despite combined antiretroviral therapy (cART), milder forms of HIV-associated neurocognitive disorders (HAND) persist in 20-50% of persons living with HIV (PLHIV).
- Conditions
- Memory Impairment, HIV/AIDS, Cognitive Impairment
- Trial name
- COGITO (NCT03268109)
- Testing
- assessment of cognitive impairment
- Where
- France
- Volunteers
- 281 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Prevention of Meningococcal Disease
Study of the Safety and Immune Response of a Meningococcal Vaccine Administered to Healthy Infants
The purpose of this study is to evaluate the safety, immunogenicity and induction of immune memory after two or three doses of Novartis (Formerly Chiron) Meningococcal ACWY Conjugate Vaccine administered to healthy infants.
- Trial name
- NCT00262002
- Testing
- MenACWY Ad- (MenACWY-CRM, non adjuvanted formulation), MenACWY Ad+ (MenACWY-CRM, adjuvanted formulation), MenACWY PS (MenACWY-CRM, polysaccharide vaccine)
- Where
- 3 sites in Canada, United Kingdom
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Head Injury
Effect of Rosuvastatin on Cytokines After Traumatic Brain Injury
The purpose of this study is to determine whether rosuvastatin could alter the immunological response after head injury by modulating TNF-alpha,IL6,IL-1.
- Trial name
- NCT00990028
- Testing
- Rosuvastatin
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Prophylaxis Pneumococcal Vaccine
Study of Immunological Memory Induced in Children by a Full 4 Dose Vaccination Schedule of 11 Valent Pneumococcal Conjugate Vaccine by Giving 1 Dose of Aventis Pasteur's 23-valent Pneumococcal Polysaccharide Vaccine (Pneumo 23)
Evaluate the immunological memory induced by 4 doses of GSK Biologicals' 11valent pneumococcal vaccine; study antibody persistence 30 months after the 4 dose vaccination with GSK Biologicals' 11-valent pneumococcal vaccine in…
- Trial name
- NCT00169507
- Testing
- Pneumococcal (vaccine)
- Where
- 4 sites in Slovakia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV-1-infection, Aging, Premature
Mental Ability Challenge Study in Adults With and Without HIV
It is estimated that by 2016, nearly 50% of HIV-positive individuals in the US will be aged 50 or older, and up to 60% of those will experience some degree of cognitive impairment as they age.
- Conditions
- HIV-1-infection, Aging, Premature, Cognitive Impairment, Memory Impairment
- Trial name
- NCT03244488
- Testing
- Scopolamine Injectable Product, Mecamylamine Pill
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
HIV
Assess the Downregulation of HIV-1 When Raltegravir is Added to a Virologically Suppressed HAART Regimen
The purpose of this study is to determine whether or not adding Raltegravir to a fully suppressive antiretroviral regimen will assist in reducing HIV-1 associated chronic inflammation and increase the t-lymphocyte memory cell…
- Trial name
- NCT00738569
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
HIV Infections
Valproic Acid and Its Effects on HIV Latent Reservoirs
The purpose of this study is to examine whether the co-administration of valproic acid (Epival®), with highly active antiretroviral therapy (HAART) can reduce the size of HIV latent reservoirs in infected CD4 cells.
- Trial name
- NCT00289952
- Testing
- Valproic Acid, HAART
- Where
- 6 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Jean-Pierre Routy
Immunogenicity, Vaccine, Immunologic Memory
Immunological Memory Against Pneumococcus Induced by 3 Infant PCV 13 Vaccination Schedules
The purpose of this study is to evaluate the establishment of immunological memory between the 3 different infant vaccination schedules with the 13-valent pneumococcal conjugate vaccine (PCV13) currently in use.
- Trial name
- NCT03405805
- Testing
- 13-valent pneumococcal conjugate vaccine (PCV13)
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aghia Sophia Children's Hospital of Athens
Prevention of Meningococcal Infection
Immunogenicity, Safety, Tolerability and Ability to Prime for Memory of Meningococcal C Conjugate Vaccine in Healthy Children
Immunogenicity, Safety, Tolerability and Ability to Prime for Memory of Meningococcal C Conjugate Vaccine in healthy children
- Trial name
- NCT00311415
- Testing
- Meningococcal C conjugate vaccine
- Where
- 2 sites in Germany, Poland
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
HIV, Pneumococcal Infections
Antibodies and Memory Cells Role After Different Pneumococcal Vaccines in HIV Adults
Streptococcus pneumoniae is a cause of high morbidity and mortality in HIV-positive subjects, representing the leading etiological agent of severe bacterial pneumonia.
- Trial name
- NCT02357823
- Testing
- Evaluation of immunological response, Nasopharyngeal swabs analysis
- Where
- 2 sites in Italy
- Sponsor
- University of Siena